{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:03:31Z","timestamp":1790283811568,"version":"4.1.0"},"reference-count":243,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Biosci."],"abstract":"<jats:p>\n                    Catalpol, an iridoid glycoside predominantly derived from the fresh or dried root tuber of\n                    <jats:italic>Rehmannia glutinosa<\/jats:italic>\n                    Libosch (a member of the\n                    <jats:italic>Scrophulariaceae<\/jats:italic>\n                    family), it is a representative compound with the highest content in\n                    <jats:italic>Rehmannia glutinosa<\/jats:italic>\n                    Libosch, and it is also a key index component for evaluating the quality of\n                    <jats:italic>Rehmannia glutinosa<\/jats:italic>\n                    Libosch. Since 2005, it has been continuously included in various editions of China Pharmacopoeia. In this review, we collected relevant data from the Web of Science, PubMed, China National Intellectual Property Administration and China Knowledge Resource Integrated databases in recent 5 years. Catalpol exhibits a broad range of therapeutic effects, addressing various diseases through intricate mechanisms. These include organ- and tissue-protective actions on the kidneys, bones, nervous system, heart, brain, liver, lungs, uterus, ovaries, and more, alongside notable anti-arthritis, anti-cancer, and anti-diabetic properties. The protective mechanisms of catalpol primarily involve its anti-inflammatory, antioxidative stress, anti- or pro-apoptotic, anti-fibrotic, metabolism-regulatory, anti-endoplasmic reticulum stress (ERS), and pyroptosis-modulating functions. Furthermore, catalpol influences a variety of signaling pathways, cells, and molecules, and through these multifaceted actions, it achieves its maximal therapeutic potential. In recent years, the development of different targeted drug delivery formulations and administration routes of catalpol maximise its efficacy has become a major focus of research. What\u2019s more worth mentioning is that \u201ccatalpol tablets\u201d, a new class I Chinese medicine developed on the basis of this monomer component, has been approved to enter the clinical trial stage in China. However, in-depth investigation is required to elucidate the mechanisms of action of catalpol, and more clinical trials are required to assess the clinical value of this compound.\n                  <\/jats:p>","DOI":"10.3389\/fmolb.2026.1768334","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T06:56:15Z","timestamp":1771397775000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Catalpol: an natural multifunctional iridoid glycoside with promising therapeutic properties"],"prefix":"10.3389","volume":"13","author":[{"given":"Guannan","family":"He","sequence":"first","affiliation":[{"name":"College of First Clinical Medical, Shandong University of Traditional Chinese Medicine","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Song","sequence":"additional","affiliation":[{"name":"Shandong Yuze Pharmaceutical Industry Technology Research Institute Co., Ltd.","place":["Dezhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixuan","family":"Ma","sequence":"additional","affiliation":[{"name":"College of First Clinical Medical, Shandong University of Traditional Chinese Medicine","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixing","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of First Clinical Medical, Shandong University of Traditional Chinese Medicine","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamin","family":"Xue","sequence":"additional","affiliation":[{"name":"College of First Clinical Medical, Shandong University of Traditional Chinese Medicine","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farong","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of First Clinical Medical, Shandong University of Traditional Chinese Medicine","place":["Jinan, China"]},{"name":"Department of Nephrology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e20191148","DOI":"10.1590\/0001-3765202020191148","article-title":"Anti-inflammatory and anti-endoplasmic reticulum stress effects of catalpol against myocardial ischemia-reperfusion injury in streptozotocin-induced diabetic rats","volume":"92","author":"Bi","year":"2020","journal-title":"An. Acad. Bras. Ciencias"},{"key":"B2","doi-asserted-by":"publisher","first-page":"333","DOI":"10.14670\/HH-18-575","article-title":"Catalpol protects mouse ATDC5 chondrocytes against interleukin-1\u03b2-induced catabolism","volume":"39","author":"Cai","year":"2024","journal-title":"Histology Histopathology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.16190\/j.cnki.45-1211\/r.2021.07.021","article-title":"Catalpol promotes femoral fracture healing in rats by up-regulating the expression of BMP-2 to activate Wnt\/\u03b2-catenin signaling pathway","volume":"38","author":"Cao","year":"2021","journal-title":"J. Guangxi Med. Univ."},{"key":"B4","article-title":"The effect of catalpol injection on the behavior, cortical vascular repair and the expression of BrdU","volume-title":"GFAP and Nestin in rats with focal permanent cerebral ischemia","author":"Chen","year":"2021"},{"key":"B6","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1186\/s12906-019-2656-8","article-title":"The protective effect and mechanism of catalpol on high glucose-induced podocyte injury","volume":"19","author":"Chen","year":"2019","journal-title":"BMC Complementary Alternative Medicine"},{"key":"B7","doi-asserted-by":"publisher","first-page":"118120","DOI":"10.1016\/j.lfs.2020.118120","article-title":"Study on the inhibitive effect of Catalpol on diabetic nephropathy","volume":"257","author":"Chen","year":"","journal-title":"Life Sciences"},{"key":"B8","first-page":"998","article-title":"The protective effects of catapol, loganin and their compatibility on diabetes induced testicular damage through inhibiting AGEs-RAGE pathway","volume":"36","author":"Chen","year":"","journal-title":"Chin. Pharmacol. Bull."},{"key":"B9","doi-asserted-by":"publisher","first-page":"655081","DOI":"10.3389\/fphar.2021.655081","article-title":"Catalpol inhibits macrophage polarization and prevents Postmenopausal atherosclerosis through regulating Estrogen receptor Alpha","volume":"12","author":"Chen","year":"","journal-title":"Front. Pharmacology"},{"key":"B10","first-page":"782","article-title":"Catalpol inhibits macrophage polarization and prevents postmenopausal atherosclerosis by regulating estrogen receptor","volume":"35","author":"Chen","year":"","journal-title":"Chinese J. Pharmacol. Toxicol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1080\/13813455.2020.1727927","article-title":"Catalpol promotes mitochondrial biogenesis in chondrocytes","volume":"128","author":"Chen","year":"2022","journal-title":"Archives Physiology Biochemistry"},{"key":"B12","first-page":"953","article-title":"Study on the mechanism and inhibitory effect of catalpol on high glucose-induced podocyte pyroptosis","volume":"24","author":"Chen","year":"2023","journal-title":"Chin. J. Integr. Traditional West. Nephrol."},{"key":"B13","first-page":"784","article-title":"Improvement effects and its mechanism of catalpol on testicular lesions in KK-Ay spontaneous diabetic mice by regulating glycolysis","volume":"34","author":"Chen","year":"2023","journal-title":"China Pharm."},{"key":"B14","doi-asserted-by":"publisher","first-page":"176356","DOI":"10.1016\/j.ejphar.2024.176356","article-title":"Catalpol ameliorates fructose-induced renal inflammation by inhibiting TLR4\/MyD88 signaling and uric acid reabsorption","volume":"967","author":"Chen","year":"2024","journal-title":"Eur. Journal Pharmacology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"155262","DOI":"10.1016\/j.phymed.2023.155262","article-title":"Catalpol attenuates osteoporosis in ovariectomized rats through promoting osteoclast apoptosis via the Sirt6-ER\u03b1-FasL axis","volume":"123","author":"Chen","year":"2024","journal-title":"Phytomedicine International Journal Phytotherapy Phytopharmacology"},{"key":"B16","first-page":"1636","article-title":"Effect of catalpol on the malignant biological behavior of oral squamous cell carcinoma cells by regulating the Keap1\/Nrf2\/HO-1signaling pathway","volume":"46","author":"Chen","year":"2024","journal-title":"Hebei Med. J."