{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:14:16Z","timestamp":1790550856048,"version":"4.1.0"},"reference-count":127,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31472166"],"award-info":[{"award-number":["31472166"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"DOI":"10.3389\/fnagi.2016.00042","type":"journal-article","created":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T08:34:44Z","timestamp":1456821284000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Role of the Retromer Complex in Neurodegenerative Diseases"],"prefix":"10.3389","volume":"8","author":[{"given":"Chaosi","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Zahid Ali","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,3,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e92648","DOI":"10.1371\/journal.pone.0092648","article-title":"Evidence of trem2 variant associated with triple risk of Alzheimer\u2019s disease","volume":"9","author":"Abduljaleel","year":"2014","journal-title":"PLoS One"},{"key":"B3","doi-asserted-by":"publisher","first-page":"13461","DOI":"10.1073\/pnas.0503689102","article-title":"Neuronal sorting protein-related receptor sorLA\/LR11 regulates processing of the amyloid precursor protein","volume":"102","author":"Andersen","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1002\/mds.25145","article-title":"VPS35 mutation in Japanese patients with typical Parkinson\u2019s disease","volume":"27","author":"Ando","year":"2012","journal-title":"Mov. Disord."},{"key":"B5","doi-asserted-by":"publisher","first-page":"5831","DOI":"10.1073\/pnas.1018645108","article-title":"Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27","volume":"108","author":"Balana","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B6","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.nbd.2012.03.030","article-title":"The location and trafficking routes of the neuronal retromer and its role in amyloid precursor protein transport","volume":"47","author":"Bhalla","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1038\/nrm1985","article-title":"Retrograde transport from endosomes to the trans-Golgi network","volume":"7","author":"Bonifacino","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1242\/jcs.018432","article-title":"Sorting nexin-1 defines an early phase of Salmonella-containing vacuole-remodeling during Salmonella infection","volume":"121","author":"Bujny","year":"2008","journal-title":"J. Cell Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1242\/jcs.003111","article-title":"The retromer component sorting nexin-1 is required for efficient retrograde transport of Shiga toxin from early endosome to the trans Golgi network","volume":"120","author":"Bujny","year":"2007","journal-title":"J. Cell Sci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"a016774","DOI":"10.1101\/cshperspect.a016774","article-title":"Retromer: a master conductor of endosome sorting","volume":"6","author":"Burd","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1038\/45816","article-title":"A kinase-regulated PDZ-domain interaction controls endocytic sorting of the \u03b22-adrenergic receptor","volume":"401","author":"Cao","year":"1999","journal-title":"Nature"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1016\/j.cub.2004.09.077","article-title":"Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides","volume":"14","author":"Carlton","year":"2004","journal-title":"Curr. Biol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1146\/annurev.cellbio.22.010305.104638","article-title":"Mitochondrial fusion and fission in mammals","volume":"22","author":"Chan","year":"2006","journal-title":"Annu. Rev. Cell. Dev. Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1126\/science.1184840","article-title":"Retromer is required for apoptotic cell clearance by phagocytic receptor recycling","volume":"327","author":"Chen","year":"2010","journal-title":"Science"},{"key":"B15","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1083\/jcb.201309084","article-title":"Fission of SNX-BAR-coated endosomal retrograde transport carriers is promoted by the dynamin-related protein Vps1","volume":"204","author":"Chi","year":"2014","journal-title":"J. Cell Biol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.nbd.2015.08.025","article-title":"FcgammaRIIB mediates the inhibitory effect of aggregated \u03b1-synuclein on microglial phagocytosis","volume":"83","author":"Choi","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"B17","doi-asserted-by":"publisher","first-page":"E2077","DOI":"10.1073\/pnas.1208635109","article-title":"Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid beta (A\u03b2) production in the trans-Golgi network","volume":"109","author":"Choy","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B18","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1002\/glia.10363","article-title":"Fibrillar