{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T19:00:51Z","timestamp":1776020451538,"version":"3.50.1"},"reference-count":69,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["PZ00P3_136822"],"award-info":[{"award-number":["PZ00P3_136822"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008464","name":"EMDO foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008464","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"DOI":"10.3389\/fnagi.2015.00241","type":"journal-article","created":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T09:07:36Z","timestamp":1453194456000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Magnetic Resonance Q Mapping Reveals a Decrease in Microvessel Density in the arcA\u03b2 Mouse Model of Cerebral Amyloidosis"],"prefix":"10.3389","volume":"7","author":[{"given":"Giovanna D.","family":"Ielacqua","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Schlegel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"F\u00fcchtemeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jael","family":"Xandry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Rudin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Klohs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2016,1,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting linear mixed-effects models using lme4","volume":"67","author":"Bates","year":"2015","journal-title":"J. Stat. Softw."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1523\/JNEUROSCI.4936-10.2011","article-title":"Noninvasive magnetic resonance imaging detection of cerebral amyloid angiopathy-related microvascular alterations using superparmagentic iron oxide particles in APP transgenic mouse models of Alzheimer's disease: application to passive A\u03b2 immunotherapy","volume":"31","author":"Beckmann","year":"2011","journal-title":"J. Neurosci."},{"key":"B3","doi-asserted-by":"crossref","first-page":"8453","DOI":"10.1523\/JNEUROSCI.23-24-08453.2003","article-title":"Age-dependent cerebrovascular abnormalities and blood flow disturbances in APP23 mice modeling Alzheimer's disease","volume":"23","author":"Beckmann","year":"2003","journal-title":"J. Neurosci."},{"key":"B4","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1017\/S0317167100037124","article-title":"The correlation of vascular capacity with the parenchymal lesions of Alzheimer's disease","volume":"13","author":"Bell","year":"1986","journal-title":"Can. J. Neurol. Sci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1002\/mrm.1910360313","article-title":"Contribution of Sinerem used as blood-pool contrast agent: detection of cerebral blood volume changes during apnea in the rabbit","volume":"36","author":"Berry","year":"1996","journal-title":"Magn. Reson. Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e23789","DOI":"10.1371\/journal.pone.0023789","article-title":"Amyloid triggers extensive cerebral angiogenesis causing blood brain barrier permeability and hypervascularity in Alzheimer's disease","volume":"6","author":"Biron","year":"2011","journal-title":"PLoS ONE"},{"key":"B7","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1097\/01.jnen.0000203077.53080.2c","article-title":"Stereologic analysis of microvascular morphology in the elderly: Alzheimer disease pathology and cognitive status","volume":"65","author":"Bouras","year":"2006","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/j.1749-6632.1997.tb48457.x","article-title":"Brain microvascular changes in Alzheimer's disease and other dementias","volume":"826","author":"Bu\u00e8e","year":"1997","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"N83","DOI":"10.1088\/0031-9155\/48\/5\/403","article-title":"An automatic approach for estimating bolus arrival time in dynamic contrast MRI using piecewise continuous regression models","volume":"48","author":"Cheong","year":"2003","journal-title":"Phys. Med. Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1093\/brain\/awq321","article-title":"Brain microbleeds and Alzheimer's disease: innocent observation or key player?","volume":"134","author":"Cordonnier","year":"2011","journal-title":"Brain"},{"key":"B11","doi-asserted-by":"publisher","first-page":"157","DOI":"10.3109\/13506129909007321","article-title":"Pathogenic amyloid beta-protein induces apoptosis in cultured human cerebrovascular smooth muscle cells","volume":"6","author":"Davis","year":"1999","journal-title":"Amyloid"},{"key":"B12","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/0149-7634(94)90052-3","article-title":"Impaired brain microcirculation may trigger Alzheimer's disease","volume":"18","author":"de la Torre","year":"1994","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B13","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1007\/s00702-009-0226-9","article-title":"Evidence of angiogenic vessels in Alzheimer's disease","volume":"116","author":"Desai","year":"2009","journal-title":"J. Neural Transm."