{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:21:34Z","timestamp":1785169294155,"version":"3.55.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Biosci."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The functions and related signal pathways of the <jats:italic>IFIT3<\/jats:italic> gene in the skin lesions of patients with psoriasis were explored through bioinformatics methods to determine the potential specific molecular markers of psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The \u201climma\u201d R package was used to analyze three datasets from the Gene Expression Omnibus database (GSE13355, GSE30999 and GSE106992), and the differential genes were screened. The STRING database was used for gene ontology (GO) enrichment analysis, Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis, and protein\u2013protein interaction network integration. Then, the <jats:italic>IFIT3<\/jats:italic> subnetwork was extracted and analyzed by gene set enrichment analysis (GSEA) using the Metascape database to verify the effectiveness of gene differentiation and disease tissue identification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this study, 426 differential genes were obtained, of which 322 were significantly upregulated and 104 were significantly downregulated. GO enrichment analysis showed that the differential genes were mainly involved in immunity and metabolism; the KEGG pathway enrichment analysis mainly included the chemokine signal pathway, PPAR signal pathway, and IL-17 signal pathway, among others. Based on the <jats:italic>IFIT3<\/jats:italic> subnetwork analysis, it was found that <jats:italic>IFIT3<\/jats:italic> was mainly involved in the biological processes of viruses, bacteria, and other microorganisms. The pathways obtained by GSEA were mainly related to immunity, metabolism, and antiviral activities. <jats:italic>IFIT3<\/jats:italic> was highly expressed in psoriatic lesions and may thus be helpful in the diagnosis of psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The differential genes, biological processes, and signal pathways of psoriasis, especially information related to and diagnostic efficiency of the <jats:italic>IFIT3<\/jats:italic> gene, were obtained by bioinformatics analysis. These results are expected to provide the theoretical basis and new directions for exploring the pathogenesis of psoriasis, in addition to helping with finding diagnostic markers and developing drug treatment targets.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmolb.2024.1439837","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T04:50:11Z","timestamp":1724302211000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Unraveling the roles of IFIT3 gene and immune-metabolic pathways in psoriasis: a bioinformatics exploration for diagnostic markers and therapeutic targets"],"prefix":"10.3389","volume":"11","author":[{"given":"Guangshan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingwu","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runtian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiao","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"802","DOI":"10.3109\/13693786.2012.678019","article-title":"Increased hydrophobicity in Malassezia species correlates with increased proinflammatory cytokine expression in human keratinocytes","volume":"50","author":"Akaza","year":"2012","journal-title":"Med. Mycol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1177\/0956462419827673","article-title":"Psoriasis in HIV infection: an update","volume":"30","author":"Alpalh\u00e3o","year":"2019","journal-title":"Int. J. STD AIDS"},{"key":"B3","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1684\/ejd.2009.0663","article-title":"High prevalence of staphylococcus aureus cultivation and superantigen production in patients with psoriasis","volume":"19","author":"Balci","year":"2009","journal-title":"Eur. J. Dermatol"},{"key":"B4","first-page":"958","article-title":"Toll-like receptor (TLR) 2 is upregulated on peripheral blood monocytes of patients with psoriatic arthritis: a role for a gram-positive inflammatory trigger?","volume":"29","author":"Carrasco","year":"2011","journal-title":"Clin. Exp. Rheumatol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"e12806","DOI":"10.1111\/dth.12806","article-title":"HIV-associated psoriasis: epidemiology, pathogenesis, and management","volume":"32","author":"Ceccarelli","year":"2019","journal-title":"Dernatol Ther."},{"key":"B6","first-page":"23","article-title":"Psoriasis and depression","volume":"36","author":"Chamoun","year":"2015","journal-title":"Rev. Med. Brux"},{"key":"B7","doi-asserted-by":"publisher","first-page":"J314","DOI":"10.1016\/j.jaut.2009.12.001","article-title":"Geoepidemiology and environmental factors of psoriasis and psoriatic arthritis","volume":"34","author":"Chandran","year":"2010","journal-title":"J. Autoimmun."},{"key":"B8","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1046\/j.1365-2133.2001.04143.x","article-title":"Cytokine gene polymorphisms in psoriasis","volume":"144","author":"Craven","year":"2001","journal-title":"Br. J. Dermatol"},{"key":"B9","article-title":"The igraph software package for complex network research","volume":"1695","author":"Csardi","year":"2006","journal-title":"InterJournal Complex Syst."