{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:59:00Z","timestamp":1793649540308,"version":"4.5.1"},"reference-count":126,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Biosci."],"abstract":"<jats:p>\n                    Salvia is a genus of Lamiaceae family with more than 1,000 species having diverse utility. The wide range of uses encompasses food, flavor, cosmetics, aromatherapy, horticulture, and medicine. It has been attributed to the presence of bioactive compounds belonging to essential oils, phenolic compounds, and flavonoids that are extensively studied using spectroscopic and chromatographic techniques. This review aims to investigate in-depth previously published literature from 2020 to 2025 on 59\n                    <jats:italic>Salvia<\/jats:italic>\n                    species. It was performed with several key search words focused on the chemical compounds in\n                    <jats:italic>Salvia<\/jats:italic>\n                    spp. and their pharmacological efficacy.\n                    <jats:italic>Salvia<\/jats:italic>\n                    species were enriched with essential oils comprising important components:\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -pinene,\n                    <jats:italic>\u03b2<\/jats:italic>\n                    -pinene, limonene, linalool, caryophyllene, germacrene, myrcene,\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -thujone, and humulene. Potential health benefits owing to anticancer, antioxidant, antidiabetic, anti-inflammatory, antithrombotic, antirheumatic, and antiviral properties were reported from\n                    <jats:italic>Salvia<\/jats:italic>\n                    species.\n                    <jats:italic>Salvia<\/jats:italic>\n                    phytochemicals have been studied as regulating anticancer mechanisms at the cellular level by effectively modulating host cell responses in multiple ways. This review summarizes and discusses recent studies on the metabolite profiling of\n                    <jats:italic>Salvia<\/jats:italic>\n                    plants and bioactivities of the extracts and compounds. It may provide future perspectives on the\n                    <jats:italic>in silico<\/jats:italic>\n                    and pharmacognostic studies on potent\n                    <jats:italic>Salvia<\/jats:italic>\n                    compounds. Isolation and evaluation of bioactive compounds from the least studied species is recommended.\n                  <\/jats:p>","DOI":"10.3389\/fmolb.2025.1678109","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T06:44:55Z","timestamp":1765349095000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Bioactive chemical composition and pharmacological insights into Salvia species"],"prefix":"10.3389","volume":"12","author":[{"given":"Tayyiba","family":"Afzal","sequence":"first","affiliation":[{"name":"Department of Plant Biology, Institute of Biology, Wroc\u0142aw University of Environmental and Life Sciences","place":["Wroc\u0142aw, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaros\u0142aw","family":"Pro\u0107k\u00f3w","sequence":"additional","affiliation":[{"name":"Department of Plant Biology, Institute of Biology, Wroc\u0142aw University of Environmental and Life Sciences","place":["Wroc\u0142aw, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"\u0141yczko","sequence":"additional","affiliation":[{"name":"Department of Food Chemistry and Biocatalysis, Wroc\u0142aw University of Environmental and Life Sciences","place":["Wroc\u0142aw, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3042","DOI":"10.3390\/molecules26103042","article-title":"Bioactive components of salvia and their potential antidiabetic properties: a review","volume":"26","author":"Abd Rashed","year":"2021","journal-title":"Molecules"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.3390\/plants12051062","article-title":"UPLC-ESI-MS\/MS profiling and cytotoxic, antioxidant, anti-inflammatory, antidiabetic, and antiobesity activities of the non-polar fractions of Salvia hispanica L. aerial parts","volume":"12","author":"Abdel Ghani","year":"2023","journal-title":"Plants"},{"key":"B3","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/B978-0-12-819485-0.00017-7","article-title":"Biologically active compounds from lamiaceae family: central nervous system effects","volume":"68","author":"Abdelhalim","year":"2021","journal-title":"Stud. Nat. Prod. Chem."},{"key":"B4","doi-asserted-by":"publisher","first-page":"9365","DOI":"10.3390\/app11209365","article-title":"Salvia species as nutraceuticals: focus on antioxidant, antidiabetic and anti-obesity properties","volume":"11","author":"Afonso","year":"2021","journal-title":"Appl. Sci."},{"key":"B5","unstructured":"Chemical composition of the essential oil of Salvia verbenaca (L.) briq. ssp. Pseudo-jaminiana\n          \n          \n            \n              Aissaoui\n              M.\n            \n            \n              Chalard\n              P.\n            \n            \n              Figu\u00e9r\u00e9do\n              G.\n            \n            \n              Marchioni\n              E.\n            \n            \n              Zao MintJe\n              Z. M.\n            \n            \n              Benayache\n              F.