{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:33:47Z","timestamp":1793043227001,"version":"4.5.0"},"reference-count":278,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"DOI":"10.3389\/fnagi.2018.00048","type":"journal-article","created":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T04:13:41Z","timestamp":1520309621000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":145,"title":["Molecular Mechanisms for Herpes Simplex Virus Type 1 Pathogenesis in Alzheimer\u2019s Disease"],"prefix":"10.3389","volume":"10","author":[{"given":"Steven A.","family":"Harris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,3,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.bbi.2016.07.153","article-title":"High avidity HSV-1 antibodies correlate with absence of amnestic Mild Cognitive Impairment conversion to Alzheimer\u2019s disease","volume":"58","author":"Agostini","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"B2","doi-asserted-by":"publisher","first-page":"101","DOI":"10.4161\/auto.5222","article-title":"Xenophagy in herpes simplex virus replication and pathogenesis","volume":"4","author":"Alexander","year":"2008","journal-title":"Autophagy"},{"key":"B3","doi-asserted-by":"publisher","first-page":"301","DOI":"10.3233\/JAD-132681","article-title":"Fungal infection in patients with Alzheimer\u2019s disease","volume":"41","author":"Alonso","year":"","journal-title":"J. Alzheimers Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1007\/s10096-013-2045-z","article-title":"Alzheimer\u2019s disease and disseminated mycoses","volume":"33","author":"Alonso","year":"","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"B5","doi-asserted-by":"publisher","first-page":"873","DOI":"10.3233\/JAD-150382","article-title":"Cerebrospinal fluid from Alzheimer\u2019s disease patients contains fungal proteins and DNA","volume":"47","author":"Alonso","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"B254","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.arcmed.2012.10.017","article-title":"Genetics of Alzheimer\u2019s disease","volume":"43","author":"Alonso Vilatela","year":"2012","journal-title":"Arch. Med. Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1002\/jnr.23003","article-title":"Herpes simplex virus type 1 induces nuclear accumulation of hyperphosphorylated tau in neuronal cells","volume":"90","author":"Alvarez","year":"2012","journal-title":"J. Neurosci. Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/s00401-006-0037-0","article-title":"Accelerated tau deposition in the brains of individuals infected with human immunodeficiency virus-1 before and after the advent of highly active anti-retroviral therapy","volume":"111","author":"Anthony","year":"2006","journal-title":"Acta Neuropathol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1111\/j.1750-3639.2009.00354.x","article-title":"Chronic cortical and subcortical pathology with associated neurological deficits ensuing experimental herpes encephalitis","volume":"20","author":"Armien","year":"2010","journal-title":"Brain Pathol."},{"key":"B9","first-page":"127","article-title":"Neuronal apoptosis in herpes simplex virus\u20141 encephalitis (HSE)","volume":"19","author":"Athmanathan","year":"2001","journal-title":"Indian J. Med. Microbiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1093\/infdis\/170.3.678","article-title":"Cytokines and other markers of intrathecal immune response in patients with herpes simplex encephalitis","volume":"170","author":"Aurelius","year":"1994","journal-title":"J. Infect. Dis."},{"key":"B11","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1124\/mi.2.6.363","article-title":"Apolipoprotein E, amyloid, and Alzheimer disease","volume":"2","author":"Bales","year":"2002","journal-title":"Mol. Interv."},{"key":"B12","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s004300050071","article-title":"Identification and localization of Chlamydia pneumoniae in the Alzheimer\u2019s brain","volume":"187","author":"Balin","year":"1998","journal-title":"Med. Microbiol. Immunol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"371","DOI":"10.3233\/jad-2008-13403","article-title":"Chlamydophila pneumoniae and the etiology of late-onset Alzheimer\u2019s disease","volume":"13","author":"Balin","year":"2008","journal-title":"J. Alzheimers Dis."},{"key":"B14","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1017\/s0317167100044115","article-title":"\u201cLimbic predilection in Alzheimer dementia: is reactivated herpes virus involved?\u201d","volume":"9","author":"Ball","year":"1982","journal-title":"Can. J. Neurol. Sci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"973","DOI":"10.2174\/1381612053381684","article-title":"Blood-brain barrier transport of cytokines: a mechanism for neuropathology","volume":"11","author":"Banks","year":"2005","journal-title":"Curr. Pharm. Des."},{"key":"B15","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/S0022-3565(24)29260-0","article-title":"Intravenous human interleukin-1\u03b1 impairs memory processing in mice: dependence on blood-brain barrier transport into posterior division of the septum","volume":"299","author":"Banks","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B17","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1111\/j.1365-2559.1995.tb00252.x","article-title":"Creutzfeldt-Jakob disease with Alzheimer-type A \u03b2-reactive amyloid plaques","volume":"26","author":"Barcikowska","year":"1995","journal-title":"Histopathology"},{"key":"B18","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1002\/ana.410360605","article-title":"Herpes simplex virus genomes in human nervous system tissue analyzed by polymerase chain reaction","volume":"36","author":"Baringer","year":"1994","journal-title":"Ann. Neurol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"867","DOI":"10.3233\/JAD-160999","article-title":"Combined creutzfeldt-jakob\/ Alzheimer\u2019s disease cases are important in search for microbes in Alzheimer\u2019s disease","volume":"56","author":"Bastian","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"B20","first-page":"201","article-title":"Distribution of herpes simplex virus type 1 DNA in selected areas of normal and Alzheimer\u2019s disease brains: a PCR study","volume":"2","author":"Bertrand","year":"1993","journal-title":"Neurodegeneration"},{"key":"B21","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.tins.2008.06.005","article-title":"Neuronal calcium mishandling and the pathogenesis of Alzheimer\u2019s disease","volume":"31","author":"Bezprozvanny","year":"2008","journal-title":"Trends Neurosci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.immuni.2012.11.004","article-title":"The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response","volume":"38","author":"Blanc","year":"2013","journal-title":"Immunity"},{"key":"B23","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nrn2038","article-title":"Microglia-mediated neurotoxicity: uncovering the molecular mechanisms","volume":"8","author":"Block","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1111\/j.1460-9568.2007.05339.x","article-title":"Inflammatory responses following Chlamydia pneumoniae infection of glial cells","volume":"25","author":"Boelen","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"6926","DOI":"10.1523\/JNEUROSCI.0800-08.2008","article-title":"Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer\u2019s disease","volume":"28","author":"Boland","year":"2008","journal-title":"J. Neurosci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.neuropharm.2010.04.005","article-title":"Oxidative stress in Alzheimer disease: a possibility for prevention","volume":"59","author":"Bonda","year":"2010","journal-title":"Neuropharmacology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s10522-014-9538-8","article-title":"\u03b2-Amyloid peptides display protective activity against the human Alzheimer\u2019s disease-associated herpes simplex virus-1","volume":"16","author":"Bourgade","year":"2015","journal-title":"Biogerontology"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.3233\/JAD-150652","article-title":"Protective effect of amyloid-\u03b2 peptides against herpes simplex virus-1 infection in a neuronal cell culture model","volume":"50","author":"Bourgade","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"B29","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1159\/000116984","article-title":"Staging of Alzheimer-related cortical destruction","volume":"33","author":"Braak","year":"1993","journal-title":"Eur. Neurol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1093\/med\/9780199937837.003.0147","article-title":"The role of tau protein in HIV-associated neurocognitive disorders","volume":"9","author":"Brown","year":"2014","journal-title":"Mol. Neurodegener."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1111\/ene.12477","article-title":"A study on the association between infectious burden and Alzheimer\u2019s disease","volume":"22","author":"Bu","year":"2015","journal-title":"Eur. J. Neurol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"5383","DOI":"10.1128\/jvi.00006-06","article-title":"Effect of Apolipoprotein E on the cerebral load of latent herpes simplex virus type 1 DNA","volume":"80","author":"Burgos","year":"2006","journal-title":"J. Virol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"8718","DOI":"10.1073\/pnas.0803526105","article-title":"Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro and the APOE \u025b4\/\u025b4 genotype accelerates HIV disease progression","volume":"105","author":"Burt","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B34","doi-asserted-by":"publisher","first-page":"307","DOI":"10.3109\/00207454.2013.833510","article-title":"Microglia, neuroinflammation, and \u03b2-amyloid protein in Alzheimer\u2019s disease","volume":"124","author":"Cai","year":"2014","journal-title":"Int. J. Neurosci."