{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:44:18Z","timestamp":1793065458052,"version":"4.5.0"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005297","name":"Uniwersytet Medyczny w Bialymstoku","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Biosci."],"abstract":"<jats:p>\n                    Psoriasis is one of the most common skin diseases and a crucial issue to manage in contemporary dermatology. The search for the details of its pathogenesis, markers and treatment is continuously ongoing. Our aim was to investigate the role of gasdermin B (GSDMB) in psoriasis, the second protein from the gasdermin family, involved in cell death and proliferation. GSDMB serum and urinary concentrations have never been studied in psoriatics, neither tissue expression of GSDMB by immunohistochemistry. The study included 60 psoriatic patients and 30 volunteers without dermatoses as controls. The serum and urinary GSDMB were evaluated by ELISA. Tissue expression of GSDMB was analyzed by immunohistochemistry. The serum and absolute urine concentrations of GSDMB were significantly higher in psoriatic patients than controls without skin diseases (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.0137,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.039 respectively). Urinary GSDMB\/creatinine concentration ratio was significantly lower in patients compared to controls (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.0241). The expression of GSDMB in the dermis and epidermis was significantly more prevalent in psoriatic plaque compared to the non-lesional skin and healthy skin of controls (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.0012,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.017, respectively). Serum GSDMB correlated positively with the age of patients (R = 0.41;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.001). Our study adds to the current state of knowledge about psoriasis concerning the potential involvement of GSDMB. Possibly it could be engaged in keratinocytes migration, which requires further research. Elevated serum GSDMB and decreased urinary GSDMB\/creatinine concentration ratio could potentially be investigated as psoriasis biomarkers. GSDMB could be investigated in the future as a potential therapeutic target.\n                  <\/jats:p>","DOI":"10.3389\/fmolb.2024.1382069","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T04:30:08Z","timestamp":1713328208000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Gasdermin B (GSDMB) in psoriatic patients\u2013a preliminary comprehensive study on human serum, urine and skin"],"prefix":"10.3389","volume":"11","author":[{"given":"Julia","family":"Nowowiejska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Baran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pryczynicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna Magdalena","family":"Hermanowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Sieklucka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Pawlak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwona","family":"Flisiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1001\/jama.2020.4006","article-title":"Pathophysiology, clinical presentation, and treatment of psoriasis: a review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/j.jaci.2019.09.006","article-title":"Asthma and psoriasis: what do they have in common? IL-17A","volume":"144","author":"Busse","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"E1128","DOI":"10.1073\/pnas.1616783114","article-title":"Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein","volume":"114","author":"Chao","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B4","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1093\/jmcb\/mjy056","article-title":"GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity","volume":"11","author":"Chen","year":"2019","journal-title":"J. Mol. Cell Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1159\/000500116","article-title":"Psoriasis and inflammatory bowel disease","volume":"37","author":"Cottone","year":"2019","journal-title":"Dig. Dis."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.ai.2017.06.001","article-title":"Chromosome 17q21 genes ORMDL3 and GSDMB in asthma and immune diseases","volume":"135","author":"Das","year":"2017","journal-title":"Adv. Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"3068","DOI":"10.1016\/j.jmb.2018.07.002","article-title":"Mechanisms of gasdermin family members in inflammasome signaling and cell death","volume":"430","author":"Feng","year":"2018","journal-title":"J. Mol. Biol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1080\/13547500310001599061","article-title":"Plasma transforming growth factor beta1 as a biomarker of psoriasis activity and treatment efficacy","volume":"8","author":"Flisiak","year":"2003","journal-title":"Biomarkers"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1001\/jamadermatol.2018.3631","article-title":"Association of psoriasis with inflammatory bowel disease: a systematic review and meta-analysis","volume":"154","author":"Fu","year":"2018","journal-title":"JAMA Dermatol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.3390\/ijms21041275","article-title":"Interleukin-17A and keratinocytes in psoriasis","volume":"21","author":"Furue","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B11","first-page":"97","article-title":"Current developments in the immunology of psoriasis","volume":"93","author":"Gr\u00e4n","year":"2020","journal-title":"Yale J. Biol. Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2764","DOI":"10.3390\/cells11172764","article-title":"Current understanding of asthma pathogenesis and biomarkers","volume":"11","author":"Habib","year":"2022","journal-title":"Cells"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e90099","DOI":"10.1371\/journal.pone.0090099","article-title":"Gasdermin-B promotes invasion and metastasis in breast cancer cells","volume":"9","author":"Hergueta-Redondo","year":"2014","journal-title":"PLoS One"},{"key":"B14","doi-asserted-by":"publisher","first-page":"4579","DOI":"10.1016\/j.molcel.2021.09.003","article-title":"Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity","volume":"81","author":"Hou","year":"2021","journal-title":"Mol. Cell"},{"key":"B15","first-page":"6","article-title":"Update on the pathophysiology of psoriasis","volume":"102","author":"Hugh","year":"2018","journal-title":"Cutis"},{"key":"B16","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.tcb.2022.06.006","article-title":"The enigmatic roles of epithelial gasdermin B: recent discoveries and controversies","volume":"33","author":"Ivanov","year":"2023","journal-title":"Trends Cell Biol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"e0279908","DOI":"10.1371\/journal.pone.0279908","article-title":"The study of GSDMB in pathogenesis of psoriasis vulgaris","volume":"18","author":"Ji","year":"2023","journal-title":"PLoS One"},{"key":"B18","doi-asserted-by":"publisher","first-page":"eadg3196","DOI":"10.1126\/sciimmunol.adg3196","article-title":"Alternative splicing of GSDMB modulates killer lymphocyte-triggered pyroptosis","volume":"8","author":"Kong","year":"2023","journal-title":"Sci. Immunol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"337","DOI":"10.5604\/01.3001.0014.8985","article-title":"Rodzina bia\u0142ek gazdermin jako czynnik permeabilizuj\u0105cy b\u0142on\u0119 kom\u00f3rkow\u0105 w procesie pyroptozy*","volume":"75","author":"Kuc-Ciepluch","year":"2021","journal-title":"Postepy Hig. Med. Dosw"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2581","DOI":"10.1080\/15384101.2019.1653099","article-title":"Skin immunity and its dysregulation in psoriasis","volume":"18","author":"Lanna","year":"2019","journal-title":"Cell Cycle"},{"key":"B21","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/j.jaci.2020.07.030","article-title":"Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways","volume":"147","author":"Li","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1146\/annurev-immunol-032713-120225","article-title":"Immunology of psoriasis","volume":"32","author":"Lowes","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"13047","DOI":"10.3390\/ijms241713047","article-title":"Gasdermin D (GSDMD) is upregulated in psoriatic skin\u2014a new potential link in the pathogenesis of psoriasis","volume":"24","author":"Nowowiejska","year":"","journal-title":"Int. J. Mol. Sci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.3390\/cells12172149","article-title":"Gasdermin E (GSDME)\u2014a new potential marker of psoriasis and its metabolic complications: the first combined study on human serum, urine and tissue","volume":"12","author":"Nowowiejska","year":"","journal-title":"Cells"},{"key":"B25","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1590\/abd1806-4841.20153038","article-title":"Psoriasis: classical and emerging comorbidities","volume":"90","author":"Oliveira Mde","year":"2015","journal-title":"Bras Dermatol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1038\/s41418-023-01143-y","article-title":"Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells","volume":"30","author":"Oltra","year":"2023","journal-title":"Cell Death Differ."