{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:20:49Z","timestamp":1787026849038,"version":"build-2736575974"},"reference-count":51,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"DOI":"10.3389\/fnagi.2017.00085","type":"journal-article","created":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T23:53:42Z","timestamp":1490831622000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Modafinil-Induced Changes in Functional Connectivity in the Cortex and Cerebellum of Healthy Elderly Subjects"],"prefix":"10.3389","volume":"9","author":[{"given":"Miriam","family":"Punzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Gili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Petrosini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Caltagirone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Spalletta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano L.","family":"Sensi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,3,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.tics.2004.02.010","article-title":"Inhibition and the right inferior frontal cortex.","volume":"8","author":"Aron","year":"2004","journal-title":"Trends Cogn. Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1093\/cercor\/bhi075","article-title":"Frontal lobe mechanisms that resolve proactive interference.","volume":"15","author":"Badre","year":"2005","journal-title":"Cereb. Cortex"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1016\/j.euroneuro.2015.07.028","article-title":"Modafinil for cognitive neuroenhancement in healthy non-sleep-deprived subjects: a systematic review.","volume":"25","author":"Battleday","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.neuroimage.2007.04.042","article-title":"A component based noise correction method (CompCor) for BOLD and perfusion based fMRI.","volume":"37","author":"Behzadi","year":"2007","journal-title":"Neuroimage"},{"key":"B5","doi-asserted-by":"publisher","first-page":"12187","DOI":"10.1073\/pnas.0611404104","article-title":"Baseline brain activity fluctuations predict somatosensory perception in humans.","volume":"104","author":"Boly","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B6","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.neuroscience.2014.08.014","article-title":"Short\u2013and long-term treatment with modafinil differentially affects adult hippocampal neurogenesis.","volume":"278","author":"Brandt","year":"2014","journal-title":"Neuroscience"},{"key":"B7","doi-asserted-by":"crossref","DOI":"10.1093\/acprof:oso\/9780199211517.001.0001","author":"Caldarelli","year":"2007","journal-title":"Scale-Free Networks."},{"issue":"e107145","key":"B8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107145","article-title":"Modafinil alters intrinsic functional connectivity of the right posterior insula: a pharmacological resting state fMRI study.","volume":"9","author":"Cera","year":"2014","journal-title":"PLoS ONE"},{"key":"B9","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/nrn755","article-title":"Control of goal-directed and stimulus-driven attention in the brain.","volume":"3","author":"Corbetta","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1038\/531S2a","article-title":"Smart drugs: a dose of intelligence.","volume":"531","author":"Dance","year":"2016","journal-title":"Nature"},{"key":"B11","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.neuroimage.2004.11.048","article-title":"Self-referential reflective activity and its relationship with rest: a PET study.","volume":"25","author":"D\u2019Argembeau","year":"2005","journal-title":"Neuroimage"},{"key":"B12","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1093\/schbul\/sbq090","article-title":"Modafinil reverses phencyclidine-induced deficits in cognitive flexibility, cerebral metabolism, and functional brain connectivity.","volume":"38","author":"Dawson","year":"2012","journal-title":"Schizophr. Bull."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1093\/cercor\/bhq187","article-title":"Dissociating inhibition, attention, and response control in the frontoparietal network using functional magnetic resonance imaging.","volume":"21","author":"Dodds","year":"2011","journal-title":"Cereb. Cortex"},{"key":"B14","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1002\/hbm.22194","article-title":"A meta-analysis of cerebellar contributions to higher cognition from PET and fMRI studies.","volume":"35","author":"E","year":"2014","journal-title":"Hum. Brain Mapp."