},{"key":"B35","doi-asserted-by":"crossref","first-page":"4898","DOI":"10.1128\/JVI.69.8.4898-4905.1995","article-title":"\u03b3 interferon expression during acute and latent nervous system infection by herpes simplex virus type 1","volume":"69","author":"Cantin","year":"1995","journal-title":"J. Virol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.neurobiolaging.2013.06.024","article-title":"Herpes virus in Alzheimer\u2019s disease: relation to progression of the disease","volume":"35","author":"Carbone","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"B37","doi-asserted-by":"crossref","first-page":"257","DOI":"10.5772\/57398","article-title":"Physiological role of amyloid \u03b2 in neural cells: the cellular trophic activity","volume-title":"Neurochemistry","author":"C\u00e1rdenas-Aguayo","year":"2014"},{"key":"B38","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.neulet.2010.07.066","article-title":"APP, APOE, complement receptor 1, clusterin and PICALM and their involvement in the herpes simplex life cycle","volume":"483","author":"Carter","year":"2010","journal-title":"Neurosci. Lett."},{"key":"B39","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.neuint.2010.12.003","article-title":"Alzheimer\u2019s disease plaques and tangles: cemeteries of a pyrrhic victory of the immune defence network against herpes simplex infection at the expense of complement and inflammation-mediated neuronal destruction","volume":"58","author":"Carter","year":"2011","journal-title":"Neurochem. Int."},{"key":"B40","doi-asserted-by":"publisher","first-page":"89ra57","DOI":"10.1126\/scitranslmed.3002156","article-title":"Human apoE isoforms differentially regulate brain amyloid-\u03b2 peptide clearance","volume":"3","author":"Castellano","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/1750-1326-7-52","article-title":"BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and \u03b2-amyloid production in Alzheimer\u2019s disease","volume":"7","author":"Chami","year":"2012","journal-title":"Mol. Neurodegener."},{"key":"B42","doi-asserted-by":"publisher","first-page":"12387","DOI":"10.1128\/jvi.01232-06","article-title":"Efficient reactivation of latent herpes simplex virus from mouse central nervous system tissues","volume":"80","author":"Chen","year":"2006","journal-title":"J. Virol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"e17966","DOI":"10.1371\/journal.pone.0017966","article-title":"Herpes simplex virus dances with amyloid precursor protein while exiting the cell","volume":"6","author":"Cheng","year":"2011","journal-title":"PLoS One"},{"key":"B44","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1002\/1522-2683(200102)22:3<445::aid-elps445>3.0.co;2-8","article-title":"Evidence for the relation of herpes simplex virus type1 to Down syndrome and Alzheimer\u2019s disease","volume":"22","author":"Cheon","year":"2001","journal-title":"Electrophoresis"},{"key":"B45","doi-asserted-by":"publisher","first-page":"10516","DOI":"10.1073\/pnas.92.23.10516","article-title":"Association of a M(r) 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2 \u03b1 and premature shutoff of protein synthesis after infection with \u03b3 134.5-mutants of herpes simplex virus 1","volume":"92","author":"Chou","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B46","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1017\/S0317167100002389","article-title":"Early olfactory involvement in Alzheimer\u2019s disease","volume":"30","author":"Christen-Zaech","year":"2003","journal-title":"Can. J. Neurol. Sci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1007\/s13365-015-0344-0","article-title":"Herpes simplex virus type 1 infection in neurons leads to production and nuclear localization of APP intracellular domain (AICD): implications for Alzheimer\u2019s disease pathogenesis","volume":"21","author":"Civitelli","year":"2015","journal-title":"J. Neurovirol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jneuroim.2009.09.013","article-title":"Herpes simplex type I (HSV-1) infection of the nervous system: is an immune response a good thing?","volume":"220","author":"Conrady","year":"2010","journal-title":"J. Neuroimmunol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1038\/2677","article-title":"HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy","volume":"4","author":"Corder","year":"1998","journal-title":"Nat. Med."},{"key":"B50","doi-asserted-by":"publisher","first-page":"5988","DOI":"10.1021\/bi000029f","article-title":"Fibril formation and neurotoxicity by a herpes simplex virus glycoprotein B fragment with homology to the Alzheimer\u2019s A\u03b2 peptide","volume":"39","author":"Cribbs","year":"2000","journal-title":"Biochemistry"},{"key":"B51","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1093\/schbul\/sbu032","article-title":"Persistent infection by HSV-1 is associated with changes in functional architecture of iPSC derived neurons and brain activation patterns underlying working memory performance","volume":"41","author":"D\u2019Aiuto","year":"2015","journal-title":"Schizophr. Bull."},{"key":"B52","doi-asserted-by":"publisher","first-page":"e13989","DOI":"10.1371\/journal.pone.0013989","article-title":"APP processing induced by herpes simplex virus type 1 (HSV-1) yields several APP fragments in human and rat neuronal cells","volume":"5","author":"De Chiara","year":"2010","journal-title":"PLoS One"},{"key":"B53","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1159\/000121389","article-title":"Association between deposition of \u03b2-amyloid and pathological prion protein in sporadic Creutzfeldt-Jakob disease","volume":"5","author":"Debatin","year":"2008","journal-title":"Neurodegener. Dis."},{"key":"B54","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/978-94-007-5416-4_14","article-title":"Alzheimer\u2019s disease","volume":"65","author":"De-Paula","year":"2012","journal-title":"Subcell. Biochem."},{"key":"B56","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1001\/archpsyc.60.5.466","article-title":"Association of serum antibodies to herpes simplex virus 1 with cognitive deficits in individuals with schizophrenia","volume":"60","author":"Dickerson","year":"2003","journal-title":"Arch. Gen. Psychiatry"},{"key":"B55","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.schres.2011.10.003","article-title":"Additive effects of elevated C-reactive protein and exposure to herpes simplex virus type 1 on cognitive impairment in individuals with schizophrenia","volume":"134","author":"Dickerson","year":"2012","journal-title":"Schizophr. Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1007\/s13365-013-0189-3","article-title":"Immunological control of herpes simplex virus infections","volume":"19","author":"Egan","year":"2013","journal-title":"J. Neurovirol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/0002-9343(82)90055-9","article-title":"Mechanism of action and selectivity of acyclovir","volume":"73","author":"Elion","year":"1982","journal-title":"Am. J. Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.nbd.2005.09.004","article-title":"Alzheimer\u2019s disease: mRNA expression profiles of multiple patients show alterations of genes involved with calcium signaling","volume":"21","author":"Emilsson","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"B60","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1136\/jnnp.65.1.29","article-title":"Prevalence of Alzheimer plaques in AIDS","volume":"65","author":"Esiri","year":"1998","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B61","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1073\/pnas.022301899","article-title":"Spontaneous molecular reactivation of herpes simplex virus type 1 latency in mice","volume":"99","author":"Feldman","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B62","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1191\/1352458505ms1185oa","article-title":"A randomized clinical trial of valacyclovir in multiple sclerosis","volume":"11","author":"Friedman","year":"2005","journal-title":"Mult. Scler."},{"key":"B63","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.schres.2015.08.036","article-title":"The impact of Herpes simplex virus type 1 on cognitive impairments in young, healthy individuals-A historical prospective study","volume":"168","author":"Fruchter","year":"2015","journal-title":"Schizophr. Res."