{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:48:20Z","timestamp":1790844500824,"version":"4.1.0"},"reference-count":140,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100008303","name":"Department for Employment and Learning, Northern Ireland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008303","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"DOI":"10.3389\/fnagi.2017.00370","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T23:23:32Z","timestamp":1510097012000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Disrupted Thalamus White Matter Anatomy and Posterior Default Mode Network Effective Connectivity in Amnestic Mild Cognitive Impairment"],"prefix":"10.3389","volume":"9","author":[{"given":"Thomas","family":"Alderson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Kehoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"Maguire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dervla","family":"Farrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Lawlor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose A.","family":"Kenny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Declan","family":"Lyons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun L. W.","family":"Bokde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Coyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,11,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3389\/fncom.2014.00065","article-title":"Compensating for thalamocortical synaptic loss in Alzheimer\u2019s disease","volume":"8","author":"Abuhassan","year":"2014","journal-title":"Front. Comput. Neurosci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"266","DOI":"10.3389\/fnagi.2014.00266","article-title":"Diffusion tensor imaging in Alzheimer\u2019s disease: insights into the limbic-diencephalic network and methodological considerations","volume":"6","author":"Acosta-Cabronero","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1111\/j.1460-9568.2010.07251.x","article-title":"Hippocampal-anterior thalamic pathways for memory: uncovering a network of direct and indirect actions","volume":"31","author":"Aggleton","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"B6","unstructured":"Non-linear registration aka Spatial normalisation FMRIB Technial Report TR07JA2. In practice AnderssonJ. L. R. JenkinsonM. SmithS. 2007"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/j.neuroimage.2015.10.019","article-title":"An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging","volume":"125","author":"Andersson","year":"2016","journal-title":"Neuroimage"},{"key":"B8","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.neuron.2005.01.035","article-title":"Cortical function: a view from the thalamus","volume":"45","author":"Basso","year":"2005","journal-title":"Neuron"},{"key":"B10","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1109\/tmi.2003.822821","article-title":"Probabilistic independent component analysis for functional magnetic resonance imaging","volume":"23","author":"Beckmann","year":"2004","journal-title":"IEEE Trans. Med. Imaging"},{"key":"B129","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.neucom.2012.10.023","article-title":"Model-based bifurcation and power spectral analyses of thalamocortical alpha rhythm slowing in Alzheimer\u2019s disease","volume":"115","author":"Bhattacharya","year":"2013","journal-title":"Neurocomputing"},{"key":"B11","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.neunet.2011.02.009","article-title":"A thalamo-cortico-thalamic neural mass model to study alpha rhythms in Alzheimer\u2019s disease","volume":"24","author":"Bhattacharya","year":"2011","journal-title":"Neural Netw."},{"key":"B12","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1002\/mrm.24528","article-title":"Generalized inverse imaging (GIN): ultrafast fMRI with physiological noise correction","volume":"70","author":"Boyacio\u011flu","year":"2013","journal-title":"Magn. Reson. Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/BF00305867","article-title":"Alzheimer\u2019s disease affects limbic nuclei of the thalamus","volume":"81","author":"Braak","year":"","journal-title":"Acta Neuropathol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/bf00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"","journal-title":"Acta Neuropathol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0197-4580(95)00021-6","article-title":"Staging of Alzheimer\u2019s disease-related neurofibrillary changes","volume":"16","author":"Braak","year":"1995","journal-title":"Neurobiol. Aging"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1196\/annals.1440.011","article-title":"The brain\u2019s default network: anatomy, function, and relevance to disease","volume":"1124","author":"Buckner","year":"2008","journal-title":"Ann. N Y Acad. Sci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1523\/JNEUROSCI.5062-08.2009","article-title":"Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer\u2019s