{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:37:41Z","timestamp":1793407061074,"version":"4.5.0"},"reference-count":112,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Biosci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Endometriosis is a common, chronic, estrogen-dependent gynecological disorder characterized by the growth of endometrial-like tissue outside the uterus and frequently associated with pelvic pain and infertility. Despite its high prevalence, the molecular mechanisms underlying lesion persistence and inflammation remain poorly understood, limiting the development of reliable non-surgical diagnostic tools and targeted therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A case-control study included 176 women with endometriosis and 124 controls. Salivary microRNA (miRNA) expression was analyzed using next-generation sequencing. Patients were stratified into untreated and treated groups (pharmacological or surgical therapy), while controls included healthy individuals and a technical control group of women with benign gynecological conditions to reduce potential confounding factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ten salivary miRNAs were associated with disease activity. Seven (hsa-miR-130a-3p, hsa-miR-130b-3p, hsa-miR-141-3p, hsa-miR-200b-3p, hsa-miR-200c-3p, hsa-miR-203b-5p, and hsa-miR-29c-3p) had previously been linked to endometriosis, while three were associated with inflammatory or cancer-related pathways. Expression levels showed a gradient across clinical groups, with intermediate levels in treated patients, suggesting therapeutic modulation. Target analysis identified PTEN as a key regulated gene, implicating the PI3K\/AKT\/mTOR pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These findings support salivary miRNAs as promising non-invasive biomarkers for the diagnosis and monitoring of endometriosis and provide further insight into the molecular pathways involved in disease pathogenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmolb.2026.1869937","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T13:47:06Z","timestamp":1784728026000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Profiling miRNA in salivary samples from subjects with endometriosis: a pilot study"],"prefix":"10.3389","volume":"13","author":[{"given":"Graziella","family":"Calugi","sequence":"first","affiliation":[{"name":"Eurofins Genoma Group, Research and Development Department","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Blandino","sequence":"additional","affiliation":[{"name":"Eurofins Genoma Group, Research and Development Department","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Proserpio","sequence":"additional","affiliation":[{"name":"Eurofins Genoma Group, Research and Development Department","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Forlani","sequence":"additional","affiliation":[{"name":"Eurofins Genoma Group, Bioinformatic Department","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemi","family":"Meschino","sequence":"additional","affiliation":[{"name":"Eurofins Genoma Group, Research and Development Department","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Giannico","sequence":"additional","affiliation":[{"name":"Eurofins Genoma Group, Bioinformatic Department","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Dalla Pozza","sequence":"additional","affiliation":[{"name":"Eurofins Genoma Group, Bioinformatic Department","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Graziani","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, The University of Kansas","place":["Lawrence, KS, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Di Pietro","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences, University of Catania","place":["Catania, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Buccarello","sequence":"additional","affiliation":[{"name":"Departmental Faculty of Medicine, UniCamillus\u2014Saint Camillus International University of Health Sciences","place":["Rome, Italy"]},{"name":"IRCCS San Camillo Hospital","place":["Venice, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco Giuseppe","family":"Martire","sequence":"additional","affiliation":[{"name":"UOC Gynecology Department of Molecular and Development Medicine, University of Siena","place":["Siena, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Dealberti","sequence":"additional","affiliation":[{"name":"Biagio and Arrigo, Obstetrics and Gynecology, University Hospital Company SS Antonio","place":["Alessandria, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Lanzo","sequence":"additional","affiliation":[{"name":"Department of Health and Surgical Science, Gynecology and Obstetrics, S. Anna Hospital, University