},{"key":"B65","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.bbi.2015.10.014","article-title":"Infectious disease burden and cognitive function in young to middle-aged adults","volume":"52","author":"Gale","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"B64","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.jaci.2014.01.032","article-title":"APO\u03b54 is associated with enhanced in vivo innate immune responses in human subjects","volume":"134","author":"Gale","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"3931","DOI":"10.1073\/pnas.95.7.3931","article-title":"Herpes simplex virus 1 induces and blocks apoptosis at multiple steps during infection and protects cells from exogenous inducers in a cell-type-dependent manner","volume":"95","author":"Galvan","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B67","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.it.2008.05.002","article-title":"Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression","volume":"29","author":"Gao","year":"2008","journal-title":"Trends Immunol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1111\/j.1574-695X.2006.00154.x","article-title":"Chlamydophila (Chlamydia) pneumoniae in the Alzheimer\u2019s brain","volume":"48","author":"G\u00e9rard","year":"2006","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1001\/archderm.129.5.582","article-title":"Long-term suppression of recurrent genital herpes with acyclovir. A 5-year benchmark. Acyclovir Study Group","volume":"129","author":"Goldberg","year":"1993","journal-title":"Arch. Dermatol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1097\/01.aids.0000161770.06158.5c","article-title":"Brain deposition of \u03b2-amyloid is a common pathologic feature in HIV positive patients","volume":"19","author":"Green","year":"2005","journal-title":"AIDS"},{"key":"B71","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1056\/NEJMcibr1214546","article-title":"Neuroinflammatory cytokine signaling and Alzheimer\u2019s disease","volume":"368","author":"Griffin","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"B72","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1111\/j.1750-3639.1998.tb00136.x","article-title":"Glial-neuronal interactions in Alzheimer\u2019s disease: the potential role of a \u2018cytokine cycle\u2019 in disease progression","volume":"8","author":"Griffin","year":"1998","journal-title":"Brain Pathol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"779","DOI":"10.3233\/JAD-2012-120070","article-title":"Aging-related neurostructural, neuropathological and behavioral changes associated with herpes simplex virus type 1 brain infection in mice","volume":"30","author":"Guzman-Sanchez","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"B74","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.4049\/jimmunol.157.8.3542","article-title":"Persistent cytokine expression in trigeminal ganglion latently infected with herpes simplex virus type 1","volume":"157","author":"Halford","year":"1996","journal-title":"J. Immunol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1006\/viro.1997.8806","article-title":"Acyclovir blocks cytokine gene expression in trigeminal ganglia latently infected with herpes simplex virus type 1","volume":"238","author":"Halford","year":"1997","journal-title":"Virology"},{"key":"B76","doi-asserted-by":"publisher","first-page":"319","DOI":"10.3233\/JAD-142853","article-title":"Herpes simplex virus type 1 and other pathogens are key causative factors in sporadic Alzheimer\u2019s disease","volume":"9","author":"Harris","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"B77","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1007\/s13365-011-0063-0","article-title":"Control of HSV-1 latency in human trigeminal ganglia\u2014current overview","volume":"17","author":"Held","year":"2011","journal-title":"J. Neurovirol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1002\/ana.10662","article-title":"Herpesviruses in brains in Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"54","author":"Hemling","year":"2003","journal-title":"Ann. Neurol."},{"key":"B79","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1523\/JNEUROSCI.21-09-03017.2001","article-title":"Mitochondrial abnormalities in Alzheimer\u2019s disease","volume":"21","author":"Hirai","year":"2001","journal-title":"J. Neurosci."},{"key":"B80","doi-asserted-by":"publisher","first-page":"247","DOI":"10.2174\/1568010053586237","article-title":"Mechanisms of cell signaling and inflammation in Alzheimer\u2019s disease","volume":"4","author":"Ho","year":"2005","journal-title":"Curr. Drug Targets Inflamm. Allergy"},{"key":"B82","doi-asserted-by":"publisher","first-page":"a006312","DOI":"10.1101\/cshperspect.a006312","article-title":"Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease","volume":"2","author":"Holtzman","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1111\/j.1471-4159.2007.05194.x","article-title":"The GSK3 hypothesis of Alzheimer\u2019s disease","volume":"104","author":"Hooper","year":"2008","journal-title":"J. Neurochem."},{"key":"B84","doi-asserted-by":"publisher","first-page":"e21456","DOI":"10.1371\/journal.pone.0021456","article-title":"Activation of PKR causes amyloid \u00df-peptide accumulation via de-repression of BACE1 expression","volume":"6","author":"Ill-Raga","year":"2011","journal-title":"PLoS One"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1016\/S0140-6736(05)62325-2","article-title":"Herpes simplex virus and risk of Alzheimer\u2019s disease","volume":"349","author":"Itabashi","year":"1997","journal-title":"Lancet"},{"key":"B93","unstructured":"ItzhakiR. F. AlzforumHerpes Simplex and Alzheimer\u2019s-Time to Think Again?2011"},{"key":"B90","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3389\/fnagi.2014.00202","article-title":"Herpes simplex virus type 1 and Alzheimer\u2019s disease: increasing evidence for a major role of the virus","volume":"6","author":"Itzhaki","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"B91","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.3233\/jad-160607","article-title":"Herpes and Alzheimer\u2019s disease: subversion in the central nervous system and how it might be halted","volume":"54","author":"Itzhaki","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"B92","doi-asserted-by":"publisher","first-page":"3216","DOI":"10.1096\/fj.201700360","article-title":"Herpes simplex virus type 1 and Alzheimer\u2019s disease: possible mechanisms and signposts","volume":"31","author":"Itzhaki","year":"2017","journal-title":"FASEB J."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/13550280701802543","article-title":"Herpes simplex virus type 1 and Alzheimer\u2019s disease: the autophagy connection","volume":"14","author":"Itzhaki","year":"2008","journal-title":"J. Neurovirol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"979","DOI":"10.3233\/JAD-160152","article-title":"Microbes and Alzheimer\u2019s disease","volume":"51","author":"Itzhaki","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"B87","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/S0140-6736(96)10149-5","article-title":"Herpes simplex virus type 1 in brain and risk of Alzheimer\u2019s disease","volume":"349","author":"Itzhaki","year":"1997","journal-title":"Lancet"},{"key":"B88","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.plipres.2005.11.003","article-title":"Herpes simplex virus type 1, apolipoprotein E, and cholesterol: a dangerous liaison in Alzheimer\u2019s disease and other disorders","volume":"45","author":"Itzhaki","year":"2006","journal-title":"Prog. Lipid Res."},{"key":"B89","doi-asserted-by":"publisher","first-page":"393","DOI":"10.3233\/jad-2008-13405","article-title":"Herpes simplex virus type 1 in Alzheimer\u2019s disease: the enemy within","volume":"13","author":"Itzhaki","year":"2008","journal-title":"J. Alzheimers Dis."},{"key":"B95","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.pharmthera.2005.03.010","article-title":"Metabolism of amyloid-\u03b2 peptide and Alzheimer\u2019s disease","volume":"108","author":"Iwata","year":"2005","journal-title":"Pharmacol. Ther."},{"key":"B96","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.jaad.2004.08.026","article-title":"Antimicrobial peptides","volume":"52","author":"Izadpanah","year":"2005","journal-title":"J. Am. Acad. Dermatol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1002\/jmv.1890330403","article-title":"Latent herpes simplex virus type 1 in normal and Alzheimer\u2019s disease brains","volume":"33","author":"Jamieson","year":"1991","journal-title":"J. Med. Virol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1002\/path.1711670403","article-title":"Herpes simplex virus type 1 DNA is present in specific regions of brain from aged people with and without senile dementia of the Alzheimer type","volume":"167","author":"Jamieson","year":"1992","journal-title":"J. Pathol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1021\/mp200419b","article-title":"Antimicrobial properties of amyloid peptides","volume":"9","author":"Kagan","year":"2012","journal-title":"Mol. Pharm."},{"key":"B100","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.jneuroim.2009.08.013","article-title":"TNF-\u03b1 and antibodies to periodontal bacteria discriminate between Alzheimer\u2019s disease patients and normal subjects","volume":"216","author":"Kamer","year":"2009","journal-title":"J. Neuroimmunol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1212\/WNL.0b013e3182896e79","article-title":"Infectious burden and cognitive function: the northern manhattan study","volume":"80","author":"Katan","year":"2013","journal-title":"Neurology"},{"key":"B102","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1167\/iovs.04-0614","article-title":"HSV-1 DNA in tears and saliva of normal adults","volume":"46","author":"Kaufman","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B103","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.preteyeres.2006.05.001","article-title":"Herpes simplex keratitis","volume":"25","author":"Kaye","year":"2006","journal-title":"Prog. Retin. Eye Res."},{"key":"B104","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1136\/jnnp.47.11.1247","article-title":"Mild forms of herpes encephalitis","volume":"47","author":"Klapper","year":"1984","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B105","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.bbrc.2012.12.054","article-title":"Increase in the IgG avidity index due to herpes simplex virus type 1 reactivation and its relationship with cognitive function in amnestic mild cognitive impairment and Alzheimer\u2019s disease","volume":"430","author":"Kobayashi","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B106","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.mad.2006.01.011","article-title":"Human cytomegalovirus infection and T cell immunosenescence: a mini review","volume":"127","author":"Koch","year":"2006","journal-title":"Mech. Ageing Dev."