disease","volume":"29","author":"Buckner","year":"2009","journal-title":"J. Neurosci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"7709","DOI":"10.1523\/JNEUROSCI.2177-05.2005","article-title":"Molecular, structural, and functional characterization of Alzheimer\u2019s disease: evidence for a relationship between default activity, amyloid, and memory","volume":"25","author":"Buckner","year":"2005","journal-title":"J. Neurosci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"b158","DOI":"10.1136\/bmj.b158","article-title":"Alzheimer\u2019s disease","volume":"338","author":"Burns","year":"2009","journal-title":"BMJ"},{"key":"B20","doi-asserted-by":"publisher","first-page":"3944","DOI":"10.1002\/hbm.20819","article-title":"Functional integrity of thalamocortical circuits differentiates normal aging from mild cognitive impairment","volume":"30","author":"Cantero","year":"2009","journal-title":"Hum. Brain Mapp."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.3233\/JAD-2010-091186","article-title":"Combined volumetry and DTI in subcortical structures of mild cognitive impairment and Alzheimer\u2019s disease patients","volume":"19","author":"Cherubini","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"B23","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.neuroimage.2005.05.015","article-title":"Using voxel-based morphometry to map the structural changes associated with rapid conversion in MCI: a longitudinal MRI study","volume":"27","author":"Ch\u00e9telat","year":"2005","journal-title":"Neuroimage"},{"key":"B24","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1212\/WNL.0b013e3182a1aafe","article-title":"Impaired default network functional connectivity in autosomal dominant Alzheimer disease","volume":"81","author":"Chhatwal","year":"2013","journal-title":"Neurology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.3174\/ajnr.a2984","article-title":"White matter alterations in cognitively normal apoE\u03b52 carriers: insight into Alzheimer resistance?","volume":"33","author":"Chiang","year":"2012","journal-title":"Am. J. Neuroradiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"828.e19","DOI":"10.1016\/j.neurobiolaging.2011.06.024","article-title":"Functional connectivity tracks clinical deterioration in Alzheimer\u2019s disease","volume":"33","author":"Damoiseaux","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"B28","doi-asserted-by":"publisher","first-page":"13848","DOI":"10.1073\/pnas.0601417103","article-title":"Consistent resting-state networks across healthy subjects","volume":"103","author":"Damoiseaux","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B29","doi-asserted-by":"publisher","first-page":"3277","DOI":"10.1093\/brain\/awn278","article-title":"Strongly reduced volumes of putamen and thalamus in Alzheimer\u2019s disease: an MRI study","volume":"131","author":"de Jong","year":"2008","journal-title":"Brain"},{"key":"B31","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1016\/j.neuroimage.2009.11.060","article-title":"Effect of hemodynamic variability on Granger causality analysis of fMRI","volume":"52","author":"Deshpande","year":"2010","journal-title":"Neuroimage"},{"key":"B33","doi-asserted-by":"publisher","first-page":"e367","DOI":"10.7717\/peerj.367","article-title":"Modulatory interactions between the default mode network and task positive networks in resting-state","volume":"2","author":"Di","year":"2014","journal-title":"PeerJ"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1093\/brain\/awr066","article-title":"Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden","volume":"134","author":"Drzezga","year":"2011","journal-title":"Brain"},{"key":"B35","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/0165-1781(92)90115-j","article-title":"Facial emotion discrimination: I. Task construction and behavioral findings in normal subjects","volume":"42","author":"Erwin","year":"1992","journal-title":"Psychiatry Res."},{"key":"B36","volume-title":"Manual for the Eysenck Personality Questionnaire (EPQ-R Adult).","author":"Eysenck","year":"1994"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.3171\/2013.2.JNS121294","article-title":"White matter fiber tractography: why we need to move beyond DTI","volume":"118","author":"Farquharson","year":"2013","journal-title":"J. Neurosurg."