of Turin","place":["Turin, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Cosma","sequence":"additional","affiliation":[{"name":"Department of Health and Surgical Science, Gynecology and Obstetrics, S. Anna Hospital, University of Turin","place":["Turin, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Marchino","sequence":"additional","affiliation":[{"name":"GVM S. Catherine of Siena Clinic","place":["Turin, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Luisi","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, AOUP Pisana Universiy-Hospital Company","place":["Pisa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca Raffaello","family":"Damiani","sequence":"additional","affiliation":[{"name":"Policlinic of Bari, Obstetrics and Gynecology, UOC University-Hospital Company","place":["Bari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Garavaglia","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sesto S. Giovanni Hospital","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Landi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Moriggia Pelascini-Gravedona General Hospital","place":["Como, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Marziali","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, New Villa Claudia Clinic","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Liprino","sequence":"additional","affiliation":[{"name":"UMR Unit of Reproduction Medicine, Hera Center","place":["Catania, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina Violante","family":"Pontello","sequence":"additional","affiliation":[{"name":"Pontello Gynecology Clinic","place":["Florence, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Fracchioli","sequence":"additional","affiliation":[{"name":"Fracchioli Gynecology Clinic","place":["Turin, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Caruso","sequence":"additional","affiliation":[{"name":"Departmental Faculty of Medicine, UniCamillus\u2014Saint Camillus International University of Health Sciences","place":["Rome, Italy"]},{"name":"IRCCS San Camillo Hospital","place":["Venice, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41389-022-00422-6","article-title":"Tumor-derived miR-130b-3p induces cancer-associated fibroblast activation by targeting SPIN90 in luminal A breast cancer","volume":"11","author":"Ahn","year":"2022","journal-title":"Oncogenesis"},{"key":"B78","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/s0015-0282(16)48430-x","article-title":"Revised american fertility society classification of endometriosis: 1985","volume":"43","year":"1985","journal-title":"Fertil. Steril."},{"key":"B79","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/s0015-0282(97)81391-x","article-title":"Revised American society for reproductive medicine classification of endometriosis: 1996","volume":"67","year":"1997","journal-title":"Fertil. Steril."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e3361","DOI":"10.7759\/cureus.3361","article-title":"The clinical anatomy of endometriosis: a review","volume":"10","author":"Alimi","year":"2018","journal-title":"Cureus"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1093\/humrep\/15.8.1744","article-title":"Relationship between endometriotic foci and nerves in rectovaginal endometriotic nodules","volume":"15","author":"Anaf","year":"2000","journal-title":"Hum. Reprod."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1016\/j.fertnstert.2006.03.057","article-title":"Pain, mast cells, and nerves in peritoneal, ovarian, and deep infiltrating endometriosis","volume":"86","author":"Anaf","year":"2006","journal-title":"Fertil. Steril."},{"key":"B5","unstructured":"Fastqc: a quality control tool for high throughput sequence data\n          \n          \n            \n              Andrews\n              S.\n            \n          \n          \n          2010"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/j.pain.2012.01.032","article-title":"Changes in regional gray matter volume in women with chronic pelvic pain: a voxel-based morphometry study","volume":"153","author":"As-Sanie","year":"2012","journal-title":"Pain"},{"key":"B7","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.fertnstert.2023.12.008","article-title":"Noninvasive diagnostic imaging for endometriosis part 1: a systematic review of recent developments in ultrasound, combination imaging, and artificial intelligence","volume":"121","author":"Avery","year":"2024","journal-title":"Fertil. Steril."},{"key":"B8","doi-asserted-by":"publisher","first-page":"102543","DOI":"10.1016\/j.tranon.2025.102543","article-title":"Extracellular vesicles as biomarkers for endometrial cancer - a systematic review","volume":"62","author":"Baxter","year":"2025","journal-title":"Transl. Oncol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"612","DOI":"10.3390\/jcm11030612","article-title":"Salivary MicroRNA signature for diagnosis of endometriosis","volume":"11","author":"Bendifallah","year":"2022","journal-title":"J. Clin. Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"EVIDoa2200282","DOI":"10.1056\/evidoa2200282","article-title":"Validation of a salivary miRNA signature of endometriosis - interim data","volume":"2","author":"Bendifallah","year":"2023","journal-title":"NEJM Evid."},{"key":"B11","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.ejogrb.2024.04.020","article-title":"Saliva-based microRNA diagnostic signature for the superficial peritoneal endometriosis phenotype","volume":"297","author":"Bendifallah","year":"2024","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"EVIDoa2400195","DOI":"10.1056\/evidoa2400195","article-title":"Validation of a saliva Micro-RNA signature for endometriosis","volume":"4","author":"Bendifallah","year":"2025","journal-title":"NEJM Evid."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1093\/biolre\/ioz219","article-title":"Erratum: MicroRNAs in endometriosis biological function and emerging biomarker candidates","volume":"101","author":"Bjorkman","year":"2019","journal-title":"Biol. Reprod."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1020827","DOI":"10.3389\/fendo.2022.1020827","article-title":"Endometriosis-associated infertility: from pathophysiology to tailored treatment","volume":"13","author":"Bonavina","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B15","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.ejogrb.2008.01.014","article-title":"Peritoneal fluid flow influences anatomical distribution of endometriotic lesions: why sampson seems to be right","volume":"138","author":"Bricou","year":"2008","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.fertnstert.2012.06.029","article-title":"Pathogenesis and pathophysiology of endometriosis","volume":"98","author":"Burney","year":"2012","journal-title":"Fertil. Steril."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1093\/humrep\/dey323","article-title":"Differential microRNA expression between decidual and peripheral blood natural killer cells in early pregnancy","volume":"33","author":"Carlino","year":"2018","journal-title":"Hum. Reprod."},{"key":"B18","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1093\/humrep\/deg009","article-title":"Anatomical distribution of deeply infiltrating endometriosis: surgical implications and proposition for a classification","volume":"18","author":"Chapron","year":"2003","journal-title":"Hum. Reprod."},{"key":"B19","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1093\/humrep\/deq017","article-title":"Surgery for bladder endometriosis: long-term results and concomitant management of associated posterior deep lesions","volume":"25","author":"Chapron","year":"2010","journal-title":"Hum. Reprod."},{"key":"B20","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1093\/humrep\/der462","article-title":"Ovarian endometrioma: severe pelvic pain is associated with deeply infiltrating endometriosis","volume":"27","author":"Chapron","year":"2012","journal-title":"Hum. Reprod."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1016\/j.fertnstert.2015.02.013","article-title":"Circulating microRNAs as potential biomarkers for endometriosis","volume":"103","author":"Cho","year":"2015","journal-title":"Fertil. Steril."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-018-0167-1","article-title":"Increased \u03b12-6 sialylation of endometrial cells contributes to the development of endometriosis","volume":"50","author":"Choi","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"D147","DOI":"10.1093\/nar\/gkae1072","article-title":"miRTarBase 2025: updates to the collection of experimentally validated microRNA-target interactions","volume":"53","author":"Cui","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.rbmo.2022.09.019","article-title":"Endometriosis-associated infertility diagnosis based on saliva microRNA signatures","volume":"46","author":"Dabi","year":"2023","journal-title":"Reprod. Biomed. Online"},{"key":"B25","doi-asserted-by":"publisher","first-page":"e12858","DOI":"10.1111\/aji.12858","article-title":"MiR-27a-3p and miR-124-3p, upregulated in endometrium and serum from women affected by chronic endometritis, are new potential molecular markers of endometrial receptivity","volume":"80","author":"Di Pietro","year":"2018","journal-title":"Am. J. Reprod. Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1093\/humrep\/det457","article-title":"ESHRE guideline: management of women with endometriosis","volume":"29","author":"Dunselman","year":"2014","journal-title":"Hum. Reprod."