{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:53:39Z","timestamp":1782845619905,"version":"3.54.5"},"reference-count":74,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"DOI":"10.3389\/fnagi.2018.00059","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T04:16:51Z","timestamp":1520223411000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Increased Resting-State Cerebellar-Cerebral Functional Connectivity Underlying Chronic Tinnitus"],"prefix":"10.3389","volume":"10","author":[{"given":"Yuan","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cun-Nan","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Bo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyou","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Jing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xindao","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,3,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.neuroimage.2005.02.018","article-title":"Unified segmentation","volume":"26","author":"Ashburner","year":"2005","journal-title":"Neuroimage"},{"key":"B2","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1097\/mao.0b013e31802b3248","article-title":"Tinnitus and neural plasticity of the brain","volume":"28","author":"Bartels","year":"2007","journal-title":"Otol. Neurotol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.heares.2012.03.009","article-title":"The cerebellum as a novel tinnitus generator","volume":"295","author":"Bauer","year":"","journal-title":"Hear. Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e64726","DOI":"10.1371\/journal.pone.0064726","article-title":"Tinnitus, unipolar brush cells, and cerebellar glutamatergic function in an animal model","volume":"8","author":"Bauer","year":"","journal-title":"PLoS One"},{"key":"B5","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s12311-014-0627-7","article-title":"Consensus paper: the role of the cerebellum in perceptual processes","volume":"14","author":"Baumann","year":"2015","journal-title":"Cerebellum"},{"key":"B6","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.heares.2014.03.001","article-title":"Tinnitus-related dissociation between cortical and subcortical neural activity in humans with mild to moderate sensorineural hearing loss","volume":"312","author":"Boyen","year":"2014","journal-title":"Hear. Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.heares.2012.02.010","article-title":"Gray matter in the brain: differences associated with tinnitus and hearing loss","volume":"295","author":"Boyen","year":"2013","journal-title":"Hear. Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.heares.2017.04.016","article-title":"Chronic tinnitus and unipolar brush cell alterations in the cerebellum and dorsal cochlear nucleus","volume":"350","author":"Brozoski","year":"2017","journal-title":"Hear. Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/s0378-5955(02)00717-7","article-title":"Expanding the biological basis of tinnitus: crossmodal origins and the role of neuroplasticity","volume":"175","author":"Cacace","year":"2003","journal-title":"Hear. Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"e4645","DOI":"10.1371\/journal.pone.0004645","article-title":"Auditory attention activates peripheral visual cortex","volume":"4","author":"Cate","year":"2009","journal-title":"PLoS One"},{"key":"B12","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3389\/fnsys.2010.00013","article-title":"DPARSF: a MATLAB toolbox for \u201cpipeline\u201d data analysis of resting-state fMRI","volume":"4","author":"Chao-Gan","year":"2010","journal-title":"Front. Syst. Neurosci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.heares.2017.03.005","article-title":"Tinnitus and hyperacusis: contributions of paraflocculus, reticular formation and stress","volume":"349","author":"Chen","year":"","journal-title":"Hear Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3389\/fnhum.2017.00022","article-title":"Resting-state brain abnormalities in chronic subjective tinnitus: a meta-analysis","volume":"11","author":"Chen","year":"","journal-title":"Front. Hum. Neurosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2384","DOI":"10.1002\/hbm.23525","article-title":"Tinnitus distress is linked to enhanced resting-state functional connectivity from the limbic system to the auditory cortex","volume":"38","author":"Chen","year":"","journal-title":"Hum. Brain Mapp."},{"key":"B14","doi-asserted-by":"publisher","first-page":"174","DOI":"10.3389\/fnagi.2016.00174","article-title":"Disrupted brain functional network architecture in chronic tinnitus patients","volume":"8","author":"Chen","year":"2016","journal-title":"Front. Aging Neurosci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"e06576","DOI":"10.7554\/eLife.06576","article-title":"Tinnitus and hyperacusis involve hyperactivity and enhanced connectivity in auditory-limbic-arousal-cerebellar network","volume":"4","author":"Chen","year":"","journal-title":"Elife"},{"key":"B19","doi-asserted-by":"publisher","first-page":"345647","DOI":"10.1155\/2015\/345647","article-title":"Altered interhemispheric functional coordination in chronic tinnitus patients","volume":"2015","author":"Chen","year":"","journal-title":"Biomed. Res. Int."