},{"key":"B17","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s13287-021-02178-z","article-title":"STAT3 activation by catalpol promotes osteogenesis-angiogenesis coupling, thus accelerating osteoporotic bone repair","volume":"12","author":"Chen L.","year":"2021","journal-title":"Stem Cell Research and Therapy"},{"key":"B18","doi-asserted-by":"publisher","first-page":"705","DOI":"10.2147\/DMSO.S246433","article-title":"Catalpol promotes the proliferation and differentiation of osteoblasts induced by high glucose by inhibiting KDM7A","volume":"13","author":"Cheng","year":"2020","journal-title":"Diabetes, Metabolic Syndrome Obesity Targets Therapy"},{"key":"B19","doi-asserted-by":"publisher","first-page":"11185","DOI":"10.1038\/s41598-020-68056-5","article-title":"Determination of behavior of catalpol hexapropionate in simulated gastric conditions by UPLC-ESI-HRMS","volume":"10","author":"Cheng","year":"2020","journal-title":"Sci. Reports"},{"key":"B20","doi-asserted-by":"publisher","first-page":"107782","DOI":"10.1016\/j.intimp.2021.107782","article-title":"Catalpol exerts antiallergic effects in IgE\/ovalbumin-activated mast cells and a murine model of ovalbumin-induced allergic asthma","volume":"96","author":"Chiu","year":"2021","journal-title":"Int. Immunopharmacology"},{"key":"B21","doi-asserted-by":"publisher","first-page":"e116","DOI":"10.1097\/FJC.0000000000001148","article-title":"Catalpol alleviates Ang II-Induced renal injury through NF-\u03baB pathway and TGF-\u03b21\/Smads pathway","volume":"79","author":"Cong","year":"2022","journal-title":"J. Cardiovascular Pharmacology"},{"key":"B22","doi-asserted-by":"publisher","first-page":"4090","DOI":"10.3390\/ma14154090","article-title":"Lipid nanoparticles loaded with selected iridoid glycosides as effective components of Hydrogel formulations","volume":"14","author":"D\u0105browska","year":"2021","journal-title":"Mater. (Basel)"},{"key":"B23","doi-asserted-by":"publisher","first-page":"56","DOI":"10.3349\/ymj.2022.63.1.56","article-title":"Catalpol inhibits Tregs-to-Th17 cell transdifferentiation by Up-Regulating Let-7g-5p to reduce STAT3 protein levels","volume":"63","author":"Di","year":"2022","journal-title":"Yonsei Med. J."},{"key":"B24","volume-title":"The mechanism of catalpol in protecting \u03b2-cell functionand improving hepatic insulin resistance","author":"Ding","year":"2023"},{"key":"B25","first-page":"2041","article-title":"Protective effect of catalpol regulating Hedgehog pathway on early-onset ovarian failure in rats","volume":"47","author":"Ding","year":"2024","journal-title":"Drug Eval. Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"409","DOI":"10.15943\/j.cnki.fdxb-jns.2009.03.014","article-title":"Separation and identification of catalpol from Rehmannia and its acute toxicity Test","volume":"2009","author":"Dong","year":"2009","journal-title":"J. Fudan Univ. Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1007\/s12640-022-00524-4","article-title":"Catalpol ameliorates neurotoxicity in N2a\/APP695swe cells and APP\/PS1 transgenic mice","volume":"40","author":"Du","year":"2022","journal-title":"Neurotox. Research"},{"key":"B28","first-page":"1220","article-title":"Effects of catalpol on H2O2-induced osteoblast injury and its mechanism","volume":"35","author":"Duan","year":"2024","journal-title":"China Pharm."},{"key":"B29","doi-asserted-by":"publisher","first-page":"7233","DOI":"10.1007\/s11033-021-06715-0","article-title":"Catalpol synergistically potentiates the anti-tumour effects of regorafenib against hepatocellular carcinoma via dual inhibition of PI3K\/Akt\/mTOR\/NF-\u03baB and VEGF\/VEGFR2 signaling pathways","volume":"48","author":"El-Hanboshy","year":"2021","journal-title":"Mol. Biology Reports"},{"key":"B30","doi-asserted-by":"publisher","first-page":"4627","DOI":"10.1080\/14786419.2019.1696794","article-title":"Effect of madecassoside and catalpol in amelioration of insulin sensitivity in pancreatic (INS-1E) \u03b2-cell line","volume":"35","author":"Elhassan","year":"2021","journal-title":"Nat. Product Research"},{"key":"B31","doi-asserted-by":"publisher","first-page":"3184","DOI":"10.12659\/MSM.907569","article-title":"Efficacy, safety, and cost of therapy of the traditional Chinese medicine, catalpol, in patients following surgical resection for locally advanced Colon cancer","volume":"24","author":"Fei","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"B32","doi-asserted-by":"publisher","first-page":"114130","DOI":"10.1016\/j.phytochem.2024.114130","article-title":"Natural products with potential hypoglycemic activity in T2DM: 2019-2023","volume":"223","author":"Fei","year":"2024","journal-title":"Phytochemistry"},{"key":"B33","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.tiv.2019.01.016","article-title":"Catalpol and panax notoginseng saponins synergistically alleviate triptolide-induced hepatotoxicity through Nrf2\/ARE pathway","volume":"56","author":"Feng","year":"2019","journal-title":"Toxicol. Vitro An International Journal Published Association BIBRA"},{"key":"B34","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.molimm.2023.11.004","article-title":"Catapol attenuates the aseptic inflammatory response to hepatic I\/R injury in vivo and in vitro by inhibiting the HMGB1\/TLR-4\/NF-\u03baB signaling pathway via the microRNA-410-3p","volume":"164","author":"Feng","year":"2023","journal-title":"Mol. Immunology"},{"key":"B35","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.phymed.2006.05.006","article-title":"Antispasmodic activity of an extract from Plantago lanceolata L. and some isolated compounds","volume":"14","author":"Fleer","year":"2007","journal-title":"Phytomedicine International Journal Phytotherapy Phytopharmacology"},{"key":"B36","doi-asserted-by":"publisher","first-page":"2424","DOI":"10.3892\/mmr.2020.11337","article-title":"Protective effects of catalpol on mitochondria of hepatocytes in cholestatic liver injury","volume":"22","author":"Gao","year":"2020","journal-title":"Mol. Medicine Reports"},{"key":"B37","doi-asserted-by":"publisher","first-page":"176125","DOI":"10.1016\/j.ejphar.2023.176125","article-title":"Catalpol ameliorates LPS-induced inflammatory response by activating AMPK\/mTOR signaling pathway in rat intestinal epithelial cells","volume":"960","author":"Gao","year":"2023","journal-title":"Eur. Journal Pharmacology"},{"key":"B38","doi-asserted-by":"publisher","first-page":"448","DOI":"10.2174\/1389200224666230705142901","article-title":"Pharmacokinetics, mass balance, tissue distribution, and metabolism of 3H.Catalpol in rats: the main bioactive component of Rehmannia glutinosa for the treatment of ischemic stroke","volume":"24","author":"Ge","year":"2023","journal-title":"Curr. Drug Metab."},{"key":"B39","first-page":"15","article-title":"Mechanism of catalpol regulating Th17 cell differentiation by interfering PKM2\/LDHA expression","volume":"35","author":"Ge","year":"2024","journal-title":"China Pharm."},{"key":"B40","doi-asserted-by":"publisher","first-page":"25","DOI":"10.13847\/j.cnki.lnmu.2024.05.018","article-title":"Effect of catalpol on the expression of PERK and CHOP in renal endoplasmic reticulum pathway with diabetic nephropathy rats","volume":"45","author":"Guo","year":"2024","journal-title":"J. Jinzhou Med. Univ."},{"key":"B41","doi-asserted-by":"publisher","first-page":"10","DOI":"10.13847\/j.cnki.lnmu.2021.05.003","article-title":"Effect of catalpol on Bcl-2 protein and YAP protein of SH-SY5Y cell apoptosis induced by high glucose","volume":"42","author":"Han","year":"2021","journal-title":"J. Jinzhou Med. Univ."},{"key":"B42","volume-title":"The research of praeparatum of catalpol by gelsiccation on its prescription and technology and the study on its pharmacokingtics","author":"He","year":"2009"},{"key":"B43","volume-title":"The mechanism of vascular endothelial injury induced by hyperhomocysteine and the effect of catalpol intervention","author":"He","year":"2022"},{"key":"B44","first-page":"738","article-title":"Effects of catalpol on MPTP-Mediated oxidative stress in mice with subacute Parkinson's Disease","volume":"53","author":"He","year":"2022","journal-title":"J. Shenyang Agric. Univ."},{"key":"B45","first-page":"2597","article-title":"Effects of Rehmannia Catalpol on S100A12,IL-1\u03b2 and Galectin-3 expressions in synovium of papain-induced knee osteoarthritis in rats","volume":"36","author":"He","year":"","journal-title":"Chin. J. Immunol."},{"key":"B46","first-page":"4626","article-title":"Protection of inflammatory osteoblasts in neonatal rats using catalpol from the root of Rehmannia glutinosa","volume":"24","author":"He","year":"","journal-title":"Chin. J. Tissue Eng. Res."},{"key":"B47","first-page":"798","article-title":"Catalpol regulates expression of lnc-NONHSAT071210 in salivary gland epithelial cells for therapy mechanism of Sj\u00f6gren \u0301s syndrome model mice","volume":"41","author":"He","year":"2024","journal-title":"Chin. J. Immunol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"4943","DOI":"10.2147\/DDDT.S482969","article-title":"Catalpol enhances osteogenic differentiation of human periodontal stem cells and modulates periodontal tissue remodeling in an orthodontic tooth movement rat model","volume":"18","author":"Hu","year":"2024","journal-title":"Drug Design, Development Therapy"},{"key":"B49","doi-asserted-by":"publisher","first-page":"117345","DOI":"10.1016\/j.jep.2023.117345","article-title":"Catalpol rescues LPS-induced cognitive impairment via inhibition of NF-\u039ab-regulated neuroinflammation and up-regulation of TrkB-mediated BDNF secretion in mice","volume":"319","author":"Hu","year":"2024","journal-title":"J. Ethnopharmacology"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.16438\/j.0513-4870.2023-1184","article-title":"Spectrum-effect relationship combined with bioactivity evaluation to discover the main antidepressant active components of Baihe Dihuang decoction","volume":"59","author":"Hu","year":"2024","journal-title":"Acta Pharm. Sin."},{"key":"B51","first-page":"1042","article-title":"Effects of catalpol on TLR4\/NF - \u03baB pathway and glomerular endothelial injury in rats with acute renal injury","volume":"21","author":"Hua","year":"2020","journal-title":"Chin. J. Integr. Traditional West. Nephrol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"199","DOI":"10.13192\/j.issn.1000-1719.2022.02.053","article-title":"Hypoglycemic effect of catalpol on type 1 diabetic rats by regulating skeletal muscle PGC1\u03b1","volume":"49","author":"Huang","year":"2022","journal-title":"Liaoning J. Traditional Chin. Med."