},{"key":"B27","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s40902-021-00303-9","article-title":"Salivary exosomal microRNAs as biomarkers for head and neck cancer detection-a literature review","volume":"43","author":"Faur","year":"2021","journal-title":"Maxillofac. Plast. Reconstr. Surg."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1080\/15476286.2016.1234658","article-title":"Distribution of microRNA biomarker candidates in solid tissues and body fluids","volume":"13","author":"Fehlmann","year":"2016","journal-title":"RNA Biol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1016\/j.fertnstert.2015.01.032","article-title":"Second surgery for recurrent unilateral endometriomas and impact on ovarian reserve: a case-control study","volume":"103","author":"Ferrero","year":"2015","journal-title":"Fertil. Steril."},{"key":"B30","doi-asserted-by":"publisher","first-page":"369549","DOI":"10.1155\/2010\/369549","article-title":"Differential expression of microRNAs between eutopic and ectopic endometrium in ovarian endometriosis","volume":"2010","author":"Filigheddu","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1186\/s12885-018-4364-z","article-title":"Salivary extracellular vesicle-associated miRNAs as potential biomarkers in oral squamous cell carcinoma","volume":"18","author":"Gai","year":"2018","journal-title":"BMC Cancer"},{"key":"B32","doi-asserted-by":"publisher","first-page":"e30679","DOI":"10.1371\/journal.pone.0030679","article-title":"The majority of microRNAs detectable in serum and saliva is concentrated in exosomes","volume":"7","author":"Gallo","year":"2012","journal-title":"PLoS One"},{"key":"B33","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/s41580-018-0045-7","article-title":"Regulation of microRNA function in animals","volume":"20","author":"Gebert","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/s12958-025-01486-w","article-title":"The influence of menstrual cycle and endometriosis on endometrial expression of epithelial-to-mesenchymal transition (EMT)-Related genes","volume":"23","author":"G\u00f3\u017ad\u017a","year":"2025","journal-title":"Reprod. Biol. Endocrinol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"655","DOI":"10.4155\/bio-2017-0010","article-title":"Saliva: a reliable sample matrix in bioanalytics","volume":"9","author":"Gr\u00f6schl","year":"2017","journal-title":"Bioanalysis"},{"key":"B36","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s13277-015-4374-2","article-title":"MicroRNAs, TGF-\u03b2 signaling, and the inflammatory microenvironment in cancer","volume":"37","author":"Guo","year":"2016","journal-title":"Tumour Biol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.ijom.2026.01.004","article-title":"Diagnostic and prognostic potential of salivary microRNA in oral and head and neck squamous cell carcinomas: a systematic review","volume":"55","author":"Hashmi","year":"2026","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"B38","doi-asserted-by":"publisher","first-page":"dmm047662","DOI":"10.1242\/dmm.047662","article-title":"miRNA interplay: mechanisms and consequences in cancer","volume":"14","author":"Hill","year":"2021","journal-title":"Dis. Model Mech."},{"key":"B39","doi-asserted-by":"publisher","first-page":"146","DOI":"10.2174\/1573397111666150619094524","article-title":"Central and peripheral pain generators in women with chronic pelvic pain: patient centered assessment and treatment","volume":"11","author":"Hoffman","year":"2015","journal-title":"Curr. Rheumatol. Rev."},{"key":"B40","doi-asserted-by":"publisher","first-page":"7460","DOI":"10.3390\/ijms26157460","article-title":"Insights into the molecular mechanisms and signaling pathways of epithelial to mesenchymal transition (EMT) in the pathophysiology of endometriosis","volume":"26","author":"Hosseinirad","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1002\/path.4295","article-title":"miRNA-199a-5p regulates VEGFA in endometrial mesenchymal stem cells and contributes to the pathogenesis of endometriosis","volume":"232","author":"Hsu","year":"2014","journal-title":"J. Pathol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1055\/s-0035-1564609","article-title":"The role of stem cells in the etiology and pathophysiology of endometriosis","volume":"33","author":"Hufnagel","year":"2015","journal-title":"Semin. Reprod. Med."