\n            \n          \n          \n          2014"},{"key":"B6","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.sajb.2024.04.044","article-title":"Sage (Salvia officinalis L.): a botanical marvel with versatile pharmacological properties and sustainable applications in functional foods","volume":"169","author":"Akacha","year":"2024","journal-title":"South Afr. J. Bot."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1007\/s42250-025-01240-0","article-title":"Investigation of the bioactive properties of Tunisian sage extracts: a detailed analysis of phytochemical composition and their antioxidant, antibacterial, and antibiofilm activities","volume":"8","author":"Akrimi","year":"2025","journal-title":"Chem. Afr."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2844880","DOI":"10.1155\/2022\/2844880","article-title":"Antioxidant, antidiabetic, and antibacterial potentials and chemical composition of Salvia officinalis and Mentha suaveolens grown wild in Morocco","volume":"2022","author":"Al-Mijalli","year":"2022","journal-title":"Adv. Pharmacol. Pharm. Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1007\/s11101-024-09987-z","article-title":"Exploring Lamiaceae-derived bioactive compounds as nature\u2019s arsenal for sustainable pest management","volume":"24","author":"Ali","year":"2024","journal-title":"Phytochem. Rev."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.3390\/plants12061247","article-title":"Advances in the phytochemical characterisation and bioactivities of Salvia aurea L. Essential Oil","volume":"12","author":"Alves-Silva","year":"2023","journal-title":"Plants"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e1900553","DOI":"10.1002\/cbdv.201900553","article-title":"Aroma profile of two populations of Salvia verbenaca collected from two bio\u2010geographical zones from Jordan","volume":"17","author":"Al\u2010Jaber","year":"2020","journal-title":"Chem. Biodivers."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.2174\/0115680266248117230922095003","article-title":"Ethnopharmacology, nutritional value, therapeutic Effects,Phytochemistry, and toxicology of Salvia hispanica L.: a review","volume":"23","author":"Amtaghri","year":"2023","journal-title":"Curr. Top. Med. Chem."},{"key":"B13","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1186\/s12906-024-04499-x","article-title":"Ethnomedicine, antibacterial activity, antioxidant potential and phytochemical screening of selected medicinal plants in Dibatie district, Metekel zone, western Ethiopia","volume":"24","author":"Anbessa","year":"2024","journal-title":"BMC Complement. Med. Ther."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.37929\/nveo.852794","article-title":"A review on the essential oil chemical profile of Salvia genus from Iran","volume":"8","author":"Asgarpanah","year":"2021","journal-title":"Nat. Volatiles Essent. Oils"},{"key":"B15","doi-asserted-by":"publisher","first-page":"5949","DOI":"10.53730\/ijhs.v6ns5.10007","article-title":"Ethnopharmacological importance of Salvia hispanica L.: an herbal panacia","volume":"6","author":"Ashish","year":"2022","journal-title":"Int. J. Health Sci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"975","DOI":"10.3390\/ph17080975","article-title":"High-altitude medicinal plants as promising source of phytochemical antioxidants to combat lifestyle-associated oxidative stress-induced disorders","volume":"17","author":"Ashraf","year":"2024","journal-title":"Pharmaceuticals"},{"key":"B17","doi-asserted-by":"publisher","first-page":"112619","DOI":"10.1016\/j.phytochem.2020.112619","article-title":"Iranian Salvia species: a phytochemical and pharmacological update","volume":"183","author":"Askari","year":"2021","journal-title":"Phytochemistry"},{"key":"B18","doi-asserted-by":"publisher","first-page":"5157","DOI":"10.3390\/molecules27165157","article-title":"Chemical analysis and investigation of biological effects of Salvia officinalis essential oils at three phenological stages","volume":"27","author":"Assaggaf","year":"2022","journal-title":"Molecules"},{"key":"B19","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s13065-020-00728-9","article-title":"Phytochemical constituents and biological activities of Salvia macrosiphon Boiss","volume":"15","author":"Balaei-Kahnamoei","year":"2021","journal-title":"BMC Chem."},{"key":"B20","doi-asserted-by":"publisher","first-page":"4921","DOI":"10.1080\/14786419.2021.1912745","article-title":"A new diterpene and other constituents of Salvia multicaulis from Jordan","volume":"36","author":"Barhoumi","year":"2022","journal-title":"Nat. Prod. Res."},{"key":"B21","unstructured":"Chemical composition of the essential oil of Salvia verbenaca (L.) Briq. ssp. clandestina (L.) Pugsl\n          \n          \n            \n              Belloum\n              Z.\n            \n            \n              Chalard\n              P.\n            \n            \n              Figu\u00e9r\u00e9do\n              G.\n            \n            \n              Marchioni\n              E.\n            \n            \n              Zao\n              M.\n            \n            \n              Benayache\n              F.\n            \n          \n          \n          2014"},{"key":"B22","doi-asserted-by":"publisher","first-page":"e70118","DOI":"10.1002\/fsn3.70118","article-title":"Pharmacological potential and bioactive components of wild anatolian sage (Salvia aethiopis L.)","volume":"13","author":"Bilgino\u011flu","year":"2025","journal-title":"Food Sci. Nutr."