{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T20:32:33Z","timestamp":1771014753686,"version":"3.50.1"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"DOI":"10.3389\/fnagi.2020.00054","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T04:53:42Z","timestamp":1583816022000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":39,"title":["Hypoxia-Inducible Factor 1\u03b1 and 2\u03b1 Have Beneficial Effects in Remote Ischemic Preconditioning Against Stroke by Modulating Inflammatory Responses in Aged Rats"],"prefix":"10.3389","volume":"12","author":[{"given":"Xiangnan","family":"Du","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuiying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sainan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chencheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huishan","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaokun","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,3,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"17462","DOI":"10.1073\/pnas.1317158110","article-title":"Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart","volume":"110","author":"Cai","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B2","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1093\/cvr\/cvm035","article-title":"Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1\u03b1","volume":"77","author":"Cai","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s12974-018-1190-9","article-title":"Splenic responses play an important role in remote ischemic preconditioning-mediated neuroprotection against stroke","volume":"15","author":"Chen","year":"2018","journal-title":"J. Neuroinflmmation"},{"key":"B4","doi-asserted-by":"publisher","first-page":"3282","DOI":"10.1093\/brain\/aws269","article-title":"The novel proteasome inhibitor BSc2118 protects against cerebral ischemia through HIF1A accumulation and enhanced angioneurogenesis","volume":"135","author":"Doeppner","year":"2012","journal-title":"Brain"},{"key":"B5","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s10741-007-9026-1","article-title":"Reperfusion injury salvage kinase signalling: taking a RISK for cardioprotection","volume":"12","author":"Hausenloy","year":"2007","journal-title":"Heart Fail. Rev."},{"key":"B6","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.brainres.2012.04.017","article-title":"Noninvasive limb remote ischemic preconditioning contributes neuroprotective effects via activation of adenosine A1 receptor and redox status after transient focal cerebral ischemia in rats","volume":"1459","author":"Hu","year":"2012","journal-title":"Brain Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2396","DOI":"10.1172\/JCI69073","article-title":"Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury","volume":"124","author":"Kapitsinou","year":"2014","journal-title":"J. Clin. Invest."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e259","DOI":"10.1016\/S2214-109X(13)70089-5","article-title":"Global and regional burden of first-ever ischemic and haemorrhagic stroke during 1990\u20132010: findings from the Global Burden of Disease Study 2010","volume":"5","author":"Krishnamurthi","year":"2013","journal-title":"Lancet Glob. Health"},{"key":"B9","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1002\/syn.20800","article-title":"Enhanced IL-1\u03b1 production in response to the activation of hippocampal glial cells impairs neurogenesis in aged mice","volume":"64","author":"Kuzumaki","year":"2010","journal-title":"Synapse"},{"key":"B10","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/cns.12448","article-title":"Remote ischemic preconditioning-mediated neuroprotection against stroke is associated with significant alterations in peripheral immune responses","volume":"22","author":"Liu","year":"2016","journal-title":"CNS Neurosci. Ther."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1124\/mol.108.053157","article-title":"Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2 to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2 has a role in NGF-promoted survival of sympathetic neurons","volume":"75","author":"Lomb","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.expneurol.2013.08.011","article-title":"Differential effects of aging and sex on stroke induced inflammation across the lifespan","volume":"249","author":"Manwani","year":"2013","journal-title":"Exp. Neurol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"137","DOI":"10.3389\/fphys.2015.00137","article-title":"Novel perspectives on the PHD-HIF oxygen sensing pathway in cardioprotection mediated by IPC and RIPC","volume":"6","author":"Martin-Puig","year":"2015","journal-title":"Front. Physiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1080\/10739680701641421","article-title":"Age-related alterations in reactivity of cerebral arterioles: role of oxidative stress","volume":"15","author":"Mayhan","year":"2008","journal-title":"Microcirculation"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1152\/japplphysiol.00169.2015","article-title":"A critical review of mechanisms regulating remote preconditioning-induced brain protection","volume":"119","author":"Meller","year":"2015","journal-title":"J. Appl. Physiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1159\/000447536","article-title":"The interventional effect of remote ischemic preconditioning on cerebral small vessel disease: a pilot randomized clinical trial","volume":"76","author":"Mi","year":"2016","journal-title":"Eur. Neurol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"H1914","DOI":"10.1152\/ajpheart.00300.2009","article-title":"Role of oxidative stress and AT1 receptors in cerebral vascular dysfunction with aging","volume":"296","author":"Modrick","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"e29","DOI":"10.1161\/CIR.0000000000000152","article-title":"Heart disease and stroke statistics\u20142015 update: a report from the american heart association","volume":"131","author":"Mozaffarian","year":"2015","journal-title":"Circulation"},{"key":"B19","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s40478-016-0371-y","article-title":"Multiplex immunoassay characterization and species comparison of inflammation in acute and non-acute ischemic infarcts in human and mouse brain tissue","volume":"4","author":"Nguyen","year":"2016","journal-title":"Acta Neuropathol. Commun."