{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:29:13Z","timestamp":1784291353466,"version":"3.55.0"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T00:00:00Z","timestamp":1597968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"DOI":"10.3389\/fnagi.2020.00248","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T13:23:45Z","timestamp":1598016225000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Chronic Periodontitis and Alzheimer Disease: A Putative Link of Serum Proteins Identification by 2D-DIGE Proteomics"],"prefix":"10.3389","volume":"12","author":[{"given":"Xianfang","family":"Rong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfa","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Defeng","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xincai","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,8,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1002\/ca.980080612","article-title":"An English translation of Alzheimer\u2019s 1907 paper, \u201cUber eine eigenartige Erkankung der Hirnrinde\u201d","volume":"8","author":"Alzheimer","year":"1995","journal-title":"Clin. Anat."},{"key":"B2","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1002\/acn3.221","article-title":"Cerebrospinal fluid aquaporin-4-immunoglobulin G disrupts blood brain barrier","volume":"2","author":"Asgari","year":"2015","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"72","DOI":"10.3389\/fninf.2019.00072","article-title":"Identifying vulnerable brain networks in mouse models of genetic risk factors for late onset alzheimer\u2019s disease","volume":"13","author":"Badea","year":"2019","journal-title":"Front. Neuroinform."},{"key":"B4","first-page":"2","article-title":"Pathologic crossroads: cardio-vascular diseases, periodontal diseases and calcium antagonists","volume":"4","author":"Balan","year":"2011","journal-title":"J. Med. Life"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.2147\/COPD.S207203","article-title":"Bacterial load and inflammatory response in sputum of \u03b1-1 antitrypsin deficiency patients with COPD","volume":"14","author":"Balbi","year":"2019","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"B6","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1021\/acschemneuro.7b00410","article-title":"Advanced glycation end products modulate amyloidogenic APP processing and tau phosphorylation: a mechanistic link between glycation and the development of Alzheimer\u2019s disease","volume":"9","author":"Batkulwar","year":"2018","journal-title":"ACS Chem. Neurosci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s13195-017-0282-6","article-title":"Association between chronic periodontitis and the risk of Alzheimer\u2019s disease: a retrospective, population-based, matched-cohort study","volume":"9","author":"Chen","year":"2017","journal-title":"Alzheimers Res. Ther."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1111\/trf.14601","article-title":"Elevated free hemoglobin and decreased haptoglobin levels are associated with adverse clinical outcomes, unfavorable physiologic measures and altered inflammatory markers in pediatric cardiac surgery patients","volume":"58","author":"Cholette","year":"2018","journal-title":"Transfusion"},{"key":"B9","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.cellimm.2011.11.003","article-title":"Tannic acid suppresses ultraviolet B-induced inflammatory signaling and complement factor B on human retinal pigment epithelial cells","volume":"273","author":"Chou","year":"2012","journal-title":"Cell Immunol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"eaau3333","DOI":"10.1126\/sciadv.aau3333","article-title":"Porphyromonas gingivalis in Alzheimer\u2019s disease brains: evidence for disease causation and treatment with small-molecule inhibitors","volume":"5","author":"Dominy","year":"2019","journal-title":"Sci. Adv."},{"key":"B11","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/978-1-4939-7268-5_19","article-title":"DIGE analysis of immunodepleted plasma","volume":"1664","author":"Dowling","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1007\/s10072-016-2647-1","article-title":"Vitamin D deficiency might pose a greater risk for ApoEvarepsilon4 non-carrier Alzheimer\u2019s disease patients","volume":"37","author":"Dursun","year":"2016","journal-title":"Neurol. Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1111\/ggi.12425","article-title":"Alzheimer\u2019s disease and chronic periodontitis: is there an association?","volume":"15","author":"Gaur","year":"2015","journal-title":"Geriatr. Gerontol. Int."