{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T00:29:06Z","timestamp":1793924946997,"version":"4.8.0"},"reference-count":164,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Biosci."],"abstract":"<jats:p>\n                    Non-alcoholic fatty liver disease (NAFLD) is increasingly recognized as a mitochondrial-driven metabolic disorder, yet the specific contributions of individual mitochondrial respiratory chain complexes remain poorly defined. In particular, inconsistent alterations in complexes I\u2013V have been reported across different NAFLD models, representing a critical knowledge gap. Here, we systematically reviewed\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    studies to evaluate changes in mitochondrial complexes I\u2013V during NAFLD progression. Overall, NAFLD is commonly associated with reduced complex activity, impaired mitochondrial respiration, and increased reactive oxygen species production. Notably, a subset of studies reported enhanced complex activity and respiration, suggesting context-dependent mitochondrial adaptations. This synthesis clarifies divergent findings and highlights mitochondrial respiratory complexes as dynamic and therapeutically relevant targets for future NAFLD intervention strategies.\n                  <\/jats:p>","DOI":"10.3389\/fmolb.2026.1752024","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T05:27:48Z","timestamp":1771824468000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Roles of mitochondrial complexes in non-alcoholic fatty liver disease"],"prefix":"10.3389","volume":"13","author":[{"given":"Kai","family":"Wang","sequence":"first","affiliation":[{"name":"Rehabilitation Medicine Department of The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen, & Longgang District People's Hospital of Shenzhen","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, The Second Hospital of Chaoyang (Women\u2019s and Children\u2019s Hospital of Chaoyang)","place":["Chaoyang, Liaoning, China"]},{"name":"School of Public Health, Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamin","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, The Second Clinical Medical College, Xi\u2019an Medical College","place":["Xi\u2019an, Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dexin","family":"Li","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Peking University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.freeradbiomed.2015.12.016","article-title":"Cytochrome P450-2E1 promotes aging-related hepatic steatosis, apoptosis and fibrosis through increased nitroxidative stress","volume":"91","author":"Abdelmegeed","year":"2016","journal-title":"Free Radic. 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