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1016\/j.jaci.2019.03.027","article-title":"IL-17-high asthma with features of a psoriasis immunophenotype","volume":"144","author":"\u00d6stling","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1016\/j.jaci.2017.11.040","article-title":"A functional splice variant associated with decreased asthma risk abolishes the ability of gasdermin B to induce epithelial cell pyroptosis","volume":"14","author":"Panganiban","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.cell.2021.12.024","article-title":"GSDMB is increased in IBD and regulates epithelial restitution\/repair independent of pyroptosis","volume":"185","author":"Rana","year":"2022","journal-title":"Cell"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.3390\/ijms20061475","article-title":"Psoriasis pathogenesis and treatment","volume":"20","author":"Rendon","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"17018","DOI":"10.1111\/febs.17018","article-title":"Gasdermin-B (GSDMB) takes center stage in antibacterial defense, inflammatory diseases, and cancer","volume":"2023","author":"Sarrio","year":"2023","journal-title":"FEBS J."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/s41419-021-04284-5","article-title":"Inhibition of keratinocyte ferroptosis suppresses psoriatic inflammation","volume":"12","author":"Shou","year":"2021","journal-title":"Cell Death Dis."},{"key":"B33","doi-asserted-by":"publisher","first-page":"106195","DOI":"10.1016\/j.isci.2023.106195","article-title":"Inflammation modulates intercellular adhesion and mechanotransduction in human epidermis via ROCK2","volume":"26","author":"Shutova","year":"2023","journal-title":"iScience"},{"key":"B34","doi-asserted-by":"publisher","first-page":"426","DOI":"10.3390\/ijms22010426","article-title":"Switching from apoptosis to pyroptosis: gasdermin-elicited inflammation and antitumor immunity","volume":"22","author":"Tsuchiya","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/s41586-023-05832-z","article-title":"Structural basis for GSDMB pore formation and its targeting by IpaH7.8","volume":"616","author":"Wang","year":"2023","journal-title":"Nature"},{"key":"B36","unstructured":"Helsinki declaration2022"},{"key":"B37","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/s41467-022-35725-0","article-title":"Insights into the GSDMB-mediated cellular lysis and its targeting by IpaH7.8","volume":"14","author":"Yin","year":"2023","journal-title":"Nat. Commun."},{"key":"B38","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1186\/s12967-022-03566-6","article-title":"Evidence of pyroptosis and ferroptosis extensively involved in autoimmune diseases at the single-cell transcriptome level","volume":"20","author":"Zhang","year":"2022","journal-title":"J. Transl. Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"175","DOI":"10.4168\/aair.2015.7.2.175","article-title":"The association of GSDMB and ORMDL3 gene polymorphisms with asthma: a meta-analysis","volume":"7","author":"Zhao","year":"2015","journal-title":"Allergy Asthma Immunol. Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"7548","DOI":"10.1126\/science.aaz7548","article-title":"Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells","volume":"368","author":"Zhou","year":"2020","journal-title":"Science"},{"key":"B41","doi-asserted-by":"publisher","first-page":"751533","DOI":"10.3389\/fimmu.2021.751533","article-title":"The versatile gasdermin family: their function and roles in diseases","volume":"12","author":"Zou","year":"2021","journal-title":"Front. Immunol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"9154","DOI":"10.1038\/s41598-020-65689-4","article-title":"Assessing the severity of psoriasis through multivariate analysis of optical images from non-lesional skin","volume":"10","author":"\u017durauskas","year":"2020","journal-title":"Sci. Rep."}],"updated-by":[{"DOI":"10.3389\/fmolb.2026.1802468","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000}}],"container-title":["Frontiers in Molecular Biosciences"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmolb.2024.1382069\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T10:29:55Z","timestamp":1771237795000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmolb.2024.1382069\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,17]]},"references-count":42,"alternative-id":["10.3389\/fmolb.2024.1382069"],"URL":"https:\/\/doi.org\/10.3389\/fmolb.2024.1382069","relation":{},"ISSN":["2296-889X"],"issn-type":[{"value":"2296-889X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,17]]},"article-number":"1382069"}}