{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:58:47Z","timestamp":1790377127524,"version":"4.1.0"},"reference-count":77,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100003086","name":"Eusko Jaurlaritza","doi-asserted-by":"publisher","award":["POS-2014-1-2"],"award-info":[{"award-number":["POS-2014-1-2"]}],"id":[{"id":"10.13039\/501100003086","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003086","name":"Eusko Jaurlaritza","doi-asserted-by":"publisher","award":["MOD:POSDOC"],"award-info":[{"award-number":["MOD:POSDOC"]}],"id":[{"id":"10.13039\/501100003086","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003086","name":"Eusko Jaurlaritza","doi-asserted-by":"publisher","award":["IT874-13"],"award-info":[{"award-number":["IT874-13"]}],"id":[{"id":"10.13039\/501100003086","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003086","name":"Eusko Jaurlaritza","doi-asserted-by":"publisher","award":["2013111162"],"award-info":[{"award-number":["2013111162"]}],"id":[{"id":"10.13039\/501100003086","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"DOI":"10.3389\/fnagi.2017.00179","type":"journal-article","created":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T23:55:32Z","timestamp":1497570932000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["White Matter Tract Integrity in Alzheimer's Disease vs. Late Onset Bipolar Disorder and Its Correlation with Systemic Inflammation and Oxidative Stress Biomarkers"],"prefix":"10.3389","volume":"9","author":[{"given":"Ariadna","family":"Besga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darya","family":"Chyzhyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itxaso","family":"Gonzalez-Ortega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Echeveste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Gra\u00f1a-Lecuona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Gra\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Gonzalez-Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,6,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/S0028-3932(99)00039-1","article-title":"Recognition of facial emotion in nine individuals with bilateral amygdala damage","volume":"37","author":"Adolphs","year":"1999","journal-title":"Neuropsychologia"},{"key":"B2","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1093\/toxsci\/kfj022","article-title":"Prostaglandin ep1 receptor contributes to excitotoxicity and focal ischemic brain damage","volume":"89","author":"Ahmad","year":"2006","journal-title":"Toxicol. Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/S0197-4580(00)00124-X","article-title":"Inflammation and Alzheimer's disease","volume":"21","author":"Akiyama","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"B4","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1146\/annurev.clinpsy.1.102803.144039","article-title":"Mild cognitive impairment and dementia","volume":"2","author":"Albert","year":"2006","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"e52859","DOI":"10.1371\/journal.pone.0052859","article-title":"Different patterns of white matter degeneration using multiple diffusion indices and volumetric data in mild cognitive impairment and Alzheimer patients","volume":"7","author":"Alves","year":"2013","journal-title":"PLoS ONE"},{"key":"B6","volume-title":"Non-linear Optimisation.","author":"Andersson","year":""},{"key":"B7","volume-title":"Non-linear Registration, aka Spatial Normalisation.","author":"Andersson","year":""},{"key":"B8","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.jagp.2012.08.013","article-title":"Cognitive impairment in euthymic older adults with bipolar disorder: a controlled study using cognitive screening tests","volume":"22","author":"Aprahamian","year":"2014","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e73107","DOI":"10.1371\/journal.pone.0073107","article-title":"Systemic inflammation in non-demented elderly human subjects: brain microstructure and cognition","volume":"8","author":"Arfanakis","year":"2013","journal-title":"PLoS ONE"},{"key":"B10","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/j.1469-8749.2011.04122.x","article-title":"Anatomy and functional role of the inferior longitudinal fasciculus: a search that has just begun","volume":"54","author":"Ashtari","year":"2012","journal-title":"Develop. Med. Child Neurol"},{"key":"B11","first-page":"206","article-title":"Eigenanatomy improves detection power for longitudinal cortical change","volume":"15","author":"Avants","year":"2012","journal-title":"Med. Image Comput. Comput. Assist. Interv."