},{"key":"B53","doi-asserted-by":"publisher","first-page":"860757","DOI":"10.3389\/fphar.2022.860757","article-title":"Catalpol as a component of Rehmannia glutinosa protects spinal cord injury by inhibiting endoplasmic reticulum stress-mediated neuronal apoptosis","volume":"13","author":"Huang","year":"2022","journal-title":"Front. Pharmacology"},{"key":"B54","first-page":"1","article-title":"Neuroprotective effect of catalpol on acute spinal cord injury in rats and its mechanism","volume":"35","author":"Huang","year":"2023","journal-title":"Strait Pharm. J."},{"key":"B55","doi-asserted-by":"publisher","first-page":"601","DOI":"10.13241\/j.cnki.pmb.2023.04.001","article-title":"The effect of catalpol on BDNF expression in A\u03b2 intoxicated SH-SY5Y cells and mechanism research","volume":"23","author":"Huang","year":"2023","journal-title":"Prog. Mod. Biomed."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1461279","DOI":"10.3389\/fphar.2024.1461279","article-title":"Catalpol promotes hippocampal neurogenesis and synaptogenesis in rats after multiple cerebral infarctions by mitochondrial regulation: involvement of the Shh signaling pathway","volume":"15","author":"Huang","year":"2024","journal-title":"Front. Pharmacology"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.16252\/j.cnki.issn1004-0501-2024.12.006","article-title":"Impact of catalpol on intestinal inflammation in rats with severe acute pancreatitis by regulating the HMGB1-RAGE signaling pathway","volume":"45","author":"Huang","year":"2024","journal-title":"Sichuan Med. J."},{"key":"B58","first-page":"5467","article-title":"Catalpol from Rehmannia glutinosa regulates senescence in ATDC5 chondrocytes","volume":"28","author":"Jia","year":"2024","journal-title":"Chin. J. Tissue Eng. Res."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.3892\/etm.2020.8743","article-title":"Catalpol ameliorates doxorubicin-induced inflammation and oxidative stress in H9C2 cells through PPAR-\u03b3 activation","volume":"20","author":"Jiang","year":"2020","journal-title":"Exp. Therapeutic Medicine"},{"key":"B60","doi-asserted-by":"publisher","first-page":"5668226","DOI":"10.1155\/2022\/5668226","article-title":"Catalpol enhances random-pattern skin flap survival by activating SIRT1-Mediated enhancement of autophagy","volume":"2022","author":"Jiang","year":"2022","journal-title":"Oxidative Medicine Cellular Longevity"},{"key":"B61","first-page":"1213","article-title":"Effects of catalpol on the proliferation of Rheumatoid arthritis fibroblast synovial cells and YAP\/TAZ signaling pathway","volume":"46","author":"Jiang","year":"2024","journal-title":"Chin. J. Cell Biol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"116736","DOI":"10.1016\/j.lfs.2019.116736","article-title":"Protective effects of catalpol on diabetes mellitus-induced male reproductive damage via suppression of the AGEs\/RAGE\/Nox4 signaling pathway","volume":"256","author":"Jiao","year":"2020","journal-title":"Life Sciences"},{"key":"B63","doi-asserted-by":"publisher","first-page":"116841","DOI":"10.1016\/j.jpba.2025.116841","article-title":"Covalent protein modification by multiple reactive dialdehyde metabolites of catalpol via intestinal bioactivation","volume":"261","author":"Jing","year":"2025","journal-title":"J. Pharmaceutical Biomedical Analysis"},{"key":"B245","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.phymed.2024.155853","article-title":"Catalpol alleviates heat stroke-induced liver injury in mice by downregulating the JAK\/STAT signaling pathway","volume":"7","author":"Ji","year":"2024","journal-title":"Phytomedicine"},{"key":"B64","doi-asserted-by":"publisher","first-page":"7756","DOI":"10.1038\/s41598-023-33403-9","article-title":"Design, synthesis and anticancer activities evaluation of novel pyrazole modified catalpol derivatives","volume":"13","author":"Kong","year":"","journal-title":"Sci. Rep."},{"key":"B65","doi-asserted-by":"publisher","first-page":"e202300185","DOI":"10.1002\/asia.202300185","article-title":"Design, synthesis and biological evaluation of novel catalpol derivatives as potential pancreatic cancer inhibitors","volume":"18","author":"Kong","year":"","journal-title":"Chem. Asian J."},{"key":"B66","article-title":"The Study of catalpol on proliferation, osteoblast-differentiation and HedgehogSignaling pathway bone mesenchymal stem cells","author":"Lai","year":"2018"},{"key":"B67","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.2147\/DDDT.S467569","article-title":"The mechanism of catalpol to improve oxidative damage of dermal fibroblasts based on Nrf2\/HO-1 signaling pathway","volume":"18","author":"Lang","year":"2024","journal-title":"Drug Design, Development Therapy"},{"key":"B68","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.biochi.2015.10.006","article-title":"6-O-Veratroyl catalpol suppresses pro-inflammatory cytokines via regulation of extracellular signal-regulated kinase and nuclear factor-\u03baB in human monocytic cells","volume":"119","author":"Le","year":"2015","journal-title":"Biochimie"},{"key":"B69","volume-title":"Effect of catalpol on Schwann cells injured by LPS and its mechanism","author":"Li","year":"2020"},{"key":"B70","volume-title":"Study on the osteogenic activity of catalpol and its osteogenic effect in combination with titanium implant","author":"Li","year":"2021"},{"key":"B71","first-page":"2060","article-title":"Effects of catalpol on schwann cells under AAPH injury conditions","volume":"35","author":"Li","year":"2020","journal-title":"China J. Traditional Chin. Med. Pharm."},{"key":"B72","doi-asserted-by":"publisher","first-page":"e23034","DOI":"10.1002\/jbt.23034","article-title":"Catalpol protects AC16 cells from hypoxia\/reoxygenation injury by regulating the miR-22-3p\/DPP4 axis","volume":"36","author":"Li","year":"2022","journal-title":"J. Biochemical Molecular Toxicology"},{"key":"B73","first-page":"2243","article-title":"Study of catalpol-induced autophagy in reducing DNA damage in high glucose-induced vascular endothelial cells","volume":"38","author":"Li","year":"2022","journal-title":"Chin. J. Pathophysiol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.13699\/j.cnki.1001-6821.2024.14.013","article-title":"Effects of catalpol on necrotic apoptosis in rats with acute myocardial infarction by regulating the RIP1\/RIP3\/MLKL signaling pathway","volume":"40","author":"Li","year":"2024","journal-title":"Chin. J. Clin. Pharmacol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.2147\/DMSO.S446318","article-title":"The active ingredient catalpol in Rehmannia glutinosa reduces blood glucose in diabetic rats via the AMPK pathway","volume":"17","author":"Li","year":"2024","journal-title":"Diabetes, Metabolic Syndrome Obesity Targets Therapy"},{"key":"B76","doi-asserted-by":"publisher","first-page":"722","DOI":"10.18502\/ijph.v52i4.12440","article-title":"Catalpol alleviates depression by inhibiting NLRP3 inflammasome via TLR4\/MAPK\/NF-Kb pathway","volume":"52","author":"Liang","year":"2023","journal-title":"Iran. Journal Public Health"},{"key":"B77","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ejim.2015.12.017","article-title":"Adverse drug reactions and organ damage: the liver","volume":"28","author":"Licata","year":"2016","journal-title":"Eur. Journal Internal Medicine"},{"key":"B78","doi-asserted-by":"publisher","first-page":"176406","DOI":"10.1016\/j.ejphar.2024.176406","article-title":"Catalpol alleviates hypoxia ischemia-induced brain damage by inhibiting ferroptosis through the PI3K\/NRF2\/system Xc-\/GPX4 axis in neonatal rats","volume":"968","author":"Lin","year":"2024","journal-title":"Eur. Journal Pharmacology"},{"key":"B79","volume-title":"Pharmacokinetics of catalpol by different administration methods","author":"Liu","year":"2014"},{"key":"B80","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1016\/j.biopha.2018.04.156","article-title":"Autophagy inhibition attenuates the induction of anti-inflammatory effect of catalpol in liver fibrosis","volume":"103","author":"Liu","year":"2018","journal-title":"Biomed. and Pharmacotherapy"},{"key":"B81","doi-asserted-by":"publisher","first-page":"20415","DOI":"10.1038\/s41598-020-77399-y","article-title":"Design, microwave synthesis, and molecular docking studies of catalpol crotonates as potential neuroprotective agent of diabetic encephalopathy","volume":"10","author":"Liu","year":"2020","journal-title":"Sci. Reports"},{"key":"B82","first-page":"2501","article-title":"Catalpol improves exercise ability and skeletal muscle function in pneumoconiosis rats","volume":"45","author":"Liu","year":"2022","journal-title":"Drug Eval. Res."},{"key":"B83","doi-asserted-by":"publisher","first-page":"116215","DOI":"10.1016\/j.taap.2022.116215","article-title":"Catalpol induces apoptosis in breast cancer in vitro and in vivo: involvement of mitochondria apoptosis pathway and post-translational modifications","volume":"454","author":"Liu","year":"2022","journal-title":"Toxicol. Applied Pharmacology"},{"key":"B84","doi-asserted-by":"publisher","first-page":"7","DOI":"10.13412\/j.cnki.zyyl.2022.02.002","article-title":"Active components of shengyu decoction in intervention of bone marrow suppression in rats based on UPLC-Q-TOF-MS technology","volume":"38","author":"Liu","year":"2022","journal-title":"Pharmacol. Clin. Chin. Materia Medica"},{"key":"B85","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1536\/ihj.23-062","article-title":"Catalpol inhibits autophagy to ameliorate doxorubicin-induced cardiotoxicity via the AKT-mTOR pathway","volume":"64","author":"Liu","year":"2023","journal-title":"Int. Heart Journal"},{"key":"B86","first-page":"6","article-title":"Repair effect and mechanism of catalpol on mature human neuroblastoma cells after oxygen-glucose deprivation\/reoxygenation injury","volume":"63","author":"Liu","year":"2023","journal-title":"Shandong Med. J."