},{"key":"B14","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1002\/1522-2594(200006)43:6845::AID-MRM103.0.CO;2-J","article-title":"Utility of simultaneously acquired gradient-echo and spin-echo cerebral blood volume and morphology maps in brain tumor patients","volume":"43","author":"Donahue","year":"2000","journal-title":"Magn. Reson. Med."},{"key":"B15","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s10334-009-0194-y","article-title":"Detection of vascular alterations by in vivo magnetic resonance angiography and histology in APP\/PS1 mouse model of Alzheimer's disease","volume":"23","author":"El Tayara Nel","year":"2010","journal-title":"MAGMA"},{"key":"B16","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.neurobiolaging.2007.07.015","article-title":"Blood-brain barrier: ageing and microvascular disease\u2013systematic review and meta-analysis","volume":"30","author":"Farrall","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"B17","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.neurobiolaging.2009.03.009","article-title":"Impaired neurogenesis, neuronal loss, and brain functional deficits in the APPxPS1-Ki mouse model of Alzheimer's disease","volume":"32","author":"Faure","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"B18","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1007\/BF00294246","article-title":"Altered angioarchitecture in selected areas of brains with Alzheimer's disease","volume":"79","author":"Fischer","year":"1990","journal-title":"Acta Neuropathol."},{"key":"B19","volume-title":"The Mouse Brain in Stereotaxic Coordinates.","author":"Franklin","year":"1997"},{"key":"B20","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1742-2094-8-26","article-title":"Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer's disease","volume":"8","author":"Grammas","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"B21","doi-asserted-by":"publisher","first-page":"13780","DOI":"10.1523\/JNEUROSCI.4762-13.2014","article-title":"Early alterations in functional connectivity and white matter structure in a transgenic mouse model of cerebral amyloidosis","volume":"34","author":"Grandjean","year":"2014","journal-title":"J. Neurosci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1002\/ana.410380219","article-title":"Apolipoprotein E epsilon 4 and cerebral hemorrhage associated with amyloid angiopathy","volume":"38","author":"Greenberg","year":"1995","journal-title":"Ann. Neurol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/nrm2101","article-title":"Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid \u03b2-peptide","volume":"8","author":"Haass","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1016\/j.neurobiolaging.2012.11.022","article-title":"Cortical atrophy and hypoperfusion in a transgenic mouse model of Alzheimer's disease","volume":"34","author":"H\u00e9bert","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1016\/j.neuroimage.2005.06.066","article-title":"The prediction of rapid conversion to Alzheimer's disease in mild cognitive impairment using regional cerebral blood flow SPECT","volume":"28","author":"Hirao","year":"2005","journal-title":"Neuroimage"},{"key":"B26","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/nrn1387","article-title":"Neurovascular regulation in the normal brain and in Alzheimer's disease","volume":"5","author":"Iadecola","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1002\/1522-2594(200008)44:2224::AID-MRM93.0.CO;2-M","article-title":"MR imaging of microvasculature","volume":"44","author":"Jensen","year":"2000","journal-title":"Magn. Reson. Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1148\/radiol.2343040197","article-title":"Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spinlabeling MR imaging: initial experience","volume":"234","author":"Johnson","year":"2005","journal-title":"Radiology"},{"key":"B29","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1016\/j.neuroimage.2011.12.055","article-title":"Monitoring blood flow alterations in the Tg2576 mouse model of Alzheimer's disease by in vivo magnetic resonance angiography at 17.6T","volume":"60","author":"Kara","year":"2012","journal-title":"Neuroimage"},{"key":"B30","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.cmpb.2009.12.005","article-title":"Toward fully automated processing of dynamic susceptibility contrast perfusion MRI for acute ischemic cerebral stroke","volume":"9","author":"Kim","year":"2010","journal-title":"Comput. Methods Programs Biomed."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1523\/JNEUROSCI.5626-11.2012","article-title":"Contrast-enhanced magnetic resonance microangiography reveals remodeling of the cerebral microvasculature in transgenic ArcA\u03b2 mice","volume":"32","author":"Klohs","year":"2012","journal-title":"J. Neurosci."