},{"key":"B39","doi-asserted-by":"publisher","first-page":"e15710","DOI":"10.1371\/journal.pone.0015710","article-title":"Multiplexed echo planar imaging for sub-second whole brain fmri and fast diffusion imaging","volume":"5","author":"Feinberg","year":"2010","journal-title":"PLoS One"},{"key":"B38","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.neuroimage.2012.01.049","article-title":"The rapid development of high speed, resolution and precision in fMRI","volume":"62","author":"Feinberg","year":"2012","journal-title":"Neuroimage"},{"key":"B40","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1002\/ana.23635","article-title":"A role for the default mode network in the bases of disorders of consciousness","volume":"72","author":"Fern\u00e1ndez-Espejo","year":"2012","journal-title":"Ann. Neurol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1016\/j.neuroimage.2007.11.003","article-title":"MMSE scores correlate with local ventricular enlargement in the spectrum from cognitively normal to Alzheimer disease","volume":"39","author":"Ferrarini","year":"2008","journal-title":"Neuroimage"},{"key":"B45","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3389\/fnagi.2014.00106","article-title":"Early brain loss in circuits affected by Alzheimer\u2019s disease is predicted by fornix microstructure but may be independent of gray matter","volume":"6","author":"Fletcher","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1089\/brain.2011.0008","article-title":"Functional and effective connectivity: a review","volume":"1","author":"Friston","year":"2011","journal-title":"Brain Connect."},{"key":"B48","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.nicl.2014.09.004","article-title":"The Default Mode Network is functionally and structurally disrupted in amnestic mild cognitive impairment\u2014a bimodal MEG-DTI study","volume":"6","author":"Garc\u00e9s","year":"2014","journal-title":"Neuroimage Clin."},{"key":"B49","doi-asserted-by":"publisher","first-page":"100","DOI":"10.3389\/fnagi.2013.00100","article-title":"Brain-wide slowing of spontaneous \u03b1 rhythms in mild cognitive impairment","volume":"5","author":"Garc\u00e9s","year":"2013","journal-title":"Front. Aging Neurosci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"424","DOI":"10.2307\/1912791","article-title":"Investigating causal relations by econometric models and cross- spectral methods","volume":"37","author":"Granger","year":"1969","journal-title":"Econometrica"},{"key":"B52","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1073\/pnas.0135058100","article-title":"Functional connectivity in the resting brain: a network analysis of the default mode hypothesis","volume":"100","author":"Greicius","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B53","doi-asserted-by":"publisher","first-page":"4637","DOI":"10.1073\/pnas.0308627101","article-title":"Default-mode network activity distinguishes Alzheimer\u2019s disease from healthy aging: evidence from functional MRI","volume":"101","author":"Greicius","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B56","doi-asserted-by":"publisher","first-page":"e159","DOI":"10.1371\/journal.pbio.0060159","article-title":"Mapping the structural core of human cerebral cortex","volume":"6","author":"Hagmann","year":"2008","journal-title":"PLoS Biol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1016\/j.neuroimage.2012.02.015","article-title":"The continuing challenge of understanding and modeling hemodynamic variation in fMRI","volume":"62","author":"Handwerker","year":"2012","journal-title":"Neuroimage"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1016\/j.neuroimage.2003.11.029","article-title":"Variation of BOLD hemodynamic responses across subjects and brain regions and their effects on statistical analyses","volume":"21","author":"Handwerker","year":"2004","journal-title":"Neuroimage"},{"key":"B59","doi-asserted-by":"publisher","first-page":"12686","DOI":"10.1523\/JNEUROSCI.3189-09.2009","article-title":"Disruption of functional connectivity in clinically normal older adults harboring amyloid burden","volume":"29","author":"Hedden","year":"2009","journal-title":"J. Neurosci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1111\/j.2044-8260.1995.tb01487.x","article-title":"CAMCOG\u2014a concise neuropsychological test to assist dementia diagnosis: socio-demographic determinants in an elderly population sample","volume":"34","author":"Huppert","year":"1995","journal-title":"Br. J. Clin. Psychol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1109\/72.761722","article-title":"Fast and robust fixed-point algorithms for independent component analysis","volume":"10","author":"Hyv\u00e4rinen","year":"1999","journal-title":"IEEE Trans. Neural Netw."},{"key":"B66","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.clinph.2007.12.002","article-title":"Global dynamical analysis of the EEG in Alzheimer\u2019s disease: frequency-specific changes of functional interactions","volume":"119","author":"Jelles","year":"2008","journal-title":"Clin. Neurophysiol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/s1053-8119(02)91132-8","article-title":"Improved optimization for the robust and accurate linear registration and motion correction of brain images","volume":"17","author":"Jenkinson","year":"2002","journal-title":"Neuroimage"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1016\/j.clinph.2004.01.001","article-title":"EEG dynamics in patients with Alzheimer\u2019s disease","volume":"115","author":"Jeong","year":"2004","journal-title":"Clin. Neurophysiol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1002\/hbm.22099","article-title":"Investigating the prevalence of complex fiber configurations in white matter tissue with diffusion magnetic resonance imaging","volume":"34","author":"Jeurissen","year":"2013","journal-title":"Hum. Brain Mapp."