{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:50:37Z","timestamp":1782190237039,"version":"3.54.5"},"reference-count":120,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Biosci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                      is a prevalent fungus that poses significant health dangers, especially for people with weakened immune systems. It may result in multiple conditions, such as allergic reactions, chronic pulmonary aspergillosis, and invasive aspergillosis, mainly impacting individuals with chronic lung diseases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims and objectives<\/jats:title>\n                    <jats:p>\n                      The main goals of this review article are to grasp the recent advancements in the knowledge of cellular and molecular mechanisms related to\n                      <jats:italic>A. fumigatus<\/jats:italic>\n                      pathogenesis, create enhanced diagnostic methods, and assess current therapies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This review emphasizes the importance of biofilms in maintaining infections and enhancing antifungal resistance. Human infections due to\n                      <jats:italic>A. fumigatus<\/jats:italic>\n                      offer chances for further investigation, and these developing research topics are examined. Progress in diagnosis and treatment includes the creation of novel antifungal medications, customized medical strategies, and innovative diagnostic technologies. The relationships between the host and fungi, as well as the pathophysiology, must be understood.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The virulence factors produced during\n                      <jats:italic>A. fumigatus<\/jats:italic>\n                      pathogenesis can harm respiratory epithelial cells and impair immune function. It can survive and grow at temperatures up to 50 \u00b0C and release toxic materials that can harm human tissues and weaken the immune system. Public health initiatives and environmental stewardship are examples of preventive strategies. The development of vaccines can safeguard groups at high risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Research on\n                      <jats:italic>A. fumigatus<\/jats:italic>\n                      pathogenesis reveals complex interactions between fungus and host cells.\n                      <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                      is a global concern, with resistance rates increasing in Asia. New antifungal medicines, lipopeptides, and marine bioactive substances are being investigated to combat infections and improve health.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmolb.2026.1829493","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:34:57Z","timestamp":1782189297000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular mechanisms driving Aspergillus fumigatus disease: host interaction, virulence, biofilms, and resistance"],"prefix":"10.3389","volume":"13","author":[{"given":"Afsona","family":"Parveen","sequence":"first","affiliation":[{"name":"Department of Bachelor in Medical Laboratory Technology, Durgapur Institute of Paramedical Science","place":["Durgapur, West Bengal, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prithviraj","family":"Karak","sequence":"additional","affiliation":[{"name":"Department of Physiology, Bankura Christian College","place":["Bankura, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atin","family":"Adhikari","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology, and Environmental Health Sciences, Jiann-Ping Hsu College of Public Health, Georgia Southern University","place":["Statesboro, GA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayandeep K.","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shri B. 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