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.3390\/ijms27041785","article-title":"Epigenetic landscape of female infertility: an integrated bioinformatics perspective on DNA methylation, MicroRNAs, and gene regulatory networks across PCOS, endometriosis, and diminished ovarian reserve","volume":"27","author":"Jalouli","year":"2026","journal-title":"Int. J. Mol. Sci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1186\/s13054-021-03775-3","article-title":"Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury","volume":"25","author":"Jiao","year":"2021","journal-title":"Crit. Care"},{"key":"B45","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1177\/1535370216681550","article-title":"Saliva diagnostics - current views and directions","volume":"242","author":"Kaczor-Urbanowicz","year":"2017","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"B46","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1093\/humrep\/des364","article-title":"Pelvic pain in women with ovarian endometrioma is mostly associated with coexisting peritoneal lesions","volume":"28","author":"Khan","year":"2013","journal-title":"Hum. Reprod."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1101\/2025.04.01.646562","article-title":"Essential role of hsa-miR-203a-3p in type I interferons immune homeostasis during influenza and NDV infection","author":"kumar","year":"2025","journal-title":"bioRxiv"},{"key":"B48","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.tips.2015.03.004","article-title":"Menstruation pulls the trigger for inflammation and pain in endometriosis","volume":"36","author":"Laux-Biehlmann","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1093\/biolre\/ioab134","article-title":"A critical appraisal of the circulating levels of differentially expressed microRNA in endometriosis\u2020","volume":"105","author":"Leonova","year":"2021","journal-title":"Biol. Reprod."},{"key":"B50","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1007\/s00404-014-3437-8","article-title":"Adenomyosis and endometriosis. Re-visiting their association and further insights into the mechanisms of auto-traumatisation. An MRI study","volume":"291","author":"Leyendecker","year":"2015","journal-title":"Arch. Gynecol. Obstet."},{"key":"B51","doi-asserted-by":"publisher","first-page":"111112","DOI":"10.1016\/j.ygeno.2025.111112","article-title":"Combination of circular RNA-miRNA-mRNA expression profiles and bioinformatic analysis in ovarian endometriosis","volume":"117","author":"Li","year":"2025","journal-title":"Genomics"},{"key":"B52","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1186\/s13287-017-0706-z","article-title":"miR-200c suppresses endometriosis by targeting MALAT1 in vitro and in vivo","volume":"8","author":"Liang","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1111\/aogs.14430","article-title":"Integrated bioinformatic analysis of dysregulated microRNA-mRNA co-expression network in ovarian endometriosis","volume":"101","author":"Liu","year":"2022","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"B54","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-Seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biology"},{"key":"B55","doi-asserted-by":"publisher","first-page":"6218","DOI":"10.1038\/s41598-026-37277-5","article-title":"Identification of candidate microRNA biomarkers of endometriosis in different bodily fluids","volume":"16","author":"Lyu","year":"2026","journal-title":"Sci. Rep."},{"key":"B56","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1080\/09513590.2019.1680627","article-title":"PI3K\/AKT pathway is altered in the endometriosis patient's endometrium and presents differences according to severity stage","volume":"36","author":"Madanes","year":"2020","journal-title":"Gynecol. Endocrinol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"721","DOI":"10.3390\/molecules29030721","article-title":"The role of the PTEN tumor suppressor gene and its anti-angiogenic activity in melanoma and other cancers","volume":"29","author":"Maphutha","year":"2024","journal-title":"Molecules"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1210\/endrev\/bnad020","article-title":"Epigenetic dysregulation in endometriosis: implications for pathophysiology and therapeutics","volume":"44","author":"Marquardt","year":"2023","journal-title":"Endocr. Rev."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.tem.2014.10.003","article-title":"Inflammation and nerve fiber interaction in endometriotic pain","volume":"26","author":"McKinnon","year":"2015","journal-title":"Trends Endocrinol. Metab."},{"key":"B60","doi-asserted-by":"publisher","first-page":"20150672","DOI":"10.1259\/bjr.20150672","article-title":"Extragenital endometriosis: assessment with MR imaging. A pictorial review","volume":"89","author":"Menni","year":"2016","journal-title":"Br. J. Radiol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1111\/j.1601-0825.2009.01604.x","article-title":"Exosomes from human saliva as a source of microRNA biomarkers","volume":"16","author":"Michael","year":"2010","journal-title":"Oral Dis."