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1142\/S0192415X24500575","article-title":"Catalpol from Rehmannia glutinosa targets Nrf2\/NF-\u03baB signaling pathway to improve renal anemia and fibrosis","volume":"52","author":"Liu","year":"2024","journal-title":"Am. Journal Chin. Medicine"},{"key":"B88","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s10020-024-00818-7","article-title":"A study on the mechanism of Beclin-1 m6A modification mediated by catalpol in protection against neuronal injury and autophagy following cerebral ischemia","volume":"30","author":"Liu","year":"2024","journal-title":"Mol. Medicine Camb. Mass. ."},{"key":"B89","doi-asserted-by":"publisher","first-page":"119808","DOI":"10.1016\/j.jep.2025.119808","article-title":"IGF-1 signaling pathway activation promotes axonal regeneration and repair: a mechanism study on catalpol-induced functional recovery after ischemic stroke","volume":"348","author":"Liu","year":"2025","journal-title":"J. Ethnopharmacology"},{"key":"B90","first-page":"3708","article-title":"The protective effect of catalpol on vascular lesions of T2DM rats and the involvement of the oxLDL\/LDL and NF-\u03baB signaling pathway","volume":"45","author":"Luo","year":"2023","journal-title":"Hebei Med. J."},{"key":"B91","article-title":"Protective effects of catalpol pretreatment on tacrine-induced liver injury and preliminary investigation of its pharmacological mechanism","author":"Lv","year":"2024"},{"key":"B92","volume-title":"Study on quality markers of Rehmannia Glutinosa intervention model for Blood Heat Syndrome","author":"Ma","year":"2022"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.26988\/d.cnki.gcdzu.2021.000569","article-title":"Study on the mechanism of Yi Wei Decoction and its active components Catalpol and Imperatorin in improving endometriosis","author":"Ma","year":"2024","journal-title":"Chengdu Univ. TCM"},{"key":"B94","first-page":"718","article-title":"Protective mechanism of catalpol on IL-1\u03b2-induced chondrocyte injury","volume":"51","author":"Ma","year":"2023","journal-title":"Tianjin Med. J."},{"key":"B95","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1097\/PRS.0000000000010650","article-title":"Effects of catalpol from Rehmannia glutinosa extract on skin flaps","volume":"153","author":"Ma","year":"2024","journal-title":"Plastic Reconstructive Surgery"},{"key":"B96","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/s41581-019-0121-z","article-title":"Immune mechanisms of salt-sensitive hypertension and renal end-organ damage","volume":"15","author":"Mattson","year":"2019","journal-title":"Nat. Reviews. Nephrol."},{"key":"B97","volume-title":"Mechanism investigation in regulatory effects of catalpol on osteoclastogenesis and osteoclast-derived bone loss","author":"Meng","year":"2020"},{"key":"B98","doi-asserted-by":"publisher","first-page":"113715","DOI":"10.1016\/j.bcp.2019.113715","article-title":"Catalpol suppresses osteoclastogenesis and attenuates osteoclast-derived bone resorption by modulating PTEN activity","volume":"171","author":"Meng","year":"2020","journal-title":"Biochem. Pharmacology"},{"key":"B99","first-page":"1059","article-title":"Study on the impact of catalpol on brain tissue damage in rats with subarachnoid hemorrhage based on Raf-MEK-ERK signal pathway","volume":"40","author":"Meng","year":"2023","journal-title":"Tianjin J. Traditional Chin. Med."},{"key":"B100","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s12640-022-00626-z","article-title":"Catalpol mitigates Alzheimer's disease progression by promoting the expression of neural stem cell exosomes released miR-138-5p","volume":"41","author":"Meng","year":"2023","journal-title":"Neurotox. Research"},{"key":"B101","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3390\/biomedicines10010099","article-title":"The salutary effects of catalpol on diesel exhaust particles-induced thrombogenic changes and cardiac oxidative stress, inflammation and apoptosis","volume":"10","author":"Nemmar","year":"2022","journal-title":"Biomedicines."},{"key":"B102","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s11064-022-03796-6","article-title":"Catalpol ameliorates oxidative stress and neuroinflammation after traumatic brain injury in rats","volume":"48","author":"Ni","year":"2023","journal-title":"Neurochem. Research"},{"key":"B103","doi-asserted-by":"publisher","first-page":"28327","DOI":"10.1038\/s41598-024-78126-7","article-title":"Catalpol regulates apoptosis and proliferation of endothelial cell via activating HIF-1\u03b1\/VEGF signaling pathway","volume":"14","author":"Ni","year":"2024","journal-title":"Sci. Reports"},{"key":"B104","doi-asserted-by":"publisher","first-page":"e14602","DOI":"10.1111\/cbdd.14602","article-title":"Promotion effect of catalpol on angiogenesis and potential mechanisms: a research based on network pharmacology","volume":"104","author":"Ni","year":"2024","journal-title":"Chem. Biology and Drug Design"},{"key":"B105","doi-asserted-by":"publisher","first-page":"4077","DOI":"10.7150\/ijbs.97362","article-title":"Catalpol attenuates hepatic glucose metabolism disorder and oxidative stress in triptolide-induced liver injury by regulating the SIRT1\/HIF-1\u03b1 pathway","volume":"20","author":"Nie","year":"2024","journal-title":"Int. Journal Biological Sciences"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.27249\/d.cnki.gnjyu.2023.000151","article-title":"The protective effect and mechanism of catalpol on mouse osteoarthritis based on NOD2\/NF-\u03baB\/MAPK signaling pathway","author":"Pang","year":"2023","journal-title":"Nanjing Med. Univ."},{"key":"B107","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.3390\/molecules28041606","article-title":"Analyses of transcriptomics upon IL-1\u03b2-Stimulated mouse chondrocytes and the protective effect of catalpol through the NOD2\/NF-\u03baB\/MAPK signaling pathway","volume":"28","author":"Pang","year":"2023","journal-title":"Mol. Basel, Switz."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1016\/j.bmcl.2006.11.086","article-title":"Novel antiproliferative analogs of the taq DNA polymerase inhibitor catalpol","volume":"17","author":"Pungitore","year":"2007","journal-title":"Bioorg. and Medicinal Chemistry Letters"},{"key":"B109","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.3892\/or.2020.7494","article-title":"Catalpol-mediated microRNA-34a suppresses autophagy and malignancy by regulating SIRT1 in colorectal cancer","volume":"43","author":"Qiao","year":"2020","journal-title":"Oncol. Reports"},{"key":"B110","first-page":"6","article-title":"Effects of catalpol of Rehmannia Glutinosa on the PI3K\/Akt\/mTOR signaling pathway following ischemia-reperfusion injury in rats","volume":"41","author":"Qiao","year":"2024","journal-title":"Inf. Traditional Chin. Med."},{"key":"B111","volume-title":"Study on the pharmacodynamic mechanism of Radix rehmanniae and catalpol in protecting renal fibrosis","author":"Ruan","year":"2020"},{"key":"B112","volume-title":"The effect of delayed catalpol administration on focal permanent cerebral ischemia rats and promoting neurogenesis","author":"Shao","year":"2020"},{"key":"B113","doi-asserted-by":"publisher","first-page":"1415445","DOI":"10.3389\/fphar.2024.1415445","article-title":"Catalpol reduced LPS induced BV2 immunoreactivity through NF-\u03baB\/NLRP3 pathways: an in vitro and in silico study","volume":"15","author":"She","year":"2024","journal-title":"Front. Pharmacology"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.27127\/d.cnki.ghlzu.2023.000651","article-title":"Mwchanism of catalpol regulation of AMPK\/GLUT4 signaling pathway in skeletal muscle of rats with type 2 diabetes","author":"Shen","year":"2023","journal-title":"Heilongjiang Univ. Chin. Med."},{"key":"B115","first-page":"1072","article-title":"Mechanism of catalpol regulating miR-143-3p to interfere with Th17 glycolysis and cell differentiation","volume":"38","author":"Shen","year":"2022","journal-title":"Chin. Pharmacol. Bull."},{"key":"B116","doi-asserted-by":"publisher","first-page":"155356","DOI":"10.1016\/j.phymed.2024.155356","article-title":"Catalpolaglycone disrupts mitochondrial thermogenesis by specifically binding to a conserved lysine residue of UCP2 on the proton leak tunnel","volume":"125","author":"Shen","year":"2024","journal-title":"Phytomedicine International Journal Phytotherapy Phytopharmacology"},{"key":"B117","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1159\/000524236","article-title":"Catalpol alleviates isoflurane-induced hippocampal learning and memory dysfunction and neuropathological changes in aged mice","volume":"29","author":"Shi","year":"2022","journal-title":"Neuroimmunomodulation"},{"key":"B118","volume-title":"Mechanism Study of catalpol, loganin and their compatibility on diabetic renal lesions caused by excessive avtivation of AGEs-RAGE axis via regulating endothelial-macrophage interaction","author":"Shu","year":"2021"},{"key":"B119","first-page":"1513","article-title":"Inhibitory effect of catalpol on macrophage activation mediated by AGEs-stimulated mouse glomerular endothelial cells","volume":"36","author":"Shu","year":"2020","journal-title":"Chin. Pharmacol. Bull."