{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T05:12:09Z","timestamp":1778562729122,"version":"3.51.4"},"reference-count":208,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Biosci."],"abstract":"<jats:p>Ischemic stroke is a leading cause of mortality and long-term disability, with single acute interventions such as thrombolysis and mechanical thrombectomy limited by narrow therapeutic windows, hemorrhage risks, and challenges in crossing the blood-brain barrier (BBB). This review focuses on targeted therapeutic strategies across the four key stages of ischemic stroke management: prevention, neuroprotection, revascularization, and adjunctive therapy. By systematically analyzing each stage of ischemic stroke, we emphasize the necessity of staged intervention and the essential role of nanomedicines during each stage. From controlled drug release in the prevention stage to the extension of therapeutic time windows for acute intervention and to enhancing adjunctive outcomes in later stages, nanomedicines provide solutions to optimize treatment efficacy and minimize side effects. Finally, we provide perspectives on spatiotemporal control in nanomedicine for precision stroke treatment, including blood pressure and infarct temperature regulation, the crosstalk between systems, and gene therapy. This review underscores the transformative role of nanomedicines in ischemic stroke treatment and the potential to revolutionize stroke management by overcoming current clinical barriers and improving patient outcomes.<\/jats:p>","DOI":"10.3389\/fmolb.2026.1794828","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:29:19Z","timestamp":1778560159000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Nanotechnology for ischemic stroke treatment: addressing challenges across stroke management stages"],"prefix":"10.3389","volume":"13","author":[{"given":"Yue","family":"Wu","sequence":"first","affiliation":[{"name":"School of Health Science and Engineering, University of Shanghai for Science and Technology","place":["Shanghai, China"]},{"name":"Oriental Pan-Vascular Devices Innovation College, University of Shanghai for Science and Technology","place":["Shanghai, China"]},{"name":"Neurovascular Center, Changhai Hospital, Naval Medical University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Wang","sequence":"additional","affiliation":[{"name":"Neurovascular Center, Changhai Hospital, Naval Medical University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Zou","sequence":"additional","affiliation":[{"name":"School of Health Science and Engineering, University of Shanghai for Science and Technology","place":["Shanghai, China"]},{"name":"Oriental Pan-Vascular Devices Innovation College, University of Shanghai for Science and Technology","place":["Shanghai, China"]},{"name":"Neurovascular Center, Changhai Hospital, Naval Medical University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianfu","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Shanghai Key Laboratory of Nautical Medicine and Translation of Drugs and Medical Devices, Changhai Hospital, Naval Medical University","place":["Shanghai, China"]},{"name":"Department of Materials Science, State Key Laboratory of Molecular Engineering of Polymers, Fudan University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Yang","sequence":"additional","affiliation":[{"name":"Oriental Pan-Vascular Devices Innovation College, University of Shanghai for Science and Technology","place":["Shanghai, China"]},{"name":"Neurovascular Center, Changhai Hospital, Naval Medical University","place":["Shanghai, China"]},{"name":"State Key Laboratory of Neurology and Oncology Drug Development","place":["Nanjing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Oriental Pan-Vascular Devices Innovation College, University of Shanghai for Science and Technology","place":["Shanghai, China"]},{"name":"Neurovascular Center, Changhai Hospital, Naval Medical University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.3390\/antiox13121440","article-title":"Neuroinflammation in age-related neurodegenerative diseases: role of mitochondrial oxidative stress","volume":"13","author":"Abadin","year":"2024","journal-title":"Antioxidants"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.3762\/bjnano.15.113","article-title":"Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals","volume":"15","author":"Adscheid","year":"2024","journal-title":"Beilstein J. 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