{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T22:32:01Z","timestamp":1774737121703,"version":"3.50.1"},"reference-count":89,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T00:00:00Z","timestamp":1597968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"DOI":"10.3389\/fnagi.2020.00251","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T12:09:33Z","timestamp":1598011773000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Antenatal Hypoxia Accelerates the Onset of Alzheimer\u2019s Disease Pathology in 5xFAD Mouse Model"],"prefix":"10.3389","volume":"12","author":[{"given":"Guofang","family":"Shen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lubo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,8,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"563","DOI":"10.2174\/156720512800617991","article-title":"Alzheimer\u2019s disease and environmental exposure to lead: the epidemiologic evidence and potential role of epigenetics","volume":"9","author":"Bakulski","year":"2012","journal-title":"Curr. Alzheimer Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1136\/jech.58.2.114","article-title":"Developmental origins of adult health and disease","volume":"58","author":"Barker","year":"2004","journal-title":"J. Epidemiol. Community Health"},{"key":"B3","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/0140-6736(93)90995-s","article-title":"Fetal nutrition and cardiovascular disease in adult life","volume":"341","author":"Barker","year":"1993","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1080\/03014460902980295","article-title":"Growth and chronic disease: findings in the Helsinki birth cohort","volume":"36","author":"Barker","year":"2009","journal-title":"Ann. Hum. Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1523\/JNEUROSCI.4335-04.2005","article-title":"The fetal basis of amyloidogenesis: exposure to lead and latent overexpression of amyloid precursor protein and \u03b2-amyloid in the aging brain","volume":"25","author":"Basha","year":"2005","journal-title":"J. Neurosci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1038\/nn.3560","article-title":"TGF-\u03b2 signaling regulates neuronal C1q expression and developmental synaptic refinement","volume":"16","author":"Bialas","year":"2013","journal-title":"Nat. Neurosci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"6764","DOI":"10.1523\/JNEUROSCI.5794-10.2011","article-title":"Common Alzheimer\u2019s disease risk variant within the CLU gene affects white matter microstructure in young adults","volume":"31","author":"Braskie","year":"2011","journal-title":"J. Neurosci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1177\/0271678x17750324","article-title":"Fetal brain sparing in a mouse model of chronic maternal hypoxia","volume":"39","author":"Cahill","year":"2019","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B9","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/s41598-018-37312-0","article-title":"Dissociable cognitive impairments in two strains of transgenic Alzheimer\u2019s disease mice revealed by a battery of object-based tests","volume":"9","author":"Creighton","year":"2019","journal-title":"Sci. Rep."},{"key":"B10","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/s00429-013-0518-6","article-title":"Spine pruning in 5xFAD mice starts on basal dendrites of layer 5 pyramidal neurons","volume":"219","author":"Crowe","year":"2014","journal-title":"Brain Struct. Funct."},{"key":"B11","doi-asserted-by":"publisher","first-page":"32046","DOI":"10.1074\/jbc.m201750200","article-title":"Oligomeric and fibrillar species of amyloid-\u03b2 peptides differentially affect neuronal viability","volume":"277","author":"Dahlgren","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B12","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/j.1479-828X.2006.00506.x","article-title":"The developmental origins of adult disease (Barker) hypothesis","volume":"46","author":"de Boo","year":"2006","journal-title":"Aust. N Z J. Obstet. Gynaecol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1002\/ana.410270502","article-title":"Synapse loss in frontal cortex biopsies in Alzheimer\u2019s disease: correlation with cognitive severity","volume":"27","author":"DeKosky","year":"1990","journal-title":"Ann. Neurol."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.10.013","article-title":"Microglial memory of early life stress and inflammation: susceptibility to neurodegeneration in adulthood","author":"Desplats","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B15","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/1742-2094-9-71","article-title":"Prenatal stress causes alterations in the morphology of microglia and the inflammatory response of the hippocampus of adult female mice","volume":"9","author":"Diz-Chaves","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1750-1326-8-2","article-title":"Neuron loss in the 5XFAD mouse model of Alzheimer\u2019s disease correlates with intraneuronal A\u03b242 accumulation and Caspase-3 activation","volume":"8","author":"Eimer","year":"2013","journal-title":"Mol. Neurodegener."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1172\/jci25100","article-title":"The role of cerebral amyloid \u03b2 accumulation in common forms of Alzheimer disease","volume":"115","author":"Gandy","year":"2005","journal-title":"J. Clin. Invest."