},{"key":"B120","doi-asserted-by":"publisher","first-page":"109625","DOI":"10.1016\/j.cbi.2021.109625","article-title":"Catalpol ameliorates endothelial dysfunction and inflammation in diabetic nephropathy via suppression of RAGE\/RhoA\/ROCK signaling pathway","volume":"348","author":"Shu","year":"2021","journal-title":"Chemico-biological Interactions"},{"key":"B121","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.brainresbull.2021.09.002","article-title":"Antidepressant effect of catalpol on corticosterone-induced depressive-like behavior involves the inhibition of HPA axis hyperactivity, central inflammation and oxidative damage probably via dual regulation of NF-\u03baB and Nrf2","volume":"177","author":"Song","year":"2021","journal-title":"Brain Research Bulletin"},{"key":"B244","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/s41574-024-00969-x","article-title":"Metabolic regulation of skeletal cell fate and function","volume":"20","author":"Stegen","year":"2024","journal-title":"Nat. Rev. Endocrinol."},{"key":"B122","article-title":"Catalpol regulates VEGF-A\/KDR to promote angiogenesis after cerebral ischemia and induces the differentiation of neural stem cells into neurons","author":"Sun","year":"2022"},{"key":"B123","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1002\/iub.2032","article-title":"Catalpol ameliorates advanced glycation end product-induced dysfunction of glomerular endothelial cells via regulating nitric oxide synthesis by inducible nitric oxide synthase and endothelial nitric oxide synthase","volume":"71","author":"Sun","year":"2019","journal-title":"IUBMB Life"},{"key":"B124","first-page":"106","article-title":"Effects of catalpol on the expression of TGF - \u03b21 and CTGF in renal tissues of 5\/6 nephrectomized rats","volume":"21","author":"Sun","year":"","journal-title":"Chin. J. Integr. Traditional West. Nephrol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"2402","DOI":"10.16368\/j.issn.1674-8999.2020.11.534","article-title":"Effect of catalpol on the expression of inflammatory factors in rats with renal fibrosis","volume":"35","author":"Sun","year":"","journal-title":"Acta Chin. Med."},{"key":"B126","first-page":"924","article-title":"Chloroquine enhances catalpol's ability to promote apoptosis by inhibiting catalpol's autophagy-promoting effect on gastric cancer","volume":"26","author":"Sun","year":"2021","journal-title":"J. B.U.ON, Official Journal Balkan Union Oncol."},{"key":"B127","first-page":"63","article-title":"Effect of Shengdi Catalpol in promoting angiogenesis and neural function remodeling by regulating vascular endothelial growth factor and its receptors to activate notch signaling pathway","volume":"29","author":"Sun","year":"2021","journal-title":"Pract. J. Cardiac Cereb. Pneumal Vasc. Dis."},{"key":"B128","doi-asserted-by":"publisher","first-page":"18689","DOI":"10.18632\/aging.203313","article-title":"Catalpol enhanced physical exercise-mediated brain functional improvement in post-traumatic stress disorder model via promoting adult hippocampal neurogenesis","volume":"13","author":"Sun","year":"2021","journal-title":"Aging"},{"key":"B129","doi-asserted-by":"publisher","first-page":"6227","DOI":"10.1007\/s12035-023-03459-9","article-title":"Catalpol alleviates ischemic stroke through promoting angiogenesis and facilitating proliferation and differentiation of neural stem cells via the VEGF-A\/KDR pathway","volume":"60","author":"Sun","year":"2023","journal-title":"Mol. Neurobiology"},{"key":"B130","doi-asserted-by":"publisher","first-page":"2820","DOI":"10.16431\/j.cnki.1671-7236.2023.07.022","article-title":"Catalpol alleviates the damaging effect of AGEs on the endothelial cells in the hepatic sinus by disrupting the interaction between Galectin-3 and CD146","volume":"50","author":"Sun","year":"","journal-title":"China Animal Husb. and Veterinary Med."},{"key":"B131","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1007\/s11596-023-2750-5","article-title":"Catalpol prevents glomerular angiogenesis induced by advanced glycation end products via inhibiting Galectin-3","volume":"43","author":"Sun","year":"","journal-title":"Curr. Medical Science"},{"key":"B132","doi-asserted-by":"publisher","first-page":"111274","DOI":"10.1016\/j.intimp.2023.111274","article-title":"Inhibitory effects of catalpol on DNCB-induced atopic dermatitis and IgE-mediated mast cells reaction","volume":"126","author":"Sun","year":"2024","journal-title":"Int. Immunopharmacology"},{"key":"B133","first-page":"999","article-title":"Neuroprotective effect of Catalpol on MPTP induced Parkinson's disease model mice and its mechanism","volume":"36","author":"Tang","year":"2024","journal-title":"Mod. Pract. Med."},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.27130\/d.cnki.ghubu.2020.000036","article-title":"The preventive effect and mechanism of catalpol on nonalcoholic fatty liver disease in mice fed with high fat diet","author":"Tian","year":"2020","journal-title":"Hubei Univ."},{"key":"B135","doi-asserted-by":"publisher","first-page":"6708061","DOI":"10.1155\/2020\/6708061","article-title":"Catalpol Attenuates hepatic steatosis by regulating lipid metabolism via AMP-activated protein kinase activation","volume":"2020","author":"Tian","year":"2020","journal-title":"BioMed Research International"},{"key":"B136","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.16438\/j.0513-4870.2020-1986","article-title":"Catalpol inhibits cell apoptosis through alleviating endoplasmic reticulum stress in nonalcoholic fatty liver disease","volume":"56","author":"Tian","year":"2021","journal-title":"Acta Pharm. Sin."},{"key":"B137","doi-asserted-by":"publisher","first-page":"177075","DOI":"10.1016\/j.ejphar.2024.177075","article-title":"Proteomic alteration in catalpol treatment of Alzheimer's disease by regulating HSPA5\/GPX4","volume":"987","author":"Tian","year":"2025","journal-title":"Eur. Journal Pharmacology"},{"key":"B138","doi-asserted-by":"publisher","first-page":"3500","DOI":"10.13699\/j.cnki.1001-6821.2020.21.026","article-title":"Inhibits effect and mechanism of catalpol on the human neuroblastoma cell injury induced by rotenone","volume":"36","author":"Wan","year":"2020","journal-title":"Chin. J. Clin. Pharmacol."},{"key":"B139","volume-title":"Neuroprotective effect and mechanism of catalpol on MPTP mouse model of Parkinson\u2019s disease","author":"Wang","year":"2020"},{"key":"B141","volume-title":"Reconstituting 3D neurovascular unit","author":"Wang","year":"2022"},{"key":"B142","volume-title":"Based on Nrf2\/HO-1 and Bcl-2\/Bax to explore the mechanism of catalpol nasal drops improving oxidative stress apoptotic injury in rats with cerebral","author":"Wang","year":"2022"},{"key":"B143","volume-title":"The mechanism of aseptic inflammation and the protective effect of catalpol during hepatic ischemia-reperfusion were studied based on the miR-410-3p\/HMGB1 axis","author":"Wang","year":"2023"},{"key":"B144","doi-asserted-by":"publisher","first-page":"316","DOI":"10.3389\/fnagi.2019.00316","article-title":"Catalpol exerts a neuroprotective effect in the MPTP mouse model of Parkinson's disease","volume":"11","author":"Wang","year":"2019","journal-title":"Front. Aging Neuroscience"},{"key":"B145","doi-asserted-by":"publisher","first-page":"153300","DOI":"10.1016\/j.phymed.2020.153300","article-title":"Catalpol protects vascular structure and promotes angiogenesis in cerebral ischemic rats by targeting HIF-1\u03b1\/VEGF","volume":"78","author":"Wang","year":"2020","journal-title":"Phytomedicine International Journal Phytotherapy Phytopharmacology"},{"key":"B146","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/s41398-021-01468-7","article-title":"Catalpol ameliorates depressive-like behaviors in CUMS mice via oxidative stress-mediated NLRP3 inflammasome and neuroinflammation","volume":"11","author":"Wang","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"B147","doi-asserted-by":"publisher","first-page":"174396","DOI":"10.1016\/j.ejphar.2021.174396","article-title":"Antidepressant mechanism of catalpol: involvement of the PI3K\/Akt\/Nrf2\/HO-1 signaling pathway in rat hippocampus","volume":"909","author":"Wang","year":"2021","journal-title":"Eur. Journal Pharmacology"},{"key":"B148","first-page":"2189","article-title":"Catalpol alleviates liver injury in T2DM rats through PPAR\u03b3\/NF-\u03baB signaling pathway","volume":"37","author":"Wang","year":"2022","journal-title":"Chin. J. Pathophysiol."},{"key":"B149","doi-asserted-by":"publisher","first-page":"279","DOI":"10.2147\/DDDT.S343928","article-title":"Feasibility of Catalpol intranasal administration and its protective effect on Acute cerebral ischemia in rats via anti-oxidative and anti-apoptotic mechanisms","volume":"16","author":"Wang","year":"2022","journal-title":"Drug Design, Development Therapy"},{"key":"B150","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1038\/s41401-021-00803-4","article-title":"Catalpol improves impaired neurovascular unit in ischemic stroke rats via enhancing VEGF-PI3K\/AKT and VEGF-MEK1\/2\/ERK1\/2 signaling","volume":"43","author":"Wang","year":"2022","journal-title":"Acta Pharmacologica Sin."},{"key":"B151","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3724\/sp.j.1329.2022.01007","article-title":"Effect and mechanism of catalpol on behavior in rats with post-stroke depression","volume":"32","author":"Wang","year":"2022","journal-title":"Rehabil. Med."