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15621500","article-title":"Quantitative assessment of microvasculopathy in arcA\u03b2 mice with USPIO-enhanced gradient echo MRI","author":"Klohs","year":"2015","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B33","doi-asserted-by":"publisher","first-page":"2282","DOI":"10.1038\/jcbfm.2011.118","article-title":"Detection of cerebral microbleeds with quantitative susceptibility mapping in the ArcAbeta mouse model of cerebral amyloidosis","volume":"31","author":"Klohs","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B34","doi-asserted-by":"publisher","first-page":"e66097","DOI":"10.1371\/journal.pone.0066097","article-title":"Longitudinal assessment of amyloid pathology in transgenic arcA\u03b2 mice using multi-parametric magnetic resonance imaging","volume":"8","author":"Klohs","year":"2013","journal-title":"PLoS ONE"},{"issue":"32","key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00032","article-title":"Imaging of cerebrovascular pathology in animal models of Alzheimer's disease","volume":"6","author":"Klohs","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1016\/j.neurobiolaging.2006.06.019","article-title":"Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice","volume":"28","author":"Knobloch","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"B37","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.ijdevneu.2005.11.011","article-title":"Developmental and amyloid plaque-related changes in cerebral cortical capillaries in transgenic Tg2576 Alzheimer mice","volume":"24","author":"Kouznetsova","year":"2006","journal-title":"Int. J. Dev. Neurosci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"e183","DOI":"10.1038\/tp.2012.109","article-title":"Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-A\u03b2 APP mutation","volume":"2","author":"Kulic","year":"2012","journal-title":"Transl. Psychiatry"},{"key":"B39","first-page":"317","article-title":"Stereological analysis of microvascular parameters in a double transgenic model of Alzheimer's disease","volume-title":"Brain Res. Bull.","author":"Lee","year":"2005"},{"key":"B40","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1002\/mrm.24218","article-title":"In vivo imaging of vessel diameter, size, and density: a comparative study between MRI and histology","volume":"69","author":"Lemasson","year":"2013","journal-title":"Magn. Reson. Med."},{"key":"B41","first-page":"S339","article-title":"The growing burden of Alzheimer's disease","volume":"13","author":"Lopez","year":"2011","journal-title":"Am. J. Manag. Care Suppl."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1088\/0031-9155\/37\/7\/010","article-title":"A simplified formulation of the gamma variate function","volume":"37","author":"Madsen","year":"1992","journal-title":"Phys. Med. Biol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/alzrt104","article-title":"Dementia prevention: current epidemiological evidence and future perspective","volume":"4","author":"Mangialasche","year":"2012","journal-title":"Alzheimers Res. Ther."},{"key":"B44","doi-asserted-by":"publisher","first-page":"e10561","DOI":"10.1371\/journal.pone.0010561","article-title":"Mitochondrial superoxide contributes to blood flow and axonal transport deficits in the Tg2576 mouse model of Alzheimer's disease","volume":"5","author":"Massaad","year":"2010","journal-title":"PLoS ONE"},{"key":"B45","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s00401-011-0834-y","article-title":"Vascular \u03b2-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcA\u03b2 mice","volume":"122","author":"Merlini","year":"2011","journal-title":"Acta Neuropathol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"3587","DOI":"10.1073\/pnas.0709788105","article-title":"Altered morphology and 3D architecture of brain vasculature in a mouse model for Alzheimer's disease","volume":"105","author":"Meyer","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B47","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/S0002-9440(10)62993-8","article-title":"Cerebral microvascular amyloid beta protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid beta precursor protein","volume":"167","author":"Miao","year":"2005","journal-title":"Am. J. Pathol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1002\/jmri.20460","article-title":"Principles of cerebral perfusion imaging by bolus tracking","volume":"22","author":"\u00d8stergaard","year":"2005","journal-title":"J. Magn. Reson. Imag"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1016\/j.neurobiolaging.2012.09.011","article-title":"The capillary dysfunction hypothesis of Alzheimer's disease","volume":"34","author":"Ostergaard","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"B50","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1002\/mrm.1252","article-title":"MR-derived cerebral blood volume maps: issues regarding histological validation and assessment of tumor angiogenesis","volume":"46","author":"Pathak","year":"2001","journal-title":"Magn. Reson. Med."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1016\/j.neurobiolaging.2011.09.026","article-title":"Increased regional cerebral glucose uptake in an APP\/PS1 model of Alzheimer's disease","volume":"33","author":"Poisnel","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"B52","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1179\/016164101101198758","article-title":"Physiological levels of beta-amyloid induce cerebral vessel dysfunction and reduce endothelial nitric oxide production","volume":"23","author":"Price","year":"2001","journal-title":"Neurol. Res."