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Targeted temperature management (TTM), including hypothermia therapy, normothermia control, and febrile intervention, has been widely investigated in laboratory and preclinical studies and has provided substantial protection for neurological function. The effect of TTM on neurological function prognosis in patients with AIS has attracted significant attention. This review summarizes the related mechanisms of action, clinical applications, and short- and long-term effects of TTM on neurological function in AIS, providing a clinical reference for the application and prognosis of TTM in patients with AIS.<\/jats:p>","DOI":"10.3389\/fmolb.2026.1728769","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T05:14:03Z","timestamp":1768454043000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Target temperature management in acute ischemic stroke"],"prefix":"10.3389","volume":"13","author":[{"given":"Lan","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longfei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinming","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1089\/ther.2019.0025","article-title":"Malignant arrhythmias during induction of target temperature management after cardiac arrest","volume":"10","author":"Adler","year":"2020","journal-title":"Ther. 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