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1212\/WNL.50.6.1563","article-title":"Preclinical prediction of Alzheimer\u2019s disease using SPECT","volume":"50","author":"Johnson","year":"1998","journal-title":"Neurology"},{"key":"B71","doi-asserted-by":"publisher","first-page":"341","DOI":"10.2217\/iim.10.21","article-title":"Challenges and limitations of quantifying brain connectivity in vivo with diffusion MRI","volume":"2","author":"Jones","year":"2010","journal-title":"Imaging Med."},{"key":"B72","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1002\/nbm.1543","article-title":"Twenty-five pitfalls in the analysis of diffusion MRI data","volume":"23","author":"Jones","year":"2010","journal-title":"NMR Biomed."},{"key":"B73","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1001\/archneurol.2010.259","article-title":"Default mode network disruption secondary to a lesion in the anterior thalamus","volume":"68","author":"Jones","year":"2011","journal-title":"Arch. Neurol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fnagi.2015.00010","article-title":"Fornix white matter is correlated with resting-state functional connectivity of the thalamus and hippocampus in healthy aging but not in mild cognitive impairment\u2014a preliminary study","volume":"7","author":"Kehoe","year":"2015","journal-title":"Front. Aging Neurosci."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1016\/j.neurobiolaging.2009.11.013","article-title":"Acceleration of cortical thinning in familial Alzheimer\u2019s disease","volume":"32","author":"Knight","year":"","journal-title":"Neurobiol. Aging"},{"key":"B76","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1093\/brain\/awq310","article-title":"Carbon-11-Pittsburgh compound B positron emission tomography imaging of amyloid deposition in presenilin 1 mutation carriers","volume":"134","author":"Knight","year":"","journal-title":"Brain"},{"key":"B78","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.neurobiolaging.2004.03.008","article-title":"Decreased EEG synchronization in Alzheimer\u2019s disease and mild cognitive impairment","volume":"26","author":"Koenig","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"B81","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1093\/brain\/awt162","article-title":"The role of the posterior cingulate cortex in cognition and disease","volume":"137","author":"Leech","year":"2014","journal-title":"Brain"},{"key":"B83","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1007\/s00234-010-0795-1","article-title":"Gray matter concentration and effective connectivity changes in Alzheimer\u2019s disease: a longitudinal structural MRI study","volume":"53","author":"Li","year":"2011","journal-title":"Neuroradiology"},{"key":"B84","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.neuroimage.2013.04.091","article-title":"Spatio-temporal Granger causality: a new framework","volume":"79","author":"Luo","year":"2013","journal-title":"Neuroimage"},{"key":"B87","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/BF02988596","article-title":"Cerebral blood flow and metabolic abnormalities in Alzheimer\u2019s disease","volume":"15","author":"Matsuda","year":"2001","journal-title":"Ann. Nucl. Med."},{"key":"B88","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1093\/brain\/122.8.1519","article-title":"Neocortical and hippocampal glucose hypometabolism following neurotoxic lesions of the entorhinal and perirhinal cortices in the non-human primate as shown by PET. Implications for Alzheimer\u2019s disease","volume":"122","author":"Meguro","year":"1999","journal-title":"Brain"},{"key":"B89","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/j.crad.2013.03.009","article-title":"High b-value diffusion tensor imaging of the remote white matter and white matter of obstructive unilateral cerebral arterial regions","volume":"68","author":"Meng","year":"2013","journal-title":"Clin. Radiol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1212\/WNL.0b013e31827689e8","article-title":"Temporal association tracts and the breakdown of episodic memory in mild cognitive impairment","volume":"79","author":"Metzler-Baddeley","year":"","journal-title":"Neurology"},{"key":"B91","doi-asserted-by":"publisher","first-page":"17612","DOI":"10.1523\/JNEUROSCI.3299-12.2012","article-title":"Cingulum microstructure predicts cognitive control in older age and mild cognitive impairment","volume":"32","author":"Metzler-Baddeley","year":"","journal-title":"J. Neurosci."},{"key":"B93","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.jalz.2011.05.2416","article-title":"Fornix integrity and hippocampal volume predict memory decline and progression to Alzheimer\u2019s disease","volume":"8","author":"Mielke","year":"2012","journal-title":"Alzheimers Dement."