},{"key":"B53","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1097\/00002093-198701000-00004","article-title":"Denervation microangiopathy in senile dementia, Alzheimer type","volume":"1","author":"Scheibel","year":"1987","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"B54","first-page":"1524","article-title":"Characterization of a first-pass gradient-echo spin-echo method to predict brain tumor grade and angiogenesis","volume":"25","author":"Schmainda","year":"2004","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1002\/1522-2586(200009)12:3411::AID-JMRI63.0.CO;2-5","article-title":"Comparison of gradient- and spin-echo imaging: CBF, CBV, and MTT measurements by bolus tracking","volume":"12","author":"Simonsen","year":"2000","journal-title":"J. Magn. Reson. Imaging"},{"key":"B56","doi-asserted-by":"publisher","first-page":"13287","DOI":"10.1073\/pnas.94.24.13287","article-title":"Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology","volume":"94","author":"Sturchler-Pierrat","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.1016\/j.neurobiolaging.2008.01.017","article-title":"Capillary cerebral amyloid angiopathy is associated with vessel occlusion and cerebral blood flow disturbances","volume":"30","author":"Thal","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"B58","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/380168a0","article-title":"b- Amyloid-mediated vasoactivity and vascular endothelial damage","volume":"80","author":"Thomas","year":"1996","journal-title":"Nature"},{"key":"B59","doi-asserted-by":"publisher","first-page":"e19592","DOI":"10.1371\/journal.pone.0019592","article-title":"In-vivo visualization of tumor microvessel density and response to anti-angiogenic treatment by high resolution MRI in mice","volume":"6","author":"Ullrich","year":"2011","journal-title":"PLoS ONE"},{"key":"B60","first-page":"216","article-title":"Pathologic cell surface amy- loid beta-protein fibril assembly in cultured human cerebrovascular smooth muscle cells","volume":"69","author":"Van Nostrand","year":"1997","journal-title":"J. Neurochem."},{"key":"B61","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1046\/j.1471-4159.1997.68031135.x","article-title":"Rapid degeneration of cultured human brain pericytes by amyloid beta protein","volume":"68","author":"Verbeek","year":"1997","journal-title":"J. Neurochem."},{"key":"B62","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1161\/01.STR.18.2.311","article-title":"Cerebral amyloid angiopathy. A critical review","volume":"18","author":"Vinters","year":"1987","journal-title":"Stroke"},{"key":"B63","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/mrm.21985","article-title":"Cortical hypoperfusion in the B6.PS2APP mouse model for Alzheimer's disease: comprehensive phenotyping of vascular and tissular parameters by MRI","volume":"62","author":"Weidensteiner","year":"2009","journal-title":"Magn. Reson. Med."},{"key":"B64","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.neulet.2004.05.004","article-title":"Regional cerebral blood volume reduction in transgenic mutant APP(V717F, K670N\/M671L) mice","volume":"365","author":"Wu","year":"2004a","journal-title":"Neurosci. Lett."},{"key":"B65","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1002\/nbm.921","article-title":"High-resolution MR imaging of mouse brain microvasculature using the relaxation rate shift index Q","volume":"17","author":"Wu","year":"2004b","journal-title":"NMR Biomed"},{"key":"B66","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1159\/000335302","article-title":"The potential of microvessel density in prediction of infarct growth: a two-month experimental study in vessel size imaging","volume":"33","author":"Xu","year":"2012","journal-title":"Cerebrovasc. Dis."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1038\/jcbfm.2011.38","article-title":"Vessel size imaging reveals pathological changes of microvessel density and size in acute ischemia","volume":"31","author":"Xu","year":"2011","journal-title":"J. Cereb. Blood. Flow Metab."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1007\/s00429-012-0448-8","article-title":"Microvascular cerebral blood volume changes in aging APP(swe)\/PS1(dE9) AD mouse model: a voxel-wise approach","volume":"218","author":"Zerbi","year":"2013","journal-title":"Brain Struct. Funct."},{"key":"B69","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/nrn3114","article-title":"Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders","volume":"12","author":"Zlokovic","year":"2011","journal-title":"Nat. Rev. Neurosci."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T09:59:31Z","timestamp":1589623171000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fnagi.2015.00241\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,19]]},"references-count":69,"URL":"https:\/\/doi.org\/10.3389\/fnagi.2015.00241","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,19]]}}}