prion peptide (106\u2013126) and scrapie prion protein hamper phagocytosis in microglia","volume":"46","author":"Ciesielski-Treska","year":"2004","journal-title":"Glia"},{"key":"B19","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/nsmb954","article-title":"Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly","volume":"12","author":"Collins","year":"2005","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"48730","DOI":"10.1074\/jbc.m206986200","article-title":"The Phox Homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation","volume":"277","author":"Cozier","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B23","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1038\/nrm2427","article-title":"Endosomal sorting and signalling: an emerging role for sorting nexins","volume":"9","author":"Cullen","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/978-94-007-3015-1_3","article-title":"Phosphoinositides in the mammalian endo-lysosomal network","volume":"59","author":"Cullen","year":"2012","journal-title":"Subcell. Biochem."},{"key":"B22","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/ncb2374","article-title":"Sorting nexins provide diversity for retromer-dependent trafficking events","volume":"14","author":"Cullen","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1756-6606-2-5","article-title":"Cathepsin D expression level affects alpha-synuclein processing, aggregation and toxicity in vivo","volume":"2","author":"Cullen","year":"2009","journal-title":"Mol. Brain"},{"key":"B25","doi-asserted-by":"publisher","first-page":"M111.014035","DOI":"10.1074\/mcp.m111.014035","article-title":"Identification of autophagosome-associated proteins and regulators by quantitative proteomic analysis and genetic screens","volume":"11","author":"Dengjel","year":"2012","journal-title":"Mol. Cell. Proteomics"},{"key":"B26","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.devcel.2009.09.010","article-title":"The Arp2\/3 activator WASH controls the fission of endosomes through a large multiprotein complex","volume":"17","author":"Derivery","year":"2009","journal-title":"Dev. Cell"},{"key":"B27","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.neuron.2014.11.027","article-title":"Parkinson\u2019s disease genes VPS35 and EIF4G1 interact genetically and converge on alpha-synuclein","volume":"85","author":"Dhungel","year":"2015","journal-title":"Neuron"},{"key":"B28","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.chom.2013.06.001","article-title":"The Legionella effector RidL inhibits retrograde trafficking to promote intracellular replication","volume":"14","author":"Finsel","year":"2013","journal-title":"Cell Host Microbe"},{"key":"B29","doi-asserted-by":"publisher","first-page":"616","DOI":"10.4161\/cib.21433","article-title":"SorLA is a molecular link for retromer-dependent sorting of the Amyloid precursor protein","volume":"5","author":"Fjorback","year":"2012","journal-title":"Commun. Integr. Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1111\/tra.12136","article-title":"The Vps35 D620N mutation linked to Parkinson\u2019s disease disrupts the cargo sorting function of retromer","volume":"15","author":"Follett","year":"2014","journal-title":"Traffic"},{"key":"B32","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1111\/imr.12212","article-title":"Phagocytosis: receptors, signal integration and the cytoskeleton","volume":"262","author":"Freeman","year":"2014","journal-title":"Immunol. Rev."},{"key":"B31","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.bbadis.2012.10.011","article-title":"The hereditary spastic paraplegia protein strumpellin: characterisation in neurons and of the effect of disease mutations on WASH complex assembly and function","volume":"1832","author":"Freeman","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"B33","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1038\/ncomms3030","article-title":"Scara1 deficiency impairs clearance of soluble amyloid-beta by mononuclear phagocytes and accelerates Alzheimer\u2019s-like disease progression","volume":"4","author":"Frenkel","year":"2013","journal-title":"Nat. Commun."