{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T05:07:55Z","timestamp":1779944875508,"version":"3.53.1"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Biosci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The resinification of Dracaena cochinchinensis wood represents a sophisticated physiological reprogramming triggered by environmental stress, culminating in the production of the high-value \u201cdragon\u2019s blood\u201d resin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, we systematically characterized the chemical space of three representative wood morphotypes\u2014hollow cork cambium (P), whole-body resin-containing (MZ), and resin-secreting aggregated (LZ)\u2014to decipher the molecular mechanisms underpinning resinogenesis within the xylem matrix. Integrating UPLC-Q-TOF-MS\/MS with Feature-Based Molecular Networking (FBMN), we overcame annotation bottlenecks inherent in complex woody tissues and successfully annotated 299 specialized metabolites, including flavonoids, phenylpropanoids, steroids, and lipids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Multivariate statistical analysis revealed significant metabolic shifts across these wood morphotypes, reflecting distinct biological strategies: the P form prioritized phenylpropanoid biosynthesis (e.g., sinapyl alcohol and coniferaldehyde) for structural barrier reinforcement of the wood cell walls; the MZ morphotype accumulated steroids and fatty acids to maintain membrane integrity during chronic adaptation; and the LZ morphotype exhibited a defensive burst of flavonoids and terpenoids, typical of acute stress responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Collectively, these findings support a putative \u201cprogressive metabolic continuum\u201d model (P\u2192MZ\u2192LZ), illustrating a hypothesized metabolic gradient and a dynamic shift in resource allocation from physical repair to chronic adaptation and finally to acute chemical defense. This study provides a comprehensive phytochemical framework for understanding specialized metabolite mobilization in resinous wood and establishes an efficient metabolomic workflow for the quality evaluation and sustainable utilization of woody medicinal resources.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmolb.2026.1795393","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T05:00:24Z","timestamp":1779944424000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrative metabolomics and molecular networking reveal the progressive metabolic continuum of resin formation in Dracaena cochinchinensis wood"],"prefix":"10.3389","volume":"13","author":[{"given":"Meijia","family":"Chen","sequence":"first","affiliation":[{"name":"College of Pharmacy, Heilongjiang University of Chinese Medicine","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Cui","sequence":"additional","affiliation":[{"name":"Yunnan Branch, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Xishuangbanna, China"]},{"name":"Yunnan Key Laboratory of Southern Medicine Utilization","place":["Xishuangbanna, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhua","family":"Su","sequence":"additional","affiliation":[{"name":"Xishuangbanna Institute for Drug Control","place":["Jinghong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Ren","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Hospital of Ya\u2019an","place":["Yaan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Yunnan Branch, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Xishuangbanna, China"]},{"name":"Yunnan Key Laboratory of Southern Medicine Utilization","place":["Xishuangbanna, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhui","family":"Wang","sequence":"additional","affiliation":[{"name":"Xishuangbanna Dai Medicine Research Institute Co., Ltd.","place":["Jinghong, Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Heilongjiang University of Chinese Medicine","place":["Harbin, China"]},{"name":"Yunnan Branch, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Xishuangbanna, China"]},{"name":"Yunnan Key Laboratory of Southern Medicine Utilization","place":["Xishuangbanna, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/S0031-9422(01)00244-8","article-title":"A weakly antimalarial biflavanone from Rhus retinorrhoea","volume":"58","author":"Ahmed","year":"2001","journal-title":"Phytochemistry"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1080\/10942912.2016.1207188","article-title":"Health functionality of apigenin: a review","volume":"20","author":"Ali","year":"2017","journal-title":"Int. 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