},{"key":"B107","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1136\/sti.2009.039735","article-title":"APOE genotype is associated with oral herpetic lesions but not genital or oral herpes simplex virus shedding","volume":"86","author":"Koelle","year":"2010","journal-title":"Sex. Transm. Infect."},{"key":"B108","doi-asserted-by":"publisher","first-page":"731526","DOI":"10.1155\/2012\/731526","article-title":"Structure and pathology of tau protein in Alzheimer disease","volume":"2012","author":"Kolarova","year":"2012","journal-title":"Int. J. Alzheimers Dis."},{"key":"B109","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1186\/s12879-017-2527-1","article-title":"Decreasing seroprevalence of herpes simplex virus type 1 and type 2 in Germany leaves many people susceptible to genital infection: time to raise awareness and enhance control","volume":"17","author":"Korr","year":"2017","journal-title":"BMC Infect. Dis."},{"key":"B110","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1080\/00207450902782083","article-title":"Increased cerebrospinal fluid Helicobacter pylori antibody in Alzheimer\u2019s disease","volume":"119","author":"Kountouras","year":"2009","journal-title":"Int. J. Neurosci."},{"key":"B111","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1097\/00001756-200102120-00021","article-title":"Olfactory centres in Alzheimer\u2019s disease: olfactory bulb is involved in early Braak\u2019s stages","volume":"12","author":"Kov\u00e1cs","year":"2001","journal-title":"Neuroreport"},{"key":"B112","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.chom.2012.03.005","article-title":"\u03b1herpesvirus infection disrupts mitochondrial transport in neurons","volume":"11","author":"Kramer","year":"2012","journal-title":"Cell Host Microbe"},{"key":"B113","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1476-511x-9-8","article-title":"Apolipoprotein E genotype and hepatitis C, HIV and herpes simplex disease risk: a literature review","volume":"9","author":"Kuhlmann","year":"2010","journal-title":"Lipids Health Dis."},{"key":"B114","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1134\/s0006297914130124","article-title":"Human herpes simplex virus: life cycle and development of inhibitors","volume":"79","author":"Kukhanova","year":"2014","journal-title":"Biochemistry (Mosc)"},{"key":"B115","doi-asserted-by":"publisher","first-page":"340ra72","DOI":"10.1126\/scitranslmed.aaf1059","article-title":"Amyloid-\u03b2 peptide protects against microbial infection in mouse and worm models of Alzheimer\u2019s disease","volume":"8","author":"Kumar","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"B116","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/bs.apcsb.2015.10.006","article-title":"Ion channels in neurological disorders","volume":"103","author":"Kumar","year":"2016","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1038\/ng.439","article-title":"Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer\u2019s disease","volume":"41","author":"Lambert","year":"2009","journal-title":"Nat. Genet."},{"key":"B119","doi-asserted-by":"publisher","first-page":"756.e11","DOI":"10.1016\/j.neurobiolaging.2010.11.022","article-title":"Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations","volume":"32","author":"Lambert","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"B120","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0306-4522(92)90003-k","article-title":"Synaptic pathology in Alzheimer\u2019s disease: immunological data for markers of synaptic and large dense-core vesicles","volume":"146","author":"Lassmann","year":"1992","journal-title":"Neuroscience"},{"key":"B121","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1007\/s13365-016-0504-x","article-title":"Distribution of cellular HSV-1 receptor expression in human brain","volume":"23","author":"Lathe","year":"2017","journal-title":"J. Neurovirol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/1471-2318-14-36","article-title":"Atherosclerosis and Alzheimer\u2014diseases with a common cause? Inflammation, oxysterols, vasculature","volume":"14","author":"Lathe","year":"2014","journal-title":"BMC Geriatr."},{"key":"B123","doi-asserted-by":"publisher","first-page":"e3637","DOI":"10.1371\/journal.pone.0003637","article-title":"Seropositivity to herpes simplex virus antibodies and risk of Alzheimer\u2019s disease: a populationbased cohort study","volume":"3","author":"Letenneur","year":"2008","journal-title":"PLoS One"},{"key":"B124","doi-asserted-by":"publisher","first-page":"469","DOI":"10.3389\/fnins.2015.00469","article-title":"Chronic glutamate toxicity in neurodegenerative diseases-what is the evidence?","volume":"9","author":"Lewerenz","year":"2015","journal-title":"Front. Neurosci."},{"key":"B125","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s13365-015-0393-4","article-title":"Reactivation of HSV-1 following explant of tree shrew brain","volume":"22","author":"Li","year":"2016","journal-title":"J. Neurovirol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.1111\/j.1471-4159.2007.04942.x","article-title":"Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain","volume":"103","author":"Liang","year":"2007","journal-title":"J. Neurochem."},{"key":"B127","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/bf02778009","article-title":"Transmissible cerebral amyloidoses as a model for Alzheimer\u2019s disease. An ultrastructural perspective","volume":"8","author":"Liberski","year":"1994","journal-title":"Mol. Neurobiol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"809","DOI":"10.3233\/JAD-2011-110755","article-title":"Gene signature in Alzheimer\u2019s disease and environmental factors: the virus chronicle","volume":"27","author":"Licastro","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"B129","doi-asserted-by":"publisher","first-page":"6547248","DOI":"10.1155\/2016\/6547248","article-title":"Redox imbalance and viral infections in neurodegenerative diseases","volume":"2016","author":"Limongi","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B131","first-page":"173","article-title":"Alzheimer\u2019s disease, herpes virus in brain, apolipoprotein E4 and herpes labialis","volume":"1","author":"Lin","year":"1998","journal-title":"Alzheimers Rep."},{"key":"B130","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/s0197-4580(01)00268-8","article-title":"Vaccination prevents latent HSV1 infection of mouse brain","volume":"22","author":"Lin","year":"2001","journal-title":"Neurobiol. Aging"},{"key":"B132","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/s0197-4580(03)00127-1","article-title":"Chlamydia pneumoniae induces Alzheimer-like amyloid plaques in brains of BALB\/c mice","volume":"25","author":"Little","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"B133","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.immuni.2012.11.005","article-title":"Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol","volume":"38","author":"Liu","year":"2013","journal-title":"Immunity"},{"key":"B134","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1080\/13550280152403254","article-title":"Robust expression of TNF-\u03b1, IL-1\u03b2, RANTES, and IP-10 by human microglial cells during nonproductive infection with herpes simplex virus","volume":"7","author":"Lokensgard","year":"2001","journal-title":"J. Neurovirol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"e0140765","DOI":"10.1371\/journal.pone.0140765","article-title":"Global and regional estimates of prevalent and incident herpes simplex virus type 1 infections in 2012","volume":"10","author":"Looker","year":"2015","journal-title":"PLoS One"},{"key":"B136","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1111\/j.1471-4159.2007.05135.x","article-title":"Increased intraneuronal resting [Ca2+] in adult Alzheimer\u2019s disease mice","volume":"105","author":"Lopez","year":"2008","journal-title":"J. Neurochem."},{"key":"B117","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.jalz.2014.04.522","article-title":"Reactivated herpes simplex infection increases the risk of Alzheimer\u2019s disease","volume":"11","author":"L\u00f6vheim","year":"","journal-title":"Alzheimers Dement."},{"key":"B137","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.jalz.2014.07.157","article-title":"Herpes simplex infection and the risk of Alzheimer\u2019s disease-A nested case-control study","volume":"11","author":"L\u00f6vheim","year":"","journal-title":"Alzheimers Dement."},{"key":"B138","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/s0197-4580(01)00311-6","article-title":"Modeling microglial activation in Alzheimer\u2019s disease with human postmortem microglial cultures","volume":"22","author":"Lue","year":"2001","journal-title":"Neurobiol. Aging"},{"key":"B139","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1097\/WNR.0b013e32833da51a","article-title":"Acyclovir or A\u03b242 peptides attenuate HSV-1-induced miRNA-146a levels in human primary brain cells","volume":"21","author":"Lukiw","year":"2010","journal-title":"Neuroreport"},{"key":"B140","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1093\/infdis\/jit210","article-title":"Virological and immunological characteristics of human cytomegalovirus infection associated with Alzheimer disease","volume":"208","author":"Lurain","year":"2013","journal-title":"J. Infect. Dis."