{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T04:47:32Z","timestamp":1768279652598,"version":"3.49.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T00:00:00Z","timestamp":1533600000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"DOI":"10.3389\/fnagi.2018.00241","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T04:26:35Z","timestamp":1533615995000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["CDH23 Methylation Status and Presbycusis Risk in Elderly Women"],"prefix":"10.3389","volume":"10","author":[{"given":"Amal","family":"Bouzid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibtihel","family":"Smeti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amine","family":"Chakroun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salma","family":"Loukil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah Ahmed","family":"Gibriel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mhamed","family":"Grati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelmonem","family":"Ghorbel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saber","family":"Masmoudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,8,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"R10","DOI":"10.1186\/gb-2011-12-1-r10","article-title":"DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines","volume":"12","author":"Bell","year":"2011","journal-title":"Genome Biol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1086\/316954","article-title":"Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of the novel cadherin-like gene CDH23","volume":"68","author":"Bork","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1080\/1354750x.2018.1427795","article-title":"Down-expression of P2RX2, KCNQ5, ERBB3 and SOCS3 through DNA hypermethylation in elderly women with presbycusis","volume":"23","author":"Bouzid","year":"2018","journal-title":"Biomarkers"},{"key":"B4","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments","volume":"55","author":"Bustin","year":"2009","journal-title":"Clin. Chem."},{"key":"B5","doi-asserted-by":"publisher","first-page":"579","DOI":"10.3892\/etm.2014.1766","article-title":"Investigation into the promoter DNA methylation of three genes (CAMK1D, CRY2 and CALM2) in the peripheral blood of patients with type 2 diabetes","volume":"8","author":"Cheng","year":"2014","journal-title":"Exp. Ther. Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.cell.2011.04.024","article-title":"Primate CpG islands are maintained by heterogeneous evolutionary regimes involving minimal selection","volume":"145","author":"Cohen","year":"2011","journal-title":"Cell"},{"key":"B7","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/nature06745","article-title":"Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning","volume":"452","author":"Cokus","year":"2008","journal-title":"Nature"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e1001025","DOI":"10.1371\/journal.pcbi.1001025","article-title":"Identifying a high fraction of the human genome to be under selective constraint using GERP++","volume":"6","author":"Davydov","year":"2010","journal-title":"PLoS Comput. Biol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/s0378-1119(01)00761-2","article-title":"Genomic structure, alternative splice forms and normal and mutant alleles of cadherin 23 (Cdh23)","volume":"281","author":"Di Palma","year":"2001","journal-title":"Gene"},{"key":"B10","doi-asserted-by":"publisher","first-page":"10604","DOI":"10.1073\/pnas.0500398102","article-title":"Epigenetic differences arise during the lifetime of monozygotic twins","volume":"102","author":"Fraga","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B11","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s00335-009-9230-5","article-title":"MicroRNAs and epigenetic regulation in the mammalian inner ear: implications for deafness","volume":"20","author":"Friedman","year":"2009","journal-title":"Mamm. Genome"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1016\/j.cca.2012.05.021","article-title":"Epigenetic biomarkers: a new perspective in laboratory diagnostics","volume":"413","author":"Garc\u00eda-Gim\u00e9nez","year":"2012","journal-title":"Clin. Chim. Acta"},{"key":"B13","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1101\/gr.143503.112","article-title":"DNA-methylation effect on cotranscriptional splicing is dependent on GC architecture of the exon-intron structure","volume":"23","author":"Gelfman","year":"2013","journal-title":"Genome Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"R97","DOI":"10.1186\/gb-2012-13-10-r97","article-title":"Aging effects on DNA methylation modules in human brain and blood tissue","volume":"13","author":"Horvath","year":"2012","journal-title":"Genome Biol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1177\/0194599812446904","article-title":"Association of Cadherin23 single nucleotide polymorphism with age-related hearing impairment in Han Chinese","volume":"147","author":"Hwang","year":"2012","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"B16","doi-asserted-by":"publisher","first-page":"44450","DOI":"10.1038\/srep44450","article-title":"Effects of Cdh23 single nucleotide substitutions on age-related hearing loss in C57BL\/6 and 129S1\/Sv mice and comparisons with congenic strains","volume":"7","author":"Johnson","year":"2017","journal-title":"Sci. Rep."