{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T05:23:16Z","timestamp":1787289796958,"version":"build-2736575974"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Biosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Micronutrients such as zinc, selenium, and vitamin D play a crucial role in prostate physiology. Deficiencies in these nutrients may be associated with prostate-specific antigen (PSA) levels and with impaired urinary tract parameters, including the International Prostate Symptom Score (IPSS), maximum urinary flow rate (Qmax), and post-void residual (PVR) volume. This retrospective study evaluated the association between serum micronutrient status and prostate health indicators in adult men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records of 400 men aged \u226545 years who underwent prostate evaluation between 2019 and 2022 were retrospectively analyzed. Serum zinc, selenium, and 25-hydroxyvitamin D levels were recorded alongside PSA values and urinary tract parameters, including IPSS, Qmax, and PVR volume. Based on reference ranges, participants were categorized into low- or normal-micronutrient groups. Correlation analyses and multivariable logistic regression were performed to identify independent predictors of elevated PSA (&amp;gt;4 ng\/mL) and severe urinary symptoms (IPSS \u226520).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>120 participants exhibited low micronutrient levels. Compared with men with normal levels, this group showed significantly higher PSA (5.2 \u00b1 2.8 vs. 2.9 \u00b1 1.5 ng\/mL), higher IPSS scores (16.5 \u00b1 5.8 vs. 10.2 \u00b1 5.2), lower Qmax (11.2 \u00b1 4.1 vs. 16.1 \u00b1 4.7 mL\/s), and higher PVR (61.7 \u00b1 20.3 vs. 42.2 \u00b1 18.5 mL) (all p &amp;lt; 0.001). Serum zinc, selenium, and vitamin D levels were inversely correlated with PSA and IPSS and positively correlated with Qmax (all p &amp;lt; 0.001). In multivariable regression analysis, low zinc (OR 2.48; 95% CI: 1.45\u20134.23), low selenium (OR 2.12; 95% CI: 1.27\u20133.52), and low vitamin D (OR 1.87; 95% CI: 1.11\u20133.16) were independent predictors of elevated PSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Micronutrient deficiencies were associated with altered PSA levels and impaired urinary tract function. Monitoring and correcting micronutrient deficiencies may represent a valuable component of prostate health management, though prospective studies are needed to confirm causality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmolb.2026.1779179","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T04:23:00Z","timestamp":1787286180000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Retrospective analysis of micronutrient status and prostate health: linking serum zinc, selenium, and vitamin D levels to prostate-specific antigen and urinary tract function"],"prefix":"10.3389","volume":"13","author":[{"given":"Changfu","family":"Feng","sequence":"first","affiliation":[{"name":"Urumqi Friendship Hospital","place":["Xinjiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Liu","sequence":"additional","affiliation":[{"name":"Urumqi Friendship Hospital","place":["Xinjiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subi","family":"Nijiati","sequence":"additional","affiliation":[{"name":"Urumqi Friendship Hospital","place":["Xinjiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangbo","family":"Ma","sequence":"additional","affiliation":[{"name":"Urumqi Friendship Hospital","place":["Xinjiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglin","family":"Yang","sequence":"additional","affiliation":[{"name":"Urumqi Friendship Hospital","place":["Xinjiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.21037\/lcm-21-49","article-title":"Role of vitamin D in common urological conditions: a narrative review of past decade literature","volume":"5","author":"Brown","year":"2022","journal-title":"Longhua Chin. 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