},{"key":"B141","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1128\/aac.47.8.2438-2441.2003","article-title":"Acyclovir levels in serum and cerebrospinal fluid after oral administration of valacyclovir","volume":"47","author":"Lycke","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"B142","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1111\/imm.12156","article-title":"The impact of neuroimmune changes on development of amyloid pathology; relevance to Alzheimer\u2019s disease","volume":"141","author":"Lynch","year":"2014","journal-title":"Immunology"},{"key":"B143","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1146\/annurev.genom.1.1.507","article-title":"Apolipoprotein E: far more than a lipid transport protein","volume":"1","author":"Mahley","year":"2000","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"B144","doi-asserted-by":"publisher","first-page":"741","DOI":"10.3233\/JAD-130977","article-title":"Titers of herpes simplex virus type 1 antibodies positively correlate with grey matter volumes in Alzheimer\u2019s disease","volume":"38","author":"Mancuso","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"B145","doi-asserted-by":"publisher","first-page":"8590578","DOI":"10.1155\/2016\/8590578","article-title":"The role of reactive oxygen species in the pathogenesis of Alzheimer\u2019s disease, Parkinson\u2019s disease, and Huntington\u2019s disease: a mini review","volume":"2016","author":"Manoharan","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B146","first-page":"E27","article-title":"Epidemiology of herpes simplex virus type 1 and 2 in Italy: a seroprevalence study from 2000 to 2014","volume":"58","author":"Marchi","year":"2017","journal-title":"J. Prev. Med. Hyg."},{"key":"B147","doi-asserted-by":"publisher","first-page":"11069","DOI":"10.1128\/jvi.00243-07","article-title":"Spontaneous reactivation of herpes simplex virus type 1 in latently infected murine sensory ganglia","volume":"81","author":"Margolis","year":"2007","journal-title":"J. Virol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1080\/135502801300069773","article-title":"Lack of association betweenHSV-1DNA in the brain, Alzheimer\u2019s disease and apolipoprotein E4","volume":"7","author":"Marques","year":"2001","journal-title":"J. Neurovirol."},{"key":"B149","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1385\/jmn:22:1-2:5","article-title":"Neprilysin regulates amyloid \u03b2 peptide levels","volume":"22","author":"Marr","year":"2004","journal-title":"J. Mol. Neurosci."},{"key":"B150","doi-asserted-by":"publisher","first-page":"849","DOI":"10.3233\/JAD-131706","article-title":"Inflammatory and neurodegeneration markers during asymptomatic HSV-1 reactivation","volume":"39","author":"Martin","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"B151","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.jemermed.2009.08.048","article-title":"Altered mental status from acyclovir","volume":"41","author":"Martinez-Diaz","year":"2011","journal-title":"J. Emerg. Med."},{"key":"B152","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/0387-7604(95)00075-m","article-title":"Mild form of acute herpes simplex encephalitis in childhood","volume":"17","author":"Marton","year":"1995","journal-title":"Brain Dev."},{"key":"B153","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1212\/WNL.56.1.127","article-title":"Altered expression of synaptic proteins occurs early during progression of Alzheimer\u2019s disease","volume":"56","author":"Masliah","year":"2001","journal-title":"Neurology"},{"key":"B154","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.neulet.2006.02.077","article-title":"Nobiletin restoring \u03b2-amyloid-impaired CREB phosphorylation rescues memory deterioration in Alzheimer\u2019s disease model rats","volume":"400","author":"Matsuzaki","year":"2006","journal-title":"Neurosci. Lett."},{"key":"B155","doi-asserted-by":"publisher","first-page":"a006239","DOI":"10.1101\/cshperspect.a006239","article-title":"Epidemiology of Alzheimer disease","volume":"2","author":"Mayeux","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"B156","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/0304-3940(89)90843-4","article-title":"Activation of the classical complement pathway in brain tissue of Alzheimer patients","volume":"107","author":"McGeer","year":"1989","journal-title":"Neurosci. Lett."},{"key":"B157","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement."},{"key":"B158","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1006\/exnr.1993.1121","article-title":"Selective lesions of neural pathways following viral inoculation of the olfactory bulb","volume":"122","author":"McLean","year":"1993","journal-title":"Exp. Neurol."},{"key":"B159","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1111\/j.1365-2990.1994.tb01168.x","article-title":"Association of measles virus with neurofibrillary tangles in subacute sclerosing panencephalitis: a combined in situ hybridization and immunocytochemical investigation","volume":"20","author":"McQuaid","year":"1994","journal-title":"Neuropathol. Appl. Neurobiol"},{"key":"B160","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/s0304-3940(98)00115-3","article-title":"Herpes simplex virus encephalitis: long-term comparative study of viral load and the expression of immunologic nitric oxide synthase in mouse brain tissue","volume":"244","author":"Meyding-Lamad\u00e9","year":"1998","journal-title":"Neurosci. Lett."},{"key":"B161","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1093\/infdis\/jiv771","article-title":"The interleukin-1 balance during encephalitis is associated with clinical severity, blood-brain barrier permeability, neuroimaging changes, and disease outcome","volume":"213","author":"Michael","year":"2016","journal-title":"J. Infect. Dis."},{"key":"B162","first-page":"45","article-title":"Chronic inflammation and amyloidogenesis in Alzheimer\u2019s disease: putative role of bacterial peptidoglycan, a potent inflammatory and amyloidogenic factor","volume":"3","author":"Miklossy","year":"1998","journal-title":"Alzheimers Rev."},{"key":"B167","doi-asserted-by":"publisher","first-page":"46","DOI":"10.3389\/fnagi.2015.00046","article-title":"Historic evidence to support a causal relationship between spirochetal infections and Alzheimer\u2019s disease","volume":"7","author":"Miklossy","year":"2015","journal-title":"Front. Aging Neurosci."},{"key":"B169","doi-asserted-by":"publisher","first-page":"e30","DOI":"10.1017\/S1462399411002006","article-title":"Emerging roles of pathogens in Alzheimer disease","volume":"13","author":"Miklossy","year":"","journal-title":"Expert Rev. Mol. Med."},{"key":"B168","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/1742-2094-8-90","article-title":"Alzheimer\u2019s disease\u2014a neurospirochetosis. Analysis of the evidence following Koch\u2019s and Hill\u2019s criteria","volume":"8","author":"Miklossy","year":"","journal-title":"J. Neuroinflammation"},{"key":"B163","first-page":"95","article-title":"Bacterial peptidoglycan in neuritic plaque in Alzheimer\u2019s disease","volume":"2","author":"Miklossy","year":"1996","journal-title":"Alzheimers Res."},{"key":"B164","doi-asserted-by":"publisher","first-page":"673","DOI":"10.3233\/jad-2004-6608","article-title":"Borrelia burgdorferi persists in the brain in chronic lyme neuroborreliosis and may be associated with Alzheimer disease","volume":"6","author":"Miklossy","year":"2004","journal-title":"J. Alzheimers Dis."},{"key":"B165","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.neurobiolaging.2005.01.018","article-title":"\u03b2-amyloid deposition and Alzheimer\u2019s type changes induced by Borrelia spirochetes","volume":"27","author":"Miklossy","year":"","journal-title":"Neurobiol. Aging"},{"key":"B166","first-page":"429","article-title":"\u03b2 amyloid deposition in the atrophic form of general paresis. Alzheimer\u2019s disease: new advances","volume-title":"Proceedings of the 10th International Congress on Alzheimer\u2019s Disease (ICAD)","author":"Miklossy","year":""},{"key":"B170","doi-asserted-by":"publisher","first-page":"e35471","DOI":"10.1371\/journal.pone.0035471","article-title":"Continuous production of prions after infectious particles are eliminated: implications for Alzheimer\u2019s disease","volume":"7","author":"Miyazawa","year":"2012","journal-title":"PLoS One"},{"key":"B171","first-page":"71","article-title":"Human immunodeficiency virus-associated dementia: a link between accumulation of viral proteins and neuronal degeneration","volume":"8","author":"Mocchetti","year":"2014","journal-title":"Curr. Trends Neurol."},{"key":"B172","doi-asserted-by":"publisher","first-page":"940603","DOI":"10.1155\/2013\/940603","article-title":"Phosphorylation of tau protein as the link between oxidative stress, mitochondrial dysfunction, and connectivity failure: implications for Alzheimer\u2019s disease","volume":"2013","author":"Mondrag\u00f3n-Rodr\u00edguez","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B173","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.neuron.2014.12.032","article-title":"Blood-brain barrier breakdown in the aging human hippocampus","volume":"85","author":"Montagne","year":"2015","journal-title":"Neuron"},{"key":"B174","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1002\/jmv.20133","article-title":"Reactivation of HSV-1 in the brain of patients with familial Alzheimer\u2019s disease","volume":"73","author":"Mori","year":"2004","journal-title":"J. Med. Virol."},{"key":"B175","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1080\/13550280590922793","article-title":"Olfactory transmission of neurotropic viruses","volume":"11","author":"Mori","year":"2005","journal-title":"J. Neurovirol."},{"key":"B176","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/ajmg.b.32499","article-title":"Genomic variants, genes, and pathways of Alzheimer\u2019s disease: an overview","volume":"174","author":"Naj","year":"2017","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"B177","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1002\/jmv.24916","article-title":"Estimating seroprevalence of herpes simplex virus type 1 among different Middle East and North African male populations residing in Qatar","volume":"90","author":"Nasrallah","year":"2018","journal-title":"J. Med. Virol."