},{"key":"B34","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.cell.2009.04.010","article-title":"The BAR domain superfamily: membrane-molding macromolecules","volume":"137","author":"Frost","year":"2009","journal-title":"Cell"},{"key":"B35","doi-asserted-by":"publisher","first-page":"E3604","DOI":"10.1073\/pnas.1410552111","article-title":"A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer","volume":"111","author":"Gallon","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B36","doi-asserted-by":"publisher","first-page":"7763","DOI":"10.1073\/pnas.1017110108","article-title":"Phox homology band 4.1\/ezrin\/radixin\/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases","volume":"108","author":"Ghai","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B38","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1242\/jcs.158204","article-title":"Phosphoinositide binding by the SNX27 FERM domain regulates its localization at the immune synapse of activated T-cells","volume":"128","author":"Ghai","year":"2015","journal-title":"J. Cell Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"4577","DOI":"10.1093\/emboj\/19.17.4577","article-title":"Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells","volume":"19","author":"Gillooly","year":"2000","journal-title":"EMBO J."},{"key":"B40","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1042\/bj20070555","article-title":"Identification of a conserved motif required for Vps35\/Vps26p interaction and assembly of the retromer complex","volume":"408","author":"Gokool","year":"2007","journal-title":"Biochem. J."},{"key":"B41","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.devcel.2009.09.009","article-title":"A FAM21-containing WASH complex regulates retromer-dependent sorting","volume":"17","author":"Gomez","year":"2009","journal-title":"Dev. Cell"},{"key":"B42","doi-asserted-by":"publisher","first-page":"3215","DOI":"10.1091\/mbc.e12-02-0101","article-title":"Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks","volume":"23","author":"Gomez","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"B43","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1523\/JNEUROSCI.2371-12.2013","article-title":"Sortilin and SorLA display distinct roles in processing and trafficking of amyloid precursor protein","volume":"33","author":"Gustafsen","year":"2013","journal-title":"J. Neurosci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1002\/mds.26104","article-title":"Genetic variability of the retromer cargo recognition complex in parkinsonism","volume":"30","author":"Gustavsson","year":"2015","journal-title":"Mov. Disord."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1016\/j.cell.2013.01.051","article-title":"Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination","volume":"152","author":"Hao","year":"2013","journal-title":"Cell"},{"key":"B47","doi-asserted-by":"publisher","first-page":"3703","DOI":"10.1242\/jcs.071472","article-title":"The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics","volume":"123","author":"Harbour","year":"2010","journal-title":"J. Cell Sci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1042\/BJ20111761","article-title":"Recruitment of the endosomal WASH complex is mediated by the extended \u2018tail\u2019 of Fam21 binding to the retromer protein Vps35","volume":"442","author":"Harbour","year":"2012","journal-title":"Biochem. J."},{"key":"B48","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1073\/pnas.1316482111","article-title":"A mechanism for retromer endosomal coat complex assembly with cargo","volume":"111","author":"Harrison","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B49","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1038\/ncb2281","article-title":"A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion","volume":"13","author":"Harterink","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1111\/boc.201200038","article-title":"Endosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromer","volume":"105","author":"Helfer","year":"2013","journal-title":"Biol. Cell"},{"key":"B51","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/nature11729","article-title":"NLRP3 is activated in Alzheimer\u2019s disease and contributes to pathology in APP\/PS1 mice","volume":"493","author":"Heneka","year":"2013","journal-title":"Nature"},{"key":"B52","doi-asserted-by":"publisher","first-page":"2677","DOI":"10.1007\/s00018-009-0043-1","article-title":"The Vps10p-domain receptor family","volume":"66","author":"Hermey","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"54291","DOI":"10.1074\/jbc.m406169200","article-title":"A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1) and G protein-coupled receptor-associated sorting protein (GASP)","volume":"279","author":"Heydorn","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B54","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/nrm3332","article-title":"Getting active: protein sorting in endocytic recycling","volume":"13","author":"Hsu","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"3481","DOI":"10.1038\/emboj.2011.286","article-title":"Endosome maturation","volume":"30","author":"Huotari","year":"2011","journal-title":"EMBO J."