},{"issue":"e69224","key":"B15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069224","article-title":"Acute effects of modafinil on brain resting state networks in young healthy subjects.","volume":"8","author":"Esposito","year":"2013","journal-title":"PLoS ONE"},{"key":"B16","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d: a practical method for grading the cognitive state of patients for the clinician.","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.psychres.2015.07.006","article-title":"Innovative mechanisms of action for pharmaceutical cognitive enhancement: a systematic review.","volume":"229","author":"Fond","year":"2015","journal-title":"Psychiatry Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/jcbfm.1993.4","article-title":"Functional connectivity: the principal-component analysis of large (PET) data sets.","volume":"13","author":"Friston","year":"1993","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B19","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1162\/0898929053279522","article-title":"Top-down enhancement and suppression of the magnitude and speed of neural activity.","volume":"17","author":"Gazzaley","year":"2005","journal-title":"J. Cogn. Neurosci."},{"key":"B20","first-page":"349","article-title":"Mechanisms of modafinil: a review of current research.","volume":"3","author":"Gerrard","year":"2007","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-016-9635-1","article-title":"Right sensory-motor functional networks subserve action observation therapy in aphasia.","author":"Gili","year":"2016","journal-title":"Brain Imaging Behav."},{"key":"B22","doi-asserted-by":"publisher","first-page":"4024","DOI":"10.1523\/JNEUROSCI.3480-12.2013","article-title":"The thalamus and brainstem act as key hubs in alterations of human brain network connectivity induced by mild propofol sedation.","volume":"33","author":"Gili","year":"2013","journal-title":"J. Neurosci."},{"issue":"e111554","key":"B23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111554","article-title":"Maximizing negative correlations in resting-state functional connectivity MRI by time-lag.","volume":"9","author":"Goelman","year":"2014","journal-title":"PLoS ONE"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.4088\/JCP.13r08560","article-title":"Modafinil augmentation therapy in unipolar and bipolar depression: a systematic review and meta-analysis of randomized controlled trials.","volume":"74","author":"Goss","year":"2013","journal-title":"J. Clin. Psychiatry"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1093\/brain\/aww003","article-title":"Network-selective vulnerability of the human cerebellum to Alzheimer\u2019s disease and frontotemporal dementia.","volume":"139","author":"Guo","year":"2016","journal-title":"Brain"},{"key":"B26","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.neuroimage.2009.12.051","article-title":"Comparison of characteristics between region-and voxel-based network analyses in resting-state fMRI data.","volume":"50","author":"Hayasaka","year":"2010","journal-title":"Neuroimage"},{"key":"B27","doi-asserted-by":"publisher","first-page":"4672","DOI":"10.1523\/JNEUROSCI.2922-12.2013","article-title":"Spontaneous and task-evoked brain activity negatively interact.","volume":"33","author":"He","year":"2013","journal-title":"J. Neurosci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/72999","article-title":"The neural mechanisms of top-down attentional control.","volume":"3","author":"Hopfinger","year":"2000","journal-title":"Nat. Neurosci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1212\/01.wnl.0000200985.04239.53","article-title":"Modafinil for fatigue in MS: a randomized placebo-controlled double-blind study.","volume":"65","author":"Kraft","year":"2005","journal-title":"Neurology"},{"issue":"e0131536","key":"B30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131536","article-title":"Successful working memory processes and cerebellum in an elderly sample: a neuropsychological and fMRI study.","volume":"10","author":"Luis","year":"2015","journal-title":"PLoS ONE"},{"key":"B31","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1080\/10550490290088027","article-title":"Clinical applications of modafinil in stimulant abusers: low abuse potential.","volume":"11","author":"Malcolm","year":"2002","journal-title":"Am. J. Addict."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1038\/sj.npp.1301534","article-title":"Modafinil: a review of neurochemical actions and effects on cognition.","volume":"33","author":"Minzenberg","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"B33","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.pbb.2007.01.015","article-title":"Modafinil improves attention, inhibitory control, and reaction time in healthy, middle-aged rats.","volume":"86","author":"Morgan","year":"2007","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"56131","key":"B34","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.70.056131","article-title":"Analysis of weighted networks.","volume":"70","author":"Newman","year":"2004","journal-title":"Phys. Rev. E Stat. Nonlin. Soft Matter Phys."