},{"key":"B178","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1111\/j.1574-6976.2011.00320.x","article-title":"The molecular basis of herpes simplex virus latency","volume":"36","author":"Nicoll","year":"2012","journal-title":"FEMS Microbiol. Rev."},{"key":"B179","doi-asserted-by":"publisher","first-page":"4081","DOI":"10.1242\/jcs.019265","article-title":"Autophagy, amyloidogenesis and Alzheimer disease","volume":"120","author":"Nixon","year":"2007","journal-title":"J. Cell Sci."},{"key":"B180","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.nbd.2011.01.021","article-title":"Autophagy failure in Alzheimer\u2019s disease\u2014locating the primary defect","volume":"43","author":"Nixon","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"B181","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1006\/exer.1999.0782","article-title":"Imbalance in corneal redox state during herpes simplex virus 1-induced keratitis in rabbits. Effectiveness of exogenous glutathione supply","volume":"70","author":"Nucci","year":"2000","journal-title":"Exp. Eye Res."},{"key":"B182","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1080\/15548627.2016.1139262","article-title":"Autophagy interaction with herpes simplex virus type-1 infection","volume":"12","author":"O\u2019Connell","year":"2016","journal-title":"Autophagy"},{"key":"B183","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1006\/jmbi.2000.3980","article-title":"Solution conformation and amyloid-like fibril formation of a polar peptide derived from a \u03b2-hairpin in the OspA single-layer \u03b2-sheet","volume":"301","author":"Ohnishi","year":"2000","journal-title":"J. Mol. Biol."},{"key":"B184","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.chom.2006.12.001","article-title":"HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein","volume":"1","author":"Orvedahl","year":"2007","journal-title":"Cell Host Microbe"},{"key":"B185","doi-asserted-by":"publisher","first-page":"280","DOI":"10.4161\/auto.5289","article-title":"Viral evasion of autophagy","volume":"4","author":"Orvedahl","year":"2008","journal-title":"Autophagy"},{"key":"B186","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1159\/000090362","article-title":"Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer\u2019s disease","volume":"2","author":"Papassotiropoulos","year":"2005","journal-title":"Neurodegener. Dis."},{"key":"B187","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/s0190-9622(96)90670-2","article-title":"Herpes simplex: evolving concepts","volume":"35","author":"Pereira","year":"1996","journal-title":"J. Am. Acad. Dermatol."},{"key":"B188","doi-asserted-by":"publisher","first-page":"262415","DOI":"10.1155\/2010\/262415","article-title":"Towards an understanding of the herpes simplex virus type 1 latency-reactivation cycle","volume":"2010","author":"Perng","year":"2010","journal-title":"Interdiscip. Perspect. Infect. Dis."},{"key":"B189","doi-asserted-by":"publisher","first-page":"2323.e13","DOI":"10.1016\/j.neurobiolaging.2010.06.009","article-title":"HSV-1 promotes Ca2+-mediated APP phosphorylation and A\u03b2 accumulation in rat cortical neurons","volume":"32","author":"Piacentini","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"B190","doi-asserted-by":"publisher","first-page":"15444","DOI":"10.1038\/srep15444","article-title":"Herpes simplex virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-\u03b2 protein accumulation","volume":"5","author":"Piacentini","year":"2015","journal-title":"Sci. Rep."},{"key":"B191","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3851\/IMP3018","article-title":"Herpes simplex virus type-1: replication, latency, reactivation and its antiviral targets","volume":"21","author":"Pires de Mello","year":"2016","journal-title":"Antivir Ther."},{"key":"B192","doi-asserted-by":"publisher","first-page":"613","DOI":"10.3233\/JAD-141386","article-title":"Direct visualization of fungal infection in brains from patients with Alzheimer\u2019s disease","volume":"43","author":"Pisa","year":"","journal-title":"J. Alzheimers Dis."},{"key":"B193","doi-asserted-by":"publisher","first-page":"15015","DOI":"10.1038\/srep15015","article-title":"Different brain regions are infected with fungi in Alzheimer\u2019s disease","volume":"5","author":"Pisa","year":"","journal-title":"Sci. Rep."},{"key":"B194","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1742-4933-7-16","article-title":"Alzheimer\u2019s disease gene signature says: beware of brain viral infections","volume":"7","author":"Porcellini","year":"2010","journal-title":"Immun. Ageing"},{"key":"B195","doi-asserted-by":"publisher","first-page":"3624","DOI":"10.1128\/AAC.01023-10","article-title":"Valacyclovir for herpes simplex encephalitis","volume":"55","author":"Pouplin","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"B196","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1093\/schbul\/sbs040","article-title":"Antiherpes virus-specific treatment and cognition in schizophrenia: a test-of concept randomized double-blind placebo-controlled trial","volume":"39","author":"Prasad","year":"2013","journal-title":"Schizophr. Bull."},{"key":"B197","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/sj.mp.4001915","article-title":"Brain morphological changes associated with exposure to HSV1 in first-episode schizophrenia","volume":"12","author":"Prasad","year":"2007","journal-title":"Mol. Psychiatry"},{"key":"B198","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1093\/schbul\/sbs046","article-title":"Exposure to herpes simplex virus type 1 and cognitive impairments in individuals with schizophrenia","volume":"38","author":"Prasad","year":"2012","journal-title":"Schizophr. Bull."},{"key":"B199","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1136\/gut.2005.079905","article-title":"Apolipoprotein \u025b3 allele is associated with persistent hepatitis C virus infection","volume":"55","author":"Price","year":"2006","journal-title":"Gut"},{"key":"B200","volume-title":"World Alzheimer Report 2016. Improving Healthcare for People Living with Dementia.","author":"Prince","year":"2016"},{"key":"B201","doi-asserted-by":"publisher","first-page":"6887","DOI":"10.1523\/JNEUROSCI.5291-04.2005","article-title":"Amyloid-\u03b2 peptide inhibits activation of the nitric oxide\/cGMP\/cAMP-responsive element-binding protein pathway during hippocampal synaptic plasticity","volume":"25","author":"Puzzo","year":"2005","journal-title":"J. Neurosci."},{"key":"B202","doi-asserted-by":"publisher","first-page":"975","DOI":"10.3233\/JAD-160612","article-title":"Amyloid-\u03b2 and phosphorylated tau accumulations cause abnormalities at synapses of Alzheimer\u2019s disease neurons","volume":"57","author":"Rajmohan","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"B203","doi-asserted-by":"publisher","first-page":"e1004730","DOI":"10.1371\/journal.ppat.1004730","article-title":"Establishment of HSV1 latency in immunodeficient mice facilitates efficient in vivo reactivation","volume":"11","author":"Ramakrishna","year":"2015","journal-title":"PLoS Pathog."},{"key":"B204","doi-asserted-by":"publisher","first-page":"173","DOI":"10.3233\/jad-2005-7203","article-title":"Differential loss of synaptic proteins in Alzheimer\u2019s disease: implications for synaptic dysfunction","volume":"7","author":"Reddy","year":"2005","journal-title":"J. Alzheimers Dis."},{"key":"B205","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1001\/jamaneurol.2015.2952","article-title":"Association between olfactory dysfunction and amnestic mild cognitive impairment and Alzheimer disease dementia","volume":"73","author":"Roberts","year":"2016","journal-title":"JAMA Neurol."},{"key":"B206","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1111\/jgs.12065","article-title":"Does Helicobacter pylori infection increase incidence of dementia? The Personnes Ag\u00e9es QUID Study","volume":"61","author":"Roubaud Baudron","year":"2013","journal-title":"J. Am. Geriatr. Soc."},{"key":"B207","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1038\/sj.embor.7400878","article-title":"Herpes simplex virus eliminates host mitochondrial DNA","volume":"8","author":"Saffran","year":"2007","journal-title":"EMBO Rep."},{"key":"B208","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1471-4159.2010.07080.x","article-title":"CREB: a multifaceted regulator of neuronal plasticity and protection","volume":"116","author":"Sakamoto","year":"2011","journal-title":"J. Neurochem."},{"key":"B209","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1136\/jnnp.49.6.613","article-title":"Detection of HSV1 DNA by in situ hybridisation in human brain after immunosuppression","volume":"49","author":"Saldanha","year":"1986","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B210","doi-asserted-by":"publisher","first-page":"815","DOI":"10.3233\/JAD-2012-112000","article-title":"Herpes simplex virus type I induces an incomplete autophagic response in human neuroblastoma cells","volume":"30","author":"Santana","year":"","journal-title":"J. Alzheimers Dis."