},{"key":"B56","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nrm3379","article-title":"Coordination between RAB GTPase and phosphoinositide regulation and functions","volume":"13","author":"Jean","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"2352","DOI":"10.1091\/mbc.E11-12-1059","article-title":"Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer","volume":"23","author":"Jia","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"B58","doi-asserted-by":"publisher","first-page":"10442","DOI":"10.1073\/pnas.0913293107","article-title":"WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes","volume":"107","author":"Jia","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1016\/j.cell.2008.12.009","article-title":"Tracing the retrograde route in protein trafficking","volume":"135","author":"Johannes","year":"2008","journal-title":"Cell"},{"key":"B60","doi-asserted-by":"publisher","first-page":"5367","DOI":"10.1242\/jcs.01379","article-title":"New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting","volume":"117","author":"Joubert","year":"2004","journal-title":"J. Cell Sci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1172\/jci16923","article-title":"Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice","volume":"111","author":"Kaifu","year":"2003","journal-title":"J. Clin. Invest."},{"key":"B62","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/sj.mp.4001258","article-title":"A developmentally regulated and psychostimulant-inducible novel rat gene mrt1 encoding PDZ-PX proteins isolated in the neocortex","volume":"8","author":"Kajii","year":"2003","journal-title":"Mol. Psychiatry"},{"key":"B63","doi-asserted-by":"publisher","first-page":"10627","DOI":"10.1128\/JVI.00757-11","article-title":"Inhibition of retromer activity by herpesvirus saimiri tip leads to CD4 downregulation and efficient T cell transformation","volume":"85","author":"Kingston","year":"2011","journal-title":"J. Virol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1002\/jcb.24873","article-title":"Highly infectious CJD particles lack prion protein but contain many viral-linked peptides by LC-MS\/MS","volume":"115","author":"Kipkorir","year":"2014","journal-title":"J. Cell. Biochem."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1512.e1","DOI":"10.1016\/j.neurobiolaging.2013.12.016","article-title":"Mutations in VPS26A are not a frequent cause of Parkinson\u2019s disease","volume":"35","author":"Koschmidder","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"B65","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/j.cell.2005.12.038","article-title":"Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes","volume":"124","author":"Lakadamyali","year":"2006","journal-title":"Cell"},{"key":"B66","doi-asserted-by":"publisher","first-page":"13110","DOI":"10.1523\/JNEUROSCI.3872-10.2010","article-title":"Diabetes-associated SorCS1 regulates Alzheimer\u2019s amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex","volume":"30","author":"Lane","year":"2010","journal-title":"J. Neurosci."},{"key":"B68","doi-asserted-by":"publisher","first-page":"7099","DOI":"10.1523\/JNEUROSCI.5270-12.2013","article-title":"Protein sorting motifs in the cytoplasmic tail of SorCS1 control generation of Alzheimer\u2019s amyloid-beta peptide","volume":"33","author":"Lane","year":"2013","journal-title":"J. Neurosci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"14080","DOI":"10.1523\/JNEUROSCI.3359-12.2012","article-title":"Vps10 family proteins and the retromer complex in aging-related neurodegeneration and diabetes","volume":"32","author":"Lane","year":"2012","journal-title":"J. Neurosci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1083\/jcb.201004060","article-title":"SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane","volume":"190","author":"Lauffer","year":"2010","journal-title":"J. Cell Biol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1750-1326-9-23","article-title":"Vacuolar protein sorting 35 (Vps35) rescues locomotor deficits and shortened lifespan in Drosophila expressing a Parkinson\u2019s disease mutant of Leucine-Rich Repeat Kinase 2 (LRRK2)","volume":"9","author":"Linhart","year":"2014","journal-title":"Mol. Neurodegener."},{"key":"B129","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1756-6606-7-10","article-title":"Vps35 haploinsufficiency results in degenerative-like deficit in mouse retinal ganglion neurons and impairment of optic nerve injury-induced gliosis","volume":"7","author":"Liu","year":"2014","journal-title":"Mol. Brain"},{"key":"B71","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.semcdb.2014.04.024","article-title":"From endosomes to the trans-Golgi network","volume":"31","author":"Lu","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1126\/science.1061663","article-title":"Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family","volume":"293","author":"Lu","year":"2001","journal-title":"Science"},{"key":"B73","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.neuron.2013.06.046","article-title":"Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer\u2019s disease","volume":"79","author":"Lucin","year":"2013","journal-title":"Neuron"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1038\/nn1953","article-title":"A unique sorting nexin regulates trafficking of potassium channels via a PDZ domain interaction","volume":"10","author":"Lunn","year":"2007","journal-title":"Nat. Neurosci."