{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T07:40:51Z","timestamp":1784446851113,"version":"3.55.0"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T00:00:00Z","timestamp":1529884800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"DOI":"10.3389\/fnagi.2018.00193","type":"journal-article","created":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T12:15:59Z","timestamp":1529928959000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":35,"title":["Amyloid-\u03b2, Tau, and Cognition in Cognitively Normal Older Individuals: Examining the Necessity to Adjust for Biomarker Status in Normative Data"],"prefix":"10.3389","volume":"10","author":[{"given":"Isabelle","family":"Bos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie J. B.","family":"Vos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willemijn J.","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rik","family":"Vandenberghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvy","family":"Gabel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainara","family":"Estanga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirian","family":"Ecay-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jori","family":"Tomassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouk","family":"den Braber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Lle\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Sala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Wallin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petronella","family":"Kettunen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L.","family":"Molinuevo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Rami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00ebl","family":"Chetelat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"de la Sayette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda","family":"Tsolaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Freund-Levi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Johannsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald P.","family":"Novak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inez","family":"Ramakers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans R.","family":"Verhey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter Jelle","family":"Visser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,6,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1093\/cercor\/bhu286","article-title":"Functional changes in the language network in response to increased amyloid beta deposition in cognitively intact older adults","volume":"26","author":"Adamczuk","year":"","journal-title":"Cereb. Cortex"},{"key":"B2","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s00259-015-3156-9","article-title":"Amyloid imaging in cognitively normal older adults: comparison between (18)F-flutemetamol and (11)C-Pittsburgh compound B","volume":"43","author":"Adamczuk","year":"","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"B3","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s13195-015-0159-5","article-title":"Diagnostic value of cerebrospinal fluid Abeta ratios in preclinical Alzheimer's disease","volume":"7","author":"Adamczuk","year":"2015","journal-title":"Alzheimers Res. Ther."},{"key":"B4","doi-asserted-by":"publisher","first-page":"157","DOI":"10.3233\/JAD-140240","article-title":"Relationship between beta-Secretase, inflammation and core cerebrospinal fluid biomarkers for Alzheimer's disease","volume":"42","author":"Alcolea","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"B5","volume-title":"Diagnostic and Statistical Manual of Mental Disorders: DSM-IV.","year":"1994"},{"key":"B6","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.dadm.2016.09.002","article-title":"Cognitive impairment and decline in cognitively normal older adults with high amyloid-\u03b2: a meta-analysis","volume":"6","author":"Baker","year":"2017","journal-title":"Alzheimers Dement."},{"key":"B7","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1056\/NEJMoa1202753","article-title":"Clinical and biomarker changes in dominantly inherited Alzheimer's disease","volume":"367","author":"Bateman","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.neurobiolaging.2017.03.034","article-title":"The frequency and influence of dementia risk factors in prodromal Alzheimer's disease","volume":"56","author":"Bos","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"B9","doi-asserted-by":"publisher","first-page":"338r","DOI":"10.1126\/scitranslmed.aaf2362","article-title":"Tau and Abeta imaging, CSF measures, and cognition in Alzheimer's disease","volume":"8","author":"Brier","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s13195-018-0369-8","article-title":"A biomarker study in long-lasting amnestic mild cognitive impairment","volume":"10","author":"Cerami","year":"2018","journal-title":"Alzheimers Res. Ther."},{"key":"B11","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s13195-016-0191-0","article-title":"High tau levels in cerebrospinal fluid predict nursing home placement and rapid progression in Alzheimer's disease","volume":"8","author":"Degerman Gunnarsson","year":"2016","journal-title":"Alzheimers Res. Ther."