},{"key":"B211","doi-asserted-by":"publisher","first-page":"430.e19","DOI":"10.1016\/j.neurobiolaging.2010.12.010","article-title":"Herpes simplex virus type I induces the accumulation of intracellular \u03b2-amyloid in autophagic compartments and the inhibition of the non-amyloidogenic pathway in human neuroblastoma cells","volume":"33","author":"Santana","year":"","journal-title":"Neurobiol. Aging"},{"key":"B212","doi-asserted-by":"publisher","first-page":"e75842","DOI":"10.1371\/journal.pone.0075842","article-title":"Oxidative stress enhances neurodegeneration markers induced by herpes simplex virus type 1 infection in human neuroblastoma cells","volume":"8","author":"Santana","year":"2013","journal-title":"PLoS One"},{"key":"B213","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1046\/j.1474-9728.2003.00069.x","article-title":"Fast anterograde transport of herpes simplex virus: role for the amyloid precursor protein of Alzheimer\u2019s disease","volume":"2","author":"Satpute-Krishnan","year":"2003","journal-title":"Aging Cell"},{"key":"B215","doi-asserted-by":"crossref","first-page":"6888","DOI":"10.1128\/JVI.72.8.6888-6892.1998","article-title":"The probability of in vivo reactivation of herpes simplex virus type 1 increases with the number of latently infected neurons in the ganglia","volume":"72","author":"Sawtell","year":"1998","journal-title":"J. Virol."},{"key":"B214","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1086\/314958","article-title":"A temporal analysis of acyclovir inhibition of induced herpes simplex virus type 1 in vivo reactivation in the mouse trigeminal ganglia","volume":"180","author":"Sawtell","year":"1999","journal-title":"J. Infect. Dis."},{"key":"B216","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/1742-2094-7-35","article-title":"Herpes simplex virus induces neural oxidative damage via microglial cell Toll-like receptor-2","volume":"7","author":"Schachtele","year":"2010","journal-title":"J. Neuroinflammation"},{"key":"B217","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2016.02.030","article-title":"Oxidative stress and hippocampal synaptic protein levels in elderly cognitively intact individuals with Alzheimer\u2019s disease pathology","volume":"42","author":"Scheff","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"B218","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.schres.2010.01.008","article-title":"Neuroanatomic and cognitive abnormalities related to herpes simplex virus type 1 in schizophrenia","volume":"118","author":"Schretlen","year":"2010","journal-title":"Schizophr. Res."},{"key":"B219","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1111\/j.1532-5415.2008.01826.x","article-title":"Olfaction and the 5-year incidence of cognitive impairment in an epidemiological study of older adults","volume":"56","author":"Schubert","year":"2008","journal-title":"J. Am. Geriatr. Soc."},{"key":"B220","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1007\/s12975-013-0297-7","article-title":"Voltage-gated potassium channels at the crossroads of neuronal function, ischemic tolerance, and neurodegeneration","volume":"5","author":"Shah","year":"2014","journal-title":"Transl Stroke Res."},{"key":"B221","doi-asserted-by":"publisher","first-page":"e0134178","DOI":"10.1371\/journal.pone.0134178","article-title":"Seroprevalence of herpes simplex virus type 1 and 2 in taiwan and risk factor analysis, 2007","volume":"10","author":"Shen","year":"2015","journal-title":"PLoS One"},{"key":"B222","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/0165-5728(95)00068-d","article-title":"Immune cell infiltration and persistence in the mouse trigeminal ganglion after infection of the cornea with herpes simplex virus type 1","volume":"61","author":"Shimeld","year":"1995","journal-title":"J. Neuroimmunol."},{"key":"B223","doi-asserted-by":"publisher","first-page":"3317","DOI":"10.1099\/0022-1317-78-12-3317","article-title":"Cytokine production in the nervous system of mice during acute and latent infection with herpes simplex virus type 1","volume":"78","author":"Shimeld","year":"1997","journal-title":"J. Gen. Virol."},{"key":"B224","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/1471-2180-5-48","article-title":"Herpes simplex virus interferes with amyloid precursor protein processing","volume":"5","author":"Shipley","year":"2005","journal-title":"BMC Microbiol."},{"key":"B225","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.schres.2008.07.017","article-title":"Antibodies to cytomegalovirus and herpes simplex virus 1 associated with cognitive function in schizophrenia","volume":"106","author":"Shirts","year":"2008","journal-title":"Schizophr. Res."},{"key":"B226","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.jneuroim.2017.03.006","article-title":"Molecular mechanisms of neuroinflammation and injury during acute viral encephalitis","volume":"308","author":"Shives","year":"2017","journal-title":"J. Neuroimmunol."},{"key":"B228","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1086\/343739","article-title":"Age-specific prevalence of infection with herpes simplex virus types 2 and 1: a global review","volume":"186","author":"Smith","year":"2002","journal-title":"J. Infect. Dis."},{"key":"B229","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1128\/JVI.26.1.102-109.1978","article-title":"Herpes simplex virus and human cytomegalovirus replication in WI-38 cells","volume":"26","author":"Smith","year":"1978","journal-title":"J. Virol."},{"key":"B227","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1128\/AAC.00729-09","article-title":"Pharmacokinetics of acyclovir and its metabolites in cerebrospinal fluid and systemic circulation after administration of high-dose valacyclovir in subjects with normal and impaired renal function","volume":"54","author":"Smith","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"B230","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1097\/QAD.0b013e32835a117c","article-title":"Cerebral \u03b2-amyloid deposition predicts HIV-associated neurocognitive disorders in APOE \u03b54 carriers","volume":"26","author":"Soontornniyomkij","year":"2012","journal-title":"AIDS"},{"key":"B231","doi-asserted-by":"publisher","first-page":"e9505","DOI":"10.1371\/journal.pone.0009505","article-title":"The Alzheimer\u2019s disease-associated amyloid \u03b2-protein is an antimicrobial peptide","volume":"5","author":"Soscia","year":"2010","journal-title":"PLoS One"},{"key":"B232","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1111\/j.1462-5822.2004.00389.x","article-title":"Herpes simplex virus: receptors and ligands for cell entry","volume":"6","author":"Spear","year":"2004","journal-title":"Cell. Microbiol."},{"key":"B233","doi-asserted-by":"publisher","first-page":"32228","DOI":"10.1038\/srep32228","article-title":"Amyloidogenic amyloid-\u03b2-peptide variants induce microbial agglutination and exert antimicrobial activity","volume":"6","author":"Spitzer","year":"2016","journal-title":"Sci. Rep."},{"key":"B234","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1007\/s13365-011-0062-1","article-title":"CD8+ T cells patrol HSV-1-infected trigeminal ganglia and prevent viral reactivation","volume":"17","author":"St. Leger","year":"2011","journal-title":"J. Neurovirol."},{"key":"B235","doi-asserted-by":"publisher","first-page":"545","DOI":"10.18632\/aging.100205","article-title":"Unfolded p53 in the pathogenesis of Alzheimer\u2019s disease: is HIPK2 the link?","volume":"2","author":"Stanga","year":"2010","journal-title":"Aging (Albany, NY)"},{"key":"B236","doi-asserted-by":"publisher","first-page":"351","DOI":"10.3233\/JAD-140822","article-title":"Herpes viruses increase the risk of Alzheimer\u2019s disease: a meta-analysis","volume":"47","author":"Steel","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"B237","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.exger.2007.01.005","article-title":"Chronic herpesvirus reactivation occurs in aging","volume":"42","author":"Stowe","year":"2007","journal-title":"Exp. Gerontol."},{"key":"B238","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1002\/jmv.23397","article-title":"Reactivation of herpes simplex virus type 1 is associated with cytomegalovirus and age","volume":"84","author":"Stowe","year":"2012","journal-title":"J. Med. Virol."},{"key":"B240","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1212\/WNL.0b013e3182897126","article-title":"Is the microbe-dementia hypothesis finally ready for a treatment trial?","volume":"80","author":"Strandberg","year":"2013","journal-title":"Neurology"},{"key":"B239","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1161\/01.str.0000086754.32238.da","article-title":"Impact of viral and bacterial burden on cognitive impairment in elderly persons with cardiovascular disease","volume":"34","author":"Strandberg","year":"2003","journal-title":"Stroke"},{"key":"B241","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1111\/pin.12520","article-title":"Plaque formation and the intraneuronal accumulation of \u03b2-amyloid in Alzheimer\u2019s disease","volume":"67","author":"Takahashi","year":"2017","journal-title":"Pathol. Int."},{"key":"B242","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1073\/pnas.012485299","article-title":"Regulation of starvation- and virus-induced autophagy by the eIF2\u03b1 kinase signaling pathway","volume":"99","author":"Tall\u00f3czy","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B243","doi-asserted-by":"publisher","first-page":"24","DOI":"10.4161\/auto.2176","article-title":"PKR-dependent autophagic degradation of herpes simplex virus type 1","volume":"2","author":"Tall\u00f3czy","year":"2006","journal-title":"Autophagy"},{"key":"B244","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1093\/infdis\/jit616","article-title":"Persistent viral pathogens and cognitive impairment across the life course in the third national health and nutrition examination survey","volume":"209","author":"Tarter","year":"2014","journal-title":"J. Infect. Dis."},{"key":"B245","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s13311-014-0327-5","article-title":"Synaptic therapy in Alzheimer\u2019s disease: a CREB-centric approach","volume":"12","author":"Teich","year":"2015","journal-title":"Neurotherapeutics"},{"key":"B246","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1111\/j.1532-5415.1995.tb07407.x","article-title":"Excitatory amino acids in health and disease","volume":"43","author":"Thomas","year":"1995","journal-title":"J. Am. Geriatr. Soc."