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1996","DOI":"10.1016\/j.ymthe.2018.05.002","article-title":"MicroRNA-148b targets the TGF-\u03b2 pathway to regulate angiogenesis and endothelial-to-mesenchymal transition during skin wound healing","volume":"26","author":"Miscianinov","year":"2018","journal-title":"Mol. Ther."},{"key":"B63","doi-asserted-by":"publisher","first-page":"557.e551","DOI":"10.1016\/j.ajog.2020.02.050","article-title":"Accurate diagnosis of endometriosis using serum microRNAs","volume":"223","author":"Moustafa","year":"2020","journal-title":"Am. J. Obstet. Gynecol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.fertnstert.2006.06.055","article-title":"Histologic analysis of endometriomas: what the surgeon needs to know","volume":"87","author":"Muzii","year":"2007","journal-title":"Fertil. Steril."},{"key":"B65","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1093\/humrep\/det451","article-title":"Is adenomyosis associated with menorrhagia?","volume":"29","author":"Naftalin","year":"2014","journal-title":"Hum. Reprod."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1177\/1933719116681519","article-title":"Serum miR-451a levels are significantly elevated in women with endometriosis and recapitulated in baboons (Papio anubis) with experimentally-induced disease","volume":"24","author":"Nothnick","year":"2017","journal-title":"Reprod. Sci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1210\/me.2008-0387","article-title":"MicroRNA-regulated pathways associated with endometriosis","volume":"23","author":"Ohlsson Teague","year":"2009","journal-title":"Mol. Endocrinol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1016\/j.fertnstert.2020.01.026","article-title":"Identification of candidate microRNA markers of endometriosis with the use of next-generation sequencing and quantitative real-time polymerase chain reaction","volume":"113","author":"Papari","year":"2020","journal-title":"Fertil. Steril."},{"key":"B69","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1080\/09513590.2022.2076830","article-title":"miR-203a-3p, ABL1 and TP63 gene expression is altered in the endometrium of women with endometriosis","volume":"38","author":"Pashaei","year":"2022","journal-title":"Gynecol. Endocrinol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.3390\/biom12081144","article-title":"Hsa-mir-135a shows potential as A putative diagnostic biomarker in saliva and plasma for endometriosis","volume":"12","author":"Perricos","year":"2022","journal-title":"Biomolecules"},{"key":"B71","doi-asserted-by":"publisher","first-page":"E1925","DOI":"10.1210\/jc.2011-1231","article-title":"MicroRNA 135 regulates HOXA10 expression in endometriosis","volume":"96","author":"Petracco","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B72","doi-asserted-by":"publisher","first-page":"181","DOI":"10.3892\/br.2019.1237","article-title":"Evaluation of miR-135a\/b expression in endometriosis lesions","volume":"11","author":"Petracco","year":"2019","journal-title":"Biomed. Rep."},{"key":"B73","doi-asserted-by":"publisher","first-page":"3146","DOI":"10.1210\/jc.2012-1558","article-title":"The impact of excision of ovarian endometrioma on ovarian reserve: a systematic review and meta-analysis","volume":"97","author":"Raffi","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B74","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1007\/s13669-012-0016-5","article-title":"Insights into assessing the genetics of endometriosis","volume":"1","author":"Rahmioglu","year":"2012","journal-title":"Curr. Obstet. Gynecol. Rep."},{"key":"B75","doi-asserted-by":"publisher","first-page":"W191","DOI":"10.1093\/nar\/gkz369","article-title":"g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)","volume":"47","author":"Raudvere","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"B76","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/j.fertnstert.2015.06.029","article-title":"Circulating miR-200-family micro-RNAs have altered plasma levels in patients with endometriosis and vary with blood collection time","volume":"104","author":"Rekker","year":"2015","journal-title":"Fertil. Steril."},{"key":"B77","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1007\/s43440-025-00732-7","article-title":"Saliva as a matrix for therapeutic drug monitoring and disease biomarkers in children and adolescents","volume":"77","author":"Resztak","year":"2025","journal-title":"Pharmacol. Rep."},{"key":"B80","doi-asserted-by":"publisher","first-page":"104521","DOI":"10.1016\/j.jri.2025.104521","article-title":"Non-invasive blood tests for earlier diagnosis and treatment of endometriosis","volume":"169","author":"Sadeghzadeh Oskouei","year":"2025","journal-title":"J. Reprod. Immunol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1093\/humrep\/dew093","article-title":"Endometriosis-related infertility: ovarian endometrioma per se is not associated with presentation for infertility","volume":"31","author":"Santulli","year":"2016","journal-title":"Hum. Reprod."