},{"key":"B152","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.3390\/antiox12061222","article-title":"Beneficial effects of catalpol supplementation during in vitro maturation of porcine cumulus-oocyte complexes","volume":"12","author":"Wang","year":"2023","journal-title":"Antioxidants Basel, Switz."},{"key":"B153","doi-asserted-by":"publisher","first-page":"473","DOI":"10.13863\/j.issn1001-4454.2025.02.033","article-title":"Effects of catalpol regulating FAK\/MEK\/ERK signaling pathway on migration, invasion and cisplatin sensitivity of colon cancer cells","author":"Wang","year":"2025","journal-title":"J. Chin. Med. Mater."},{"key":"B154","doi-asserted-by":"publisher","first-page":"6035","DOI":"10.1038\/s41467-025-60909-9","article-title":"Analysis of the Rehmannia chingii geneome identifies RcCYP72H7 as an epoxidase in iridoid glycoside biosynthesis","volume":"16","author":"Wang","year":"2025","journal-title":"Nat. Communications"},{"key":"B155","first-page":"384","article-title":"Research progress on visual evaluation of food functions using zebrafish as an animal model","volume":"46","author":"Wang","year":"2025","journal-title":"Food Sci."},{"key":"B156","first-page":"809","article-title":"Protective effects of catalpol and rhein in murine experimental autoimmune encephalomyelitis via regulation of T helper (Th) 1, Th2, Th17, and regulatory T cell responses","volume":"39","author":"Wei","year":"2019","journal-title":"J. Traditional Chin. Medicine = Chung I Tsa Chih Ying Wen pan"},{"key":"B157","doi-asserted-by":"publisher","first-page":"17","DOI":"10.20047\/j.issn1673-7210.2021.19.004","article-title":"Effects and mechanism of catalpol on retinopathy in mice with diabetes mellitus","volume":"18","author":"Wu","year":"2021","journal-title":"China Med. Her."},{"key":"B158","doi-asserted-by":"publisher","first-page":"305","DOI":"10.3724\/SP.J.1123.2018.11022","article-title":"Rapid screening of anti-osteoporosis active ingredients from Liuwei Dihuang Decoction by osteoblast membrane chromatography\/ultra-high performance liquid chromatography-time of flight mass spectrometry","volume":"37","author":"Wu","year":"2019","journal-title":"Se Pu"},{"key":"B159","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3892\/mmr.2020.11667","article-title":"Catalpol inhibits the proliferation, migration and metastasis of HCC cells by regulating miR-140-5p expression","volume":"23","author":"Wu","year":"","journal-title":"Mol. Medicine Reports"},{"key":"B160","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.neuroscience.2021.07.029","article-title":"Catalpol weakens depressive-like behavior in mice with streptozotocin-induced hyperglycemia via PI3K\/AKT\/Nrf2\/HO-1 signaling pathway","volume":"473","author":"Wu","year":"","journal-title":"Neuroscience"},{"key":"B161","doi-asserted-by":"publisher","first-page":"2975","DOI":"10.1007\/s11064-022-03641-w","article-title":"Catalpol exerts antidepressant-like effects by enhancing anti-oxidation and neurotrophy and inhibiting neuroinflammation via activation of HO-1","volume":"47","author":"Wu","year":"","journal-title":"Neurochem. Research"},{"key":"B162","doi-asserted-by":"publisher","first-page":"7074157","DOI":"10.1155\/2022\/7074157","article-title":"Catalpol regulates oligodendrocyte regeneration and remyelination by activating the GEF-Cdc42\/Rac1 signaling pathway in EAE mice","volume":"2022","author":"Wu","year":"","journal-title":"Evidence-based Complementary Alternative Medicine eCAM."},{"key":"B163","first-page":"2340","article-title":"Exploration on the antidepressant effects of Rehmanniae Radix based on the efficacy of nourishing yin and clearing heat","volume":"38","author":"Wu","year":"2023","journal-title":"China J. Traditional Chin. Med. Pharm."},{"key":"B164","doi-asserted-by":"publisher","first-page":"e18242","DOI":"10.1111\/jcmm.18242","article-title":"Catalpol promotes articular cartilage repair by enhancing the recruitment of endogenous mesenchymal stem cells","volume":"28","author":"Wu","year":"","journal-title":"J. Cellular Molecular Medicine"},{"key":"B165","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1186\/s12872-024-04046-z","article-title":"Catalpol inhibits HHcy-induced EndMT in endothelial cells by modulating ROS\/NF-\u03baB signaling","volume":"24","author":"Wu","year":"","journal-title":"BMC Cardiovascular Disorders"},{"key":"B166","doi-asserted-by":"publisher","first-page":"118448","DOI":"10.1016\/j.jep.2024.118448","article-title":"The role of TrkB signaling-mediated synaptic plasticity in the antidepressant properties of catalpol, the main active compound of Rehmannia glutinosa Libosch","volume":"333","author":"Wu","year":"","journal-title":"J. Ethnopharmacology"},{"key":"B167","doi-asserted-by":"publisher","first-page":"156120","DOI":"10.1016\/j.phymed.2024.156120","article-title":"Role of SIRT1-mediated synaptic plasticity and neurogenesis: Sex-differences in antidepressant-like efficacy of catalpol","volume":"135","author":"Wu","year":"","journal-title":"Phytomedicine International Journal Phytotherapy Phytopharmacology"},{"key":"B168","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1007\/s10067-024-07261-3","article-title":"Protective effects of Catalpol to attenuate TNF- \u03b1 and collagen-induced inflammation in vitro HFLS-RA cells and in vivo mice models for the treatment of rheumatoid arthritis","volume":"44","author":"Wu","year":"2025","journal-title":"Clin. Rheumatology"},{"key":"B169","doi-asserted-by":"publisher","first-page":"630222","DOI":"10.3389\/fphar.2020.630222","article-title":"Catalpol protects against spinal cord injury in mice through regulating MicroRNA-142-Mediated HMGB1\/TLR4\/NF-\u03baB signaling pathway","volume":"11","author":"Xia","year":"2021","journal-title":"Front. Pharmacology"},{"key":"B170","doi-asserted-by":"publisher","first-page":"2210","DOI":"10.1080\/13880209.2022.2142801","article-title":"Catalpol relieved angiotensin II-induced blood-brain barrier destruction via inhibiting the TLR4 pathway in brain endothelial cells","volume":"60","author":"Xia","year":"2022","journal-title":"Pharm. Biology"},{"key":"B171","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.22038\/ijbms.2024.78543.16982","article-title":"Catalpol alleviates amyloid-generation and neuronal oxidative stress injury via activating the Keap1-Nrf2\/ARE signaling pathway in the immortalized lymphocytes from patients with late-onset alzheimer's disease and SKNMC cells co-culture model","volume":"27","author":"Xiang","year":"2024","journal-title":"Iran. Journal Basic Medical Sciences"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.27180\/d.cnki.gjxzc.2021.000259","article-title":"Protective effects and its mechanism of catalpol on the H2O2-induced oxidative damage in INS-1 cells","author":"Xiao","year":"2021","journal-title":"Jiangxi Univ. Chin. Med."},{"key":"B173","doi-asserted-by":"publisher","first-page":"4403","DOI":"10.19540\/j.cnki.cjcmm.20220119.402","article-title":"Anti-oxidative and anti-apoptotic effects and molecular mechanisms of catalpol against H_2O_2-induced oxidative damage in pancreatic \u03b2 cells (INS-1 cells)","volume":"47","author":"Xiao","year":"2022","journal-title":"China Journal Chin. Materia Medica"},{"key":"B174","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s12033-021-00407-7","article-title":"Protective effects of catalpol on Limb motor function and ultrastructure of hippocampal neurons in rats with cerebral ischemia","volume":"64","author":"Xie","year":"2022","journal-title":"Mol. Biotechnology"},{"key":"B175","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1007\/s12079-022-00716-9","article-title":"Catalpol inhibits hepatic stellate cell activation by reducing the formation and changing the contents of hepatocyte-derived extracellular vesicles","volume":"17","author":"Xie","year":"2023","journal-title":"J. Cell Communication Signaling"},{"key":"B176","volume-title":"Catalpol improving lipid accumulation, cell apoptosis and oxidative stress in PA treated HepG2 cells by upregulating miR-96-5p to inhibit p66shc\/cytochrome C cascade","author":"Xu","year":"2020"},{"key":"B177","volume-title":"Effects of catalpol on porcine oocyte in titro maturation","author":"Xu","year":"2023"},{"key":"B178","volume-title":"Catalpol activation of hypothalamic TAS2R108\/PLC\u03b22 pathway mediates TRH\/TSH\/T3 regulation of hepatic lipid metabolism in mice fed a high-fat diet","author":"Xu","year":"2024"},{"key":"B179","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1002\/jcsm.12581","article-title":"A potential therapeutic effect of catalpol in Duchenne muscular dystrophy revealed by binding with TAK1","volume":"11","author":"Xu","year":"","journal-title":"J. Cachexia, Sarcopenia Muscle"},{"key":"B180","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1038\/s41401-019-0345-2","article-title":"The hypoglycemic mechanism of catalpol involves increased AMPK-mediated mitochondrial biogenesis","volume":"41","author":"Xu","year":"","journal-title":"Acta Pharmacologica Sin."},{"key":"B181","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1139\/apnm-2020-0075","article-title":"Hypoglycaemic effect of catalpol in a mouse model of high-fat diet-induced prediabetes","volume":"45","author":"Xu","year":"","journal-title":"Appl. Physiology, Nutr. Metabolism = Physiologie Appliquee, Nutr. Metabolism"},{"key":"B182","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1038\/s41401-020-00515-1","article-title":"Catalpol counteracts the pathology in a mouse model of Duchenne muscular dystrophy by inhibiting the TGF-\u03b21\/TAK1 signaling pathway","volume":"42","author":"Xu","year":"2021","journal-title":"Acta Pharmacologica Sin."