},{"key":"B14","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/ger.12431","article-title":"Systemic inflammatory impact of periodontitis on cognitive impairment","volume":"37","author":"Gil Montoya","year":"2020","journal-title":"Gerodontology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1902\/jop.2017.170071","article-title":"Association between periodontitis and amyloid \u03b2 peptide in elderly people with and without cognitive impairment","volume":"88","author":"Gil-Montoya","year":"2017","journal-title":"J. Periodontol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"337","DOI":"10.3233\/jad-170046","article-title":"Can better management of periodontal disease delay the onset and progression of Alzheimer\u2019s disease?","volume":"58","author":"Harding","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"B17","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer\u2019s disease: the amyloid cascade hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"B18","doi-asserted-by":"publisher","first-page":"fcz003","DOI":"10.1093\/braincomms\/fcz003","article-title":"Clusterin accumulates in synapses in Alzheimer\u2019s disease and is increased in apolipoprotein E4 carriers","volume":"1","author":"Jackson","year":"2019","journal-title":"Brain Commun."},{"key":"B19","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.neurobiolaging.2014.10.038","article-title":"Periodontal disease associates with higher brain amyloid load in normal elderly","volume":"36","author":"Kamer","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"B20","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/sj.bdj.2009.818","article-title":"Gingivitis as a risk factor in periodontal disease","volume":"36","author":"Lang","year":"2009","journal-title":"J. Clin. Periodontol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1111\/eos.12227","article-title":"Periodontal disease classifications revisited","volume":"123","author":"L\u00f3pez","year":"2015","journal-title":"Eur. J. Oral Sci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"e95684","DOI":"10.1371\/journal.pone.0095684","article-title":"Specific changes of serum proteins in Parkinson\u2019s disease patients","volume":"9","author":"Lu","year":"2014","journal-title":"PLoS One"},{"key":"B23","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1177\/0022034515611876","article-title":"Epigenetic modifications of histones in periodontal disease","volume":"95","author":"Martins","year":"2016","journal-title":"J. Dent. Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.pscychresns.2018.06.009","article-title":"Dental health in advanced age and Alzheimer\u2019s disease: a possible link with bacterial toxins entering the brain?","volume":"282","author":"Maurer","year":"2018","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"B25","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/978-1-4939-7268-5_10","article-title":"DIGE analysis of proteominer(TM) fractionated serum\/plasma samples","volume":"1664","author":"Murphy","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"479","DOI":"10.3233\/jad-190298","article-title":"Porphyromonas gingivalis infection induces Amyloid-\u03b2 accumulation in monocytes\/macrophages","volume":"72","author":"Nie","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1676486","DOI":"10.1080\/20002297.2019.1676486","article-title":"Is there a link between genetic defects in the complement cascade and Porphyromonas gingivalis in Alzheimer\u2019s disease?","volume":"12","author":"Olsen","year":"2020","journal-title":"J. Oral Microbiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1097\/mib.0000000000000035","article-title":"Mucosal toll-like receptor 3-dependent synthesis of complement factor B and systemic complement activation in inflammatory bowel disease","volume":"20","author":"Ostvik","year":"2014","journal-title":"Inflamm. Bowel Dis."},{"key":"B29","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/978-1-4939-7231-9_17","article-title":"2D-DIGE in proteomics","volume":"1654","author":"Pasquali","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.nrl.2016.07.013","article-title":"Association between periodontal disease and dementia: a literature review","volume":"33","author":"Pazos","year":"2018","journal-title":"Neurologia"},{"key":"B31","doi-asserted-by":"publisher","first-page":"21071","DOI":"10.1074\/jbc.m117.811448","article-title":"A mechanistic model to predict effects of cathepsin B and cystatin C on \u03b2-amyloid aggregation and degradation","volume":"292","author":"Perlenfein","year":"2017","journal-title":"J. Biol. Chem."},{"key":"B32","doi-asserted-by":"publisher","first-page":"336","DOI":"10.3389\/fnagi.2017.00336","article-title":"Periodontitis, microbiomes and their role in Alzheimer\u2019s disease","volume":"9","author":"Pritchard","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"344","DOI":"10.4103\/0028-3886.227315","article-title":"Can oral microbial infections be a risk factor for neurodegeneration? A review of the literature","volume":"66","author":"Ranjan","year":"2018","journal-title":"Neurol. India"},{"key":"B34","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3390\/antibiotics8040209","article-title":"Impact of periodontal inflammation on nutrition and inflammation markers in hemodialysis patients","volume":"8","author":"Rapone","year":"2019","journal-title":"Antibiotics"},{"key":"B35","doi-asserted-by":"publisher","first-page":"123","DOI":"10.2147\/dnnd.s228939","article-title":"Alzheimer\u2019s disease\u2014why we need early diagnosis","volume":"9","author":"Rasmussen","year":"2019","journal-title":"Degener Neurol. Neuromuscul. Dis."