},{"key":"B94","first-page":"598","article-title":"Automatic choice of dimensionality for PCA","volume-title":"Advances in Neural Information Processing Systems","author":"Minka","year":"2001"},{"key":"B95","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1007\/978-1-4899-6704-6_17","article-title":"Posterior cingulate cortex in Alzheimer\u2019s disease","volume":"344","author":"Minoshima","year":"1994","journal-title":"Lancet"},{"key":"B96","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/ana.410420114","article-title":"Metabolic reduction in the posterior cingulate cortex in very early Alzheimer\u2019s disease","volume":"42","author":"Minoshima","year":"1997","journal-title":"Ann. Neurol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1212\/01.WNL.0000228230.26044.a4","article-title":"[11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease","volume":"67","author":"Mintun","year":"2006","journal-title":"Neurology"},{"key":"B99","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3389\/fnagi.2015.00031","article-title":"Theta and \u03b1 EEG frequency interplay in subjects with mild cognitive impairment: evidence from EEG, MRI, and SPECT brain modifications","volume":"7","author":"Moretti","year":"2015","journal-title":"Front. Aging Neurosci."},{"key":"B100","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1093\/cercor\/bhr025","article-title":"Relationships between \u03b2-amyloid and functional connectivity in different components of the default mode network in aging","volume":"21","author":"Mormino","year":"2011","journal-title":"Cereb. Cortex"},{"key":"B101","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1212\/WNL.39.9.1159","article-title":"The consortium to establish a registry for Alzheimer\u2019s disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer\u2019s disease","volume":"39","author":"Morris","year":"1989","journal-title":"Neurology"},{"key":"B102","doi-asserted-by":"publisher","first-page":"390","DOI":"10.2967\/jnumed.107.045385","article-title":"Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer\u2019s disease, and other dementias","volume":"49","author":"Mosconi","year":"2008","journal-title":"J. Nucl. Med."},{"key":"B103","doi-asserted-by":"publisher","first-page":"582","DOI":"10.3389\/fnins.2016.00582","article-title":"Connectivity disruption, atrophy and hypometabolism within posterior cingulate networks in Alzheimer\u2019s disease","volume":"10","author":"Mutlu","year":"2016","journal-title":"Front. Neurosci."},{"key":"B105","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1002\/ana.10669","article-title":"Limbic hypometabolism in Alzheimer\u2019s disease and mild cognitive impairment","volume":"54","author":"Nestor","year":"2003","journal-title":"Ann. Neurol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1001\/archneurpsyc.1937.02260220069003","article-title":"A proposed mechanism of emotion","volume":"38","author":"Papez","year":"1937","journal-title":"Arch. Neurol. Psychiatry"},{"key":"B108","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.neures.2008.06.009","article-title":"Decreased EEG synchronization and its correlation with symptom severity in Alzheimer\u2019s disease","volume":"62","author":"Park","year":"2008","journal-title":"Neurosci. Res."},{"key":"B109","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1002\/mrm.22055","article-title":"Free water elimination and mapping from diffusion MRI","volume":"62","author":"Pasternak","year":"2009","journal-title":"Magn. Reson. Med."},{"key":"B110","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/s11682-012-9187-y","article-title":"Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers","volume":"7","author":"Patel","year":"2013","journal-title":"Brain Imaging Behav."},{"key":"B111","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1159\/000342118","article-title":"Volumetric brain changes in thalamus, corpus callosum and medial temporal structures: mild alzheimer\u2019s disease compared with amnestic mild cognitive impairment","volume":"34","author":"Pedro","year":"2012","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"B113","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/j.1365-2796.2004.01388.x","article-title":"Mild cognitive impairment as a diagnostic entity","volume":"256","author":"Petersen","year":"2004","journal-title":"J. Intern. Med."},{"key":"B114","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1001\/archneur.56.3.303","article-title":"Mild cognitive impairment: clinical characterization and outcome","volume":"56","author":"Petersen","year":"1999","journal-title":"Arch. Neurol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3233\/BEN-2009-0231","article-title":"Functional MRI assessment of task-induced deactivation of the default mode network in Alzheimer\u2019s disease and at-risk older individuals","volume":"21","author":"Pihlajam\u00e4ki","year":"2009","journal-title":"Behav. Neurol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1002\/(sici)1522-2594(199911)42:5<952::aid-mrm16>3.3.co;2-j","article-title":"SENSE: sensitivity encoding for fast MRI","volume":"42","author":"Pruessmann","year":"1999","journal-title":"Magn. Reson. Med."