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e79518","DOI":"10.1371\/journal.pone.0079518","article-title":"Protective roles of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) in dengue virus infection of human lung epithelial cells","volume":"8","author":"Hsu","year":"2013","journal-title":"PLoS One"},{"key":"B11","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1056\/NEJM198511283132210","article-title":"AIDS exacerbates psoriasis","volume":"313","author":"Johnson","year":"1985","journal-title":"N. Engl. J. Med."},{"key":"B12","article-title":"Ggpubr: \u2018ggplot2\u2019 based publication ready plots","author":"Kassambara","year":"2020","journal-title":"R. package"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1038\/jid.2014.28","article-title":"Transcriptome analysis of psoriasis in a large case-control sample: RNAseq provides insights into disease mechanisms","volume":"134","author":"Li","year":"2014","journal-title":"J. Invest Dermatol"},{"key":"B14","first-page":"296","article-title":"Treatment of acute guttate psoriasis with rifampicin","volume":"66","author":"Masood","year":"2000","journal-title":"Indian J. Dermatol Venereol. Leprol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1111\/bjd.15366","article-title":"Risks for Staphylococcus aureus colonization in patients with psoriasis: a systematic review and meta-analysis","volume":"177","author":"Ng","year":"2017","journal-title":"Br. J. Dermatol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1017\/s0022215100082694","article-title":"Improvement of recalcitrant psoriasis vulgaris after tonsillectomy","volume":"90","author":"Nyfors","year":"1976","journal-title":"J. Laryngol. Otol."},{"key":"B17","first-page":"1326","article-title":"Predicting biomedical metadata in CEDAR:a study of gene exppression Omnibus(GEO)","volume":"72","author":"Panahiazar","year":"2017","journal-title":"J Biomed form"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinforma."},{"key":"B20","doi-asserted-by":"publisher","first-page":"118484","DOI":"10.1016\/j.jep.2024.118484","article-title":"Er-Dong-Xiao-Ke decoction regulates lipid metabolism via PPARG-mediated UCP2\/AMPK signaling to alleviate diabetic meibomian gland dysfunction","volume":"333","author":"Shi","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s13578-024-01246-0","article-title":"TAZ deficiency exacerbates psoriatic pathogenesis by increasing the histamine-releasing factor","volume":"14","author":"Song","year":"2024","journal-title":"Cell Biosci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.it.2009.07.008","article-title":"Psoriasis\u2014\u2014as an autoimmune disease caused by molecular mimicry","volume":"30","author":"Valdimarsson","year":"2009","journal-title":"Trends Immunol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"200","DOI":"10.7150\/ijbs.5613","article-title":"Interferon induced IFIT family genes in host antiviral defense","volume":"9","author":"Xiang","year":"2013","journal-title":"Int. J. Biol. Sci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1002\/hep.29156","article-title":"Hepatic IFIT3 predicts interferon-\u03b1 therapeutic response in patients of hepatocellular carcinoma","volume":"66","author":"Yang","year":"2017","journal-title":"Hepatology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Yingyao","year":"2019","journal-title":"Nat. Commun."},{"key":"B26","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1002\/hep.29156","article-title":"Hepatic IFIT3 predicts interferon-\u03b1 therapeutic response in patients of hepatocellular carcinoma","volume":"66","author":"Ying-yun","year":"2017","journal-title":"Hepatology"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-2090873\/v1","article-title":"Identification of IFIT3 as potential biomarker in Psoriasis based on integrated bioinformatics analysis","author":"Zhang","year":"","journal-title":"Res. Square"},{"key":"B28","doi-asserted-by":"publisher","first-page":"e28259","DOI":"10.1002\/jmv.28259","article-title":"The emerging roles of IFIT3 in antiviral innate immunity and cellular biology","volume":"95","author":"Zhang","year":"2023","journal-title":"J. Med. Virol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1388690","DOI":"10.3389\/fimmu.2024.1388690","article-title":"Discovery of biomarkers in the psoriasis through machine learning and dynamic immune infiltration in three types of skin lesions","volume":"15","author":"Zhou","year":"2024","journal-title":"Front. Immunol."}],"container-title":["Frontiers in Molecular Biosciences"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmolb.2024.1439837\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T04:50:19Z","timestamp":1724302219000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmolb.2024.1439837\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,22]]},"references-count":29,"alternative-id":["10.3389\/fmolb.2024.1439837"],"URL":"https:\/\/doi.org\/10.3389\/fmolb.2024.1439837","relation":{},"ISSN":["2296-889X"],"issn-type":[{"value":"2296-889X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,22]]},"article-number":"1439837"}}