{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T11:16:40Z","timestamp":1789903000715,"version":"4.0.1"},"reference-count":48,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"DOI":"10.3389\/fnagi.2017.00050","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T07:57:49Z","timestamp":1488873469000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":83,"title":["Hippocampal and Amygdala Gray Matter Loss in Elderly Controls with Subtle Cognitive Decline"],"prefix":"10.3389","volume":"9","author":[{"given":"Davide","family":"Zanchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panteleimon","family":"Giannakopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Borgwardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristelle","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Haller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,3,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The diagnosis of mild cognitive impairment due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease.","volume":"7","author":"Albert","year":"2011","journal-title":"Alzheimers Dement."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2723","DOI":"10.1016\/j.neurobiolaging.2012.01.014","article-title":"Gray matter network associated with risk for Alzheimer\u2019s disease in young to middle-aged adults.","volume":"33","author":"Alexander","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"B3","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1097\/01.wad.0000213857.89613.10","article-title":"3D mapping of mini-mental state examination performance in clinical and preclinical Alzheimer disease.","volume":"20","author":"Apostolova","year":"2006","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010783.pub2","article-title":"Mini-Mental State Examination (MMSE) for the detection of Alzheimer\u2019s disease and other dementias in people with mild cognitive impairment (MCI).","author":"Arevalo-Rodriguez","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"B5","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1097\/00002093-200307000-00010","article-title":"Structural magnetic resonance imaging in established and prodromal Alzheimer disease: a review.","volume":"17","author":"Atiya","year":"2003","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"B6","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1212\/WNL.48.4.989","article-title":"Diagnosis of early dementia by the Double Memory Test: encoding specificity improves diagnostic sensitivity and specificity.","volume":"48","author":"Buschke","year":"1997","journal-title":"Neurology"},{"key":"B7","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1056\/NEJMoa0809437","article-title":"Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect.","volume":"361","author":"Caselli","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"3277","DOI":"10.1093\/brain\/awn278","article-title":"Strongly reduced volumes of putamen and thalamus in Alzheimer\u2019s disease: an MRI study.","volume":"131","author":"de Jong","year":"2008","journal-title":"Brain"},{"key":"B9","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.neurobiolaging.2016.01.010","article-title":"Atrophy of hippocampal subfields and adjacent extrahippocampal structures in dementia with Lewy bodies and Alzheimer\u2019s disease.","volume":"40","author":"Delli Pizzi","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"B10","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1001\/archpsyc.63.1.57","article-title":"Use of hippocampal and amygdalar volumes on magnetic resonance imaging to predict dementia in cognitively intact elderly people.","volume":"63","author":"den Heijer","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"issue":"e0162889","key":"B11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162889","article-title":"Anatomic correlation of the mini-mental state examination: a voxel-based morphometric study in older adults.","volume":"11","author":"Dinomais","year":"2016","journal-title":"PLoS ONE"},{"key":"B12","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3233\/JAD-150128","article-title":"Subtle cognitive decline and biomarker staging in preclinical Alzheimer\u2019s Disease.","volume":"47","author":"Edmonds","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1002\/ana.20730","article-title":"Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.","volume":"59","author":"Fagan","year":"2006","journal-title":"Ann. Neurol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1002\/emmm.200900048","article-title":"Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimer\u2019s disease.","volume":"1","author":"Fagan","year":"2009","journal-title":"EMBO Mol. Med."},{"key":"B15","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician.","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"56","DOI":"10.2174\/156720510790274446","article-title":"High PIB retention in Alzheimer\u2019s disease is an early event with complex relationship with CSF biomarkers and functional parameters.","volume":"7","author":"Forsberg","year":"2010","journal-title":"Curr. Alzheimer Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00401-006-0144-y","article-title":"Assessing the cognitive impact of Alzheimer disease pathology and vascular burden in the aging brain: the Geneva experience.","volume":"113","author":"Giannakopoulos","year":"2007","journal-title":"Acta Neuropathol. (Berl.)"},{"key":"B18","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1177\/0891988713509138","article-title":"Lower hippocampal volume predicts decrements in lane control among drivers with amnestic mild cognitive impairment.","volume":"26","author":"Griffith","year":"2013","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s12031-002-0006-6","article-title":"Brain MRI hippocampal volume and prediction of clinical status in a mild cognitive impairment trial.","volume":"19","author":"Grundman","year":"2002","journal-title":"J. Mol. Neurosci. MN"},{"key":"B20","doi-asserted-by":"publisher","first-page":"14123","DOI":"10.1523\/JNEUROSCI.0801-15.2015","article-title":"Hippocampal volume reduction in humans predicts impaired allocentric spatial memory in virtual-reality navigation.","volume":"35","author":"Guderian","year":"2015","journal-title":"J. Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1192\/bjp.140.6.566","article-title":"A new clinical scale for the staging of dementia.","volume":"140","author":"Hughes","year":"1982","journal-title":"Br. J. Psychiatry J. Ment. Sci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/j.jalz.2014.11.002","article-title":"The transitional association between \u03b2-amyloid pathology and regional brain atrophy.","volume":"11","author":"Insel","year":"2015","journal-title":"Alzheimers Dement. J. Alzheimers Assoc."