},{"key":"B117","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1073\/pnas.98.2.676","article-title":"A default mode of brain function","volume":"98","author":"Raichle","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B118","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/j.neuron.2011.12.040","article-title":"A network diffusion model of disease progression in dementia","volume":"73","author":"Raj","year":"2012","journal-title":"Neuron"},{"key":"B119","first-page":"195","article-title":"Cognitive reserve questionnaire. Scores obtained in a healthy elderly population and in one with Alzheimer\u2019s disease","volume":"52","author":"Rami","year":"2011","journal-title":"Rev. Neurol."},{"key":"B120","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1007\/s00415-010-5872-1","article-title":"Volume reduction in subcortical regions according to severity of Alzheimer\u2019s disease","volume":"258","author":"Roh","year":"2011","journal-title":"J. Neurol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1146\/annurev.med.47.1.387","article-title":"Apolipoprotein E alleles as risk factors in Alzheimer\u2019s disease","volume":"47","author":"Roses","year":"1996","journal-title":"Annu. Rev. Med."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1093\/brain\/awt065","article-title":"Magnetic resonance imaging evidence for presymptomatic change in thalamus and caudate in familial Alzheimer\u2019s disease","volume":"136","author":"Ryan","year":"2013","journal-title":"Brain"},{"key":"B123","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1126\/science.1223082","article-title":"The pulvinar regulates information transmission between cortical areas based on attention demands","volume":"337","author":"Saalmann","year":"2012","journal-title":"Science"},{"key":"B124","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00221-005-2361-3","article-title":"Projections from the entorhinal cortex, perirhinal cortex, presubiculum and parasubiculum to the medial thalamus in macaque monkeys: identifying different pathways using disconnection techniques","volume":"167","author":"Saunders","year":"2005","journal-title":"Exp. Brain Res."},{"key":"B126","doi-asserted-by":"crossref","DOI":"10.1002\/9783527609970","volume-title":"Handbook of Time Series Analysis.","author":"Schelter","year":"2006"},{"key":"B127","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.neuroimage.2011.02.008","article-title":"The effect of intra- and inter-subject variability of hemodynamic responses on group level Granger causality analyses","volume":"57","author":"Schippers","year":"2011","journal-title":"Neuroimage"},{"key":"B128","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.neuroimage.2004.01.047","article-title":"The thalamus as the generator and modulator of EEG alpha rhythm: a combined PET\/EEG study with lorazepam challenge in humans","volume":"22","author":"Schreckenberger","year":"2004","journal-title":"Neuroimage"},{"key":"B130","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.neuroimage.2012.09.049","article-title":"Granger causality analysis of fMRI BOLD signals is invariant to hemodynamic convolution but not downsampling","volume":"65","author":"Seth","year":"2013","journal-title":"Neuroimage"},{"key":"B131","doi-asserted-by":"publisher","first-page":"17035","DOI":"10.1523\/JNEUROSCI.3987-10.2010","article-title":"APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF A\u03b242","volume":"30","author":"Sheline","year":"2010","journal-title":"J. Neurosci."},{"key":"B132","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.biopsych.2009.08.024","article-title":"Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly","volume":"67","author":"Sheline","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"B133","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.conb.2007.07.003","article-title":"The thalamus is more than just a relay","volume":"17","author":"Sherman","year":"2007","journal-title":"Curr. Opin. Neurobiol."},{"key":"B134","volume-title":"Exploring the Thalamus.","author":"Sherman","year":"2006"},{"key":"B135","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.neuroimage.2006.06.010","article-title":"Four subgroups of Alzheimer\u2019s disease based on patterns of atrophy using VBM and a unique pattern for early onset disease","volume":"33","author":"Shiino","year":"2006","journal-title":"Neuroimage"},{"key":"B137","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1002\/hbm.10062","article-title":"Fast robust automated brain extraction","volume":"17","author":"Smith","year":"2002","journal-title":"Hum. Brain Mapp."