},{"key":"B75","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nrm1315","article-title":"Endocytic recycling","volume":"5","author":"Maxfield","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"e00606","DOI":"10.1128\/mbio.00606-12","article-title":"Host pathways important for Coxiella burnetii infection revealed by genome-wide RNA interference screening","volume":"4","author":"McDonough","year":"2013","journal-title":"MBio"},{"key":"B77","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1016\/j.cub.2014.06.024","article-title":"Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation","volume":"24","author":"McGough","year":"2014","journal-title":"Curr. Biol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"3359","DOI":"10.1074\/jbc.M114.619940","article-title":"SorLA complement-type repeat domains protect the amyloid precursor protein against processing","volume":"290","author":"Mehmedbasic","year":"2015","journal-title":"J. Biol. Chem."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nbd.2014.07.014","article-title":"VPS35 dysfunction impairs lysosomal degradation of \u03b1-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson\u2019s disease","volume":"71","author":"Miura","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"B130","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.nbd.2013.12.017","article-title":"Hyperleucinemia causes hippocampal retromer deficiency linking diabetes to Alzheimer\u2019s disease","volume":"65","author":"Morabito","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"B80","doi-asserted-by":"publisher","first-page":"7327","DOI":"10.1073\/pnas.0802545105","article-title":"Retromer deficiency observed in Alzheimer\u2019s disease causes hippocampal dysfunction, neurodegeneration and Abeta accumulation","volume":"105","author":"Muhammad","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1093\/hmg\/ddu582","article-title":"Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson\u2019s disease VPS35 mutation p.D620N","volume":"24","author":"Munsie","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"B82","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1111\/j.1600-0854.2010.01035.x","article-title":"Regulation of P2Y1 receptor traffic by sorting Nexin 1 is retromer independent","volume":"11","author":"Nisar","year":"2010","journal-title":"Traffic"},{"key":"B83","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/j.1600-0854.2010.01124.x","article-title":"Assembly and solution structure of the core retromer protein complex","volume":"12","author":"Norwood","year":"2011","journal-title":"Traffic"},{"key":"B84","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.1096\/fj.09-146357","article-title":"Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing","volume":"24","author":"Okada","year":"2010","journal-title":"FASEB J."},{"key":"B85","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.1242\/jcs.003020","article-title":"The retromer complex and clathrin define an early endosomal retrograde exit site","volume":"120","author":"Popoff","year":"2007","journal-title":"J. Cell Sci."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1016\/j.neuroscience.2006.03.058","article-title":"Triggering receptor expressed in myeloid cells 2 (TREM2) trafficking in microglial cells: continuous shuttling to and from the plasma membrane regulated by cell stimulation","volume":"140","author":"Prada","year":"2006","journal-title":"Neuroscience"},{"key":"B87","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1111\/tra.12237","article-title":"Molecular Insights into Rab7-mediated endosomal recruitment of core retromer: deciphering the role of Vps26 and Vps35","volume":"16","author":"Priya","year":"2015","journal-title":"Traffic"},{"key":"B89","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/s00438-014-0939-9","article-title":"The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review","volume":"290","author":"Reitz","year":"2015","journal-title":"Mol. Genet. Genomics"},{"key":"B88","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/ana.22308","article-title":"SORCS1 Alters amyloid precursor protein processing and variants may increase Alzheimer\u2019s disease risk","volume":"69","author":"Reitz","year":"2011","journal-title":"Ann. Neurol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/ng1943","article-title":"The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease","volume":"39","author":"Rogaeva","year":"2007","journal-title":"Nat. Genet."