},{"key":"B23","doi-asserted-by":"publisher","first-page":"e06986","DOI":"10.1016\/j.heliyon.2021.e06986","article-title":"Antidiabetic, anticholinergic and antioxidant activities of aerial parts of shaggy bindweed (Convulvulus betonicifolia Miller subsp.)\u2013profiling of phenolic compounds by LC-HRMS","volume":"7","author":"Bingol","year":"2021","journal-title":"Heliyon"},{"key":"B24","doi-asserted-by":"publisher","first-page":"988","DOI":"10.2174\/1381612829666230809094242","article-title":"Medicinal plant-derived phytochemicals in detoxification","volume":"30","author":"Bj\u00f8rklund","year":"2024","journal-title":"Curr. Pharm. Des."},{"key":"B25","first-page":"349","article-title":"Biochemical potential of Salvia sclarea L.: in vitro cultivation and chemical profiling approaches","volume":"28","author":"Bojan","year":"2024","journal-title":"J. Hortic. For. Biotechnol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"116","DOI":"10.3390\/ph14020116","article-title":"Pharmacokinetics and pharmacodynamics of salvinorin A and Salvia divinorum: clinical and forensic aspects","volume":"14","author":"Brito-da-Costa","year":"2021","journal-title":"Pharmaceuticals"},{"key":"B27","doi-asserted-by":"publisher","first-page":"e5975","DOI":"10.1002\/bmc.5975","article-title":"Comprehensive phytochemical analysis of Salvia hispanica L. callus extracts using LC\u2013MS\/MS","volume":"38","author":"\u00c7elik","year":"2024","journal-title":"Biomed. Chromatogr."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2394","DOI":"10.3390\/molecules29102394","article-title":"Bioactive compounds from medicinal plants as potential adjuvants in the treatment of mild Acne vulgaris","volume":"29","author":"Cristani","year":"2024","journal-title":"Molecules"},{"key":"B29","first-page":"65","article-title":"Salvia aristata essential oil: chemical composition, cholinesterase inhibition, and neuroprotective effects against oxidative stress in PC12 cells","volume":"12","author":"Dabaghian","year":"2025","journal-title":"Res. J. Pharmacogn."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2438069","DOI":"10.1080\/17518253.2024.2438069","article-title":"Phytochemical screening and evaluation of anti-oxidant, anti-inflammatory and anticancer activities of leaves of Vernonia amygdalina, Otostegia integrifolia, and Salvia rosmarinus","volume":"18","author":"Dejene","year":"2025","journal-title":"Green Chem. Lett. Rev."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.3390\/foods14111893","article-title":"The application of natural phenolic substances as antimicrobial agents in agriculture and food industry","volume":"14","author":"Dembi\u0144ska","year":"2025","journal-title":"Foods"},{"key":"B32","doi-asserted-by":"publisher","first-page":"634","DOI":"10.3390\/life13030634","article-title":"Essential oil composition analysis, antimicrobial activities, and biosystematic studies on six species of Salvia","volume":"13","author":"Demirpolat","year":"2023","journal-title":"Life"},{"key":"B33","doi-asserted-by":"publisher","first-page":"5948","DOI":"10.1093\/jxb\/eraa295","article-title":"ABA-responsive transcription factor bZIP1 is involved in modulating biosynthesis of phenolic acids and tanshinones in Salvia miltiorrhiza","volume":"71","author":"Deng","year":"2020","journal-title":"J. Exp. Bot."},{"key":"B34","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1201\/9781003281702-27","article-title":"Phytochemistry and Pharmacology of Salvia officinalis L.: a review","author":"Deshmukh","year":"2022","journal-title":"Bioact. Pharmacol. Med. Plants"},{"key":"B35","doi-asserted-by":"publisher","first-page":"171","DOI":"10.3390\/ph16020171","article-title":"A focused review on cognitive improvement by the genus Salvia L.(Sage)\u2014From ethnopharmacology to clinical evidence","volume":"16","author":"Ertas","year":"2023","journal-title":"Pharmaceuticals"},{"key":"B36","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.3390\/agronomy12102455","article-title":"Diversity of chemical composition and morphological traits of eight Iranian wild Salvia species during the first step of domestication","volume":"12","author":"Esmaeili","year":"2022","journal-title":"Agronomy"},{"key":"B37","doi-asserted-by":"publisher","first-page":"e08763","DOI":"10.1016\/j.heliyon.2022.e08763","article-title":"Therapeutic benefits of Salvia species: a focus on cancer and viral infection","volume":"8","author":"Ezema","year":"2022","journal-title":"Heliyon"},{"key":"B38","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1007\/s13596-023-00726-x","article-title":"Salvia africana-lutea L.: a review of ethnobotany, phytochemistry, pharmacology applications and future prospects","volume":"24","author":"Ezema","year":"2024","journal-title":"Adv. Tradit. Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"5811","DOI":"10.3390\/ma13245811","article-title":"Identification of phenolic compounds and determination of antioxidant activity in extracts and infusions of Salvia leaves","volume":"13","author":"Francik","year":"2020","journal-title":"Materials"},{"key":"B40","doi-asserted-by":"publisher","first-page":"104889","DOI":"10.1016\/j.fbio.2024.104889","article-title":"Comparative analysis of the nutritional composition, phytochemicals, and antioxidant activity of chia seeds, flax seeds, and psyllium husk","volume":"61","author":"Gebremeskal","year":"2024","journal-title":"Food Biosci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1186\/s12906-023-04004-w","article-title":"Chemical composition, cholinesterase, and \u03b1-glucosidase inhibitory activity of the essential oils of some Iranian native Salvia species","volume":"23","author":"Gharehbagh","year":"2023","journal-title":"BMC Complement. Med. Ther."