},{"key":"B12","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.neuroimage.2013.09.048","article-title":"Sparse canonical correlation analysis relates network-level atrophy to multivariate cognitive measures in a neurodegenerative population","volume":"84","author":"Avants","year":"2014","journal-title":"Neuroimage"},{"key":"B13","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.neuroimage.2014.06.021","article-title":"Methodological considerations on tract-based spatial statistics (tbss)","volume":"100","author":"Bach","year":"2014","journal-title":"Neuroimage"},{"key":"B14","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.jad.2011.12.034","article-title":"Executive dysfunction in euthymic bipolar disorder patients and its association with plasma biomarkers","volume":"137","author":"Barbosa","year":"2012","journal-title":"J. Affect. Disord."},{"key":"B15","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/S0006-3495(94)80775-1","article-title":"MR diffusion tensor spectroscopy and imaging","volume":"66","author":"Basser","year":"1994","journal-title":"Biophys. J."},{"key":"B16","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.jpsychires.2014.04.017","article-title":"Inflammatory mediators of cognitive impairment in bipolar disorder","volume":"56","author":"Bauer","year":"2014","journal-title":"J. Psychiat. Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.eurpsy.2014.10.005","article-title":"Influence of birth cohort on age of onset cluster analysis in bipolar i disorder","volume":"30","author":"Bauer","year":"","journal-title":"Euro. Psychiatry"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jpsychires.2015.03.013","article-title":"Influence of light exposure during early life on the age of onset of bipolar disorder","volume":"64","author":"Bauer","year":"","journal-title":"J. Psychiat. Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.jad.2014.05.032","article-title":"Relationship between sunlight and the age of onset of bipolar disorder: an international multisite study","volume":"167","author":"Bauer","year":"2014","journal-title":"J. Affect. Disord."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1002\/mrm.10609","article-title":"Characterization and propagation of uncertainty in diffusion-weighted MR imaging","volume":"50","author":"Behrens","year":"2003","journal-title":"Magn. Reson. Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"e0147319","DOI":"10.1371\/journal.pone.0147319","article-title":"An Alzheimer's disease-derived biomarker signature identifies parkinson's disease patients with dementia","volume":"11","author":"Berlyand","year":"2016","journal-title":"PLoS ONE"},{"key":"B22","doi-asserted-by":"publisher","first-page":"557","DOI":"10.2174\/1567205013666151116125349","article-title":"Eigenanatomy on fractional anisotropy imaging provides white matter anatomical features discriminating between Alzheimer's disease and late onset bipolar disorder","volume":"13","author":"Besga","year":"2016","journal-title":"Curr. Alzheimer Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3389\/fnagi.2015.00231","article-title":"Discrimination between Alzheimer's disease and late onset bipolar disorder using multivariate analysis","volume":"7","author":"Besga","year":"2015","journal-title":"Front. Aging Neurosci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.maturitas.2011.07.005","article-title":"The role of white matter damage in late onset bipolar disorder","volume":"70","author":"Besga","year":"2011","journal-title":"Maturitas"},{"key":"B25","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.neulet.2012.05.033","article-title":"Discovering Alzheimer's disease and bipolar disorder white matter effects building computer aided diagnostic systems on brain diffusion tensor imaging features","volume":"520","author":"Besga","year":"2012","journal-title":"Neurosci. Lett."},{"key":"B26","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.bbi.2008.09.007","article-title":"Synergistic effects of psychological and immune stressors on inflammatory cytokine and sickness responses in humans","volume":"23","author":"Brydon","year":"2009","journal-title":"Brain Behav. Immun."},{"key":"B27","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.psym.2012.01.006","article-title":"New onset of bipolar disorder in late life","volume":"54","author":"Carlino","year":"2013","journal-title":"Psychosomatics"},{"key":"B28","doi-asserted-by":"publisher","first-page":"74","DOI":"10.3389\/fendo.2014.00074","article-title":"Neuropsychiatric comorbidity in obesity: role of inflammatory processes","volume":"5","author":"Castanon","year":"2014","journal-title":"Front. Endocrinol (Lausanne)."