},{"key":"B21","doi-asserted-by":"publisher","first-page":"475382","DOI":"10.1155\/2015\/475382","article-title":"Altered intra-and interregional synchronization in resting-state cerebral networks associated with chronic tinnitus","volume":"2015","author":"Chen","year":"","journal-title":"Neural Plast."},{"key":"B20","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.nicl.2014.09.011","article-title":"Aberrant spontaneous brain activity in chronic tinnitus patients revealed by resting-state functional MRI","volume":"6","author":"Chen","year":"2014","journal-title":"Neuroimage Clin."},{"key":"B22","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1142\/s0219635211002762","article-title":"Neural circuits of the cerebellum: hypothesis for function","volume":"10","author":"D\u2019Angelo","year":"2011","journal-title":"J. Integr. Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.neuroimage.2008.06.037","article-title":"Combining multivariate voxel selection and support vector machines for mapping and classification of fMRI spatial patterns","volume":"43","author":"De Martino","year":"2008","journal-title":"Neuroimage"},{"key":"B24","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.brs.2014.04.004","article-title":"Targeting the parahippocampal area by auditory cortex stimulation in tinnitus","volume":"7","author":"De Ridder","year":"2014","journal-title":"Brain Stimul."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1016\/s1359-6446(05)03542-7","article-title":"Tinnitus: neurobiological substrates","volume":"10","author":"Eggermont","year":"2005","journal-title":"Drug Discov. Today"},{"key":"B26","doi-asserted-by":"publisher","first-page":"7900","DOI":"10.1073\/pnas.1602413113","article-title":"Cluster failure: why fMRI inferences for spatial extent have inflated false-positive rates","volume":"113","author":"Eklund","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B27","doi-asserted-by":"publisher","first-page":"8586","DOI":"10.1523\/JNEUROSCI.1868-09.2009","article-title":"Distinct cerebellar contributions to intrinsic connectivity networks","volume":"29","author":"Habas","year":"2009","journal-title":"J. Neurosci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1186\/1472-6963-11-302","article-title":"Treatment options for subjective tinnitus: self reports from a sample of general practitioners and ENT physicians within Europe and the USA","volume":"11","author":"Hall","year":"2011","journal-title":"BMC Health Serv. Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1044\/1092-4388(2005\/084)","article-title":"General review of tinnitus: prevalence, mechanisms, effects, and management","volume":"48","author":"Henry","year":"2005","journal-title":"J. Speech Lang. Hear. Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0006-8993(82)90897-6","article-title":"Projections from the cochlear nucleus to the cerebellum","volume":"244","author":"Huang","year":"1982","journal-title":"Brain Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/0165-0173(90)90005-9","article-title":"The descending auditory pathway and acousticomotor systems: connections with the inferior colliculus","volume":"15","author":"Huffman","year":"1990","journal-title":"Brain Res. Rev."},{"key":"B32","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.heares.2013.07.010","article-title":"Using resting state functional connectivity to unravel networks of tinnitus","volume":"307","author":"Husain","year":"2014","journal-title":"Hear. Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1097\/00129492-200105000-00023","article-title":"A century of eighth nerve surgery","volume":"22","author":"Jackler","year":"2001","journal-title":"Otol. Neurotol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/0168-0102(90)90031-9","article-title":"Phantom auditory perception (tinnitus): mechanisms of generation and perception","volume":"8","author":"Jastreboff","year":"1990","journal-title":"Neurosci. Res."},{"key":"B35","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1055\/s-0042-1748042","article-title":"Tinnitus retraining therapy (TRT) as a method for treatment of tinnitus and hyperacusis patients","volume":"11","author":"Jastreboff","year":"2000","journal-title":"J. Am. Acad. Audiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.heares.2005.02.013","article-title":"Tinnitus as a plastic phenomenon and its possible neural underpinnings in the dorsal cochlear nucleus","volume":"206","author":"Kaltenbach","year":"2005","journal-title":"Hear. Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.neuroimage.2014.10.047","article-title":"A comparative analysis of mouse and human medial geniculate nucleus connectivity: a DTI and anterograde tracing study","volume":"105","author":"Keifer","year":"2015","journal-title":"Neuroimage"},{"key":"B38","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1159\/000067570","article-title":"Psychometric normalization of a hyperacusis questionnaire","volume":"64","author":"Khalfa","year":"2002","journal-title":"ORL J. Otorhinolaryngol. Relat. Spec."