},{"key":"B42","doi-asserted-by":"publisher","first-page":"15647","DOI":"10.1038\/s41598-020-73193-y","article-title":"Chemical composition and antimicrobial activity of essential oils obtained from leaves and flowers of Salvia hydrangea DC. ex Benth","volume":"10","author":"Ghavam","year":"2020","journal-title":"Sci. Rep."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.3390\/plants9121645","article-title":"Tools to tie: flower characteristics, voc emission profile, and glandular trichomes of two mexican Salvia species to attract bees","volume":"9","author":"Giuliani","year":"2020","journal-title":"Plants"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.3390\/chemistry4040115","article-title":"Comparative analysis of the chemical composition and antimicrobial activity of four Moroccan north middle Atlas medicinal plants\u2019 essential oils: rosmarinus officinalis L., Mentha pulegium L., Salvia officinalis L., and Thymus zygis subsp. gracilis (Boiss.) R. Morales","volume":"4","author":"Gourich","year":"2022","journal-title":"Rosmarinus Officinalis L. Morales."},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2020.1758093","article-title":"Angiotensin-converting enzyme inhibitors from Salvia elegans Vahl","author":"Guti\u00e9rrez-Rom\u00e1n","year":"2022","journal-title":"Nat. Prod. Res"},{"key":"B46","first-page":"245","volume-title":"An overview of bioactive constituents and pharmacological actions of iranian sage","author":"Hadkar","year":"2023"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.3390\/molecules27031128","article-title":"Uncommon terpenoids from Salvia species: chemistry, biosynthesis and biological activities","volume":"27","author":"Hafez Ghoran","year":"2022","journal-title":"Molecules"},{"key":"B48","doi-asserted-by":"publisher","first-page":"117022","DOI":"10.1016\/j.jep.2023.117022","article-title":"Adjuvant role of Salvia miltiorrhiza bunge in cancer chemotherapy: a review of its bioactive components, health-promotion effect and mechanisms","volume":"318","author":"Huang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"9637","DOI":"10.1007\/s13762-024-05613-9","article-title":"Biogenic gold nanoparticles of Salvia species in dyes degradation and detection of lead(II)","volume":"21","author":"Ihsan","year":"2024","journal-title":"Int. J. Environ. Sci. Technol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"859","DOI":"10.3390\/ph17070859","article-title":"Salvia verticillata (L.)\u2014Biological activity, chemical profile, and future perspectives","volume":"17","author":"Ivanova","year":"2024","journal-title":"Pharmaceuticals"},{"key":"B51","doi-asserted-by":"publisher","first-page":"e15854","DOI":"10.14814\/phy2.15854","article-title":"Salvia officinalis flowers extract ameliorates liver and kidney injuries induced by simultaneous intoxication with ethanol\/castor oil","volume":"11","author":"Jedidi","year":"2023","journal-title":"Physiol. Rep."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1080\/14786419.2022.2096605","article-title":"Structural characterisation and antioxidant activities in vitro and in vivo of a novel polysaccharide from Salvia miltiorrhiza","volume":"37","author":"Jing","year":"2023","journal-title":"Nat. Prod. Res."},{"key":"B53","doi-asserted-by":"publisher","first-page":"5179","DOI":"10.3390\/ijms24065179","article-title":"Salvia sclarea essential oil chemical composition and biological activities","volume":"24","author":"Ka\u010d\u00e1niov\u00e1","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"6436","DOI":"10.3390\/ijms26136436","article-title":"Taxonomy, phylogeny, genomes, and repeatomes in the subgenera Salvia, Sclarea, and Glutinaria (Salvia, Lamiaceae)","volume":"26","author":"Kalnyuk","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.2174\/012772574X350275241230053727","article-title":"Therapeutic potential of plant phenolic acids combating cancer drug resistance","volume":"16","author":"Kapil","year":"2025","journal-title":"Recent Adv. Food Nutr. Agric."},{"key":"B56","doi-asserted-by":"publisher","first-page":"5638","DOI":"10.1007\/s11694-024-02594-8","article-title":"Phytochemical contents and bioactivity of four endemic Salvia seeds from Turkey: a comparative study to chia seed","volume":"18","author":"Karadeniz-Pekg\u00f6z","year":"2024","journal-title":"J. Food Meas. Charact."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.3390\/molecules28041739","article-title":"Comprehensive metabolite profiling of Berdav propolis using LC-MS\/MS: determination of antioxidant, anticholinergic, antiglaucoma, and antidiabetic effects","volume":"28","author":"Karagecili","year":"2023","journal-title":"Molecules"},{"key":"B58","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.sajb.2023.12.019","article-title":"Untargeted metabolite profiling: a comprehensive study using data analysis workflow in Salvia L. species (Lamiaceae)","volume":"165","author":"Kharazian","year":"2024","journal-title":"South Afr. J. Bot."