},{"key":"B18","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.nbd.2016.01.001","article-title":"Cerebrovascular pathology during the progression of experimental Alzheimer\u2019s disease","volume":"88","author":"Giannoni","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"B19","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s42000-018-0007-7","article-title":"Perinatal hypoxia as a risk factor for psychopathology later in life: the role of dopamine and neurotrophins","volume":"17","author":"Giannopoulou","year":"2018","journal-title":"Hormones"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1126\/science.1095292","article-title":"Living with the past: evolution, development, and patterns of disease","volume":"305","author":"Gluckman","year":"2004","journal-title":"Science"},{"key":"B21","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1056\/NEJMra0708473","article-title":"Effect of in utero and early-life conditions on adult health and disease","volume":"359","author":"Gluckman","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.nbd.2014.01.020","article-title":"Fetal hypoxia increases vulnerability of hypoxic-ischemic brain injury in neonatal rats: role of glucocorticoid receptors","volume":"65","author":"Gonzalez-Rodriguez","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"B23","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1159\/000085895","article-title":"Hypoxia-induced intrauterine growth retardation: effects on pulmonary development and surfactant protein transcription","volume":"88","author":"Gortner","year":"2005","journal-title":"Biol. Neonate"},{"key":"B24","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.conb.2017.10.007","article-title":"Environment matters: microglia function and dysfunction in a changing world","volume":"47","author":"Hanamsagar","year":"2017","journal-title":"Curr. Opin. Neurobiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"B26","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.yhbeh.2010.06.007","article-title":"Glucocorticoids, prenatal stress and the programming of disease","volume":"59","author":"Harris","year":"2011","journal-title":"Horm. Behav."},{"key":"B27","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/s0736-5748(98)00028-8","article-title":"Maternal stress induces synaptic loss and developmental disabilities of offspring","volume":"16","author":"Hayashi","year":"1998","journal-title":"Int. J. Dev. Neurosci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1212\/WNL.0b013e31828726f5","article-title":"Alzheimer disease in the United States (2010\u20132050) estimated using the 2010 census","volume":"80","author":"Hebert","year":"2013","journal-title":"Neurology"},{"key":"B29","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s00401-018-1834-y","article-title":"Capillary cerebral amyloid angiopathy in Alzheimer\u2019s disease: association with allocortical\/hippocampal microinfarcts and cognitive decline","volume":"135","author":"Hecht","year":"2018","journal-title":"Acta Neuropathol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"e818","DOI":"10.1542\/peds.2014-3556","article-title":"Late preterm birth and neurocognitive performance in late adulthood: a birth cohort study","volume":"135","author":"Heinonen","year":"2015","journal-title":"Pediatrics"},{"key":"B31","doi-asserted-by":"publisher","first-page":"233","DOI":"10.3389\/fnagi.2019.00233","article-title":"Microglia in Alzheimer disease: well-known targets and new opportunities","volume":"11","author":"Hemonnot","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"16755","DOI":"10.1523\/JNEUROSCI.4521-10.2010","article-title":"Reimagining Alzheimer\u2019s disease\u2014an age-based hypothesis","volume":"30","author":"Herrup","year":"2010","journal-title":"J. Neurosci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1126\/science.aad8373","article-title":"Complement and microglia mediate early synapse loss in Alzheimer mouse models","volume":"352","author":"Hong","year":"2016","journal-title":"Science"},{"key":"B34","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA research framework: toward a biological definition of Alzheimer\u2019s disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement."},{"key":"B35","doi-asserted-by":"publisher","first-page":"196.e29","DOI":"10.1016\/j.neurobiolaging.2010.05.027","article-title":"Motor deficits, neuron loss and reduced anxiety coinciding with axonal degeneration and intraneuronal A\u03b2 aggregation in the 5XFAD mouse model of Alzheimer\u2019s disease","volume":"33","author":"Jawhar","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"B36","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1006\/ebeh.2001.0158","article-title":"Current management of epilepsy and pregnancy: fetal outcome, congenital malformations, and developmental delay","volume":"2","author":"Katz","year":"2001","journal-title":"Epilepsy Behav."},{"key":"B37","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1186\/s12877-016-0342-y","article-title":"Environmental risk factors for dementia: a systematic review","volume":"16","author":"Killin","year":"2016","journal-title":"BMC Geriatr."},{"key":"B38","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1038\/mp.2009.82","article-title":"The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases","volume":"14","author":"Lahiri","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"B39","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1159\/000273066","article-title":"Developmental origins of adult disease","volume":"19","author":"Langley-Evans","year":"2010","journal-title":"Med. Princ. Pract."