},{"key":"B29","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.jcgg.2014.05.002","article-title":"Late onset bipolar disorder: a case report and review of the literature","volume":"6","author":"Chou","year":"2015","journal-title":"J. Clin. Gerontol. Geriatr."},{"key":"B30","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1111\/j.1399-5618.2004.00139.x","article-title":"Bipolar disorder in older adults: a critical review","volume":"6","author":"Depp","year":"2004","journal-title":"Bipolar Disord."},{"key":"B31","doi-asserted-by":"publisher","first-page":"e73520","DOI":"10.1371\/journal.pone.0073520","article-title":"A combined marker of inflammation in individuals with mania","volume":"8","author":"Dickerson","year":"2013","journal-title":"PLoS ONE"},{"key":"B32","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.euroneuro.2014.07.018","article-title":"The influence of cognitive reserve on psychosocial and neuropsychological functioning in bipolar disorder","volume":"25","author":"Forcada","year":"2015","journal-title":"Euro. Neuropsychopharmacol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1093\/schbul\/sbt001","article-title":"Proanti-inflammatory dysregulation in patients with first episode of psychosis: toward an integrative inflammatory hypothesis of schizophrenia","volume":"40","author":"Garcia-Bueno","year":"2014","journal-title":"Schizophr. Bull."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1177\/1352458514530022","article-title":"Forceps minor damage and co-occurrence of depression and fatigue in multiple sclerosis","volume":"20","author":"Gobbi","year":"2014","journal-title":"Multiple Scleros. J."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.4088\/JCP.08r04505","article-title":"Inflammation and the phenomenology, pathophysiology, comorbidity, and treatment of bipolar disorder: a systematic review of the literature","volume":"70","author":"Goldstein","year":"2009","journal-title":"J. Clin. Psychiatry"},{"key":"B36","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.neulet.2011.07.049","article-title":"Computer aided diagnosis system for Alzheimer disease using brain diffusion tensor imaging features selected by pearson's correlation","volume":"502","author":"Gra\u00f1a","year":"2011","journal-title":"Neurosci. Lett."},{"key":"B37","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1111\/acps.12268","article-title":"Staging bipolar disorder: clinical, biochemical, and functional correlates","volume":"129","author":"Grande","year":"2014","journal-title":"Acta Psychiatr. Scand."},{"key":"B38","doi-asserted-by":"publisher","first-page":"2952","DOI":"10.1093\/brain\/awt205","article-title":"White matter structural connectivity underlying semantic processing: evidence from brain damaged patients","volume":"136","author":"Han","year":"2013","journal-title":"Brain"},{"key":"B39","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.schres.2015.04.004","article-title":"Inflammatory markers are associated with general cognitive abilities in schizophrenia and bipolar disorder patients and healthy controls","volume":"165","author":"Hope","year":"2015","journal-title":"Schizophr. Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.jalz.2007.08.004","article-title":"Inflammation and Alzheimer's disease: possible role of periodontal diseases","volume":"4","author":"Kamer","year":"2008","journal-title":"Alzheimer Dement."},{"key":"B41","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1017\/S1461145708009310","article-title":"Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder","volume":"12","author":"Kauer-Sant'Anna","year":"2009","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1212\/01.WNL.0000055813.36504.BF","article-title":"Visual memory predicts Alzheimer's disease more than a decade before diagnosis","volume":"60","author":"Kawas","year":"2003","journal-title":"Neurology"},{"key":"B43","volume-title":"The Advanced Theory of Statistics, Volume 2: Inference and Relationship","author":"Kendall","year":"1973"},{"key":"B44","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.nbd.2011.01.025","article-title":"Mitochondria, oligodendrocytes and inflammation in bipolar disorder: evidence from transcriptome studies points to intriguing parallels with multiple sclerosis","volume":"45","author":"Konradi","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"B45","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.encep.2007.12.007","article-title":"Dementia following bipolar disorder","volume":"34","author":"Lebert","year":"2008","journal-title":"Encephale"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jad.2011.12.049","article-title":"Can bipolar disorder be viewed as a multi-system inflammatory disease?","volume":"141","author":"Leboyer","year":"2012","journal-title":"J. Affect. Disord."