},{"key":"B36","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.4049\/jimmunol.1801045","article-title":"Circulating truncated \u03b1-1 antitrypsin glycoprotein in patient plasma retains anti-inflammatory capacity","volume":"202","author":"Reeves","year":"2019","journal-title":"J. Immunol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1111\/cns.12716","article-title":"The pathological roles of NDRG2 in Alzheimer\u2019s disease, a study using animal models and APPwt-overexpressed cells","volume":"23","author":"Rong","year":"2017","journal-title":"CNS Neurosci. Ther."},{"key":"B38","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3389\/fnagi.2014.00071","article-title":"Possible modification of Alzheimer\u2019s disease by statins in midlife: interactions with genetic and non-genetic risk factors","volume":"6","author":"Shinohara","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"137357","DOI":"10.1155\/2015\/137357","article-title":"Porphyromonas gingivalis periodontal infection and its putative links with Alzheimer\u2019s disease","volume":"2015","author":"Singhrao","year":"2015","journal-title":"Mediators Inflamm."},{"key":"B39","doi-asserted-by":"publisher","first-page":"219","DOI":"10.3233\/adr-180080","article-title":"Are Porphyromonas gingivalis outer membrane vesicles microbullets for sporadic Alzheimer\u2019s disease manifestation?","volume":"2","author":"Singhrao","year":"2018","journal-title":"J. Alzheimers Dis. Rep."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1563405","DOI":"10.1080\/20002297.2018.1563405","article-title":"Assessing the role of Porphyromonas gingivalis in periodontitis to determine a causative relationship with Alzheimer\u2019s disease","volume":"11","author":"Singhrao","year":"2019","journal-title":"J. Oral Microbiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1016\/j.bbamcr.2018.06.015","article-title":"Modeling endophilin-mediated A\u03b2 disposal in glioma cells","volume":"1865","author":"Sun","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"269","DOI":"10.3233\/jad-142805","article-title":"Translational study of Alzheimer\u2019s disease (AD) biomarkers from brain tissues in A\u03b2PP\/PS1 mice and serum of AD patients","volume":"45","author":"Sun","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"B44","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1111\/jgs.16275","article-title":"The risk of head injuries associated with antipsychotic use among persons With Alzheimer\u2019s disease","volume":"68","author":"Tapiainen","year":"2020","journal-title":"J. Am. Geriatr. Soc."},{"key":"B45","doi-asserted-by":"publisher","first-page":"327","DOI":"10.3389\/fnagi.2017.00327","article-title":"Periodontitis and Alzheimer\u2019s disease: a possible comorbidity between oral chronic inflammatory condition and neuroinflammation","volume":"9","author":"Teixeira","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.bbi.2019.07.002","article-title":"Systemic inflammation linking chronic periodontitis to cognitive decline","volume":"81","author":"Wang","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"B47","doi-asserted-by":"publisher","first-page":"471342","DOI":"10.1155\/2015\/471342","article-title":"Lessons from microglia aging for the link between inflammatory bone disorders and Alzheimer\u2019s disease","volume":"2015","author":"Wu","year":"2015","journal-title":"J. Immunol. Res."},{"key":"B48","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.bbi.2017.06.002","article-title":"Cathepsin B plays a critical role in inducing Alzheimer\u2019s disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice","volume":"65","author":"Wu","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"B49","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/joim.12619","article-title":"The haptoglobin \u03b2 subunit sequesters HMGB1 toxicity in sterile and infectious inflammation","volume":"282","author":"Yang","year":"2017","journal-title":"J. Intern. Med."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnagi.2020.00248\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T13:23:49Z","timestamp":1598016229000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnagi.2020.00248\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,21]]},"references-count":49,"alternative-id":["10.3389\/fnagi.2020.00248"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2020.00248","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,21]]},"article-number":"248"}}