{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:28:54Z","timestamp":1784125734611,"version":"3.55.0"},"reference-count":44,"publisher":"Frontiers Media SA","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Aging Neurosci."],"DOI":"10.3389\/fnagi.2014.00106","type":"journal-article","created":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T10:12:21Z","timestamp":1401271941000},"source":"Crossref","is-referenced-by-count":34,"title":["Early Brain Loss in Circuits Affected by Alzheimer\u00e2\u20ac\u2122s Disease is Predicted by Fornix Microstructure but may be Independent of Gray Matter"],"prefix":"10.3389","volume":"6","author":[{"given":"Evan","family":"Fletcher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen","family":"Carmichael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofer","family":"Pasternak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus H.","family":"Maier-Hein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"DeCarli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2014,5,28]]},"reference":[{"issue":"Pt 2","key":"B1","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1093\/brain\/awp257","article-title":"Absolute diffusivities define the landscape of white matter degeneration in Alzheimer\u00e2\u20ac\u2122s disease","volume":"133","author":"Acosta-Cabronero","year":"2010","journal-title":"Brain"},{"key":"B2","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1148\/radiol.10101284","article-title":"White matter damage in Alzheimer disease and its relationship to gray matter atrophy","volume":"258","author":"Agosta","year":"2011","journal-title":"Radiology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.neuroimage.2014.01.031","article-title":"CSF contamination contributes to apparent microstructural alterations in mild cognitive impairment","volume":"92","author":"Berlot","year":"2014","journal-title":"Neuroimage"},{"key":"B4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/j.1600-0404.1996.tb05866.x","article-title":"Evolution of the neuropathology of Alzheimer\u00e2\u20ac\u2122s disease","volume":"94","author":"Braak","year":"1996","journal-title":"Acta Neurol. Scand."},{"key":"B5","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.neurobiolaging.2010.01.021","article-title":"MRI predictors of cognitive change in a diverse and carefully characterized elderly population","volume":"33","author":"Carmichael","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"B6","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life-tables","volume":"34","author":"Cox","year":"1972","journal-title":"J. R. Stat. Soc. Ser. B"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.1523\/JNEUROSCI.4437-12.2013","article-title":"Brain microstructure reveals early abnormalities more than two years prior to clinical progression from mild cognitive impairment to Alzheimer\u00e2\u20ac\u2122s disease","volume":"33","author":"Douaud","year":"2013","journal-title":"J. Neurosci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1001\/jamaneurol.2013.3263","article-title":"Loss of fornix white matter volume as a predictor of cognitive impairment in cognitively normal elderly individuals","volume":"95616","author":"Fletcher","year":"2013a","journal-title":"JAMA Neurol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1109\/TMI.2012.2220153","article-title":"Combining boundary-based methods with tensor-based morphometry in the measurement of longitudinal brain change","volume":"32","author":"Fletcher","year":"2013b","journal-title":"IEEE Trans. Med. Imaging"},{"key":"B10","doi-asserted-by":"publisher","first-page":"5319","DOI":"10.1109\/EMBC.2012.6347195","article-title":"Adaptive image segmentation for robust measurement of longitudinal brain tissue change","volume":"2012","author":"Fletcher","year":"2012","journal-title":"Conf. Proc. IEEE Eng. Med. Biol. Soc."},{"key":"B11","doi-asserted-by":"publisher","first-page":"4637","DOI":"10.1073\/pnas.0308627101","article-title":"Default-mode network activity distinguishes Alzheimer\u00e2\u20ac\u2122s disease from healthy aging: evidence from functional MRI","volume":"101","author":"Greicius","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B12","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1073\/pnas.0135058100","article-title":"Functional connectivity in the resting brain: a network analysis of the default mode hypothesis","volume":"100","author":"Greicius","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B13","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1093\/cercor\/bhn059","article-title":"Resting-state