},{"key":"B247","doi-asserted-by":"publisher","first-page":"17301","DOI":"10.1007\/978-3-319-67199-4_100522","article-title":"\u03b2-amyloid-(1\u201342) impairs activity-dependent cAMP-response element-binding protein signaling in neurons at concentrations in which cell survival Is not compromised","volume":"276","author":"Tong","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B248","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.3233\/JAD-161088","article-title":"Oxidative stress, synaptic dysfunction and Alzheimer\u2019s disease","volume":"57","author":"T\u00f6nnies","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"B249","doi-asserted-by":"publisher","first-page":"e1003005","DOI":"10.1371\/journal.ppat.1003005","article-title":"Exploring new biological functions of amyloids: bacteria cell agglutination mediated by host protein aggregation","volume":"8","author":"Torrent","year":"2012","journal-title":"PLoS Pathog."},{"key":"B250","doi-asserted-by":"publisher","first-page":"e32737","DOI":"10.1371\/journal.pone.0032737","article-title":"Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer\u2019s disease","volume":"7","author":"Trushina","year":"2012","journal-title":"PLoS One"},{"key":"B251","doi-asserted-by":"publisher","first-page":"S40","DOI":"10.1086\/342966","article-title":"Valacyclovir for herpes simplex virus infection: long-term safety and sustained efficacy after 20 years\u2032 experience with acyclovir","volume":"186","author":"Tyring","year":"2002","journal-title":"J. Infect. Dis."},{"key":"B252","doi-asserted-by":"publisher","first-page":"957","DOI":"10.14670\/HH-20.957","article-title":"Role of oxidative damage in the pathogenesis of viral infections of the nervous system","volume":"20","author":"Valyi-Nagy","year":"2005","journal-title":"Histol. Histopathol."},{"key":"B253","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s004019570001","article-title":"Early complement components in Alzheimer\u2019s disease brains","volume":"91","author":"Veerhuis","year":"1996","journal-title":"Acta Neuropathol."},{"key":"B255","doi-asserted-by":"publisher","first-page":"13217","DOI":"10.1073\/pnas.172504199","article-title":"Amyloid \u03b2-peptide inhibition of the PKA\/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling","volume":"99","author":"Vitolo","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B256","doi-asserted-by":"publisher","first-page":"19318","DOI":"10.1073\/pnas.0804871105","article-title":"Amyloid-\u03b2 overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission\/fusion proteins","volume":"105","author":"Wang","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B257","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/j.1471-4159.2009.05867.x","article-title":"The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer\u2019s disease","volume":"109","author":"Wang","year":"2009","journal-title":"J. Neurochem."},{"key":"B258","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1016\/j.bbadis.2013.10.015","article-title":"Oxidative stress and mitochondrial dysfunction in Alzheimer\u2019s disease","volume":"1842","author":"Wang","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"B259","doi-asserted-by":"publisher","first-page":"66","DOI":"10.3389\/fnagi.2014.00066","article-title":"Helicobacter pylori filtrate impairs spatial learning and memory in rats and increases \u03b2-amyloid by enhancing expression of presenilin-2","volume":"6","author":"Wang","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"B260","doi-asserted-by":"publisher","first-page":"e101364","DOI":"10.1371\/journal.pone.0101364","article-title":"Alzheimer\u2019s associated \u03b2-amyloid protein inhibits influenza A virus and modulates viral interactions with phagocytes","volume":"9","author":"White","year":"2014","journal-title":"PLoS One"},{"key":"B261","doi-asserted-by":"publisher","first-page":"e1005449","DOI":"10.1371\/journal.ppat.1005449","article-title":"The herpes simplex virus neurovirulence factor \u03b334.5: revealing virus-host interactions","volume":"12","author":"Wilcox","year":"2016","journal-title":"PLoS Pathog."},{"key":"B262","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/1742-2094-10-127","article-title":"Antimicrobial peptide \u03b2-defensin-1 expression is upregulated in Alzheimer\u2019s brain","volume":"10","author":"Williams","year":"2013","journal-title":"J. Neuroinflammation"},{"key":"B263","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1212\/CPJ.0000000000000293","article-title":"Validation of olfactory deficit as a biomarker of Alzheimer disease","volume":"7","author":"Woodward","year":"2017","journal-title":"Neurol. Clin. Pract."},{"key":"B264","unstructured":"Herpes simplex virus2017"},{"key":"B265","doi-asserted-by":"publisher","first-page":"341","DOI":"10.3233\/JAD-2009-0963","article-title":"Alzheimer\u2019s disease-specific tau phosphorylation is induced by herpes simplex virus type 1","volume":"16","author":"Wozniak","year":"","journal-title":"J. Alzheimers Dis."},{"key":"B269","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1002\/path.2449","article-title":"Herpes simplex virus type 1 DNA is located within Alzheimer\u2019s disease amyloid plaques","volume":"217","author":"Wozniak","year":"","journal-title":"J. Pathol."},{"key":"B266","doi-asserted-by":"publisher","first-page":"e25152","DOI":"10.1371\/journal.pone.0025152","article-title":"Antivirals reduce the formation of key Alzheimer\u2019s disease molecules in cell cultures acutely infected with Herpes simplex virus type 1","volume":"6","author":"Wozniak","year":"2011","journal-title":"PLoS One"},{"key":"B267","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1053\/jhep.2002.34745","article-title":"Apolipoprotein E-\u025b 4 protects against severe liver disease caused by hepatitis C virus","volume":"36","author":"Wozniak","year":"2002","journal-title":"Hepatology"},{"key":"B268","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.neulet.2007.09.077","article-title":"Herpes simplex virus infection causes cellular amyloid accumulation and secretase up-regulation","volume":"429","author":"Wozniak","year":"2007","journal-title":"Neurosci. Lett."},{"key":"B270","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1002\/jmv.20271","article-title":"Productive herpes virus in brain of elderly normal subjects and Alzheimer\u2019s disease patients","volume":"75","author":"Wozniak","year":"2005","journal-title":"J. Med. Virol."},{"key":"B271","doi-asserted-by":"publisher","first-page":"a006346","DOI":"10.1101\/cshperspect.a006346","article-title":"Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature","volume":"2","author":"Wyss-Coray","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"B272","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3109\/13550289909029743","article-title":"Chemokines\/chemokine receptors in the central nervous system and Alzheimer\u2019s disease","volume":"5","author":"Xia","year":"1999","journal-title":"J. Neurovirol."},{"key":"B273","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/s0006-8993(99)01220-2","article-title":"Impaired phosphorylation of cyclic AMP response element binding protein in the hippocampus of dementia of the Alzheimer type","volume":"824","author":"Yamamoto-Sasaki","year":"1999","journal-title":"Brain Res."},{"key":"B274","doi-asserted-by":"publisher","first-page":"11264","DOI":"10.1128\/JVI.01616-14","article-title":"In vivo reactivation of latent herpes simplex virus 1 in mice can occur in the brain before occurring in the trigeminal ganglion","volume":"88","author":"Yao","year":"2014","journal-title":"J. Virol."},{"key":"B275","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/s0304-3940(00)01675-x","article-title":"Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of \u03b2-amyloid peptide","volume":"297","author":"Yasojima","year":"2001","journal-title":"Neurosci. Lett."},{"key":"B276","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.schres.2011.01.020","article-title":"Serological evidence of exposure to herpes simplex virus type 1 is associated with cognitive deficits in the CATIE schizophrenia sample","volume":"128","author":"Yolken","year":"2011","journal-title":"Schizophr. Res."},{"key":"B277","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s12985-016-0528-0","article-title":"The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways","volume":"13","author":"Yu","year":"2016","journal-title":"Virol. J."},{"key":"B278","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3233\/jad-2008-14301","article-title":"Neuronal cytoskeletal dynamic modification and neurodegeneration induced by infection with herpes simplex virus type 1","volume":"14","author":"Zambrano","year":"2008","journal-title":"J. Alzheimers Dis."},{"key":"B279","doi-asserted-by":"publisher","first-page":"316523","DOI":"10.1155\/2013\/316523","article-title":"Oxidative stress and the pathogenesis of Alzheimer\u2019s disease","volume":"2013","author":"Zhao","year":"2013","journal-title":"Oxid. Med. Cell. Longev."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnagi.2018.00048\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T10:37:45Z","timestamp":1751452665000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnagi.2018.00048\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,6]]},"references-count":278,"alternative-id":["10.3389\/fnagi.2018.00048"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2018.00048","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,6]]},"article-number":"48"}}