},{"key":"B12","doi-asserted-by":"publisher","first-page":"9685","DOI":"10.1038\/s41598-017-10235-y","article-title":"Functional and effective whole brain connectivity using magnetoencephalography to identify monozygotic twin pairs","volume":"7","author":"Demuru","year":"2017","journal-title":"Sci. Rep."},{"key":"B13","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.jalz.2016.02.002","article-title":"Preclinical Alzheimer's disease: definition, natural history, and diagnostic criteria","volume":"12","author":"Dubois","year":"2016","journal-title":"Alzheimers Dement."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.3233\/JAD-170511","article-title":"Alzheimer's disease biomarkers and future decline in cognitive normal older adults","volume":"60","author":"Dumurgier","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"B15","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.neurobiolaging.2016.10.013","article-title":"Beneficial effect of bilingualism on Alzheimer's disease CSF biomarkers and cognition","volume":"50","author":"Estanga","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"B16","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state.\u201d a practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"909","DOI":"10.3233\/jad-2010-100678","article-title":"Increased cortical thickness and caudate volume precede atrophy in PSEN1 mutation carriers","volume":"22","author":"Fortea","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"B18","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1093\/gerona\/glu057","article-title":"Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases","volume":"69","author":"Franceschi","year":"2014","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/1742-2094-5-51","article-title":"Inflammaging as a prodrome to Alzheimer's disease","volume":"5","author":"Giunta","year":"2008","journal-title":"J. Neuroinflammation"},{"key":"B20","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.neurobiolaging.2016.03.014","article-title":"Certified normal: Alzheimer's disease biomarkers and normative estimates of cognitive functioning","volume":"43","author":"Hassenstab","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1212\/WNL.0b013e31828ab35d","article-title":"Meta-analysis of amyloid-cognition relations in cognitively normal older adults","volume":"80","author":"Hedden","year":"2013","journal-title":"Neurology"},{"key":"B22","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/s1474-4422(12)70291-0","article-title":"Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers","volume":"12","author":"Jack","year":"2013","journal-title":"Lancet Neurol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1001\/jama.2015.4668","article-title":"Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis","volume":"313","author":"Jansen","year":"2015","journal-title":"JAMA"},{"key":"B24","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1001\/jamapsychiatry.2017.3391","article-title":"Association of cerebral amyloid-beta aggregation with cognitive functioning in persons without dementia","volume":"75","author":"Jansen","year":"2017","journal-title":"JAMA Psychiatry"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1016\/j.neuron.2014.01.026","article-title":"Intrinsic connectivity identifies the hippocampus as a main crossroad between Alzheimer's and semantic dementia-targeted networks","volume":"81","author":"La Joie","year":"2014","journal-title":"Neuron"},{"key":"B26","volume-title":"Neuropsychological Assessment.","author":"Lezak","year":"2004"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1212\/WNL.0000000000002604","article-title":"Abeta-related memory decline in APOE epsilon4 noncarriers: implications for Alzheimer disease","volume":"86","author":"Lim","year":"2016","journal-title":"Neurology"},{"key":"B28","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1212\/WNL.47.5.1113","article-title":"Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop","volume":"47","author":"McKeith","year":"1996","journal-title":"Neurology"},{"key":"B29","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of department of health and human services task force on Alzheimer's Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"B30","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.jalz.2015.09.010","article-title":"Influence of amyloid and APOE on cognitive performance in a late middle-aged cohort","volume":"12","author":"Mielke","year":"2016","journal-title":"Alzheimers Dement."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1001\/jamaneurol.2014.2031","article-title":"Synergistic effect of beta-amyloid and neurodegeneration on cognitive decline in clinically normal individuals","volume":"71","author":"Mormino","year":"2014","journal-title":"JAMA Neurol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.jalz.2005.06.003","article-title":"Ways toward an early diagnosis in Alzheimer's disease: the Alzheimer's Disease Neuroimaging Initiative (ADNI)","volume":"1","author":"Mueller","year":"2005","journal-title":"Alzheimers Dement."