{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T20:20:40Z","timestamp":1774988440841,"version":"3.50.1"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T00:00:00Z","timestamp":1553817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91332201"],"award-info":[{"award-number":["91332201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"DOI":"10.3389\/fnagi.2019.00071","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T13:53:33Z","timestamp":1553867613000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Decreased Function of Delayed Recall in Non-demented Elderly Subjects With Apolipoprotein E \u03b54 Allele"],"prefix":"10.3389","volume":"11","author":[{"given":"Lijun","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqiang","family":"Fei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changpeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbin","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoming","family":"Sang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunjiu","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,3,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1212\/wnl.45.12.2203","article-title":"Episodic memory changes are associated with the APOE-epsilon 4 allele in nondemented older adults.","volume":"45","author":"Bondi","year":"1995","journal-title":"Neurology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1212\/01.wnl.0000055875.26908.24","article-title":"The role of APOE-epsilon4 in longitudinal cognitive decline: macarthur studies of successful aging.","volume":"60","author":"Bretsky","year":"2003","journal-title":"Neurology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/nrn2620","article-title":"Apolipoprotein E and its receptors in Alzheimer\u2019s disease: pathways, pathogenesis and therapy.","volume":"10","author":"Bu","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"10539","DOI":"10.1523\/jneurosci.22-24-10539.2002","article-title":"Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation.","volume":"22","author":"Buttini","year":"2002","journal-title":"J. Neurosci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1056\/NEJMoa0809437","article-title":"Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect.","volume":"361","author":"Caselli","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"B6","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1001\/archneur.64.9.1306","article-title":"Cognitive domain decline in healthy apolipoprotein E epsilon4 homozygotes before the diagnosis of mild cognitive impairment.","volume":"64","author":"Caselli","year":"2007","journal-title":"Arch. Neurol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"12011","DOI":"10.1073\/pnas.0914984107","article-title":"ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling.","volume":"107","author":"Chen","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B8","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer\u2019s disease in late onset families.","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"B9","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.exger.2008.11.005","article-title":"APOE polymorphism affects episodic memory among non demented elderly subjects.","volume":"44","author":"De Blasi","year":"2009","journal-title":"Exp. Gerontol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1212\/wnl.46.6.1592","article-title":"Cerebral amyloid angiopathy in the brains of patients with Alzheimer\u2019s disease: the CERAD experience, Part XV.","volume":"46","author":"Ellis","year":"1996","journal-title":"Neurology"},{"key":"B11","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1037\/0894-4105.19.2.199","article-title":"Effects of apolipoprotein E genotype on spatial attention, working memory, and their interaction in healthy, middle-aged adults: results from the national institute of mental health\u2019s BIOCARD study.","volume":"19","author":"Greenwood","year":"2005","journal-title":"Neuropsychology"},{"key":"B12","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1037\/\/0882-7974.17.2.194","article-title":"Change in cognitive functioning associated with ApoE genotype in a community sample of older adults.","volume":"17","author":"Hofer","year":"2002","journal-title":"Psychol. Aging"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006312","article-title":"Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease.","volume":"2","author":"Holtzman","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1037\/0894-4105.21.1.1","article-title":"APOE genotype and cognitive functioning in a large age-stratified population sample.","volume":"21","author":"Jorm","year":"2007","journal-title":"Neuropsychology"},{"key":"B15","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1212\/WNL.43.1_Part_1.13","article-title":"Education and the prevalence of dementia and Alzheimer\u2019s disease.","volume":"43","author":"Katzman","year":"1993","journal-title":"Neurology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/0092-8674","article-title":"LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation.","volume":"82","author":"Kounnas","year":"1995","journal-title":"Cell"},{"key":"B17","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.neulet.2005.11.070","article-title":"Reduced hippocampal volume in non-demented carriers of the apolipoprotein E epsilon4: relation to chronological age and recognition memory.","volume":"396","author":"Lind","year":"2006","journal-title":"Neurosci. Lett."},{"key":"B18","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/nrneurol.2012.263","article-title":"Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy.","volume":"9","author":"Liu","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1037\/a0014014","article-title":"The influence of apolipoprotein E genotype on visuospatial attention dissipates after age 80.","volume":"23","author":"Negash","year":"2009","journal-title":"Neuropsychology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1111\/j.1532-5415.2007.01415.x","article-title":"Association between apolipoprotein E4 and cognitive decline in elderly adults.","volume":"55","author":"Packard","year":"2007","journal-title":"J. Am. Geriatr. Soc."},{"key":"B21","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1212\/WNL.48.4.985","article-title":"Apolipoprotein E epsilon 4 allele and hippocampal volume in twins with normal cognition.","volume":"48","author":"Plassman","year":"1997","journal-title":"Neurology"},{"key":"B22","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/0140-6736(93)91705-Q","article-title":"Apolipoprotein E polymorphism and Alzheimer\u2019s disease.","volume":"342","author":"Poirier","year":"1993","journal-title":"Lancet"},{"key":"B23","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1002\/gps.4186","article-title":"APOE epsilon4 allele is associated with worse performance in memory dimensions of the mini-mental state examination: the bambui cohort study of aging.","volume":"30","author":"Quintino-Santos","year":"2015","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2013.00011","article-title":"Alzheimer\u2019s Disease neuroimaging initiative, the role of apolipoprotein E (APOE) genotype in early mild cognitive impairment (E-MCI).","volume":"5","author":"Risacher","year":"2013","journal-title":"Front. Aging Neurosci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1037\/a0032707","article-title":"Age and apolipoprotein E genotype influence rate of arttitle cognitive decline in nondemented elderly.","volume":"27","author":"Salmon","year":"2013","journal-title":"Neuropsychology"},{"key":"B26","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1037\/0882-7974.13.1.80","article-title":"Three-year changes in cognitive performance as a function of apolipoprotein E genotype: evidence from very old adults without dementia.","volume":"13","author":"Small","year":"1998","journal-title":"Psychol. Aging"},{"key":"B27","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1037\/0882-7974.19.4.592","article-title":"Apolipoprotein E and cognitive performance: a meta-analysis.","volume":"19","author":"Small","year":"2004","journal-title":"Psychol. Aging"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1172\/JCI124853","article-title":"APOE4-mediated amyloid-beta pathology depends on its neuronal receptor LRP1.","volume":"129","author":"Tachibana","year":"2019","journal-title":"J. Clin. Invest."},{"key":"B29","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.biopsych.2017.03.003","article-title":"Apolipoprotein E, receptors, and modulation of Alzheimer\u2019s Disease.","volume":"83","author":"Zhao","year":"2018","journal-title":"Biol. Psychiatry"}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnagi.2019.00071\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T13:53:34Z","timestamp":1553867614000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnagi.2019.00071\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,29]]},"references-count":29,"alternative-id":["10.3389\/fnagi.2019.00071"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2019.00071","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,29]]},"article-number":"71"}}