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2485","DOI":"10.1093\/cercor\/bhp135","article-title":"Segregated fronto-cerebellar circuits revealed by intrinsic functional connectivity","volume":"19","author":"Krienen","year":"2009","journal-title":"Cereb. Cortex"},{"key":"B40","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1097\/00003446-199012000-00005","article-title":"The psychometric properties of a tinnitus handicap questionnaire","volume":"11","author":"Kuk","year":"1990","journal-title":"Ear Hear."},{"key":"B41","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/S1474-4422(13)70160-1","article-title":"Tinnitus: causes and clinical management","volume":"12","author":"Langguth","year":"2013","journal-title":"Lancet Neurol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"e110704","DOI":"10.1371\/journal.pone.0110704","article-title":"Unilateral tinnitus: changes in connectivity and response lateralization measured with FMRI","volume":"9","author":"Lanting","year":"2014","journal-title":"PLoS One"},{"key":"B43","doi-asserted-by":"publisher","first-page":"e87839","DOI":"10.1371\/journal.pone.0087839","article-title":"Memory networks in tinnitus: a functional brain image study","volume":"9","author":"Laureano","year":"2014","journal-title":"PLoS One"},{"key":"B44","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.neuron.2010.12.002","article-title":"Dysregulation of limbic and auditory networks in tinnitus","volume":"69","author":"Leaver","year":"2011","journal-title":"Neuron"},{"key":"B45","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3389\/fnsys.2012.00021","article-title":"Cortico-limbic morphology separates tinnitus from tinnitus distress","volume":"6","author":"Leaver","year":"2012","journal-title":"Front. Syst. Neurosci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"2717","DOI":"10.1002\/hbm.23204","article-title":"Intrinsic network activity in tinnitus investigated using functional MRI","volume":"37","author":"Leaver","year":"2016","journal-title":"Hum. Brain Mapp."},{"key":"B47","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1056\/NEJMra013395","article-title":"Tinnitus","volume":"347","author":"Lockwood","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"B48","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1212\/WNL.50.1.114","article-title":"The functional neuroanatomy of tinnitus: evidence for limbic system links and neural plasticity","volume":"50","author":"Lockwood","year":"1998","journal-title":"Neurology"},{"key":"B49","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1006\/nimg.1997.0315","article-title":"Functional connectivity in single and multislice echoplanar imaging using resting-state fluctuations","volume":"7","author":"Lowe","year":"1998","journal-title":"Neuroimage"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1002\/mrm.21391","article-title":"Sparse MRI: the application of compressed sensing for rapid MR imaging","volume":"58","author":"Lustig","year":"2007","journal-title":"Magn. Reson. Med."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1016\/s1053-8119(03)00169-1","article-title":"An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets","volume":"19","author":"Maldjian","year":"2003","journal-title":"Neuroimage"},{"key":"B52","doi-asserted-by":"publisher","first-page":"e36222","DOI":"10.1371\/journal.pone.0036222","article-title":"Auditory resting-state network connectivity in tinnitus: a functional MRI study","volume":"7","author":"Maudoux","year":"2012","journal-title":"PLoS One"},{"key":"B53","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1046\/j.1365-2273.2001.00490.x","article-title":"Guidelines for the grading of tinnitus severity: the results of a working group commissioned by the British Association of Otolaryngologists, Head and Neck Surgeons, 1999","volume":"26","author":"McCombe","year":"2001","journal-title":"Clin. Otolaryngol. Allied Sci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1093\/cercor\/bhh197","article-title":"Grabbing your ear: rapid auditory-somatosensory multisensory interactions in low-level sensory cortices are not constrained by stimulus alignment","volume":"15","author":"Murray","year":"2005","journal-title":"Cereb. Cortex"},{"key":"B55","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1093\/cercor\/bhp157","article-title":"Distinct and overlapping functional zones in the cerebellum defined by resting state functional connectivity","volume":"20","author":"O\u2019Reilly","year":"2010","journal-title":"Cereb. Cortex"},{"key":"B56","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.heares.2011.09.008","article-title":"Increased activation of the human cerebellum during pitch discrimination: a positron emission tomography (PET) study","volume":"282","author":"Petacchi","year":"2011","journal-title":"Hear. Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1002\/hbm.20137","article-title":"Cerebellum and auditory function: an ALE meta-analysis of functional neuroimaging studies","volume":"25","author":"Petacchi","year":"2005","journal-title":"Hum. Brain Mapp."