},{"key":"B91","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1083\/jcb.200804048","article-title":"Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7","volume":"183","author":"Rojas","year":"2008","journal-title":"J. Cell Biol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuron.2014.12.045","article-title":"Linking the VPS35 and EIF4G1 pathways in Parkinson\u2019s disease","volume":"85","author":"Ross","year":"2015","journal-title":"Neuron"},{"key":"B93","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1001\/archneur.61.8.1200","article-title":"Loss of apolipoprotein E receptor LR11 in Alzheimer disease","volume":"61","author":"Scherzer","year":"2004","journal-title":"Arch. Neurol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/emboj.2011.352","article-title":"Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer\u2019s disease","volume":"31","author":"Schmidt","year":"2012","journal-title":"EMBO J."},{"key":"B95","doi-asserted-by":"publisher","first-page":"32956","DOI":"10.1074\/jbc.m705073200","article-title":"SorLA\/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1","volume":"282","author":"Schmidt","year":"2007","journal-title":"J. Biol. Chem."},{"key":"B98","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1083\/jcb.200312034","article-title":"Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer","volume":"165","author":"Seaman","year":"2004","journal-title":"J. Cell Biol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.tcb.2013.04.010","article-title":"Retromer-mediated endosomal protein sorting: all WASHed up!","volume":"23","author":"Seaman","year":"2013","journal-title":"Trends Cell Biol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.1242\/jcs.048686","article-title":"Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5","volume":"122","author":"Seaman","year":"2009","journal-title":"J. Cell Sci."},{"key":"B97","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1083\/jcb.142.3.665","article-title":"A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast","volume":"142","author":"Seaman","year":"1998","journal-title":"J. Cell Biol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1958.e1","DOI":"10.1016\/j.neurobiolaging.2014.03.004","article-title":"Genetic variation of the retromer subunits VPS26A\/B-VPS29 in Parkinson\u2019s disease","volume":"35","author":"Shannon","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"B101","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/nsmb1103","article-title":"The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain","volume":"13","author":"Shi","year":"2006","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.neuron.2008.11.007","article-title":"Linking Abeta and tau in late-onset Alzheimer\u2019s disease: a dual pathway hypothesis","volume":"60","author":"Small","year":"2008","journal-title":"Neuron"},{"key":"B103","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1002\/ana.20667","article-title":"Model-guided microarray implicates the retromer complex in Alzheimer\u2019s disease","volume":"58","author":"Small","year":"2005","journal-title":"Ann. Neurol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/42166","article-title":"Alpha-synuclein in Lewy bodies","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"key":"B105","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/ncb2721","article-title":"A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport","volume":"15","author":"Steinberg","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.nbd.2011.04.002","article-title":"Retromer disruption promotes amyloidogenic APP processing","volume":"43","author":"Sullivan","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"B107","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1111\/j.1471-4159.2011.07623.x","article-title":"Beta-site APP-cleaving enzyme 1 trafficking and Alzheimer\u2019s disease pathogenesis","volume":"120","author":"Tan","year":"2012","journal-title":"J. Neurochem."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1016\/j.celrep.2015.08.001","article-title":"VPS35 deficiency or mutation causes dopaminergic neuronal loss by impairing mitochondrial fusion and function","volume":"12","author":"Tang","year":"2015","journal-title":"Cell Rep."},{"key":"B109","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1038\/ncb2252","article-title":"SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors","volume":"13","author":"Temkin","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"4466","DOI":"10.1038\/emboj.2012.283","article-title":"Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules","volume":"31","author":"van Weering","year":"2012","journal-title":"EMBO J."