{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T02:30:41Z","timestamp":1767925841313,"version":"3.49.0"},"reference-count":126,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374452"],"award-info":[{"award-number":["82374452"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Biosci."],"abstract":"<jats:p>Breast cancer bone metastasis involves dynamic reprogramming of transcriptional networks and cellular homeostasis. Current primary treatment strategy relies on palliative care, and the search for effective therapeutic targets remains a critical challenge. MicroRNAs (miRNAs), endogenous non-coding RNA molecules, exert precise regulation of gene expression through sequence-specific binding to the 3\u2032 UTR of target mRNAs. Accumulating evidence has established miRNAs as pivotal regulators of breast cancer and its metastatic bone disease. Depending on their target genes, individual miRNAs may function as oncogenic miRNAs (oncomiRs) or as tumor suppressor miRNAs (tsmiRs), and hold potential as biomarkers for diagnosis and prognosis. This review systematically analyzes the regulatory mechanisms of critical miRNAs and their target genes in breast cancer bone metastasis, offering novel insights for early diagnosis and targeted therapeutic strategies.<\/jats:p>","DOI":"10.3389\/fmolb.2025.1680908","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T06:25:08Z","timestamp":1761632708000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Dual-regulatory miRNAs: master regulators and therapeutic targets in bone-metastatic breast cancer"],"prefix":"10.3389","volume":"12","author":[{"given":"Feifei","family":"Meng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengdi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongqing","family":"Pu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangxi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"304","DOI":"10.3390\/biom11020304","article-title":"Small in size, but large in action: microRNAs as potential modulators of PTEN in breast and lung cancers","volume":"11","author":"Abadi","year":"2021","journal-title":"Biomolecules"},{"key":"B2","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1007\/s12032-024-02450-1","article-title":"Targeted gene therapy for cancer: the impact of microRNA multipotentiality","volume":"41","author":"Abou Madawi","year":"2024","journal-title":"Med. 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