},{"key":"B58","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1016\/j.neuroimage.2011.10.018","article-title":"Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion","volume":"59","author":"Power","year":"2012","journal-title":"Neuroimage"},{"key":"B59","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.neuron.2010.04.032","article-title":"Tuning out the noise: limbic-auditory interactions in tinnitus","volume":"66","author":"Rauschecker","year":"2010","journal-title":"Neuron"},{"key":"B60","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1111\/j.1365-2273.2004.00879.x","article-title":"Tinnitus and psychological morbidity: a cross-sectional study to investigate psychological morbidity in tinnitus patients and its relationship with severity of symptoms and illness perceptions","volume":"29","author":"Reynolds","year":"2004","journal-title":"Clin. Otolaryngol. Allied Sci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"166","DOI":"10.3109\/05384916709074285","article-title":"Cerebellifugal fibres to the cochlear nuclei and superior olivary complex","volume":"63","author":"Rossi","year":"1967","journal-title":"Acta Otolaryngol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"258524","DOI":"10.1155\/2012\/258524","article-title":"A medley of midbrain maladies: a brief review of midbrain anatomy and syndromology for radiologists","volume":"2012","author":"Ruchalski","year":"2012","journal-title":"Radiol. Res. Pract."},{"key":"B63","doi-asserted-by":"publisher","first-page":"142","DOI":"10.3389\/fnsys.2010.00142","article-title":"Identifying abnormal connectivity in patients using dynamic causal modeling of FMRI responses","volume":"4","author":"Seghier","year":"2010","journal-title":"Front. Syst. Neurosci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.brainres.2012.08.052","article-title":"Functional MRI evidence for a role of ventral prefrontal cortex in tinnitus","volume":"1485","author":"Seydell-Greenwald","year":"2012","journal-title":"Brain Res."},{"key":"B65","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/nrneurol.2016.12","article-title":"Maladaptive plasticity in tinnitus\u2014triggers, mechanisms, and treatment","volume":"12","author":"Shore","year":"2016","journal-title":"Nat. Rev. Neurol."},{"key":"B66","first-page":"13","article-title":"SPECT imaging of brain and tinnitus-neurotologic\/neurologic implications","volume":"1","author":"Shulman","year":"1995","journal-title":"Int. Tinnitus. J."},{"key":"B67","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.neuroimage.2008.08.039","article-title":"Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies","volume":"44","author":"Stoodley","year":"2009","journal-title":"Neuroimage"},{"key":"B68","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.cortex.2009.06.009","article-title":"The human cerebellum contributes to motor, emotional and cognitive associative learning. A review","volume":"46","author":"Timmann","year":"2010","journal-title":"Cortex"},{"key":"B69","doi-asserted-by":"publisher","first-page":"e0137291","DOI":"10.1371\/journal.pone.0137291","article-title":"Alterations of regional cerebral blood flow in tinnitus patients as assessed using single-photon emission computed tomography","volume":"10","author":"Ueyama","year":"2015","journal-title":"PLoS One"},{"key":"B70","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.neuroimage.2015.12.002","article-title":"Deafferentation-based pathophysiological differences in phantom sound: tinnitus with and without hearing loss","volume":"129","author":"Vanneste","year":"2016","journal-title":"Neuroimage"},{"key":"B71","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1111\/j.1460-9568.2011.07793.x","article-title":"The neural network of phantom sound changes over time: a comparison between recent-onset and chronic tinnitus patients","volume":"34","author":"Vanneste","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"B72","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3389\/fneur.2017.00036","article-title":"Acoustic coordinated reset neuromodulation: a systematic review of a novel therapy for tinnitus","volume":"8","author":"Wegger","year":"2017","journal-title":"Front. Neurol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.neuroimage.2014.01.060","article-title":"Permutation inference for the general linear model","volume":"92","author":"Winkler","year":"2014","journal-title":"Neuroimage"},{"key":"B74","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s12021-016-9299-4","article-title":"DPABI: data processing & analysis for (resting-state) brain imaging","volume":"14","author":"Yan","year":"2016","journal-title":"Neuroinformatics"},{"key":"B76","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/s0033-3182(71)71479-0","article-title":"A rating instrument for anxiety disorders","volume":"12","author":"Zung","year":"1971","journal-title":"Psychosomatics"},{"key":"B75","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/978-3-642-70486-4_21","article-title":"Zung self-rating depression scale and depression status inventory","volume-title":"Assessment of Depression","author":"Zung","year":"1986"}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnagi.2018.00059\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T05:40:41Z","timestamp":1660542041000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnagi.2018.00059\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,5]]},"references-count":74,"alternative-id":["10.3389\/fnagi.2018.00059"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2018.00059","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,5]]},"article-number":"59"}}