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.33263\/BRIAC122.14371469","article-title":"Ethnomedicinal use, phytochemistry, pharmacology, and toxicology of Salvia verbenaca L.: a review","volume":"12","author":"Khouchlaa","year":"2021","journal-title":"Biointerface Res. Appl. Chem."},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.25135\/rnp.370.2210.2598","article-title":"Analysis of phenolic compounds by LC-HRMS and determination of antioxidant and enzyme inhibitory properties of Verbascum speciousum schrad","volume":"17","author":"K\u0131z\u0131lta\u015f","year":"2023","journal-title":"Rec. Nat. Prod."},{"key":"B61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.62313\/ijpbp.2022.8","article-title":"Chemical composition and cholinesterase, tyrosinase, alpha-amylase and alpha-glucosidase inhibitory activity of the essential oil of Salvia tomentosa","volume":"2","author":"Ko\u00e7er","year":"2022","journal-title":"Int. J. Plant Based Pharm."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1034455","DOI":"10.3389\/fcell.2023.1034455","article-title":"Effects of Salvia miltiorrhiza active compounds on placenta-mediated pregnancy complications","volume":"11","author":"Kong","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1055\/a-1453-0964","article-title":"White sage (Salvia apiana)\u2013a ritual and medicinal plant of the chaparral: plant characteristics in comparison with other Salvia species","volume":"88","author":"Krol","year":"2022","journal-title":"Planta Med."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1216199","DOI":"10.3389\/fphar.2024.1216199","article-title":"Salvia officinalis L. exerts oncostatic effects in rodent and in vitro models of breast carcinoma","volume":"15","author":"Kubatka","year":"2024","journal-title":"Front. Pharmacol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"798","DOI":"10.3390\/plants9060798","article-title":"The essential oil of Salvia rosmarinus Spenn. from Italy as a source of health-promoting compounds: chemical profile and antioxidant and cholinesterase inhibitory activity","volume":"9","author":"Leporini","year":"2020","journal-title":"Plants"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.3390\/molecules30051142","article-title":"A review of botany, phytochemistry, and biological activities of eight salvia species widespread in Kazakhstan","volume":"30","author":"Levaya","year":"2025","journal-title":"Molecules"},{"key":"B67","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.ijbiomac.2021.08.112","article-title":"Targeted mutagenesis of CYP76AK2 and CYP76AK3 in Salvia miltiorrhiza reveals their roles in tanshinones biosynthetic pathway","volume":"189","author":"Li","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"3129","DOI":"10.1002\/jcp.26150","article-title":"Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction","volume":"233","author":"Lim","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1093\/mutage\/geaa021","article-title":"Toxicogenetic and antiproliferative effects of chrysin in urinary bladder cancer cells","volume":"35","author":"Lima","year":"2020","journal-title":"Mutagenesis"},{"key":"B70","doi-asserted-by":"publisher","first-page":"106812","DOI":"10.1016\/j.phrs.2023.106812","article-title":"Phenolic metabolites as therapeutic in inflammation and neoplasms: molecular pathways explaining their efficacy","volume":"193","author":"Liu","year":"2023","journal-title":"Pharmacol. Res."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.3390\/antiox12081514","article-title":"Chemical profile and bioactivity evaluation of Salvia species from Eastern Europe","volume":"12","author":"Luca","year":"2023","journal-title":"Antioxidants"},{"key":"B72","doi-asserted-by":"publisher","first-page":"106309","DOI":"10.1016\/j.actatropica.2022.106309","article-title":"Antileishmanial potential of species from the family Lamiaceae: chemical and biological aspects of non-volatile compounds","volume":"228","author":"Maciel","year":"2022","journal-title":"Acta Trop."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.3390\/antiox11061140","article-title":"Non-volatile and volatile bioactives of Salvia officinalis L., Thymus serpyllum L. and Laurus nobilis L. extracts with potential use in the development of functional beverages","volume":"11","author":"Male\u0161","year":"2022","journal-title":"Antioxidants"},{"key":"B74","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1002\/tax.12818","article-title":"Hiding in plain sight: integrative analyses uncover a cryptic salvia species in Europe","volume":"72","author":"M\u00e1tis","year":"2023","journal-title":"TAXON"},{"key":"B75","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.bjp.2017.01.009","article-title":"Cytotoxic diterpenoids from the roots of Salvia lachnocalyx","volume":"27","author":"Mirzaei","year":"2017","journal-title":"Rev. Bras. Farmacogn."},{"key":"B76","doi-asserted-by":"publisher","first-page":"85","DOI":"10.22037\/ijpr.2019.15429.13095","article-title":"Diterpenoids from roots of Salvia lachnocalyx; in-silico and in-vitro toxicity against human cancer cell lines","volume":"19","author":"Mirzaei","year":"2020","journal-title":"Iran. J. Pharm. Res. IJPR"},{"key":"B77","doi-asserted-by":"publisher","first-page":"0","DOI":"10.21608\/ejchem.2024.303803.10000","article-title":"Phytochemical profiling, cytotoxicity and anti-inflammatory potential of Salvia hispanica L. seeds","volume":"67","author":"Mohamed","year":"2024","journal-title":"Egypt. J. Chem."