{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:53:45Z","timestamp":1792036425739,"version":"4.4.0"},"reference-count":35,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HD061363"],"award-info":[{"award-number":["R01 HD061363"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"DOI":"10.3389\/fnagi.2017.00010","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T22:56:03Z","timestamp":1487285763000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Crossed Cerebellar Atrophy of the Lateral Cerebellar Nucleus in an Endothelin-1-Induced, Rodent Model of Ischemic Stroke"],"prefix":"10.3389","volume":"9","author":[{"given":"Hugh H.","family":"Chan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Cooperrider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Joo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor A.","family":"Wathen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Gale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth B.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre G.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,2,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1212\/wnl.39.4.541","article-title":"Crossed cerebellar and uncrossed basal ganglia and thalamic diaschisis in Alzheimer\u2019s disease","volume":"39","author":"Akiyama","year":"1989","journal-title":"Neurology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3109\/00207459708988465","article-title":"The effects of nitric oxide synthase inhibitor, L-NAME on NO production during focal cerebral ischemia in rats: could L-NAME be the future treatment of sudden deafness?","volume":"89","author":"Balkan","year":"1997","journal-title":"Int. J. Neurosci"},{"key":"B3","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/j.1600-0404.1997.tb00085.x","article-title":"Effects of Lamotrigine on brain nitrite and cGMP levels during focal cerebral ischemia in rats","volume":"95","author":"Balkan","year":"1997","journal-title":"Acta Neurol. Scand."},{"key":"B4","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/s0079-6123(08)63367-1","article-title":"Salient anatomic features of the cortico-ponto-cerebellar pathway","volume":"114","author":"Brodal","year":"1997","journal-title":"Prog. Brain Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0006-8993(83)91035-1","article-title":"The corticopontocerebellar pathway to crus I in the cat as studied with anterograde and retrograde transport of horseradish peroxidase","volume":"267","author":"Brodal","year":"1983","journal-title":"Brain Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2408","DOI":"10.1093\/brain\/awu101","article-title":"Diaschisis: past, present, future","volume":"137","author":"Carrera","year":"2014","journal-title":"Brain"},{"key":"B7","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1073\/pnas.0406173102","article-title":"Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease","volume":"102","author":"Chiesa","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B8","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1093\/brain\/108.4.881","article-title":"Retrograde crossed cerebellar atrophy","volume":"108","author":"Chung","year":"1985","journal-title":"Brain"},{"key":"B9","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.brainresrev.2005.02.002","article-title":"Different pontine projections to the two sides of the cerebellum","volume":"49","author":"Cicirata","year":"2005","journal-title":"Brain Res. Rev."},{"key":"B10","doi-asserted-by":"publisher","first-page":"9040","DOI":"10.1523\/JNEUROSCI.0953-14.2014","article-title":"Chronic deep cerebellar stimulation promotes long-term potentiation, microstructural plasticity, and reorganization of perilesional cortical representation in a rodent model","volume":"34","author":"Cooperrider","year":"2014","journal-title":"J. Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1001\/archneur.61.2.283","article-title":"The Monakow concept of diaschisis: origins and perspectives","volume":"61","author":"Finger","year":"2004","journal-title":"Arch. Neurol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1007\/s00381-006-0067-x","article-title":"Crossed cerebellar atrophy of prenatal onset","volume":"22","author":"Gallini","year":"2006","journal-title":"Childs Nerv. Syst."},{"key":"B14","doi-asserted-by":"publisher","first-page":"7699","DOI":"10.1073\/pnas.112012499","article-title":"Neuronal deactivation explains decreased cerebellar blood flow in response to focal cerebral ischemia or suppressed neocortical function","volume":"99","author":"Gold","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B15","doi-asserted-by":"publisher","first-page":"235","DOI":"10.4103\/0976-3147.102588","article-title":"Crossed cerebellar atrophy: update","volume":"3","author":"Jim\u00e9nez-Caballero","year":"2012","journal-title":"J. Neurosci. Rural Pract."},{"key":"B16","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1161\/01.str.0000109771.56160.f5","article-title":"Crossed cerebellar diaschisis in patients with cortical infarction: logistic regression analysis to control for confounding effects","volume":"35","author":"Komaba","year":"2004","journal-title":"Stroke"},{"key":"B17","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3389\/fnint.2012.00020","article-title":"Upside down crossed cerebellar diaschisis: proposing chronic stimulation of the dentatothalamocortical pathway for post-stroke motor recovery","volume":"6","author":"Machado","year":"2012","journal-title":"Front. Integr. Neurosci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.brainres.2009.05.007","article-title":"Chronic electrical stimulation of the contralesional lateral cerebellar nucleus enhances recovery of motor function after cerebral ischemia in rats","volume":"1280","author":"Machado","year":"2009","journal-title":"Brain Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1227\/01.neu.0000430766.80102.ac","article-title":"Chronic 30-Hz deep cerebellar stimulation coupled with training enhances post-ischemia motor recovery and peri-infarct synaptophysin expression in rodents","volume":"73","author":"Machado","year":"2013","journal-title":"Neurosurgery"},{"key":"B20","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/0006-8993(94)91133-9","article-title":"Identification of pontocerebellar axon collateral synaptic boutons in the rat cerebellar nuclei","volume":"648","author":"Mihailoff","year":"1994","journal-title":"Brain Res."