},{"key":"B20","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.nbd.2011.10.020","article-title":"Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1\u03b1","volume":"45","author":"Ogle","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"B21","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1160\/TH14-07-0592","article-title":"Akt protects the heart against ischaemia-reperfusion injury by modulating mitochondrial morphology","volume":"113","author":"Ong","year":"2015","journal-title":"Thromb. Haemost."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2013.07.008","article-title":"Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice","volume":"35","author":"Orre","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"B24","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1179\/016164111x13007856084241","article-title":"Remote ischemic post-conditioning reduced brain damage in experimental ischemia\/reperfusion injury","volume":"33","author":"Ren","year":"2011","journal-title":"Neurol. Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.brainres.2009.07.029","article-title":"Limb remote ischemic postconditioning protects against focal ischemia in rats","volume":"1288","author":"Ren","year":"2009","journal-title":"Brain Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.cell.2012.01.021","article-title":"Hypoxia-inducible factors in physiology and medicine","volume":"148","author":"Semenza","year":"2012","journal-title":"Cell"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pneurobio.2013.04.001","article-title":"Brain development in rodents and humans: identifying benchmarks of maturation and vulnerability to injury across species","author":"Semple","year":"2013","journal-title":"Prog. Neurobiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1515\/bc.2004.016","article-title":"HIF-1 and oxygen sensing in the brain","volume":"5","author":"Sharp","year":"2004","journal-title":"Nat. Rev."},{"key":"B28","doi-asserted-by":"publisher","first-page":"E64","DOI":"10.3390\/ijms17010064","article-title":"Ischemia, immunosuppression and infection\u2014tackling the predicaments of post-stroke complications","volume":"17","author":"Shim","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.expneurol.2015.03.021","article-title":"White matter injury and microglia\/macrophage polarization are strongly linked with age-related long-term deficits in neurological function after stroke","volume":"272","author":"Suenaga","year":"2015","journal-title":"Exp. Neurol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.neulet.2012.08.078","article-title":"Protection by silibinin against experimental ischemic stroke: upregulated pAkt, pmTOR, HIF-1\u03b1 and Bcl-2, down-regulated Bax, NF-\u03baB expression","volume":"1","author":"Wang","year":"2012","journal-title":"Neurosci. Lett."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1007\/s10753-017-0573-x","article-title":"Salidroside inhibits inflammation through PI3K\/Akt\/HIF signaling after focal cerebral ischemia in rats","volume":"40","author":"Wei","year":"2017","journal-title":"Inflammation"},{"key":"B31","doi-asserted-by":"publisher","first-page":"e30892","DOI":"10.1371\/journal.pone.0030892","article-title":"The chronic protective effects of limb remote preconditioning and the underlying mechanisms involved in inflammatory factors in rat stroke","volume":"7","author":"Wei","year":"2012","journal-title":"PLoS One"},{"key":"B33","doi-asserted-by":"publisher","first-page":"e0171521","DOI":"10.1371\/journal.pone.0171521","article-title":"Gut dysbiosis is associated with metabolism and systemic inflammation in patients with ischemic stroke","volume":"12","author":"Yamashiro","year":"2017","journal-title":"PLoS One"},{"key":"B34","doi-asserted-by":"publisher","first-page":"e007589","DOI":"10.1161\/JAHA.117.007589","article-title":"Hypoxia inducible factor 1\u03b1 plays a key role in remote ischemic preconditioning against stroke by modulating inflammatory responses in rats","volume":"7","author":"Yang","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1007\/s10571-015-0203-9","article-title":"Electroacupuncture pretreatment attenuates cerebral ischemic injury via notch pathway-mediated up-regulation of hypoxia inducible factor-1\u03b1 in rats","volume":"35","author":"Zhao","year":"2015","journal-title":"Cell Mol. Neurobiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1161\/circulationaha.116.024807","article-title":"Safety and efficacy of remote ischemic preconditioning in patients with severe carotid artery stenosis before carotid artery stenting: a proof-of-concept, randomized controlled trial","volume":"135","author":"Zhao","year":"2017","journal-title":"Circulation"},{"key":"B35","doi-asserted-by":"publisher","first-page":"9794","DOI":"10.1523\/JNEUROSCI.3163-05.2005","article-title":"Akt contributes to neuroprotection by hypothermia against cerebral ischemia in rats","volume":"25","author":"Zhao","year":"2005","journal-title":"J. Neurosci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1038\/aps.2017.122","article-title":"Age-related differences in interferon regulatory factor-4 and -5 signaling in ischemic brains of mice","volume":"38","author":"Zhao","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.1089\/scd.2011.0604","article-title":"Hypoxia-inducible factor 1-a-AA-modified bone marrow stem cells protect PC12 cells from hypoxia-induced apoptosis, partially through VEGF\/PI3K\/Akt\/FoxO1 pathway","volume":"21","author":"Zhong","year":"2012","journal-title":"Stem Cells Dev."},{"key":"B40","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s12868-015-0235-6","article-title":"Limb remote ischemic postconditioning protects cerebral ischemia from injury associated with expression of HIF-1\u03b1 in rats","volume":"16","author":"Zong","year":"2015","journal-title":"BMC Neurosci."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnagi.2020.00054\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T04:53:44Z","timestamp":1583816024000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnagi.2020.00054\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,10]]},"references-count":40,"alternative-id":["10.3389\/fnagi.2020.00054"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2020.00054","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,10]]},"article-number":"54"}}