},{"key":"B78","doi-asserted-by":"publisher","first-page":"7801","DOI":"10.3390\/molecules28237801","article-title":"In vitro antibacterial, antioxidant, anticholinesterase, and antidiabetic activities and chemical composition of Salvia balansae","volume":"28","author":"Mokhtar","year":"2023","journal-title":"Molecules"},{"key":"B79","doi-asserted-by":"publisher","first-page":"32064","DOI":"10.1038\/s41598-024-83756-y","article-title":"Screening of native wild Salvia nemorosa populations for chemical compositions, antioxidant activity and UHPLC-HRMS profiling","volume":"14","author":"Moshari-Nasirkandi","year":"2024","journal-title":"Sci. Rep."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.3390\/molecules27041207","article-title":"The current state of knowledge on Salvia hispanica and Salviae hispanicae semen (chia seeds)","volume":"27","author":"Motyka","year":"2022","journal-title":"Molecules"},{"key":"B81","doi-asserted-by":"publisher","first-page":"3787818","DOI":"10.1155\/2022\/3787818","article-title":"Phytochemistry and biological properties of Salvia verbenaca L.: a comprehensive review","volume":"2022","author":"Mrabti","year":"2022","journal-title":"Biomed. Res. Int."},{"key":"B82","doi-asserted-by":"publisher","first-page":"22309","DOI":"10.1038\/s41598-023-49695-w","article-title":"Phytochemical screening and biological evaluation of Greek sage (Salvia fruticosa Mill.) extracts","volume":"13","author":"Mr\u00f3z","year":"2023","journal-title":"Sci. Rep."},{"key":"B83","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.ejbt.2024.12.002","article-title":"Antioxidant, and enzyme inhibition effects of chia (Salvia hispanica) seed oil: a comprehensive phytochemical screening using LC-HR\/MS","volume":"74","author":"Mutlu","year":"2025","journal-title":"Electron. J. Biotechnol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"107076","DOI":"10.1016\/j.phrs.2024.107076","article-title":"Mitigation of sciatica injury-induced neuropathic pain through active metabolites derived from medicinal plants","volume":"200","author":"Nasir","year":"2024","journal-title":"Pharmacol. Res."},{"key":"B85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-319-73900-7_1","article-title":"European species of Genus salvia: distribution, chemodiversity and biological activity","volume-title":"Salvia biotechnology","author":"Nikolova","year":"2017"},{"key":"B86","doi-asserted-by":"publisher","first-page":"e70012","DOI":"10.1002\/efd2.70012","article-title":"Exploring the chemical composition and biological effects of four salvia hybrids: an innovative perspective on functional yields","volume":"5","author":"Nilofar","year":"2024","journal-title":"eFood"},{"key":"B87","doi-asserted-by":"publisher","first-page":"104950","DOI":"10.1016\/j.jff.2022.104950","article-title":"Metabolomics combined with systematic pharmacology reveals the therapeutic effects of Salvia miltiorrhiza and Radix Pueraria lobata herb pair on type 2 diabetes rats","volume":"89","author":"Niu","year":"2022","journal-title":"J. Funct. Foods"},{"key":"B88","doi-asserted-by":"publisher","first-page":"e127031","DOI":"10.5812\/ijpr-127031","article-title":"Phytochemical analysis and biological activity of Salvia compressa Vent","volume":"21","author":"Noorbakhsh","year":"2022","journal-title":"Iran. J. Pharm. Res. IJPR"},{"key":"B89","doi-asserted-by":"publisher","first-page":"35","DOI":"10.53388\/tmr20201027204","article-title":"Traditional Chinese medicine of Salvia miltiorrhiza Bunge: a review of phytochemistry, pharmacology and pharmacokinetics","volume":"6","author":"Nwafor","year":"2021","journal-title":"Tradit. Med. Res."},{"key":"B90","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1080\/10942912.2022.2157425","article-title":"Antioxidant, phytochemical, and therapeutic properties of medicinal plants: a review","volume":"26","author":"Nwozo","year":"2023","journal-title":"Int. J. Food Prop."},{"key":"B91","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.sajb.2022.07.030","article-title":"The characterization of phenolic compounds via LC-ESI-MS\/MS, antioxidant, enzyme inhibitory activities of Salvia absconditiflora, Salvia sclarea, and Salvia palaestina: a comparative analysis","volume":"150","author":"Onder","year":"2022","journal-title":"South Afr. J. Bot."},{"key":"B92","doi-asserted-by":"publisher","first-page":"867892","DOI":"10.3389\/fphar.2022.867892","article-title":"A review on the ethnopharmacology and phytochemistry of the neotropical sages (Salvia subgenus Calosphace; Lamiaceae) emphasizing Mexican species","volume":"13","author":"Ortiz-Mendoza","year":"2022","journal-title":"Front. Pharmacol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"133802","DOI":"10.1016\/j.foodchem.2022.133802","article-title":"Chemical investigation on Salvia officinalis L. Affected by multiple drying techniques\u2013the comprehensive analytical approach (HS-SPME, GC\u2013MS, LC-MS\/MS, GC-O and NMR)","volume":"397","author":"Pachura","year":"2022","journal-title":"Food Chem."