{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T21:41:51Z","timestamp":1787348511458,"version":"build-2736575974"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T00:00:00Z","timestamp":1525737600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"DOI":"10.3389\/fnagi.2018.00130","type":"journal-article","created":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T04:45:15Z","timestamp":1525754715000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Cerebrospinal Fluid Concentration of Key Autophagy Protein Lamp2 Changes Little During Normal Aging"],"prefix":"10.3389","volume":"10","author":[{"given":"David A.","family":"Loeffler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea C.","family":"Klaver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary P.","family":"Coffey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan O.","family":"Aasly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,5,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1083\/jcb.137.4.825","article-title":"An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation","volume":"137","author":"Agarraberes","year":"1997","journal-title":"J. Cell Biol."},{"key":"B2","first-page":"159","article-title":"Assay of antioxidant capacity of human plasma and CSF in aging and disease","volume":"12","author":"Alho","year":"1998","journal-title":"Restor. Neurol. Neurosci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1001\/archneurol.2010.198","article-title":"Chaperone-mediated autophagy markers in Parkinson disease brains","volume":"67","author":"Alvarez-Erviti","year":"2010","journal-title":"Arch. Neurol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1007\/s12017-013-8269-3","article-title":"Lysosomal network proteins as potential novel CSF biomarkers for Alzheimer\u2019s disease","volume":"16","author":"Armstrong","year":"2014","journal-title":"Neuromolecular Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1007\/s12028-016-0351-x","article-title":"Autophagy biomarkers beclin 1 and p62 are increased in cerebrospinal fluid after traumatic brain injury","volume":"26","author":"Au","year":"2017","journal-title":"Neurocrit. Care"},{"key":"B6","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.ajpath.2011.10.024","article-title":"Age-dependent changes in the cerebrospinal fluid proteome by slow off-rate modified aptamer array","volume":"180","author":"Baird","year":"2012","journal-title":"Am. J. Pathol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/S0065-2423(03)37010-6","article-title":"Total antioxidant capacity","volume":"37","author":"Bartosz","year":"2003","journal-title":"Adv. Clin. Chem."},{"key":"B8","doi-asserted-by":"publisher","first-page":"307","DOI":"10.3233\/JPD-150759","article-title":"Distinct lysosomal network protein profiles in Parkinsonian syndrome cerebrospinal fluid","volume":"6","author":"Boman","year":"2016","journal-title":"J. Parkinsons Dis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.tcb.2003.12.002","article-title":"Autophagy: in sickness and in health","volume":"14","author":"Cuervo","year":"2004","journal-title":"Trends Cell Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1126\/science.273.5274.501","article-title":"A receptor for the selective uptake and degradation of proteins by lysosomes","volume":"273","author":"Cuervo","year":"1996","journal-title":"Science"},{"key":"B11","doi-asserted-by":"publisher","first-page":"31505","DOI":"10.1074\/jbc.M002102200","article-title":"Age-related decline in chaperone-mediated autophagy","volume":"275","author":"Cuervo","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B12","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/s0531-5565(03)00002-0","article-title":"Ageing-related changes in the in vivo function of rat liver macroautophagy and proteolysis","volume":"38","author":"Del Roso","year":"2003","journal-title":"Exp. Gerontol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1083\/jcb.201005144","article-title":"Protein homeostasis and aging in neurodegeneration","volume":"190","author":"Douglas","year":"2010","journal-title":"J. Cell. Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.bbrc.2015.03.025","article-title":"An RNautophagy\/DNautophagy receptor, LAMP2C, possesses an arginine-rich motif that mediates RNA\/DNA-binding","volume":"460","author":"Fujiwara","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B15","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1038\/emboj.2009.29","article-title":"Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3","volume":"28","author":"Gamerdinger","year":"2009","journal-title":"EMBO J."},{"key":"B16","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1089\/dna.1995.14.863","article-title":"The family of LAMP-2 proteins arises by alternative splicing from a single gene: characterization of the avian LAMP-2 gene and identification of mammalian homologs of LAMP-2b and LAMP-2c","volume":"14","author":"Gough","year":"1995","journal-title":"DNA Cell Biol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.clinbiochem.2012.06.016","article-title":"Age-related decrease of the LAMP-2 gene expression in human leukocytes","volume":"45","author":"Huang","year":"2012","journal-title":"Clin. Biochem."},{"key":"B18","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.pneurobio.2011.04.013","article-title":"DNA repair deficiency in neurodegeneration","volume":"94","author":"Jeppesen","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"553","DOI":"10.4161\/auto.4615","article-title":"Cytosolic LC3 ratio as a sensitive index of macroautophagy in isolated rat hepatocytes and H4-II-E cells","volume":"3","author":"Karim","year":"2007","journal-title":"Autophagy"},{"key":"B20","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/j.1463-1326.2010.01263.x","article-title":"Autophagic pathways and metabolic stress","volume":"12","author":"Kaushik","year":"2010","journal-title":"Diabetes Obes. Metab."