},{"key":"B138","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/j.neuroimage.2010.08.063","article-title":"Network modelling methods for FMRI","volume":"54","author":"Smith","year":"2011","journal-title":"Neuroimage"},{"key":"B139","doi-asserted-by":"publisher","first-page":"18760","DOI":"10.1073\/pnas.0708803104","article-title":"Selective changes of resting-state networks in individuals at risk for Alzheimer\u2019s disease","volume":"104","author":"Sorg","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B141","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1038\/mp.2011.147","article-title":"The neuropathological profile of mild cognitive impairment (MCI): a systematic review","volume":"17","author":"Stephan","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"B142","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1007\/s00259-015-3222-3","article-title":"Does posterior cingulate hypometabolism result from disconnection or local pathology across preclinical and clinical stages of Alzheimer\u2019s disease?","volume":"43","author":"Teipel","year":"2016","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1038\/nn.2905","article-title":"A lateralized brain network for visuospatial attention","volume":"14","author":"Thiebaut de Schotten","year":"2011","journal-title":"Nat. Neurosci."},{"key":"B143","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1016\/j.neuroimage.2007.02.016","article-title":"Robust determination of the fibre orientation distribution in diffusion MRI: non-negativity constrained super-resolved spherical deconvolution","volume":"35","author":"Tournier","year":"2007","journal-title":"Neuroimage"},{"key":"B144","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/ima.22005","article-title":"MRtrix: diffusion tractography in crossing fiber regions","volume":"22","author":"Tournier","year":"2012","journal-title":"Int. J. Imaging Syst. Technol."},{"key":"B145","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1016\/j.neuroimage.2004.07.037","article-title":"Direct estimation of the fiber orientation density function from diffusion-weighted MRI data using spherical deconvolution","volume":"23","author":"Tournier","year":"2004","journal-title":"Neuroimage"},{"key":"B146","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.neuroimage.2008.05.002","article-title":"Resolving crossing fibres using constrained spherical deconvolution: validation using diffusion-weighted imaging phantom data","volume":"42","author":"Tournier","year":"2008","journal-title":"Neuroimage"},{"key":"B147","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1523\/JNEUROSCI.21-13-04923.2001","article-title":"Energy hypometabolism in posterior cingulate cortex of Alzheimer\u2019s patients: superficial laminar cytochrome oxidase associated with disease duration","volume":"21","author":"Valla","year":"2001","journal-title":"J. Neurosci."},{"key":"B149","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.neuroimage.2013.05.041","article-title":"The WU-minn human connectome project: an overview","volume":"80","author":"Van Essen","year":"2013","journal-title":"Neuroimage"},{"key":"B150","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1038\/nrn2733","article-title":"What does the retrosplenial cortex do?","volume":"10","author":"Vann","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"B151","doi-asserted-by":"publisher","first-page":"6174","DOI":"10.1523\/JNEUROSCI.1392-08.2008","article-title":"Relationships between hippocampal atrophy, white matter disruption and gray matter hypometabolism in Alzheimer\u2019s disease","volume":"28","author":"Villain","year":"2008","journal-title":"J. Neurosci."},{"key":"B152","doi-asserted-by":"publisher","first-page":"2550","DOI":"10.1109\/TBME.2014.2323078","article-title":"Generation of the probabilistic template of default mode network derived from resting-state fMRI","volume":"61","author":"Wang","year":"2014","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"B153","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1002\/ana.23643","article-title":"Alzheimer disease family history impacts resting state functional connectivity","volume":"72","author":"Wang","year":"2012","journal-title":"Ann. Neurol."},{"key":"B155","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1001\/archneur.1991.00530150046016","article-title":"Detection of abnormal memory decline in mild cases of Alzheimer\u2019s disease using CERAD neuropsychological measures","volume":"48","author":"Welsh","year":"1991","journal-title":"Arch. Neurol."},{"key":"B154","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1001\/archneur.1992.00530290030008","article-title":"Detection and staging of dementia in Alzheimer\u2019s disease. Use of the neuropsychological measures developed for the consortium to establish a registry for Alzheimer\u2019s disease","volume":"49","author":"Welsh","year":"1992","journal-title":"Arch. Neurol."