},{"key":"B94","doi-asserted-by":"publisher","first-page":"120800","DOI":"10.1016\/j.indcrop.2025.120800","article-title":"Phytochemical and pharmacological profiles of various Salvia miltiorrhiza Bunge cultivars grown in Korea","volume":"227","author":"Park","year":"2025","journal-title":"Ind. Crops Prod."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1337785","DOI":"10.3389\/fmed.2024.1337785","article-title":"Essential oils: a systematic review on revolutionizing health, nutrition, and omics for optimal well-being","volume":"11","author":"Pezantes-Orellana","year":"2024","journal-title":"Front. Med."},{"key":"B96","doi-asserted-by":"publisher","first-page":"113113","DOI":"10.1016\/j.indcrop.2020.113113","article-title":"Identification and quantification of phenolic compounds in Salvia cadmica Boiss. and their biological potential","volume":"160","author":"Pi\u0105tczak","year":"2021","journal-title":"Ind. Crops Prod."},{"key":"B97","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1055\/a-1087-8276","article-title":"Current State of the Art on the Antioxidant Activity of Sage (Salvia spp.) and its Bioactive Components","volume":"86","author":"Poulios","year":"2020","journal-title":"Planta Med."},{"key":"B98","doi-asserted-by":"publisher","first-page":"68498","DOI":"10.1007\/s11356-021-15407-y","article-title":"Bioactive phytochemicals from Salvia officinalis attenuate cadmium-induced oxidative damage and genotoxicity in rats","volume":"28","author":"Rashwan","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"key":"B99","doi-asserted-by":"publisher","first-page":"113940","DOI":"10.1016\/j.jep.2021.113940","article-title":"Phenolic profile, safety assessment, and anti-inflammatory activity of Salvia verbenaca L","volume":"272","author":"Righi","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"7286","DOI":"10.3390\/molecules27217286","article-title":"Anticancer, cardio-protective and anti-inflammatory potential of natural-sources-derived phenolic acids","volume":"27","author":"Saleem","year":"2022","journal-title":"Molecules"},{"key":"B101","doi-asserted-by":"publisher","first-page":"e010422202998","DOI":"10.2174\/2215083808666220401152135","article-title":"A review of traditional uses, phytochemistry, and pharmacology of Salvia chloroleuca Rech. f. and Aellen","volume":"8","author":"Salimikia","year":"2022","journal-title":"Curr. Tradit. Med."},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.22034\/jchemlett.2024.453132.1179","article-title":"Antioxidant and phytochemical classification of medicinal plants used in the treatment of cancer disease","volume":"1","author":"Samuel","year":"2024","journal-title":"J. Chem. Lett."},{"key":"B103","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1080\/14786419.2022.2161538","article-title":"A new diterpenoid from Salvia santolinifolia boiss","volume":"38","author":"Sargazifar","year":"2024","journal-title":"Nat. Prod. Res."},{"key":"B104","doi-asserted-by":"publisher","first-page":"113310","DOI":"10.1016\/j.phytochem.2022.113310","article-title":"Cytotoxic abietane diterpenoids from Salvia leriifolia Benth","volume":"202","author":"Sarhadi","year":"2022","journal-title":"Phytochemistry"},{"key":"B105","doi-asserted-by":"publisher","first-page":"2198542","DOI":"10.1155\/tswj\/2198542","article-title":"Hydroethanolic extract of Salvia officinalis L. leaves improves memory and alleviates neuroinflammation in ICR mice","volume":"2025","author":"Sefah","year":"2025","journal-title":"Sci. World J."},{"key":"B106","doi-asserted-by":"publisher","first-page":"104185","DOI":"10.1016\/j.fbio.2024.104185","article-title":"Enhancing bioactive compound production in Salvia mirzayanii through elicitor application: insights from in vitro and in silico studies","volume":"60","author":"Shahraki","year":"2024","journal-title":"Food Biosci."},{"key":"B107","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1007\/s40200-023-01301-6","article-title":"Comparison of inhibitory activities of 50 salvia species against \u03b1-Glucosidase","volume":"22","author":"Shojaeifard","year":"2023","journal-title":"J. Diabetes Metab. Disord."},{"key":"B108","doi-asserted-by":"publisher","first-page":"112384","DOI":"10.1016\/j.plantsci.2025.112384","article-title":"New insights of advanced biotechnological engineering strategies for tanshinone biosynthesis in Salvia miltiorrhiza","volume":"352","author":"Shou","year":"2025","journal-title":"Plant Sci."},{"key":"B109","doi-asserted-by":"publisher","first-page":"211","DOI":"10.46939\/j.sci.arts-22.1-b02","article-title":"Biological activity of essential sage oil","volume":"22","author":"Stanciu","year":"2022","journal-title":"J. Sci. Arts"},{"key":"B110","doi-asserted-by":"publisher","first-page":"111932","DOI":"10.1016\/j.indcrop.2019.111932","article-title":"Bioactivity, biocompatibility and phytochemical assessment of lilac sage, Salvia verticillata L.(Lamiaceae)-A plant rich in rosmarinic acid","volume":"143","author":"Stankovi\u0107","year":"2020","journal-title":"Ind. Crops Prod."},{"key":"B111","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.3390\/molecules30071427","article-title":"Phytochemical profile, antioxidant capacity and anticancer potential of water extracts from in vitro cultivated Salvia aethiopis","volume":"30","author":"Tasheva","year":"2025","journal-title":"Molecules"},{"key":"B112","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.sajb.2025.03.044","article-title":"Exogenous nitric oxide induces production of phenolic compounds, enzyme inhibitory properties and antioxidant capacity through activating the phenylpropanoid pathway in sage (Salvia officinalis) leaves","volume":"180","author":"Terzi","year":"2025","journal-title":"South Afr. J. Bot."