},{"key":"B17","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1006\/geno.2000.6377","article-title":"A major gene affecting age-related hearing loss is common to at least ten inbred strains of mice","volume":"70","author":"Johnson","year":"2000","journal-title":"Genomics"},{"key":"B18","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1097\/ede.0b013e318245996e","article-title":"Heritability of hearing loss","volume":"23","author":"Kvestad","year":"2012","journal-title":"Epidemiology"},{"key":"B19","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.ydbio.2005.01.015","article-title":"Spatiotemporal pattern and isoforms of cadherin 23 in wild type and waltzer mice during inner ear hair cell development","volume":"280","author":"Lagziel","year":"2005","journal-title":"Dev. Biol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/0888-7543(92)90024-m","article-title":"CpG islands as gene markers in the human genome","volume":"13","author":"Larsen","year":"1992","journal-title":"Genomics"},{"key":"B21","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1101\/gr.101907.109","article-title":"Dynamic changes in the human methylome during differentiation","volume":"20","author":"Laurent","year":"2010","journal-title":"Genome Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.tig.2015.03.002","article-title":"The alternative role of DNA methylation in splicing regulation","volume":"31","author":"Lev Maor","year":"2015","journal-title":"Trends Genet."},{"key":"B23","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1002\/ar.a.20297","article-title":"Genetics of hearing loss: Allelism and modifier genes produce a phenotypic continuum","volume":"288","author":"McHugh","year":"2006","journal-title":"Anat. Rec. A Discov. Mol. Cell. Evol. Biol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.molmed.2007.08.003","article-title":"The peripheral-blood transcriptome: new insights into disease and risk assessment","volume":"13","author":"Mohr","year":"2007","journal-title":"Trends Mol. Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/ng1226","article-title":"Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss","volume":"35","author":"Noben-Trauth","year":"2003","journal-title":"Nat. Genet."},{"key":"B26","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1159\/000363215","article-title":"Cardiovascular risk factors as causes for hearing impairment","volume":"19","author":"Oron","year":"2014","journal-title":"Audiol. Neurootol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1146\/annurev.genet.35.102401.091224","article-title":"Molecular genetics of hearing loss","volume":"35","author":"Petit","year":"2001","journal-title":"Annu. Rev. Genet."},{"key":"B28","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/0378-5955(84)90041-8","article-title":"Cross-links between stereocilia in the guinea pig organ of Corti and their possible relation to sensory transduction","volume":"15","author":"Pickles","year":"1984","journal-title":"Hear. Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.heares.2007.07.002","article-title":"A role for epigenetics in hearing: establishment and maintenance of auditory specific gene expression patterns","volume":"233","author":"Provenzano","year":"2007","journal-title":"Hear. Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative CT method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"B31","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.heares.2015.08.013","article-title":"A comprehensive catalogue of the coding and non-coding transcripts of the human inner ear","volume":"333","author":"Schrauwen","year":"2016","journal-title":"Hear. Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1038\/nature02483","article-title":"Cadherin 23 is a component of the tip link in hair-cell stereocilia","volume":"428","author":"Siemens","year":"2004","journal-title":"Nature"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1101\/gr.3715005","article-title":"Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes","volume":"15","author":"Siepel","year":"2005","journal-title":"Genome Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/nrg2341","article-title":"DNA methylation landscapes: provocative insights from epigenomics","volume":"9","author":"Suzuki","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"B36","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1002\/lio2.134","article-title":"Age-related hearing loss: unraveling the pieces","volume":"21","author":"Tu","year":"2018","journal-title":"Laryngoscope Investig. Otolaryngol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.bbrc.2014.08.063","article-title":"Reduced expression of Connexin26 and its DNA promoter hypermethylation in the inner ear of mimetic aging rats induced by d-galactose","volume":"452","author":"Wu","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B39","doi-asserted-by":"publisher","first-page":"11269","DOI":"10.1523\/JNEUROSCI.3833-08.2008","article-title":"MAGI-1, A candidate stereociliary scaffolding protein, associates with the tip-link component cadherin (23)","volume":"28","author":"Xu","year":"2008","journal-title":"J. Neurosci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"347","DOI":"10.3892\/mmr.2017.6565","article-title":"Elevated SLC26A4 gene promoter methylation is associated with the risk of presbycusis in men","volume":"16","author":"Xu","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"B40","doi-asserted-by":"publisher","first-page":"276","DOI":"10.3389\/fncel.2015.00276","article-title":"Age-related hearing impairment and the triad of acquired hearing loss","volume":"9","author":"Yang","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/ng1929","article-title":"Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription","volume":"39","author":"Zilberman","year":"2007","journal-title":"Nat. Genet."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnagi.2018.00241\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T04:26:36Z","timestamp":1533615996000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnagi.2018.00241\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,7]]},"references-count":40,"alternative-id":["10.3389\/fnagi.2018.00241"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2018.00241","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,7]]},"article-number":"241"}}