},{"key":"B40","doi-asserted-by":"publisher","first-page":"522","DOI":"10.2174\/1389202919666171229145156","article-title":"Early life stress and epigenetics in late-onset Alzheimer\u2019s dementia: a systematic review","volume":"19","author":"Lemche","year":"2018","journal-title":"Curr. Genomics"},{"key":"B41","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s13195-018-0422-7","article-title":"Vulnerability and resilience to Alzheimer\u2019s disease: early life conditions modulate neuropathology and determine cognitive reserve","volume":"10","author":"Lesuis","year":"2018","journal-title":"Alzheimers Res. Ther."},{"key":"B42","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.nlm.2017.05.016","article-title":"Early postnatal handling reduces hippocampal amyloid plaque formation and enhances cognitive performance in APPswe\/PS1dE9 mice at middle age","volume":"144","author":"Lesuis","year":"2017","journal-title":"Neurobiol. Learn. Mem."},{"key":"B43","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.pneurobio.2012.05.010","article-title":"Fetal stress and programming of hypoxic\/ischemic-sensitive phenotype in the neonatal brain: mechanisms and possible interventions","volume":"98","author":"Li","year":"2012","journal-title":"Prog. Neurobiol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"3988","DOI":"10.1007\/s12035-016-9957-4","article-title":"Inhibition of DNA methylation in the developing rat brain disrupts sexually dimorphic neurobehavioral phenotypes in adulthood","volume":"54","author":"Li","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.expneurol.2015.10.007","article-title":"Fetal stress-mediated hypomethylation increases the brain susceptibility to hypoxic-ischemic injury in neonatal rats","volume":"275","author":"Li","year":"2016","journal-title":"Exp. Neurol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"R803","DOI":"10.1152\/ajpregu.00218.2019","article-title":"Perinatal nicotine exposure alters Akt\/GSK-3\u03b2\/mTOR\/autophagy signaling, leading to development of hypoxic-ischemic-sensitive phenotype in rat neonatal brain","volume":"317","author":"Li","year":"2019","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"B48","doi-asserted-by":"publisher","first-page":"323","DOI":"10.3389\/fphys.2019.00323","article-title":"Antenatal hypoxia and programming of glucocorticoid receptor expression in the adult rat heart","volume":"10","author":"Lv","year":"2019","journal-title":"Front. Physiol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.nbd.2016.02.011","article-title":"Inhibition of microRNA-210 provides neuroprotection in hypoxic-ischemic brain injury in neonatal rats","volume":"89","author":"Ma","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1016\/j.drudis.2014.09.010","article-title":"Gestational hypoxia and epigenetic programming of brain development disorders","volume":"19","author":"Ma","year":"2014","journal-title":"Drug Discov. Today"},{"key":"B51","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13024-018-0286-0","article-title":"Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-\u03b242 by LRP1-dependent apolipoprotein E isoform-specific mechanism","volume":"13","author":"Ma","year":"2018","journal-title":"Mol. Neurodegener."},{"key":"B52","doi-asserted-by":"publisher","first-page":"80249","DOI":"10.18632\/oncotarget.17801","article-title":"MicroRNA-210 suppresses glucocorticoid receptor expression in response to hypoxia in fetal rat cardiomyocytes","volume":"8","author":"Martinez","year":"2017","journal-title":"Oncotarget"},{"key":"B53","doi-asserted-by":"publisher","first-page":"328","DOI":"10.3390\/genes11030328","article-title":"Fetal hypoxia impacts on proliferation and differentiation of Sca-1+ cardiac progenitor cells and maturation of cardiomyocytes: a role of MicroRNA-210","volume":"11","author":"Meng","year":"2020","journal-title":"Genes"},{"key":"B54","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1113\/jp271402","article-title":"The consequences of fetal growth restriction on brain structure and neurodevelopmental outcome","volume":"594","author":"Miller","year":"2016","journal-title":"J. Physiol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1212\/wnl.54.2.415","article-title":"Early-life risk factors and the development of Alzheimer\u2019s disease","volume":"54","author":"Moceri","year":"2000","journal-title":"Neurology"},{"key":"B56","doi-asserted-by":"publisher","first-page":"e1002609","DOI":"10.1371\/journal.pmed.1002609","article-title":"Associations between birth characteristics and age-related cognitive impairment and dementia: a registry-based cohort study","volume":"15","author":"Mosing","year":"2018","journal-title":"PLoS Med."},{"key":"B57","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1146\/annurev-immunol-032713-120240","article-title":"Microglia development and function","volume":"32","author":"Nayak","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal \u03b2-amyloid aggregates, neurodegeneration and neuron loss in transgenic mice with five familial Alzheimer\u2019s disease mutations: potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J. Neurosci."},{"key":"B59","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/s0896-6273(03)00810-9","article-title":"BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer\u2019s disease","volume":"41","author":"Ohno","year":"2004","journal-title":"Neuron"},{"key":"B60","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.bbr.2017.09.009","article-title":"Motor function deficits in the 12 month-old female 5xFAD mouse model of Alzheimer\u2019s disease","volume":"337","author":"O\u2019Leary","year":"2018","journal-title":"Behav. Brain Res."