},{"key":"B35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hbm.1058","article-title":"Nonparametric permutation tests for functional neuroimaging: a primer with examples.","volume":"15","author":"Nichols","year":"2002","journal-title":"Hum. Brain Mapp."},{"issue":"218","key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/srep00218","article-title":"Controlling centrality in complex networks.","volume":"2","author":"Nicosia","year":"2012","journal-title":"Sci. Rep."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1016\/j.neuroimage.2011.10.018","article-title":"Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion.","volume":"59","author":"Power","year":"2012","journal-title":"Neuroimage"},{"key":"B38","doi-asserted-by":"publisher","first-page":"8462","DOI":"10.1523\/JNEUROSCI.1819-08.2008","article-title":"Dopaminergic D1 and D2 receptors are essential for the arousal effect of modafinil.","volume":"28","author":"Qu","year":"2008","journal-title":"J. Neurosci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"4022","DOI":"10.1172\/JCI32829","article-title":"Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin\/orexin neurons.","volume":"117","author":"Rao","year":"2007","journal-title":"J. Clin. Invest."},{"key":"B40","doi-asserted-by":"publisher","first-page":"123","DOI":"10.2165\/00003088-200342020-00002","article-title":"Clinical pharmacokinetic profile of modafinil.","volume":"42","author":"Robertson","year":"2003","journal-title":"Clin. Pharmacokinet."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.neuroimage.2009.10.003","article-title":"Complex network measures of brain connectivity: uses and interpretations.","volume":"52","author":"Rubinov","year":"2010","journal-title":"Neuroimage"},{"key":"B42","doi-asserted-by":"publisher","first-page":"2663","DOI":"10.1162\/jocn.2009.21382","article-title":"Cognitive and motor loops of the human cerebro-cerebellar system.","volume":"22","author":"Salmi","year":"2010","journal-title":"J. Cogn. Neurosci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1037\/a0014366","article-title":"Modafinil and memory: effects of modafinil on morris water maze learning and Pavlovian fear conditioning.","volume":"123","author":"Shuman","year":"2009","journal-title":"Behav. Neurosci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.neuroimage.2008.03.061","article-title":"Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference.","volume":"44","author":"Smith","year":"2009","journal-title":"Neuroimage"},{"key":"B45","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.neuroimage.2008.08.039","article-title":"Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies.","volume":"44","author":"Stoodley","year":"2009","journal-title":"Neuroimage"},{"key":"B46","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.neuropharm.2010.03.010","article-title":"The psychostimulant modafinil facilitates water maze performance and augments synaptic potentiation in dentate gyrus.","volume":"59","author":"Tsanov","year":"2010","journal-title":"Neuropharmacology"},{"key":"B47","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1007\/s00415-009-5351-8","article-title":"Modafinil for Parkinson\u2019s disease fatigue.","volume":"257","author":"Tyne","year":"2010","journal-title":"J. Neurol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"12554","DOI":"10.1073\/pnas.0705087104","article-title":"Modafinil enhances thalamocortical activity by increasing neuronal electrotonic coupling.","volume":"104","author":"Urbano","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B49","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.jneumeth.2006.11.004","article-title":"Transformation of arbitrary distributions to the normal distribution with application to EEG test\u2013retest reliability.","volume":"161","author":"van Albada","year":"2007","journal-title":"J. Neurosci. Methods"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1001\/jama.2009.1308","article-title":"Evaluating dopamine reward pathway in ADHD: clinical implications.","volume":"302","author":"Volkow","year":"2009","journal-title":"JAMA"},{"key":"B51","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/30918","article-title":"Collective dynamics of \u201csmall-world\u201d networks.","volume":"393","author":"Watts","year":"1998","journal-title":"Nature"}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnagi.2017.00085\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T09:48:35Z","timestamp":1498384115000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnagi.2017.00085\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,30]]},"references-count":51,"URL":"https:\/\/doi.org\/10.3389\/fnagi.2017.00085","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,30]]}}}