{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:11:08Z","timestamp":1790806268079,"version":"4.1.0"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T00:00:00Z","timestamp":1580774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"DOI":"10.3389\/fnagi.2020.00016","type":"journal-article","created":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T05:30:48Z","timestamp":1580794248000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Genetic Association of FERMT2, HLA-DRB1, CD2AP, and PTK2B Polymorphisms With Alzheimer\u2019s Disease Risk in the Southern Chinese Population"],"prefix":"10.3389","volume":"12","author":[{"given":"Yi","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aonan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghui","family":"Qui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulei","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,2,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"215.e1","DOI":"10.1016\/j.neurobiolaging.2016.09.008","article-title":"Mutation analysis of sporadic early-onset Alzheimer\u2019s disease using the NeuroX array.","volume":"49","author":"Barber","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"B2","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1101\/gr.155192.113","article-title":"Characterizing the genetic basis of transcriptome diversity through RNA-sequencing of 922 individuals.","volume":"24","author":"Battle","year":"2014","journal-title":"Genome Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1007\/s11033-014-3806-1","article-title":"Association of MTHFR and PICALM polymorphisms with Alzheimer\u2019s disease.","volume":"42","author":"Belcavello","year":"2015","journal-title":"Mol. Biol. Rep."},{"key":"B4","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/s0140-6736(06)69113-7","article-title":"Alzheimer\u2019s disease.","volume":"368","author":"Blennow","year":"2006","journal-title":"Lancet"},{"key":"B5","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/447655a","article-title":"Replicating genotype-phenotype associations.","volume":"447","author":"Chanock","year":"2007","journal-title":"Nature"},{"key":"B6","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1007\/s00401-016-1652-z","article-title":"Genome-wide, high-content siRNA screening identifies the Alzheimer\u2019s genetic risk factor FERMT2 as a major modulator of APP metabolism.","volume":"133","author":"Chapuis","year":"2017","journal-title":"Acta Neuropathol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12035-014-8834-2","article-title":"Analyzing 54,936 samples supports the association between CD2AP rs9349407 polymorphism and Alzheimer\u2019s disease susceptibility.","volume":"52","author":"Chen","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer\u2019s disease in late onset families.","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1007\/s00439-012-1154-6","article-title":"The prevalence of CD33 and MS4A6A variant in Chinese Han population with Alzheimer\u2019s disease.","volume":"131","author":"Deng","year":"2012","journal-title":"Hum. Genet."},{"key":"B10","doi-asserted-by":"publisher","first-page":"952","DOI":"10.2174\/1567205013666160314150501","article-title":"Molecular basis of familial and sporadic Alzheimer\u2019s disease.","volume":"13","author":"Dorszewska","year":"2016","journal-title":"Curr. Alzheimer Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1038\/mp.2016.59","article-title":"Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology.","volume":"22","author":"Dourlen","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"B12","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/s1474-4422(07)70178-3","article-title":"Research criteria for the diagnosis of Alzheimer\u2019s disease: revising the NINCDS-ADRDA criteria.","volume":"6","author":"Dubois","year":"2007","journal-title":"Lancet Neurol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.jalz.2017.10.002","article-title":"Blood DNA methylation as a potential biomarker of dementia: a systematic review.","volume":"14","author":"Fransquet","year":"2018","journal-title":"Alzheimers Dement."},{"key":"B14","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1001\/archpsyc.63.2.168","article-title":"Role of genes and environments for explaining Alzheimer disease.","volume":"63","author":"Gatz","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"B15","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.expneurol.2018.05.020","article-title":"PTK2B\/Pyk2 overexpression improves a mouse model of Alzheimer\u2019s disease.","volume":"307","author":"Giralt","year":"2018","journal-title":"Exp. Neurol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/s0166-2236(96)01030-2","article-title":"Amyloid, the presenilins and Alzheimer\u2019s disease.","volume":"20","author":"Hardy","year":"1997","journal-title":"Trends Neurosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA research framework: toward a biological definition of Alzheimer\u2019s disease.","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement."},{"key":"B18","doi-asserted-by":"publisher","first-page":"e867","DOI":"10.1212\/WNL.0000000000006082","article-title":"CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease.","volume":"91","author":"Janelidze","year":"2018","journal-title":"Neurology"},{"key":"B19","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/s41588-018-0311-9","article-title":"Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer\u2019s disease risk.","volume":"51","author":"Jansen","year":"2019","journal-title":"Nat. Genet."},{"key":"B20","doi-asserted-by":"publisher","first-page":"852","DOI":"10.2174\/15672050113109990155","article-title":"Epidemiology and etiology of Alzheimer\u2019s disease: from genetic to non-genetic factors.","volume":"10","author":"Jiang","year":"2013","journal-title":"Curr. Alzheimer Res."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144898","article-title":"Polygenic analysis of late-onset Alzheimer\u2019s disease from mainland China.","volume":"10","author":"Jiao","year":"2015","journal-title":"PLoS One"},{"key":"B22","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1038\/nature10523","article-title":"Spatio-temporal transcriptome of the human brain.","volume":"478","author":"Kang","year":"2011","journal-title":"Nature"},{"key":"B23","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.biopsych.2014.05.006","article-title":"Alzheimer\u2019s disease risk genes and mechanisms of disease pathogenesis.","volume":"77","author":"Karch","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"B24","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1038\/s41588-019-0358-2","article-title":"Genetic meta-analysis of diagnosed Alzheimer\u2019s disease identifies new risk loci and implicates Abeta, tau, immunity and lipid processing.","volume":"51","author":"Kunkle","year":"2019","journal-title":"Nat. Genet."