},{"key":"B82","doi-asserted-by":"publisher","first-page":"131","DOI":"10.3892\/ol.2026.15484","article-title":"Effect of the hsa-microRNA 200c-3p\/ZEB1 loop in epithelial-mesenchymal transition of ovarian cancer cells","volume":"31","author":"Senturk","year":"2026","journal-title":"Oncol. Lett."},{"key":"B83","doi-asserted-by":"publisher","first-page":"907","DOI":"10.3390\/ijms21030907","article-title":"Salivary MicroRNA for diagnosis of cancer and systemic diseases: a systematic review","volume":"21","author":"Setti","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B84","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1093\/humrep\/17.3.555","article-title":"Genetic factors contribute to the risk of developing endometriosis","volume":"17","author":"Stefansson","year":"2002","journal-title":"Hum. Reprod."},{"key":"B85","doi-asserted-by":"publisher","first-page":"3294","DOI":"10.1093\/humrep\/des274","article-title":"In women with endometriosis Anti-Mullerian hormone levels are decreased only in those with previous endometrioma surgery","volume":"27","author":"Streuli","year":"2012","journal-title":"Hum. Reprod."},{"key":"B86","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1161\/CIRCRESAHA.108.191270","article-title":"MicroRNAs as novel regulators of angiogenesis","volume":"104","author":"Su\u00e1rez","year":"2009","journal-title":"Circ. Res."},{"key":"B87","doi-asserted-by":"publisher","first-page":"4568","DOI":"10.1111\/jcmm.13700","article-title":"The regulatory role of microRNAs in angiogenesis-related diseases","volume":"22","author":"Sun","year":"2018","journal-title":"J. Cell Mol. Med."},{"key":"B88","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1158\/1078-0432.CCR-12-2726","article-title":"Plasma microRNAs as novel biomarkers for endometriosis and endometriosis-associated ovarian cancer","volume":"19","author":"Suryawanshi","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"B89","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1002\/ijgo.12521","article-title":"An evidence-based approach to assessing surgical versus clinical diagnosis of symptomatic endometriosis","volume":"142","author":"Taylor","year":"2018","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"B90","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/s0015-0282(98)00540-8","article-title":"Genet. Influ. Endometr. Aust. twin sample. sueT@qimr.edu.au","volume":"71","author":"Treloar","year":"1999","journal-title":"Fertil Steril"},{"key":"B91","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/s0015-0282(02)03341-1","article-title":"The International Endogene Study: a collection of families for genetic research in endometriosis","volume":"78","author":"Treloar","year":"2002","journal-title":"Fertil. Steril."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1093\/humrep\/dez116","article-title":"Plasma miRNAs as biomarkers for endometriosis","volume":"34","author":"Vanhie","year":"2019","journal-title":"Hum. Reprod."},{"key":"B93","doi-asserted-by":"publisher","first-page":"888","DOI":"10.3390\/biomedicines12040888","article-title":"Circulating microRNAs as non-invasive biomarkers in endometriosis Diagnosis-A systematic review","volume":"12","author":"Vanhie","year":"2024","journal-title":"Biomedicines"},{"key":"B94","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1093\/humrep\/deu041","article-title":"Uterine adenomyosis and in vitro fertilization outcome: a systematic review and meta-analysis","volume":"29","author":"Vercellini","year":"","journal-title":"Hum. Reprod."},{"key":"B95","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/nrendo.2013.255","article-title":"Endometriosis: pathogenesis and treatment","volume":"10","author":"Vercellini","year":"","journal-title":"Nat. Rev. Endocrinol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1038\/s41419-025-08022-z","article-title":"Endometrial cancer progression driven by PTEN-deficiency requires miR-424 (322)\u223c 503","volume":"16","author":"Vidal-Saban\u00e9s","year":"2025","journal-title":"Cell Death and Dis."},{"key":"B97","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1210\/jc.2012-2415","article-title":"Circulating microRNAs identified in a genome-wide serum microRNA expression analysis as noninvasive biomarkers for endometriosis","volume":"98","author":"Wang","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B98","doi-asserted-by":"publisher","first-page":"136","DOI":"10.4149\/neo_2021_210815n1158","article-title":"LINC00536 promotes hepatocellular carcinoma progression via the miR-203b-5p\/VEGFA axis","volume":"69","author":"Wang","year":"2022","journal-title":"Neoplasma"},{"key":"B99","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1373\/clinchem.2010.147405","article-title":"The microRNA spectrum in 12 body fluids","volume":"56","author":"Weber","year":"2010","journal-title":"Clin. Chem."