},{"key":"B21","doi-asserted-by":"publisher","first-page":"4829","DOI":"10.1091\/mbc.e04-06-0477","article-title":"Activation of chaperone-mediated autophagy during oxidative stress","volume":"15","author":"Kiffin","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"B22","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.brainres.2018.01.016","article-title":"CSF lamp2 concentrations are decreased in female Parkinson\u2019s disease patients with LRRK2 mutations","volume":"1683","author":"Klaver","year":"2018","journal-title":"Brain Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1096\/fj.09-144519","article-title":"Inhibitory effect of intracellular lipid load on macroautophagy","volume":"6","author":"Koga","year":"2010","journal-title":"Autophagy"},{"key":"B24","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1186\/s12967-015-0726-3","article-title":"Autophagy biomarkers in CSF correlates with infarct size, clinical severity and neurological outcome in AIS patients","volume":"13","author":"Li","year":"2015","journal-title":"J. Transl. Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/j.devcel.2010.05.005","article-title":"A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions","volume":"18","author":"Lipinski","year":"","journal-title":"Dev. Cell"},{"key":"B26","doi-asserted-by":"publisher","first-page":"14164","DOI":"10.1073\/pnas.1009485107","article-title":"Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer\u2019s disease","volume":"107","author":"Lipinski","year":"","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B27","doi-asserted-by":"publisher","first-page":"178","DOI":"10.3389\/fnagi.2016.00178","article-title":"Age-related decrease in heat shock 70-kDa protein 8 in cerebrospinal fluid is associated with increased oxidative stress","volume":"8","author":"Loeffler","year":"2016","journal-title":"Front. Aging Neurosci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.neulet.2006.03.013","article-title":"Total antioxidant capacity of cerebrospinal fluid is decreased in patients with motor neuron disease","volume":"401","author":"Mandrioli","year":"2006","journal-title":"Neurosci. Lett."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.arr.2009.08.002","article-title":"Energy expenditure and aging","volume":"9","author":"Manini","year":"2010","journal-title":"Ageing Res. Rev."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1002\/mds.26141","article-title":"Lysosomal-associated membrane protein 2 isoforms are differentially affected in early Parkinson\u2019s disease","volume":"30","author":"Murphy","year":"2015","journal-title":"Mov. Disord."},{"key":"B31","doi-asserted-by":"publisher","first-page":"R985","DOI":"10.1152\/ajpregu.00537.2001","article-title":"Behavioral dysfunction, brain oxidative stress and impaired mitochondrial electron transfer in aging mice","volume":"282","author":"Navarro","year":"2002","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1038\/35022604","article-title":"Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease)","volume":"406","author":"Nishino","year":"2000","journal-title":"Nature"},{"key":"B33","unstructured":"Biospecimen collection, processing, and shipment manual2014"},{"key":"B34","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.biochi.2007.08.014","article-title":"Regulation of macroautophagy by mTOR and Beclin 1 complexes","volume":"90","author":"Pattingre","year":"2008","journal-title":"Biochimie"},{"key":"B35","doi-asserted-by":"publisher","first-page":"E705","DOI":"10.1073\/pnas.1113036109","article-title":"Inhibitory effect of dietary lipids on chaperone-mediated autophagy","volume":"109","author":"Rodriguez-Navarro","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B36","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1242\/jcs.184770","article-title":"Danon disease\u2014dysregulation of autophagy in a multisystem disorder with cardiomyopathy","volume":"129","author":"Rowland","year":"2016","journal-title":"J. Cell Sci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"14474","DOI":"10.1074\/jbc.M600364200","article-title":"Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1","volume":"281","author":"Shibata","year":"2006","journal-title":"J. Biol. Chem."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.4161\/auto.26448","article-title":"HSPA8\/HSC70 chaperone protein: structure, function, and chemical targeting","volume":"9","author":"Stricher","year":"2013","journal-title":"Autophagy"},{"key":"B39","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3389\/fnagi.2011.00008","article-title":"The hippocampal neuroproteome with aging and cognitive decline: past progress and future directions","volume":"3","author":"Vanguilder","year":"2011","journal-title":"Front. Aging Neurosci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.arr.2016.07.001","article-title":"Chaperone mediated autophagy in aging: starve to prosper","volume":"32","author":"Xilouri","year":"2016","journal-title":"Ageing Res. Rev."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnagi.2018.00130\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T04:45:48Z","timestamp":1525754748000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnagi.2018.00130\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,8]]},"references-count":40,"alternative-id":["10.3389\/fnagi.2018.00130"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2018.00130","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,8]]},"article-number":"130"}}