functional connectivity reflects structural connectivity in the default mode network","volume":"19","author":"Greicius","year":"2009","journal-title":"Cereb. Cortex"},{"key":"B14","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1097\/WAD.0b013e3181c1ee01","article-title":"Recruitment of a community-based cohort for research on diversity and risk of dementia","volume":"24","author":"Hinton","year":"2010","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"B15","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.neuroimage.2008.07.013","article-title":"Tensor-based morphometry as a neuroimaging biomarker for Alzheimer\u00e2\u20ac\u2122s disease: an MRI study of 676 AD, MCI, and normal subjects","volume":"43","author":"Hua","year":"2008","journal-title":"Neuroimage"},{"key":"B16","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S1474-4422(09)70299-6","article-title":"Hypothetical model of dynamic biomarkers of the Alzheimer\u00e2\u20ac\u2122s pathological cascade","volume":"9","author":"Jack","year":"2010","journal-title":"Lancet Neurol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1016\/j.neuron.2013.12.003","article-title":"Biomarker modeling of Alzheimer\u00e2\u20ac\u2122s disease","volume":"80","author":"Jack","year":"2013","journal-title":"Neuron"},{"key":"B18","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.neuroimage.2011.09.015","article-title":"Fsl","volume":"62","author":"Jenkinson","year":"2012","journal-title":"Neuroimage"},{"key":"B19","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1097\/00004728-200109000-00023","article-title":"Regional spatial normalization: toward and optimal target","volume":"25","author":"Kochunov","year":"2001","journal-title":"J. Comput. Assist. Tomogr."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnagi.2012.00001","article-title":"Sub-regional hippocampal injury is associated with fornix degeneration in Alzheimer\u00e2\u20ac\u2122s disease","volume":"4","author":"Lee","year":"2012","journal-title":"Front. Aging Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/hbm.22311","article-title":"Midlife measurements of white matter microstructure predict subsequent regional white matter atrophy in healthy adults","author":"Ly","year":"2013","journal-title":"Hum. Brain Mapp."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1016\/j.neuroimage.2011.08.043","article-title":"How and how not to correct for CSF-contamination in diffusion MRI","volume":"59","author":"Metzler-Baddeley","year":"2012","journal-title":"Neuroimage"},{"key":"B23","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.neuroimage.2009.01.054","article-title":"Regionally-specific diffusion tensor imaging in mild cognitive impairment and Alzheimer\u00e2\u20ac\u2122s disease","volume":"46","author":"Mielke","year":"2009","journal-title":"Neuroimage"},{"key":"B24","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1017\/S1041610297004870","article-title":"Clinical dementia rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type","volume":"9","author":"Morris","year":"1997","journal-title":"Int. Psychogeriatr."},{"key":"B25","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1037\/a0019502","article-title":"Heterogeneity of cognitive trajectories in diverse older person","volume":"25","author":"Mungas","year":"2011","journal-title":"Psychol. Aging"},{"key":"B26","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1002\/ana.10669","article-title":"Limbic hypometabolism in Alzheimer\u00e2\u20ac\u2122s disease and mild cognitive impairment","volume":"54","author":"Nestor","year":"2003","journal-title":"Ann. Neurol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/hbm.1058","article-title":"Nonparametric permutation tests for functional neuroimaging: a primer with examples","volume":"15","author":"Nichols","year":"2001","journal-title":"Hum. Brain Mapp."},{"key":"B28","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/j.1552-6569.2011.00633.x","article-title":"The fornix sign: a potential sign for Alzheimer\u00e2\u20ac\u2122s disease based on diffusion tensor imaging","volume":"22","author":"Oishi","year":"2012","journal-title":"J. Neuroimaging"},{"key":"B29","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1002\/mrm.22055","article-title":"Free water elimination and mapping from diffusion MRI","volume":"62","author":"Pasternak","year":"2009","journal-title":"Magn. Reson. Med."