},{"key":"B100","doi-asserted-by":"publisher","first-page":"e12645","DOI":"10.1002\/rmb2.12645","article-title":"Combined targeting of TCF7L1\/2, PTEN, CDK6, and BCCIP by microRNA miR-29c-3p is associated with reduced invasion and proliferation of endometriotic cells","volume":"24","author":"Wentges","year":"2025","journal-title":"Reprod. Med. Biol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"3266","DOI":"10.1007\/s43032-022-00974-3","article-title":"AP-1 subunit JUNB promotes invasive phenotypes in endometriosis","volume":"29","author":"Wilson","year":"2022","journal-title":"Reprod. Sci."},{"key":"B102","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1159\/000546836","article-title":"Mechanisms of KLF10 in regulating proliferation of endometriotic stromal cells in endometriosis","volume":"91","author":"Xia","year":"2026","journal-title":"Gynecol. Obstet. Invest."},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1002\/bab.70134","article-title":"Exploring molecular signature and prognostic biomarkers in ovarian cancer: insights from Late-Stage, recurrent, and metastatic tumors","author":"Yadav","year":"2026","journal-title":"Biotechnol. Appl. Biochem"},{"key":"B104","doi-asserted-by":"publisher","first-page":"2941","DOI":"10.1080\/21655979.2021.1943111","article-title":"Upregulation of microRNA miR-141-3p and its prospective targets in endometrial carcinoma: a comprehensive study","volume":"12","author":"Yang","year":"2021","journal-title":"Bioengineered"},{"key":"B105","doi-asserted-by":"publisher","first-page":"102511","DOI":"10.1016\/j.tranon.2025.102511","article-title":"Luteolin suppresses cell migration and invasion via targeting miR-6809-5p\/FLOT1\/FAK and eliciting EMT in hepatocellular carcinoma","volume":"61","author":"Yang","year":"2025","journal-title":"Transl. Oncol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/s44294-025-00116-5","article-title":"Translation of miRNA blood-based discovery to molecular testing for clinical diagnosis of endometriosis","volume":"3","author":"Yu","year":"2025","journal-title":"Npj Women's Health"},{"key":"B107","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1080\/14737159.2021.1960508","article-title":"microRNAs as novel diagnostic biomarkers in endometriosis patients: a systematic review and meta-analysis","volume":"22","author":"Zafari","year":"2022","journal-title":"Expert Rev. Mol. Diagn"},{"key":"B108","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1093\/humrep\/dep427","article-title":"Nerve fibres in ovarian endometriotic lesions in women with ovarian endometriosis","volume":"25","author":"Zhang","year":"2010","journal-title":"Hum. Reprod."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1177\/1933719116641763","article-title":"Cellular changes consistent with epithelial-mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation in the progression of experimental endometriosis in baboons","volume":"23","author":"Zhang","year":"2016","journal-title":"Reprod. Sci."},{"key":"B110","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1080\/09168451.2019.1694860","article-title":"MiR-203a-3p targets PTEN to promote hepatocyte proliferation by regulating PI3K\/Akt pathway in BRL-3A cells","volume":"84","author":"Zhang","year":"2020","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"B111","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1186\/s12872-021-01980-0","article-title":"MicroRNA-200b-3p promotes endothelial cell apoptosis by targeting HDAC4 in atherosclerosis","volume":"21","author":"Zhang","year":"2021","journal-title":"BMC Cardiovasc Disord."},{"key":"B112","doi-asserted-by":"publisher","first-page":"6637","DOI":"10.3390\/ijms24076637","article-title":"Assessment of BMP7, SMAD4, and CDH1 expression profile and regulatory miRNA-542-3p in eutopic and ectopic endometrium of women with endometriosis","volume":"24","author":"Zubrzycka","year":"2023","journal-title":"Int. J. Mol. Sci."}],"container-title":["Frontiers in Molecular Biosciences"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmolb.2026.1869937\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T13:47:09Z","timestamp":1784728029000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmolb.2026.1869937\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":112,"alternative-id":["10.3389\/fmolb.2026.1869937"],"URL":"https:\/\/doi.org\/10.3389\/fmolb.2026.1869937","relation":{},"ISSN":["2296-889X"],"issn-type":[{"value":"2296-889X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]},"article-number":"1869937"}}