},{"key":"B47","doi-asserted-by":"publisher","first-page":"e66847","DOI":"10.1371\/journal.pone.0066847","article-title":"Inflammation's association with metabolic profiles before and after a twelve-week clinical trial in drug-naive patients with bipolar ii disorder","volume":"8","author":"Lee","year":"2013","journal-title":"PLoS ONE"},{"key":"B48","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1017\/S0033291710001042","article-title":"Evolution of neuropsychological dysfunction during the course of schizophrenia and bipolar disorder","volume":"41","author":"Lewandowski","year":"2011","journal-title":"Psychol. Med."},{"key":"B49","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.schres.2014.03.025","article-title":"Basal low antioxidant capacity correlates with cognitive deficits in early onset psychosis. a 2-year follow-up study","volume":"156","author":"Martinez-Cengotitabengoa","year":"2014","journal-title":"Schizophr. Res."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1001\/jamaneurol.2015.1807","article-title":"Nerve growth factor gene therapy: activation of neuronal responses in Alzheimer disease","volume":"72","author":"Tuszynski","year":"2015","journal-title":"JAMA Neurol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"2","DOI":"10.4161\/pri.21767","article-title":"Dysregulation of neural calcium signaling in Alzheimer disease, bipolar disorder and schizophrenia","volume":"7","author":"Berridge","year":"2013","journal-title":"Prion"},{"key":"B52","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1159\/000324508","article-title":"Computerized testing of neurocognitive function in euthymic bipolar patients compared to those with mild cognitive impairment and cognitively healthy controls","volume":"80","author":"Osher","year":"2011","journal-title":"Psychother. Psychosomat."},{"key":"B53","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1098\/rspl.1895.0041","article-title":"Notes on regression and inheritance in the case of two parents","volume":"58","author":"Pearson","year":"1895","journal-title":"Proc. R. Soc. Lond."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1017\/S0954579408000515","article-title":"Charting the typical and atypical development of the social brain","volume":"20","author":"Pelphrey","year":"2008","journal-title":"Dev. Psychopathol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1148\/radiology.201.3.8939209","article-title":"Diffusion tensor MR imaging of the human brain","volume":"201","author":"Pierpaoli","year":"1996","journal-title":"Radiology"},{"key":"B56","first-page":"34","article-title":"Late-onset bipolar disorder a case for careful appraisal","volume":"7","author":"Prabhakar","year":"2010","journal-title":"Psychiatry (Edgmont)"},{"key":"B57","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1109\/ISBI.2010.5490408","article-title":"Early Alzheimer's disease diagnosis using partial least squares and random forests","volume-title":"Biomedical Imaging: From Nano to Macro, 2010 IEEE International Symposium on","author":"Ramirez","year":"2010"},{"key":"B58","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.jad.2006.02.016","article-title":"A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder","volume":"93","author":"Robinson","year":"2006","journal-title":"J. Affect. Disord."},{"key":"B59","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.neulet.2009.05.056","article-title":"Analysis of SPECT brain images for the diagnosis of Alzheimer's disease using moments and support vector machines","volume":"461","author":"Salas-Gonzalez","year":"2009","journal-title":"Neurosci. Lett."},{"key":"B60","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.autrev.2011.09.005","article-title":"Alzheimer's disease, autoimmunity and inflammation. the good, the bad and the ugly","volume":"11","author":"Sardi","year":"2011","journal-title":"Autoimmun. Rev."},{"key":"B61","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.compbiomed.2011.05.010","article-title":"Neurocognitive disorder detection based on feature vectors extracted from vbm analysis of structural mri","volume":"41","author":"Savio","year":"2011","journal-title":"Comput. Biol. Med."