},{"key":"B33","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1212\/WNL.51.6.1546","article-title":"Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria","volume":"51","author":"Neary","year":"1998","journal-title":"Neurology"},{"key":"B34","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1097\/NEN.0b013e31825018f7","article-title":"Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature","volume":"71","author":"Nelson","year":"2012","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2746","DOI":"10.1016\/j.neurobiolaging.2012.02.008","article-title":"Effects of age and beta-amyloid on cognitive changes in normal elderly people","volume":"33","author":"Oh","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"B36","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1001\/jamaneurol.2015.3098","article-title":"Association of elevated amyloid levels with cognition and biomarkers in cognitively normal people from the community","volume":"73","author":"Petersen","year":"2016","journal-title":"JAMA Neurol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.neuropsychologia.2015.09.024","article-title":"Relationship between cerebrospinal fluid biomarkers of Alzheimer's disease and cognition in cognitively normal older adults","volume":"78","author":"Pettigrew","year":"2015","journal-title":"Neuropsychologia"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.3233\/jad-170564","article-title":"Relation of odor identification with Alzheimer's disease markers in cerebrospinal fluid and cognition","volume":"60","author":"Reijs","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"B39","volume-title":"Trail-Making Test","author":"Reitan","year":"1979"},{"key":"B40","volume-title":"L'examen Clinique en Psychologie [The Psychological Examination].","author":"Rey","year":"1958"},{"key":"B41","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1212\/WNL.43.2.250","article-title":"Vascular dementia: diagnostic criteria for research studies. report of the NINDS-AIREN international workshop","volume":"43","author":"Roman","year":"1993","journal-title":"Neurology"},{"key":"B42","doi-asserted-by":"publisher","first-page":"909","DOI":"10.3233\/jad-170073","article-title":"Diagnostic and prognostic value of the combination of two measures of verbal memory in mild cognitive impairment due to Alzheimer's disease","volume":"58","author":"Sala","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"B43","author":"Schmand","year":"2003","journal-title":"Norms for Stroop Color Word Test, Trail Making Test, and Story Recall of Rivermead Behavioural Memory Test"},{"key":"B44","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1177\/2040622311399145","article-title":"Cognitive dysfunction with aging and the role of inflammation","volume":"2","author":"Simen","year":"2011","journal-title":"Ther. Adv. Chronic Dis."},{"key":"B45","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1017\/s1355617705050344","article-title":"Rey's verbal learning test: normative data for 1855 healthy participants aged 24-81 years and the influence of age, sex, education, and mode of presentation","volume":"11","author":"Van der Elst","year":"2005","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"B46","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1017\/S1355617706060115","article-title":"Normative data for the animal, profession and letter m naming verbal fluency tests for dutch speaking participants and the effects of age, education, and sex","volume":"12","author":"Van der Elst","year":"2006","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"B47","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1016\/j.bbadis.2015.09.013","article-title":"The role of cerebrovascular disease when there is concomitant Alzheimer disease","volume":"1862","author":"Vemuri","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1212\/01.wnl.0000238517.59286.c5","article-title":"Ten-year risk of dementia in subjects with mild cognitive impairment","volume":"67","author":"Visser","year":"2006","journal-title":"Neurology"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1093\/brain\/awv029","article-title":"Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage","volume":"138","author":"Vos","year":"2015","journal-title":"Brain"},{"key":"B50","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/s1474-4422(13)70194-7","article-title":"Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study","volume":"12","author":"Vos","year":"2013","journal-title":"Lancet Neurol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/jcbfm.2015.148","article-title":"Alzheimer's disease\u2013subcortical vascular disease spectrum in a hospital-based setting: overview of results from the Gothenburg MCI and dementia studies","volume":"36","author":"Wallin","year":"2016","journal-title":"J. Cereb. Blood Flow. Metab."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnagi.2018.00193\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T12:16:05Z","timestamp":1529928965000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnagi.2018.00193\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,25]]},"references-count":51,"alternative-id":["10.3389\/fnagi.2018.00193"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2018.00193","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,25]]},"article-number":"193"}}