{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:07:21Z","timestamp":1759565241310,"version":"3.41.2"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T00:00:00Z","timestamp":1551139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371408","81630029","81430022"],"award-info":[{"award-number":["81371408","81630029","81430022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"DOI":"10.3389\/fnagi.2019.00024","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T05:25:02Z","timestamp":1551158702000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Lack of Association Between DJ-1 Gene Promoter Polymorphism and the Risk of Parkinson\u2019s Disease"],"prefix":"10.3389","volume":"11","author":[{"given":"Lu","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzhen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruinan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengdi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianqing","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,2,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1002\/ana.10675","article-title":"The role of pathogenic DJ-1 mutations in Parkinson\u2019s disease.","volume":"54","author":"Abou-Sleiman","year":"2003","journal-title":"Ann. Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1126\/science.1077209","article-title":"Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism.","volume":"299","author":"Bonifati","year":"2003","journal-title":"Science"},{"key":"B3","doi-asserted-by":"publisher","first-page":"9103","DOI":"10.1073\/pnas.0402959101","article-title":"The Parkinson\u2019s disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization.","volume":"101","author":"Canet-Aviles","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00232","article-title":"MicroRNA-4639 Is a regulator of DJ-1 expression and a potential early diagnostic marker for Parkinson\u2019s disease.","volume":"9","author":"Chen","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/S1474-4422(06)70471-9","article-title":"Epidemiology of Parkinson\u2019s disease.","volume":"5","author":"de Lau","year":"2006","journal-title":"Lancet Neurol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/j.1399-0004.2009.01310.x","article-title":"DJ-1 is a Parkinson\u2019s disease susceptibility gene in southern Italy.","volume":"77","author":"De Marco","year":"2010","journal-title":"Clin. Genet."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.1242\/jcs.127340","article-title":"ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1.","author":"Duplan","year":"2013","journal-title":"J. Cell Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1212\/01.WNL.0000083992.28066.7E","article-title":"Assessment of a DJ-1 (PARK7) polymorphism in Finnish PD.","volume":"61","author":"Eerola","year":"2003","journal-title":"Neurology"},{"key":"B9","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1136\/jnnp.51.6.745","article-title":"The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson\u2019s disease.","volume":"51","author":"Gibb","year":"1988","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B10","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s00702-013-1094-x","article-title":"Screening of two indel polymorphisms in the 5\u2019UTR of the DJ-1 gene in South African Parkinson\u2019s disease patients.","volume":"121","author":"Glanzmann","year":"2014","journal-title":"J. Neural Transm."},{"key":"B11","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1002\/ana.10663","article-title":"Early-onset Parkinson\u2019s disease caused by a compound heterozygous DJ-1 mutation.","volume":"54","author":"Hague","year":"2003","journal-title":"Ann. Neurol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1002\/humu.20089","article-title":"Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7).","volume":"24","author":"Hering","year":"2004","journal-title":"Hum. Mutat."},{"key":"B13","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1093\/brain\/awq008","article-title":"DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson\u2019s disease.","author":"Hong","year":"2010","journal-title":"Brain"},{"key":"B14","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease.","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"B15","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1111\/ane.12563","article-title":"The genetic background of Parkinson\u2019s disease: current progress and future prospects.","volume":"134","author":"Kalinderi","year":"2016","journal-title":"Acta Neurol. Scand."},{"key":"B16","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.neulet.2003.08.037","article-title":"Polymorphism in the human DJ-1 gene is not associated with sporadic dementia with Lewy bodies or Parkinson\u2019s disease.","volume":"352","author":"Morris","year":"2003","journal-title":"Neurosci. Lett."},{"key":"B17","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1038\/ng.3043","article-title":"Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson\u2019s disease.","volume":"46","author":"Nalls","year":"2014","journal-title":"Nat. Genet."},{"key":"B18","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1002\/ana.23687","article-title":"Meta-analysis of early nonmotor features and risk factors for Parkinson disease.","volume":"72","author":"Noyce","year":"2012","journal-title":"Ann. Neurol."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-4-23","article-title":"Dissembled DJ-1 high molecular weight complex in cortex mitochondria from Parkinson\u2019s disease patients.","volume":"4","author":"Nural","year":"2009","journal-title":"Mol. Neurodegener."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1212\/01.wnl.0000285082.18969.3a","article-title":"Globus pallidus dopamine and Parkinson motor subtypes: clinical and brain biochemical correlation.","author":"Rajput","year":"2008","journal-title":"Neurology"},{"key":"B21","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3233\/dma-2012-0913","article-title":"DJ-1 variants in Indian Parkinson\u2019s disease patients.","volume":"33","author":"Sadhukhan","year":"2012","journal-title":"Dis. Markers"},{"key":"B22","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.neulet.2013.10.048","article-title":"DJ1 analysis in a large cohort of Italian early onset Parkinson disease patients.","author":"Sironi","year":"2013","journal-title":"Neurosci. Lett."},{"key":"B23","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1002\/mds.22214","article-title":"Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson\u2019s disease?","volume":"24","author":"Sutherland","year":"2009","journal-title":"Mov. Disord."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1093\/brain\/aww080","article-title":"DJ-1 linked parkinsonism (PARK7) is associated with Lewy body pathology.","author":"Taipa","year":"2016","journal-title":"Brain"},{"key":"B25","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/S0378-1119(00)00590-4","article-title":"Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter.","volume":"263","author":"Taira","year":"2001","journal-title":"Gene"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-016-0052-6","article-title":"Methylation status of DJ-1 in leukocyte DNA of Parkinson\u2019s disease patients.","volume":"5","author":"Tan","year":"2016","journal-title":"Transl. Neurodegener."},{"key":"B27","doi-asserted-by":"publisher","first-page":"2649","DOI":"10.1002\/mds.23429","article-title":"Systematic review of levodopa dose equivalency reporting in Parkinson\u2019s disease.","volume":"25","author":"Tomlinson","year":"2010","journal-title":"Mov. Disord."},{"key":"B28","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1002\/ana.22514","article-title":"DJ-1 modulates the expression of Cu\/Zn-superoxide dismutase-1 through the Erk1\/2-Elk1 pathway in neuroprotection.","volume":"70","author":"Wang","year":"2011","journal-title":"Ann. Neurol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1002\/mds.25863","article-title":"Alcohol intake and risk of Parkinson\u2019s disease: a meta-analysis of observational studies.","volume":"29","author":"Zhang","year":"2014","journal-title":"Mov. Disord."},{"key":"B30","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/s0140-6736(05)17909-4","article-title":"Parkinson\u2019s disease in China: prevalence in Beijing, Xian, and Shanghai.","volume":"365","author":"Zhang","year":"2005","journal-title":"Lancet"},{"key":"B31","doi-asserted-by":"publisher","first-page":"14941","DOI":"10.1074\/jbc.M110.211029","article-title":"Phenylbutyrate up-regulates the DJ-1 protein and protects neurons in cell culture and in animal models of Parkinson disease.","volume":"286","author":"Zhou","year":"2011","journal-title":"J. Biol. Chem."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnagi.2019.00024\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T05:25:04Z","timestamp":1551158704000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnagi.2019.00024\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,26]]},"references-count":31,"alternative-id":["10.3389\/fnagi.2019.00024"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2019.00024","relation":{},"ISSN":["1663-4365"],"issn-type":[{"type":"electronic","value":"1663-4365"}],"subject":[],"published":{"date-parts":[[2019,2,26]]},"article-number":"24"}}