{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:10:40Z","timestamp":1788844240403,"version":"build-2803163510"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002480","name":"Gimcheon University","doi-asserted-by":"publisher","award":["gc24002"],"award-info":[{"award-number":["gc24002"]}],"id":[{"id":"10.13039\/501100002480","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022R1F1A1075053"],"award-info":[{"award-number":["2022R1F1A1075053"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Biosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oxaliplatin-induced peripheral neuropathy (OIPN) is a common and severe adverse event in patients with gastrointestinal (GI) cancer who undergo oxaliplatin-based chemotherapy. Assessments remain largely dependent on a numeric rating scale (NRS), which is needed for early detection and objective quantification of pain intensity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study aimed to identify differentially expressed microRNAs (miRNAs) in plasma samples from 22 patients with GI cancer treated with oxaliplatin to elucidate the association between candidate miRNA expression levels, nerve growth factor (NGF), catecholamines, and NRS scores for peripheral neuropathic pain. High-throughput RNA sequencing was used to analyze miRNA expression profiles, and patients were stratified into Groups 1 (\n                      <jats:italic>n<\/jats:italic>\n                      = 10, no or mild pain) and 2 (\n                      <jats:italic>n<\/jats:italic>\n                      = 12, moderate or severe pain) based on their NRS scores. Correlations between variables were assessed using Spearman\u2019s rank-order correlation (r = 0.4031,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0629).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In Group 2, hsa-miR-98-5p was significantly upregulated and demonstrated the greatest potential to stratify patients by pain severity among the candidate miRNAs (The area under the curve = 0.8083, 95% CI: 0.6222\u20130.9944). Gene ontology enrichment analysis revealed that hsa-miR-98-5p was significantly associated with critical neuronal injury and repair signaling pathways. Patients in Group 2 exhibited decreased norepinephrine and dopamine levels, elevated NGF levels, and elevated cortisol levels, indicating potential alterations in the OIPN neuromodulatory systems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that miR-98-5p is a candidate biomarker of pain severity in OIPN and may play a role in OIPN pathophysiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmolb.2026.1884789","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T04:26:51Z","timestamp":1788841611000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Plasma miR-98-5p as a candidate biomarker of pain severity in oxaliplatin-induced peripheral neuropathy related to NGF and catecholamine dysregulation"],"prefix":"10.3389","volume":"13","author":[{"given":"Yeongdon","family":"Ju","sequence":"first","affiliation":[{"name":"Gimcheon University","place":["Gimcheon-si, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go-Eun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Laboratory Science, College of Health Sciences, Catholic University of Pusan","place":["Busan, Republic of Korea"]},{"name":"Next-Generation Industrial Field-Based Specialist Program for Molecular Diagnostics, Brain Busan 21 Plus Project, Graduate School, Catholic University of Pusan","place":["Busan, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aelee","family":"Jang","sequence":"additional","affiliation":[{"name":"University of Ulsan","place":["Ulsan, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"851","DOI":"10.2147\/JPR.S158847","article-title":"Test\u2013retest reliability, validity, and minimum detectable change of visual analog, numerical rating, and verbal rating scales for measurement of osteoarthritic knee pain","volume":"11","author":"Alghadir","year":"2018","journal-title":"J. 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