},{"key":"B62","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.clim.2004.09.008","article-title":"15d-pgj2: The anti-inflammatory prostaglandin?","volume":"114","author":"Scher","year":"2005","journal-title":"Clin. Immunol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/j.eswa.2006.01.026","article-title":"An expert system for supervised classifier design: application to Alzheimer diagnosis","volume":"32","author":"Sigut","year":"2007","journal-title":"Expert Syst. Applic."},{"key":"B64","doi-asserted-by":"publisher","first-page":"315","DOI":"10.3389\/fnins.2014.00315","article-title":"Inflammasomes in neuroinflammation and changes in brain function: a focused review","volume":"8","author":"Singhal","year":"2014","journal-title":"Front. Neurosci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1016\/j.neuroimage.2006.02.024","article-title":"Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data","volume":"31","author":"Smith","year":"2006","journal-title":"Neuroimage"},{"key":"B66","doi-asserted-by":"publisher","first-page":"S208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","volume":"23","author":"Smith","year":"2004","journal-title":"Neuroimage"},{"key":"B67","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.neuroimage.2008.03.061","article-title":"Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference","volume":"44","author":"Smith","year":"2009","journal-title":"Neuroimage"},{"key":"B68","doi-asserted-by":"publisher","first-page":"e0115562","DOI":"10.1371\/journal.pone.0115562","article-title":"Cognitive functioning in clinically stable patients with bipolar disorder i and ii","volume":"10","author":"Sparding","year":"2015","journal-title":"PLoS ONE"},{"key":"B69","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.neucom.2012.08.044","article-title":"Lattice independent component analysis feature selection on diffusion weighted imaging for Alzheimer's disease classification","volume":"114","author":"Termenon","year":"2013","journal-title":"Neurocomputing"},{"key":"B70","doi-asserted-by":"publisher","first-page":"e899","DOI":"10.4088\/JCP.11m07471","article-title":"Long-term outcome of cognitive impairment in bipolar disorder","volume":"73","author":"Torrent","year":"2012","journal-title":"J. Clin. Psychiatry"},{"key":"B71","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/nm1239","article-title":"A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease","volume":"11","author":"Tuszynski","year":"2005","journal-title":"Nat. Med."},{"key":"B72","doi-asserted-by":"publisher","first-page":"a006171","DOI":"10.1101\/cshperspect.a006171","article-title":"The neuropsychological profile of Alzheimer disease","volume":"2","author":"Weintraub","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1016\/j.neuroimage.2010.08.044","article-title":"Multivariate analysis of mri data for Alzheimer's disease, mild cognitive impairment and healthy controls","volume":"54","author":"Westman","year":"2011","journal-title":"Neuroimage"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1007\/s11064-016-1829-9","article-title":"The emerging therapeutic role of ngf in Alzheimer's disease","volume":"41","author":"Xu","year":"2016","journal-title":"Neurochem. Res."},{"key":"B75","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.jagp.2013.03.014","article-title":"Longitudinal relationships between Alzheimer disease progression and psychosis, depressed mood, and agitation\/aggression","volume":"23","author":"Zahodne","year":"2015","journal-title":"Am. J. Geriat. Psychiatry"},{"key":"B76","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.pnpbp.2006.10.004","article-title":"Late onset bipolar disorder associated with white matter hyperintensities: a pathophysiological hypothesis","volume":"31","author":"Zanetti","year":"2007","journal-title":"Progr. Neuro Psychopharmacol. Biol. Psychiatry"},{"key":"B77","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/sj.jcbfm.9600233","article-title":"15d-prostaglandin j2 activates peroxisome proliferator-activated receptor-\u03b3, promotes expression of catalase, and reduces inflammation, behavioral dysfunction, and neuronal loss after intracerebral hemorrhage in rats","volume":"26","author":"Zhao","year":"2006","journal-title":"J. Cereb. Blood Flow Metab."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnagi.2017.00179\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T23:55:38Z","timestamp":1497570938000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnagi.2017.00179\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,16]]},"references-count":77,"alternative-id":["10.3389\/fnagi.2017.00179"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2017.00179","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,16]]},"article-number":"179"}}