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1001\/jamaneurol.2017.1518","article-title":"Early-onset Alzheimer disease and candidate risk genes involved in endolysosomal transport.","volume":"74","author":"Kunkle","year":"2017","journal-title":"JAMA Neurol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.biocel.2009.10.015","article-title":"The role of kindlins in cell biology and relevance to human disease.","volume":"42","author":"Lai-Cheong","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1038\/ng.439","article-title":"Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer\u2019s disease.","volume":"41","author":"Lambert","year":"2009","journal-title":"Nat. Genet."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer\u2019s disease.","volume":"45","author":"Lambert","year":"2013","journal-title":"Nat. Genet."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j5375","article-title":"Modifiable pathways in Alzheimer\u2019s disease: mendelian randomisation analysis.","volume":"359","author":"Larsson","year":"2017","journal-title":"BMJ Clin. Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1038\/376737a0","article-title":"Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions.","volume":"376","author":"Lev","year":"1995","journal-title":"Nature"},{"key":"B31","doi-asserted-by":"publisher","first-page":"F785","DOI":"10.1152\/ajprenal.2000.279.4.F785","article-title":"CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere.","volume":"279","author":"Li","year":"2000","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/nrneurol.2012.263","article-title":"Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy.","volume":"9","author":"Liu","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"93219","DOI":"10.18632\/oncotarget.21479","article-title":"Association of HLA-DRB1 polymorphism with Alzheimer\u2019s disease: a replication and meta-analysis.","volume":"8","author":"Lu","year":"2017","journal-title":"Oncotarget"},{"key":"B34","doi-asserted-by":"publisher","first-page":"21805","DOI":"10.1074\/jbc.M211407200","article-title":"A cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton.","volume":"278","author":"Lynch","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B35","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.neuroscience.2005.06.052","article-title":"Disruption of ephrin-A\/EphA binding alters synaptogenesis and neural connectivity in the hippocampus.","volume":"135","author":"Martinez","year":"2005","journal-title":"Neuroscience"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.56","article-title":"Alzheimer\u2019s disease.","volume":"1","author":"Masters","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"B37","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease.","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement."},{"key":"B38","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/ng.801","article-title":"Common variants at MS4A4\/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer\u2019s disease.","volume":"43","author":"Naj","year":"2011","journal-title":"Nat. Genet."},{"key":"B39","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1111\/j.1600-065x.1999.tb01398.x","article-title":"The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple immunopathological diseases.","volume":"167","author":"Price","year":"1999","journal-title":"Immunol. Rev."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-019-0151-2","article-title":"Cognitive decline is related to high blood glucose levels in older Chinese adults with the ApoE epsilon3\/epsilon3 genotype.","volume":"8","author":"Qiu","year":"2019","journal-title":"Transl. Neurodegener."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1038\/nn.3801","article-title":"Genetic variability in the regulation of gene expression in ten regions of the human brain.","volume":"17","author":"Ramasamy","year":"2014","journal-title":"Nat. Neurosci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1159\/000356529","article-title":"Innate immune system and inflammation in Alzheimer\u2019s disease: from pathogenesis to treatment.","volume":"21","author":"Serpente","year":"2014","journal-title":"Neuroimmunomodulation"},{"key":"B43","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1007\/s12272-015-0648-x","article-title":"Involvement of inflammation in Alzheimer\u2019s disease pathogenesis and therapeutic potential of anti-inflammatory agents.","volume":"38","author":"Shadfar","year":"2015","journal-title":"Arch. Pharm. Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1093\/hmg\/ddy376","article-title":"Candidate-based screening via gene modulation in human neurons and astrocytes implicates FERMT2 in Abeta and TAU proteostasis.","volume":"28","author":"Sullivan","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"B45","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.jalz.2012.08.007","article-title":"Association of GWAS-linked loci with late-onset Alzheimer\u2019s disease in a northern Han Chinese population.","volume":"9","author":"Tan","year":"2013","journal-title":"Alzheimers Dement."},{"key":"B46","doi-asserted-by":"publisher","first-page":"212.e5","DOI":"10.1016\/j.neurobiolaging.2017.03.013","article-title":"Decreased gene expression of CD2AP in Chinese patients with sporadic Alzheimer\u2019s disease.","volume":"56","author":"Tao","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"B47","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.nrl.2015.08.002","article-title":"Early- and late-onset Alzheimer disease: are they the same entity?","volume":"33","author":"Tellechea","year":"2018","journal-title":"Neurologia"},{"key":"B48","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1146\/annurev-genom-091212-153455","article-title":"Major histocompatibility complex genomics and human disease.","volume":"14","author":"Trowsdale","year":"2013","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"B49","doi-asserted-by":"publisher","first-page":"3181","DOI":"10.1007\/s12035-016-9890-6","article-title":"Effects of HLA-DRB1\/DQB1 genetic variants on neuroimaging in healthy, mild cognitive impairment, and Alzheimer\u2019s disease cohorts.","volume":"54","author":"Wang","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"3113","DOI":"10.1007\/s12035-015-9211-5","article-title":"Education and risk of dementia: dose-response meta-analysis of prospective cohort studies.","volume":"53","author":"Xu","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1016\/j.bbrc.2016.09.018","article-title":"Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of gamma-secretase.","volume":"478","author":"Yonemura","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B52","doi-asserted-by":"publisher","first-page":"39044","DOI":"10.18632\/oncotarget.9679","article-title":"FERMT2 rs17125944 polymorphism with Alzheimer\u2019s disease risk: a replication and meta-analysis.","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnagi.2020.00016\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T05:30:50Z","timestamp":1580794250000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnagi.2020.00016\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,4]]},"references-count":52,"alternative-id":["10.3389\/fnagi.2020.00016"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2020.00016","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,4]]},"article-number":"16"}}