},{"key":"B156","doi-asserted-by":"publisher","first-page":"e67428","DOI":"10.1371\/journal.pone.0067428","article-title":"Is granger causality a viable technique for analyzing fMRI data?","volume":"8","author":"Wen","year":"2013","journal-title":"PLoS One"},{"key":"B157","doi-asserted-by":"publisher","first-page":"S12","DOI":"10.1007\/s00259-007-0698-5","article-title":"A new integrative model of cerebral activation, deactivation and default mode function in Alzheimer\u2019s disease","volume":"35","author":"Wermke","year":"2008","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"B158","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1002\/mrm.21965","article-title":"About \u201caxial\u201d and \u201cradial\u201d diffusivities","volume":"61","author":"Wheeler-Kingshott","year":"2009","journal-title":"Magn. Reson. Med."},{"key":"B159","first-page":"323","article-title":"The theory of prediction","volume-title":"Modern Mathematics for Engineers","author":"Wiener","year":"1956"},{"key":"B160","doi-asserted-by":"publisher","first-page":"e0120773","DOI":"10.1371\/journal.pone.0120773","article-title":"How does B-value affect HARDI reconstruction using clinical diffusion MRI data?","volume":"10","author":"Xie","year":"2015","journal-title":"PLoS One"},{"key":"B161","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1093\/brain\/114.3.1363","article-title":"Nerve cell loss in the thalamus in Alzheimer\u2019s disease and Parkinson\u2019s disease","volume":"114","author":"Xuereb","year":"1991","journal-title":"Brain"},{"key":"B162","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1007\/s00259-011-1882-1","article-title":"Functional implications of hippocampal degeneration in early Alzheimer\u2019s disease: a combined DTI and PET study","volume":"38","author":"Yakushev","year":"2011","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"B164","doi-asserted-by":"publisher","first-page":"E5214","DOI":"10.1073\/pnas.1418503111","article-title":"The vertical occipital fasciculus: a century of controversy resolved by in vivo measurements","volume":"111","author":"Yeatman","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B165","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/0022-3956(82)90033-4","article-title":"Development and validation of a geriatric depression screening scale: a preliminary report","volume":"17","author":"Yesavage","year":"1983","journal-title":"J. Psychiatr. Res."},{"key":"B166","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.neuroimage.2012.10.071","article-title":"Functional segmentation of the hippocampus in the healthy human brain and in Alzheimer\u2019s disease","volume":"66","author":"Zarei","year":"2013","journal-title":"Neuroimage"},{"key":"B167","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuroimage.2009.09.001","article-title":"Combining shape and connectivity analysis: an MRI study of thalamic degeneration in Alzheimer\u2019s disease","volume":"49","author":"Zarei","year":"2010","journal-title":"Neuroimage"},{"key":"B171","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1109\/42.906424","article-title":"Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm","volume":"20","author":"Zhang","year":"2001","journal-title":"IEEE Trans. Med. Imaging"},{"key":"B172","doi-asserted-by":"publisher","first-page":"e66367","DOI":"10.1371\/journal.pone.0066367","article-title":"MRI markers for mild cognitive impairment: comparisons between white matter integrity and gray matter volume measurements","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS One"},{"key":"B168","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1152\/jn.90463.2008","article-title":"Intrinsic functional relations between human cerebral cortex and thalamus","volume":"100","author":"Zhang","year":"2008","journal-title":"J. Neurophysiol."},{"key":"B169","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1093\/cercor\/bhp182","article-title":"Noninvasive functional and structural connectivity mapping of the human thalamocortical system","volume":"20","author":"Zhang","year":"2010","journal-title":"Cereb. Cortex"},{"key":"B173","doi-asserted-by":"publisher","first-page":"969","DOI":"10.3233\/JAD-121879","article-title":"Alzheimer\u2019s disease and amnestic mild cognitive impairment weaken connections within the default-mode network: a multi-modal imaging study","volume":"34","author":"Zhu","year":"2013","journal-title":"J. Alzheimers Dis."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnagi.2017.00370\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,5]],"date-time":"2019-10-05T15:55:58Z","timestamp":1570290958000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnagi.2017.00370\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,8]]},"references-count":140,"alternative-id":["10.3389\/fnagi.2017.00370"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2017.00370","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,8]]},"article-number":"370"}}