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/j.brs.2015.06.020","article-title":"Modulation of cortical motor evoked potential after stroke during electrical stimulation of the lateral cerebellar nucleus","volume":"8","author":"Park","year":"2015","journal-title":"Brain Stimul."},{"key":"B22","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jneumeth.2012.12.010","article-title":"Semi-automated method for estimating lesion volumes","volume":"213","author":"Park","year":"2013","journal-title":"J. Neurosci. Methods"},{"key":"B23","volume-title":"The Rat Brain in Stereotoxic Coordinates.","author":"Paxinos","year":"1998"},{"key":"B11","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/s0303-8467(96)00561-6","article-title":"Crossed cerebellar diaschisis after middle cerebral artery infarction","volume":"99","author":"De Reuck","year":"1997","journal-title":"Clin. Neurol. Neurosurg."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1046\/j.1460-9568.2002.01993.x","article-title":"Laterality of the pontocerebellar projections in the rat","volume":"15","author":"Serapide","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1034\/j.1600-0404.2001.00142.x","article-title":"Biochemical evidence of crossed cerebellar diaschisis in terms of nitric oxide indicators and lipid peroxidation products in rats during focal cerebral ischemia","volume":"103","author":"Serteser","year":"2001","journal-title":"Acta Neurol. Scand."},{"key":"B26","doi-asserted-by":"publisher","first-page":"S19","DOI":"10.1017\/s0317167100048496","article-title":"Organization of excitatory inputs from the cerebral cortex to the cerebellar dentate nucleus","volume":"20","author":"Shinoda","year":"1993","journal-title":"Can. J. Neurol. Sci."},{"key":"B27","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1152\/jn.1992.67.3.547","article-title":"Axon collaterals of mossy fibers from the pontine nucleus in the cerebellar dentate nucleus","volume":"67","author":"Shinoda","year":"1992","journal-title":"J. Neurophysiol."},{"key":"B28","first-page":"189","article-title":"Prognostic value of subacute crossed cerebellar diaschisis: single-photon emission CT study in patients with middle cerebral artery territory infarct","volume":"23","author":"Takasawa","year":"2002","journal-title":"Am. J. Neuroradiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.brainres.2013.09.023","article-title":"Hemodynamic changes during neural deactivation in awake mice: a measurement by laser-Doppler flowmetry in crossed cerebellar diaschisis","volume":"1537","author":"Takuwa","year":"2013","journal-title":"Brain Res."},{"key":"B30","first-page":"862","article-title":"Cortical hypometabolism and crossed cerebellar diaschisis suggest subcortically induced disconnection in CADASIL: an 18F-FDG PET study","volume":"44","author":"Tatsch","year":"2003","journal-title":"J. Nucl. Med."},{"key":"B31","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/j.1750-3639.2006.00017.x","article-title":"Consequential apoptosis in the cerebellum following injury to the developing rat forebrain","volume":"16","author":"Taylor","year":"2006","journal-title":"Brain Pathol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.2214\/ajr.158.5.1566683","article-title":"Crossed cerebellar diaschisis and crossed cerebellar atrophy: correlation of MR findings, clinical symptoms, and supratentorial diseases in 26 patients","volume":"158","author":"Tien","year":"1992","journal-title":"Am. J. Roentgenol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.bbr.2013.04.019","article-title":"Optogenetics in the cerebellum: Purkinje cell-specific approaches for understanding local cerebellar functions","volume":"255","author":"Tsubota","year":"2013","journal-title":"Behav. Brain Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1089\/neu.2016.4411","article-title":"Comprehensive profiling of modulation of nitric oxide levels and mitochondrial activity in the injured brain: an experimental study based on the fluid percussion injury model in rats","volume":"34","author":"\u00dc\u00e7al","year":"2017","journal-title":"J. Neurotrauma."},{"key":"B35","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/s0304-3940(02)00108-8","article-title":"Corticopontocerebellar pathway from the prearcuate region to hemispheric lobule VII of the cerebellum: an anterograde and retrograde tracing study in the monkey","volume":"322","author":"Xiong","year":"2002","journal-title":"Neurosci. Lett."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnagi.2017.00010\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T16:12:29Z","timestamp":1568823149000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnagi.2017.00010\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,17]]},"references-count":35,"URL":"https:\/\/doi.org\/10.3389\/fnagi.2017.00010","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,17]]}}}