},{"key":"B183","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.jphs.2023.10.002","article-title":"Catalpol ameliorates dexamethasone-induced osteoporosis by promoting osteogenic differentiation of bone marrow mesenchymal stem cells via the activation of PKD1 promoter","volume":"153","author":"Xu","year":"2023","journal-title":"J. Pharmacological Sciences"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.26402\/jpp.2024.3.05","article-title":"Catalpol improves insulin resistance and lipid metabolism disorder in diabetic mice by inhibiting microRNA-101-3p to up-regulate FOS-related antigen 2","volume":"75","author":"Xu","year":"2024","journal-title":"J. Physiology Pharmacology An Official Journal Pol. Physiological Soc."},{"key":"B185","first-page":"1","article-title":"Effects of catalpol on myocardial fibrosis and myocardial cells morphology in rats with type 2 diabetes mellitus","volume":"37","author":"Xu","year":"2024","journal-title":"West. J. Traditional Chin. Med."},{"key":"B186","doi-asserted-by":"publisher","first-page":"BSR20194032","DOI":"10.1042\/BSR20194032","article-title":"Catalpol protects rat ovarian granulosa cells against oxidative stress and apoptosis through modulating the PI3K\/Akt\/mTOR signaling pathway","volume":"40","author":"Yan","year":"2020","journal-title":"Biosci. Reports"},{"key":"B187","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s13568-020-00986-9","article-title":"Therapeutic efficacy of catalpol against apoptosis in cardiomyocytes derived from human induced pluripotent stem cells","volume":"10","author":"Yang","year":"2020","journal-title":"Amb. Express"},{"key":"B188","doi-asserted-by":"publisher","first-page":"690","DOI":"10.3389\/fphar.2020.00690","article-title":"Neuroprotective effect of catalpol via Anti-Oxidative, anti-inflammatory, and anti-apoptotic mechanisms","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Pharmacology"},{"key":"B189","doi-asserted-by":"publisher","first-page":"594139","DOI":"10.3389\/fphar.2020.594139","article-title":"Catalpol protects against pulmonary fibrosis through inhibiting TGF-\u03b21\/Smad3 and Wnt\/\u03b2-Catenin signaling pathways","volume":"11","author":"Yang","year":"2021","journal-title":"Front. Pharmacology"},{"key":"B190","doi-asserted-by":"publisher","first-page":"12","DOI":"10.13457\/j.cnki.jncm.2021.17.003","article-title":"Effect of catalpol on oxidative stress response in the liver of mice with hyperthyroidism","volume":"53","author":"Yang","year":"2021","journal-title":"New Chin. Med."},{"key":"B191","doi-asserted-by":"publisher","first-page":"29544","DOI":"10.1021\/acsomega.4c02322","article-title":"Enhancement of local osseointegration and implant stability of titanium implant in osteoporotic rats by biomimetic multilayered structures containing catalpol","volume":"9","author":"Yang","year":"2024","journal-title":"ACS Omega"},{"key":"B192","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.3390\/biom10101360","article-title":"Catalpol ameliorates insulin sensitivity and mitochondrial respiration in skeletal muscle of Type-2 diabetic mice through insulin signaling pathway and AMPK\/SIRT1\/PGC-1\u03b1\/PPAR-\u03b3 activation","volume":"10","author":"Yap","year":"2020","journal-title":"Biomolecules"},{"key":"B193","doi-asserted-by":"publisher","first-page":"5","DOI":"10.20085\/j.cnki.issn1005-0205.241102","article-title":"Effect of catalpol on cartilage damage in rheumatoid arthritis rats","volume":"32","author":"Yin","year":"2024","journal-title":"Chin. J. Traditional Med. Traumatology and Orthop."},{"key":"B194","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.3390\/cells10102635","article-title":"Catalpol protects ARPE-19 cells against oxidative stress via activation of the Keap1\/Nrf2\/ARE pathway","volume":"10","author":"You","year":"2021","journal-title":"Cells"},{"key":"B195","doi-asserted-by":"publisher","first-page":"878601","DOI":"10.3389\/fmed.2022.878601","article-title":"Catalpol attenuates pulmonary fibrosis by inhibiting Ang II\/AT1 and TGF-\u03b2\/Smad-Mediated epithelial mesenchymal transition","volume":"9","author":"Yu","year":"2022","journal-title":"Front. Medicine"},{"key":"B196","doi-asserted-by":"publisher","first-page":"13","DOI":"10.13847\/j.cnki.lnmu.2024.03.011","article-title":"Protective effect and mechanism of catalpol on rats with diabetic cardiomyopathy through NLRP3\/Caspase-1 pathway","volume":"45","author":"Yu","year":"2024","journal-title":"J. Jinzhou Med. Univ."},{"key":"B197","first-page":"2474","article-title":"Catalpol induces oligodendrocyte precursor cell-mediated remyelination in vitro","volume":"7","author":"Yuan","year":"2015","journal-title":"Am. Journal Translational Research"},{"key":"B198","doi-asserted-by":"publisher","first-page":"237","DOI":"10.3390\/nu15010237","article-title":"Catalpol attenuates oxidative stress and inflammation via mechanisms involving Sirtuin-1 activation and NF-\u03baB inhibition in experimentally-induced chronic kidney disease","volume":"15","author":"Zaaba","year":"2023","journal-title":"Nutrients"},{"key":"B199","first-page":"3006","article-title":"Effect of catalpol on hepatic and renal complications and hepatic bile acid in db\/db mice","volume":"17","author":"Zeng","year":"2022","journal-title":"World Chin. Med."},{"key":"B200","doi-asserted-by":"publisher","first-page":"587","DOI":"10.16016\/j.2097-0927.202312145","article-title":"Catalpol protects hepatopulmonary syndrome rats against liver and lung injury","volume":"46","author":"Zeng","year":"2024","journal-title":"J. Army Med. Univ."},{"key":"B201","volume-title":"Study on the anti-inflammatory mechanism of catalpol by inhibiting NF-\u03baB\/MAPK signal pathway and its effect on endometritis","author":"Zhang","year":"2021"},{"key":"B202","volume-title":"Roles of catapol in regulating macrophage polarization and promoting osteogenesis","author":"Zhang","year":"2021"},{"key":"B203","volume-title":"Study on the mechanism of catalpol regulating neural stem cells and local microenvironment promoting neurogenesis and migration in rats with cerebral ischemia based on SDF-1\u03b1\/CXCR4","author":"Zhang","year":"2022"},{"key":"B204","volume-title":"Catalpol ameliorates postmenopausal atherosclerosis by modulating DNA methylation donors of the estrogen receptor gene","author":"Zhang","year":"2022"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.27282\/d.cnki.gsdzu.2023.000022","article-title":"Clinical observation on the treatment of vitiligo with Baibo NO.1 recipe and mechanism research on complannatuside and catalpol for melanocytes ferroptosis","author":"Zhang","year":"2023","journal-title":"Shandong Univ. Traditional Chin. Med."},{"key":"B206","volume-title":"Catalpol improves implant osseointegration in type 2 diabetic mice via the AKT\/GSK-3\u03b2\/FYN\/NRF2 pathway","author":"Zhang","year":"2024"},{"key":"B207","doi-asserted-by":"publisher","first-page":"2182","DOI":"10.1002\/tox.23855","article-title":"Catalpol ameliorates inflammation and oxidative stress via regulating Sirt1 and activating Nrf2\/HO-1 signaling against acute kidney injury","volume":"38","author":"Zhang","year":"2023","journal-title":"Environ. Toxicology"},{"key":"B208","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1186\/s12882-017-0673-8","article-title":"Non-steroidal anti-inflammatory drug induced acute kidney injury in the community dwelling general population and people with chronic kidney disease: systematic review and meta-analysis","volume":"18","author":"Zhang","year":"2017","journal-title":"BMC Nephrology"},{"key":"B209","doi-asserted-by":"publisher","first-page":"4558","DOI":"10.1111\/bph.14822","article-title":"Catalpol alleviates adriamycin-induced nephropathy by activating the SIRT1 signalling pathway in vivo and in vitro","volume":"176","author":"Zhang","year":"2019","journal-title":"Br. Journal Pharmacology"},{"key":"B210","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1631\/jzus.B1900071","article-title":"Catalpol ameliorates LPS-induced endometritis by inhibiting inflammation and TLR4\/NF-\u03baB signaling","volume":"20","author":"Zhang","year":"2019","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"B211","doi-asserted-by":"publisher","first-page":"3025","DOI":"10.3892\/etm.2020.9077","article-title":"Treatment with catalpol protects against cisplatin-induced renal injury through Nrf2 and NF-\u03baB signaling pathways","volume":"20","author":"Zhang","year":"2020","journal-title":"Exp. Therapeutic Medicine"},{"key":"B212","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.18632\/aging.102721","article-title":"Targeting of miR-96-5p by catalpol ameliorates oxidative stress and hepatic steatosis in LDLr-\/- mice via p66shc\/cytochrome C cascade","volume":"12","author":"Zhang","year":"2020","journal-title":"Aging"},{"key":"B213","first-page":"4656","article-title":"Effect of catalpol from the root of Rehmannia glutinosa on the expression of inflammatory proteins in synovium of the knee joint in rats with early osteoarthritis","volume":"24","author":"Zhang","year":"2020","journal-title":"Eng. Res."