},{"key":"B30","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.euroneuro.2012.11.010","article-title":"Structural networks in Alzheimer\u00e2\u20ac\u2122s disease","volume":"23","author":"Reid","year":"2013","journal-title":"Eur. Neuropsychopharmacol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1007\/11866763_86","article-title":"Diffeomorphic registration using b-splines","volume":"4191","author":"Rueckert","year":"2006","journal-title":"Med. Image Comput. Comput. Assist. Interv."},{"key":"B32","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1097\/YCO.0b013e32835ed6e8","article-title":"Is Alzheimer\u00e2\u20ac\u2122s a disease of the white matter?","volume":"26","author":"Sachdev","year":"2013","journal-title":"Curr. Opin. Psychiatry"},{"key":"B33","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.neuron.2009.03.024","article-title":"Neurodegenerative diseases target large-scale human brain networks","volume":"62","author":"Seeley","year":"2009","journal-title":"Neuron"},{"issue":"5 Suppl.","key":"B34","doi-asserted-by":"publisher","first-page":"S112","DOI":"10.1016\/j.jalz.2011.07.001","article-title":"White matter imaging changes in subjective and mild cognitive impairment","volume":"8","author":"Selnes","year":"2012","journal-title":"Alzheimers Dement."},{"key":"B35","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.pscychresns.2010.07.005","article-title":"MRI correlates of episodic memory in Alzheimer\u00e2\u20ac\u2122s disease, mild cognitive impairment, and healthy aging","volume":"184","author":"Sexton","year":"2010","journal-title":"Psychiatry Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","article-title":"Toward defining the preclinical stages of Alzheimer\u00e2\u20ac\u2122s disease: recommendations from the National Institute on Aging-Alzheimer\u00e2\u20ac\u2122s Association workgroups on diagnostic guidelines for Alzheimer\u00e2\u20ac\u2122s disease","volume":"7","author":"Sperling","year":"2011","journal-title":"Alzheimers Dement."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1148\/rg.314105729","article-title":"The fornix in health and disease: an imaging review","volume":"31","author":"Thomas","year":"2011","journal-title":"Radiographics"},{"key":"B38","doi-asserted-by":"publisher","first-page":"6174","DOI":"10.1523\/JNEUROSCI.1392-08.2008","article-title":"Relationships between hippocampal atrophy, white matter disruption, and gray matter hypometabolism in Alzheimer\u00e2\u20ac\u2122s disease","volume":"28","author":"Villain","year":"2008","journal-title":"J. Neurosci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"3301","DOI":"10.1093\/brain\/awq203","article-title":"Sequential relationships between grey matter and white matter atrophy and brain metabolic abnormalities in early Alzheimer\u00e2\u20ac\u2122s disease","volume":"133","author":"Villain","year":"2010","journal-title":"Brain"},{"key":"B40","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.bbadis.2011.08.002","article-title":"Selective changes in white matter integrity in MCI and older adults with cognitive complaints","volume":"1822","author":"Wang","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"B41","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1212\/01.wnl.0000250326.77323.01","article-title":"Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease","volume":"68","author":"Zhang","year":"2007","journal-title":"Neurology"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1016\/j.neuroimage.2010.05.049","article-title":"Atlas-guided tract reconstruction for automated and comprehensive examination of the white matter anatomy","volume":"52","author":"Zhang","year":"2010","journal-title":"Neuroimage"},{"key":"B43","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1212\/WNL.0b013e3182661f4d","article-title":"Microstructural white matter changes in cognitively normal individuals at risk of amnestic MCI","volume":"79","author":"Zhuang","year":"2012","journal-title":"Neurology"},{"key":"B44","doi-asserted-by":"publisher","first-page":"e58887","DOI":"10.1371\/journal.pone.0058887","article-title":"Microstructural white matter changes, not hippocampal atrophy, detect early amnestic mild cognitive impairment","volume":"8","author":"Zhuang","year":"2013","journal-title":"PLoS ONE"}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"deposited":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T03:12:51Z","timestamp":1716779571000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnagi.2014.00106\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,28]]},"references-count":44,"URL":"https:\/\/doi.org\/10.3389\/fnagi.2014.00106","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,28]]}}}