},{"key":"B113","doi-asserted-by":"publisher","first-page":"e202403017","DOI":"10.1002\/cbdv.202403017","article-title":"Therapeutic efficacy of Salvia chudaei ethanol extract in hyperlipidemia, hyperglycemia, and oxidative stress in Triton X\u2010100\u2010Induced Wistar rats","volume":"22","author":"Tlili","year":"2025","journal-title":"Chem. Biodivers."},{"key":"B114","doi-asserted-by":"publisher","first-page":"104940","DOI":"10.1016\/j.fitote.2021.104940","article-title":"Exploring the phytochemical variation of non-volatile metabolites within three South African Salvia species using UPLC-MS fingerprinting and chemometric analysis","volume":"152","author":"Tock","year":"2021","journal-title":"Fitoterapia"},{"key":"B115","doi-asserted-by":"publisher","first-page":"2420843","DOI":"10.1080\/23311932.2024.2420843","article-title":"Physicochemical, phytochemical and antioxidant properties of medicinal plant roots Dan sam (Salvia miltiorrhiza Bunge) prepared under different drying conditions","volume":"10","author":"Tran","year":"2024","journal-title":"Cogent Food Agric."},{"key":"B116","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3390\/microorganisms13010177","article-title":"In vitro determination of antimicrobial, antioxidant and antiviral properties of Greek plant extracts","volume":"13","author":"Tsakni","year":"2025","journal-title":"Microorganisms"},{"key":"B117","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.3390\/agronomy13051224","article-title":"Biological activities of Lamiaceae species: Bio-Guided isolation of active metabolites from Salvia officinalis L","volume":"13","author":"Tsitsigianni","year":"2023","journal-title":"Agronomy"},{"key":"B118","doi-asserted-by":"publisher","first-page":"5826","DOI":"10.3390\/molecules25245826","article-title":"Salvia officinalis L. from Italy: a comparative chemical and biological study of its essential oil in the mediterranean context","volume":"25","author":"Tundis","year":"2020","journal-title":"Molecules"},{"key":"B119","doi-asserted-by":"publisher","first-page":"140","DOI":"10.13189\/app.2023.110206","article-title":"Pharmacological and nutritional properties: Genus Salvia","volume":"11","author":"Uysal","year":"2023","journal-title":"Adv. Pharmacol. Pharm."},{"key":"B120","doi-asserted-by":"publisher","first-page":"9373","DOI":"10.2147\/IJN.S479959","article-title":"Multiomic profiling and neuroprotective bioactivity of Salvia Hairy Root-Derived extracellular vesicles in a cellular model of parkinson\u2019s disease","volume":"19","author":"Vestuto","year":"2024","journal-title":"Int. J. Nanomedicine"},{"key":"B121","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.3390\/plants10061169","article-title":"Selective BuChE inhibitory activity, chemical composition, and enantiomeric content of the essential oil from Salvia leucantha Cav. collected in Ecuador","volume":"10","author":"Villalta","year":"2021","journal-title":"Plants"},{"key":"B122","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1093\/chromsci\/bmab125","article-title":"Development and validation of a novel LC\u2013MS\/MS method for the quantitation of 19 fingerprint phytochemicals in salvia species: a chemometric approach","volume":"60","author":"Yilmaz","year":"2022","journal-title":"J. Chromatogr. Sci."},{"key":"B123","doi-asserted-by":"publisher","first-page":"872085","DOI":"10.3389\/fphar.2022.872085","article-title":"Salvia miltiorrhiza in breast cancer treatment: a review of its phytochemistry, derivatives, nanoparticles, and potential mechanisms","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Pharmacol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"104261","DOI":"10.1016\/j.bioorg.2020.104261","article-title":"Antiproliferative abietane quinone diterpenoids from the roots of Salvia deserta","volume":"104","author":"Zheng","year":"2020","journal-title":"Bioorg. Chem."},{"key":"B125","doi-asserted-by":"publisher","first-page":"e202401427","DOI":"10.1002\/cbdv.202401427","article-title":"Phytochemicals from Salvia substolonifera with anti\u2010angiogenic properties and substolide H decreased oxygen\u2010induced retinal neovascularization","volume":"22","author":"Zhong","year":"2025","journal-title":"Chem. Biodivers."},{"key":"B126","doi-asserted-by":"publisher","first-page":"3151","DOI":"10.3390\/biomedicines11123151","article-title":"Natural compounds of Salvia L. genus and molecular mechanism of their biological activity","volume":"11","author":"Zhumaliyeva","year":"2023","journal-title":"Biomedicines"}],"container-title":["Frontiers in Molecular Biosciences"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmolb.2025.1678109\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T07:26:02Z","timestamp":1769585162000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmolb.2025.1678109\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,10]]},"references-count":126,"alternative-id":["10.3389\/fmolb.2025.1678109"],"URL":"https:\/\/doi.org\/10.3389\/fmolb.2025.1678109","relation":{},"ISSN":["2296-889X"],"issn-type":[{"value":"2296-889X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,10]]},"article-number":"1678109"}}