},{"key":"B214","doi-asserted-by":"publisher","first-page":"7467156","DOI":"10.1155\/2021\/7467156","article-title":"Catalpol-Induced AMPK activation alleviates cisplatin-induced nephrotoxicity through the mitochondrial-dependent pathway without compromising its anticancer properties","volume":"2021","author":"Zhang","year":"2021","journal-title":"Oxidative Medicine Cellular Longevity"},{"key":"B215","doi-asserted-by":"publisher","first-page":"9","DOI":"10.13193\/j.issn.1673-7717.2021.09.003","article-title":"Effect of Bushen Huayu Shengxin decoction on paracrine effect and differentiation rate of mesenchymal stem cells by optimizing ischemic and hypoxic microenvironment","volume":"39","author":"Zhang","year":"2021","journal-title":"Chin. Archives Traditional Chin. Med."},{"key":"B216","first-page":"78","article-title":"Microwave-assisted synthesis of catalpol perpropionylated product and its neuroprotective effect","volume":"36","author":"Zhang","year":"2021","journal-title":"J. Light Industry"},{"key":"B217","doi-asserted-by":"publisher","first-page":"e12759","DOI":"10.7717\/peerj.12759","article-title":"Protection of catalpol against triptolide-induced hepatotoxicity by inhibiting excessive autophagy via the PERK-ATF4-CHOP pathway","volume":"10","author":"Zhang","year":"2022","journal-title":"PeerJ"},{"key":"B218","doi-asserted-by":"publisher","first-page":"192","DOI":"10.15921\/j.cnki.cyxb.2022.03.005","article-title":"Protective effects of catalpol on the diabetic nephropathy in STZ-induced diabetic rats","volume":"39","author":"Zhang","year":"2022","journal-title":"J. Chengde Med. Univ."},{"key":"B219","doi-asserted-by":"publisher","first-page":"113269","DOI":"10.1016\/j.yexcr.2022.113269","article-title":"Catalpol modulating the crosstalking between mesenchymal stromal cells and macrophages via paracrine to enhance angiogenesis and osteogenesis","volume":"418","author":"Zhang","year":"2022","journal-title":"Exp. Cell Research"},{"key":"B220","first-page":"881","article-title":"Catalpol regulates the proliferation and apoptosis of breast cancer MCF-7 cells through the FOXO3-FOXM1 signal axis","volume":"30","author":"Zhang","year":"2023","journal-title":"Chin. J. Cancer Biotherapy"},{"key":"B221","doi-asserted-by":"publisher","first-page":"1280049","DOI":"10.3389\/fimmu.2023.1280049","article-title":"Serum, spleen metabolomics and gut microbiota reveals effect of catalpol on blood deficiency syndrome caused by cyclophosphamide and acetylphenylhydrazine","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Immunology"},{"key":"B222","doi-asserted-by":"publisher","first-page":"156047","DOI":"10.1016\/j.phymed.2024.156047","article-title":"Catalpol ameliorates liver fibrosis via inhibiting aerobic glycolysis by EphA2\/FAK\/Src signaling pathway","volume":"135","author":"Zhang","year":"2024","journal-title":"Phytomedicine International Journal Phytotherapy Phytopharmacology"},{"key":"B223","doi-asserted-by":"publisher","first-page":"56","DOI":"10.13422\/j.cnki.syfjx.20241701","article-title":"Rehmanniae Radix iridoid glycosides protect kidneys of diabetic mice by regulating TGF-\u03b21\/Smads signaling pathway","volume":"2","author":"Zhang","year":"2024","journal-title":"Chin. J. Exp. Traditional Med. Formulae"},{"key":"B224","doi-asserted-by":"publisher","first-page":"152118","DOI":"10.1016\/j.acthis.2023.152118","article-title":"Catalpol antagonizes LPS-mediated inflammation and promotes osteoblast differentiation through the miR-124-3p\/DNMT3b\/TRAF6 axis","volume":"126","author":"Zhang","year":"2024","journal-title":"Acta Histochemical"},{"key":"B225","doi-asserted-by":"publisher","first-page":"155362","DOI":"10.1016\/j.phymed.2024.155362","article-title":"Catalpol attenuates ischemic stroke by promoting neurogenesis and angiogenesis via the SDF-1\u03b1\/CXCR4 pathway","volume":"128","author":"Zhang","year":"2024","journal-title":"Phytomedicine International Journal Phytotherapy Phytopharmacology"},{"key":"B226","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.3390\/molecules29071497","article-title":"Study on the neuroprotective effects of eight iridoid components using cell metabolomics","volume":"29","author":"Zhang","year":"2024","journal-title":"Mol. Basel, Switz."},{"key":"B227","doi-asserted-by":"publisher","first-page":"5761","DOI":"10.1021\/acsomega.3c08518","article-title":"Catalpol promotes osseointegration of titanium implants under conditions of type 2 diabetes via AKT\/GSK3\u03b2\/FYN pathway-mediated NRF2 activation","volume":"9","author":"Zhang","year":"2024","journal-title":"ACS Omega"},{"key":"B228","volume-title":"Mechanism of catalpol inhibiting epithelial mesenchymal transformation in HGC-27 gastric cancer cells","author":"Zhao","year":"2023"},{"key":"B229","doi-asserted-by":"publisher","first-page":"626621","DOI":"10.3389\/fphar.2021.626621","article-title":"Catalpol protects against high glucose-induced bone loss by regulating osteoblast function","volume":"12","author":"Zhao","year":"2021","journal-title":"Front. Pharmacology"},{"key":"B230","doi-asserted-by":"publisher","first-page":"1010483","DOI":"10.3389\/fphar.2022.1010483","article-title":"Catalpol ameliorates CFA-induced inflammatory pain by targeting spinal cord and peripheral inflammation","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Pharmacology"},{"key":"B231","doi-asserted-by":"publisher","first-page":"100671","DOI":"10.1016\/j.repbio.2022.100671","article-title":"Catalpol attenuates polycystic ovarian syndrome by regulating sirtuin 1 mediated NF-\u03baB signaling pathway","volume":"22","author":"Zhao","year":"2022","journal-title":"Reprod. Biology"},{"key":"B232","first-page":"4460","article-title":"Effects of catalpol, an active component of rehmannia glutinosa, on the senescence of caenorhabditis elegans","volume":"43","author":"Zhao","year":"2023","journal-title":"Chin. J. Gerontology"},{"key":"B233","first-page":"2189","article-title":"Effects of catalpol on the life span of daf-2 and daf-16 nematodes","volume":"44","author":"Zhao","year":"2024","journal-title":"Chin. J. Gerontology"},{"key":"B234","doi-asserted-by":"publisher","first-page":"29240","DOI":"10.1038\/s41598-024-80505-z","article-title":"Catalpol improved energy metabolism and inflammation through the SIRT5-mediated signaling pathway to ameliorate myocardial injury","volume":"14","author":"Zheng","year":"","journal-title":"Sci. Reports"},{"key":"B235","first-page":"1417","article-title":"The effects of Catalpol on proliferation, apoptosis and immune escape of lung cancer cells by regulating the cGAS-STING signaling pathway","volume":"32","author":"Zheng","year":"","journal-title":"J. Mod. Oncol."},{"key":"B236","volume-title":"Study on the effect of catalpol on neuroinflammation of BV-2 microglia by inhibiting NLRP3 inflammasome","author":"Zhou","year":"2022"},{"key":"B237","doi-asserted-by":"publisher","first-page":"e2503909","DOI":"10.1002\/advs.202503909","article-title":"Inhibition of heat shock protein 90\u03b2 by catalpol: a potential therapeutic approach for alleviating inflammation-induced cartilage injuries in osteoarthritis","volume":"12","author":"Zhou","year":"2025","journal-title":"Adv. Science"},{"key":"B238","first-page":"78","article-title":"Study on transdermal experiment of catalpol in rehmannia glutinosa in rabbits in vivo","volume":"35","author":"Zhu","year":"2019","journal-title":"Today Animal Husb. Veterinary Med."},{"key":"B239","first-page":"6413","article-title":"Inhibitory effects of catalpol coordinated with budesonide and their relationship with cytokines and Interleukin-13 expression","volume":"11","author":"Zhu","year":"2019","journal-title":"Am. Journal Translational Research"},{"key":"B240","first-page":"1311","article-title":"Catalpol improves axonal outgrowth and reinnervation of injured sciatic nerve by activating Akt\/mTOR pathway and regulating BDNF and PTEN expression","volume":"11","author":"Zhu","year":"2019","journal-title":"Am. Journal Translational Research"},{"key":"B241","doi-asserted-by":"publisher","first-page":"453","DOI":"10.16846\/j.issn.1004-3101.2021.06.016","article-title":"Catalpol reduces the endothelial cells injury induced by high glucose through activating Nrf2signaling pathway","volume":"43","author":"Zhu","year":"2021","journal-title":"J. Shandong Second Med. Univ."},{"key":"B242","doi-asserted-by":"publisher","first-page":"118881","DOI":"10.1016\/j.lfs.2020.118881","article-title":"Catalpol ameliorates diabetes-induced testicular injury and modulates gut microbiota","volume":"267","author":"Zhu","year":"2021","journal-title":"Life Sciences"},{"key":"B243","doi-asserted-by":"publisher","first-page":"3432","DOI":"10.1080\/15384101.2019.1673619","article-title":"Inhibition of lncRNA Neat1 by catalpol via suppressing transcriptional activity of NF-\u03baB attenuates cardiomyocyte apoptosis","volume":"18","author":"Zou","year":"2019","journal-title":"Cell CycleGeorget. Tex."}],"container-title":["Frontiers in Molecular Biosciences"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmolb.2026.1768334\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T06:56:47Z","timestamp":1771397807000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmolb.2026.1768334\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,18]]},"references-count":243,"alternative-id":["10.3389\/fmolb.2026.1768334"],"URL":"https:\/\/doi.org\/10.3389\/fmolb.2026.1768334","relation":{},"ISSN":["2296-889X"],"issn-type":[{"value":"2296-889X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,18]]},"article-number":"1768334"}}