{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:36:20Z","timestamp":1773815780504,"version":"3.50.1"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Biosci."],"abstract":"<jats:p>Marchiafava-Bignami disease (MBD) represents a rare neurological disorder predominantly associated with chronic ethanol consumption and thiamine insufficiency. However, its possible correlation with cobalamin deficiency resulting from anti-parietal cell antibodies (APCA) remained inadequately characterized in the literature. Timely diagnosis and therapeutic intervention were critical for optimizing clinical outcomes. This case suggested that APCA screening and vitamin B12 assessment should be considered in the diagnostic workup of MBD, especially in patients without classic thiamine deficiency.<\/jats:p>","DOI":"10.3389\/fmolb.2026.1787073","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:39:28Z","timestamp":1773812368000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Marchiafava-Bignami disease: anti-parietal cell antibodies as a potential etiological factor in a novel case presentation"],"prefix":"10.3389","volume":"13","author":[{"given":"Junhao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of North Sichuan Medical College","place":["Nanchong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of North Sichuan Medical College","place":["Nanchong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuangfeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yuechi County People\u2019s Hospital","place":["Guangan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinhong","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of North Sichuan Medical College","place":["Nanchong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengcheng","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of North Sichuan Medical College","place":["Nanchong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of North Sichuan Medical College","place":["Nanchong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Guangyuan First People\u2019s Hospital","place":["Guangyuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanfeng","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tongliang District People\u2019s Hospital","place":["Chongqing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunxian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of North Sichuan Medical College","place":["Nanchong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengxiong","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of North Sichuan Medical College","place":["Nanchong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of North Sichuan Medical College","place":["Nanchong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yuechi County People\u2019s Hospital","place":["Guangan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yuechi County People\u2019s Hospital","place":["Guangan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yuechi County People\u2019s Hospital","place":["Guangan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Forensic Pathology, School of Basic Medicine and Forensic Medicine, North Sichuan Medical College","place":["Nanchong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of North Sichuan Medical College","place":["Nanchong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.rmed.2017.12.011","article-title":"Anti-parietal cell autoimmunity is associated with an accelerated decline of lung function in IPF patients","volume":"135","author":"Beltramo","year":"2018","journal-title":"Respir. 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