},{"key":"B112","doi-asserted-by":"publisher","first-page":"2231.e15","DOI":"10.1016\/j.neurobiolaging.2012.04.020","article-title":"Identification of Alzheimer disease-associated variants in genes that regulate retromer function","volume":"33","author":"Vardarajan","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"B113","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.ajhg.2011.06.001","article-title":"VPS35 mutations in Parkinson disease","volume":"89","author":"Vilari\u00f1o-G\u00fcell","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"B114","doi-asserted-by":"publisher","first-page":"415","DOI":"10.3233\/JPD-130216","article-title":"Limelight on alpha-synuclein: pathological and mechanistic implications in neurodegeneration","volume":"3","author":"Wales","year":"2013","journal-title":"J. Parkinsons. Dis."},{"key":"B116","doi-asserted-by":"publisher","first-page":"22962","DOI":"10.1074\/jbc.m500464200","article-title":"Crystal structure of human vacuolar protein sorting protein 29 reveals a phosphodiesterase\/nuclease-like fold and two protein-protein interaction sites","volume":"280","author":"Wang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"B118","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/j.celrep.2014.09.037","article-title":"Sorting nexin 27 regulates Abeta production through modulating gamma-secretase activity","volume":"9","author":"Wang","year":"2014","journal-title":"Cell Rep."},{"key":"B115","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1242\/bio.20122451","article-title":"VPS35 regulates developing mouse hippocampal neuronal morphogenesis by promoting retrograde trafficking of BACE1","volume":"1","author":"Wang","year":"2012","journal-title":"Biol. Open"},{"key":"B117","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/nm.3983","article-title":"Parkinson\u2019s disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes","volume":"22","author":"Wang","year":"2016","journal-title":"Nat. Med."},{"key":"B119","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/nm.3117","article-title":"Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down\u2019s syndrome","volume":"19","author":"Wang","year":"2013","journal-title":"Nat. Med."},{"key":"B120","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1091\/mbc.e01-11-0131","article-title":"Down-regulation of protease-activated receptor-1 is regulated by sorting nexin 1","volume":"13","author":"Wang","year":"2002","journal-title":"Mol. Biol. Cell"},{"key":"B121","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1083\/jcb.201105109","article-title":"VPS35 haploinsufficiency increases Alzheimer\u2019s disease neuropathology","volume":"195","author":"Wen","year":"2011","journal-title":"J. Cell Biol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"10837","DOI":"10.1073\/pnas.162350199","article-title":"Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer\u2019s mice","volume":"99","author":"Wyss-Coray","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B123","doi-asserted-by":"publisher","first-page":"211","DOI":"10.3233\/JAD-2009-0957","article-title":"Gamma-secretase catalyzes sequential cleavages of the AbetaPP transmembrane domain","volume":"16","author":"Xu","year":"2009","journal-title":"J. Alzheimers Dis."},{"key":"B124","doi-asserted-by":"publisher","first-page":"3828","DOI":"10.1038\/ncomms4828","article-title":"Mutation in VPS35 associated with Parkinson\u2019s disease impairs WASH complex association and inhibits autophagy","volume":"5","author":"Zavodszky","year":"2014","journal-title":"Nat. Commun."},{"key":"B125","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1111\/j.1600-0854.2007.00658.x","article-title":"Dominant-negative behavior of mammalian Vps35 in yeast requires a conserved PRLYL motif involved in retromer assembly","volume":"8","author":"Zhao","year":"2007","journal-title":"Traffic"},{"key":"B126","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1097\/WCO.0b013e3283484b87","article-title":"Genetics of Parkinson\u2019s disease and essential tremor","volume":"24","author":"Zimprich","year":"2011","journal-title":"Curr. Opin. Neurol."},{"key":"B127","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/ng1341","article-title":"Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A","volume":"36","author":"Z\u00fcchner","year":"2004","journal-title":"Nat. Genet."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"deposited":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T08:34:46Z","timestamp":1456821286000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnagi.2016.00042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,1]]},"references-count":127,"URL":"https:\/\/doi.org\/10.3389\/fnagi.2016.00042","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,1]]}}}