},{"issue":"119","key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70299-6","article-title":"Hypothetical model of dynamic biomarkers of the Alzheimer\u2019s pathological cascade.","volume":"9","author":"Jack","year":"2010","journal-title":"Lancet Neurol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1002\/ana.410430307","article-title":"Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer\u2019s disease.","volume":"43","author":"Jack","year":"1998","journal-title":"Ann. Neurol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1001\/jamaneurol.2014.4821","article-title":"Age, sex and APOE \u03b54 effects on memory, brain structure and \u03b2-amyloid across the adult lifespan.","volume":"72","author":"Jack","year":"2015","journal-title":"JAMA Neurol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S1052-5149(03)00025-X","article-title":"Neuroimaging in Alzheimer disease: an evidence-based review.","volume":"13","author":"Kantarci","year":"2003","journal-title":"Neuroimaging Clin. N. Am."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.11.006","article-title":"Sleep changes without medial temporal lobe or brain cortical changes in community-dwelling individuals with subjective cognitive decline.","author":"Lauriola","year":"2016","journal-title":"Alzheimers Dement."},{"issue":"127","key":"B28","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-10-127","article-title":"Preclinical Alzheimer disease: identification of cases at risk among cognitively intact older individuals.","volume":"10","author":"Lazarczyk","year":"2012","journal-title":"BMC Med."},{"issue":"e22153","key":"B29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022153","article-title":"Functional disconnection and compensation in mild cognitive impairment: evidence from DLPFC connectivity using resting-state fMRI.","volume":"6","author":"Liang","year":"2011","journal-title":"PLoS ONE"},{"key":"B30","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.neurobiolaging.2015.12.023","article-title":"The effect of increased genetic risk for Alzheimer\u2019s disease on hippocampal and amygdala volume.","volume":"40","author":"Lupton","year":"2016","journal-title":"Neurobiol. Aging"},{"issue":"e25546","key":"B31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025546","article-title":"Altered connectivity pattern of hubs in default-mode network with Alzheimer\u2019s Disease: an granger causality modeling approach.","volume":"6","author":"Miao","year":"2011","journal-title":"PLoS ONE"},{"key":"B32","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.nicl.2013.09.001","article-title":"The diffeomorphometry of temporal lobe structures in preclinical Alzheimer\u2019s disease.","volume":"3","author":"Miller","year":"2013","journal-title":"Neuroimage Clin."},{"key":"B33","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1093\/clinchem\/46.5.722","article-title":"Evaluation of the apo E genotyping kit on the LightCycler.","volume":"46","author":"Nauck","year":"2000","journal-title":"Clin. Chem."},{"key":"B34","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.neuroimage.2011.02.046","article-title":"A Bayesian model of shape and appearance for subcortical brain segmentation.","volume":"56","author":"Patenaude","year":"2011","journal-title":"Neuroimage"},{"key":"B35","doi-asserted-by":"publisher","first-page":"S141","DOI":"10.3233\/JAD-150087","article-title":"Hippocampal subfield volumetry and 3D surface mapping in subjective cognitive decline.","volume":"48 Suppl","author":"Perrotin","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.08.011","article-title":"Subjective cognitive decline in cognitively normal elders from the community or from a memory clinic: differential affective and imaging correlates.","author":"Perrotin","year":"2016","journal-title":"Alzheimers Dement."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1001\/archneur.58.12.1985","article-title":"Current concepts in mild cognitive impairment.","volume":"58","author":"Petersen","year":"2001","journal-title":"Arch. Neurol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1001\/2013.jamaneurol.286","article-title":"Posterior cingulate glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal, late-middle-aged persons at 3 levels of genetic risk for Alzheimer disease.","volume":"70","author":"Protas","year":"2013","journal-title":"JAMA Neurol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1073\/pnas.2635903100","article-title":"Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer\u2019s dementia.","volume":"101","author":"Reiman","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B40","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/S1474-4422(07)70106-0","article-title":"Cortical morphology in children and adolescents with different apolipoprotein E gene polymorphisms: an observational study.","volume":"6","author":"Shaw","year":"2007","journal-title":"Lancet Neurol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"S208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL.","volume":"23(Suppl 1)","author":"Smith","year":"2004","journal-title":"Neuroimage"},{"key":"B42","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1006\/nimg.2002.1040","article-title":"Accurate, robust, and automated longitudinal and cross-sectional brain change analysis.","volume":"17","author":"Smith","year":"2002","journal-title":"Neuroimage"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1212\/WNL.0000000000001401","article-title":"Spatially distinct atrophy is linked to \u03b2-amyloid and tau in preclinical Alzheimer disease.","volume":"84","author":"Wang","year":"2015","journal-title":"Neurology"},{"key":"B44","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1212\/WNL.44.4.609","article-title":"The Consortium to Establish a Registry for Alzheimer\u2019s Disease (CERAD). Part V. A normative study of the neuropsychological battery.","volume":"44","author":"Welsh","year":"1994","journal-title":"Neurology"},{"key":"B45","doi-asserted-by":"publisher","first-page":"S173","DOI":"10.1016\/j.neuroimage.2008.10.055","article-title":"Bayesian analysis of neuroimaging data in FSL.","volume":"45","author":"Woolrich","year":"2009","journal-title":"Neuroimage"},{"key":"B46","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1148\/radiol.14140680","article-title":"Arterial spin labeling may contribute to the prediction of cognitive deterioration in healthy elderly individuals.","volume":"274","author":"Xekardaki","year":"2015","journal-title":"Radiology"},{"key":"B47","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.nicl.2014.04.009","article-title":"Inferring changepoint times of medial temporal lobe morphometric change in preclinical Alzheimer\u2019s disease.","volume":"5","author":"Younes","year":"2014","journal-title":"Neuroimage Clin."},{"key":"B48","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale.","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr. Scand."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnagi.2017.00050\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T09:25:23Z","timestamp":1601717123000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnagi.2017.00050\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,7]]},"references-count":48,"URL":"https:\/\/doi.org\/10.3389\/fnagi.2017.00050","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,7]]}}}