},{"key":"B61","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.pneurobio.2016.01.001","article-title":"Astrogliosis: an integral player in the pathogenesis of Alzheimer\u2019s disease","volume":"144","author":"Osborn","year":"2016","journal-title":"Prog. Neurobiol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1126\/science.1202529","article-title":"Synaptic pruning by microglia is necessary for normal brain development","volume":"333","author":"Paolicelli","year":"2011","journal-title":"Science"},{"key":"B63","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/nrneurol.2014.38","article-title":"Microglial priming in neurodegenerative disease","volume":"10","author":"Perry","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/pr.2015.4","article-title":"Impact of inhaled nitric oxide on white matter damage in growth-restricted neonatal rats","volume":"77","author":"Pham","year":"2015","journal-title":"Pediatr. Res."},{"key":"B65","doi-asserted-by":"publisher","first-page":"9079","DOI":"10.1038\/s41598-017-06300-1","article-title":"Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development","volume":"7","author":"Phillips","year":"2017","journal-title":"Sci. Rep."},{"key":"B66","doi-asserted-by":"publisher","first-page":"566","DOI":"10.3389\/fnhum.2016.00566","article-title":"The indispensable roles of microglia and astrocytes during brain development","volume":"10","author":"Reemst","year":"2016","journal-title":"Front. Hum. Neurosci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"e9665","DOI":"10.15252\/emmm.201809665","article-title":"Inhibition of Stat3-mediated astrogliosis ameliorates pathology in an Alzheimer\u2019s disease model","volume":"11","author":"Reichenbach","year":"2019","journal-title":"EMBO Mol. Med."},{"key":"B68","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1097\/00005072-199655100-00001","article-title":"The pathogenesis of Alzheimer disease: an alternative to the amyloid hypothesis","volume":"56","author":"Rosenblum","year":"1997","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"3240","DOI":"10.1172\/JCI90606","article-title":"Microglia in Alzheimer\u2019s disease","volume":"127","author":"Sarlus","year":"2017","journal-title":"J. Clin. Invest."},{"key":"B70","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.neuron.2012.03.026","article-title":"Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner","volume":"74","author":"Schafer","year":"2012","journal-title":"Neuron"},{"key":"B71","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1159\/000439568","article-title":"Early life epidemiology of Alzheimer\u2019s disease\u2019a critical review","volume":"45","author":"Seifan","year":"2015","journal-title":"Neuroepidemiology"},{"key":"B72","doi-asserted-by":"publisher","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"B73","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1146\/annurev.pharmtox.43.100901.140248","article-title":"Alzheimer\u2019s disease: molecular understanding predicts amyloid-based therapeutics","volume":"43","author":"Selkoe","year":"2003","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.neurobiolaging.2012.05.012","article-title":"Behavioral and neurobiological effects of prenatal stress exposure in male and female APPswe\/PS1dE9 mice","volume":"34","author":"Sierksma","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"B75","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/2050-7283-1-16","article-title":"The impact of early life factors on cognitive function in old age: the Hordaland Health Study (HUSK)","volume":"1","author":"Skogen","year":"2013","journal-title":"BMC Psychol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3389\/fncel.2015.00082","article-title":"Prenatal stress is a vulnerability factor for altered morphology and biological activity of microglia cells","volume":"9","author":"\u015alusarczyk","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1016\/j.cell.2007.10.036","article-title":"The classical complement cascade mediates CNS synapse elimination","volume":"131","author":"Stevens","year":"2007","journal-title":"Cell"},{"key":"B78","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1002\/ana.410300410","article-title":"Physical basis of cognitive alterations in Alzheimer\u2019s disease: synapse loss is the major correlate of cognitive impairment","volume":"30","author":"Terry","year":"1991","journal-title":"Ann. Neurol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"R312","DOI":"10.1152\/ajpregu.00425.2009","article-title":"Magnetic resonance imaging of hypoxic injury to the murine placenta","volume":"298","author":"Tomlinson","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1002\/dneu.20770","article-title":"Maternal hypoxia increases the activity of MMPs and decreases the expression of TIMPs in the brain of neonatal rats","volume":"70","author":"Tong","year":"2010","journal-title":"Dev. Neurobiol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/gim.2015.117","article-title":"The genetic landscape of Alzheimer disease: clinical implications and perspectives","volume":"18","author":"Van Cauwenberghe","year":"2016","journal-title":"Genet. Med."},{"key":"B82","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.pneurobio.2008.09.015","article-title":"The astrocyte odyssey","volume":"86","author":"Wang","year":"2008","journal-title":"Prog. Neurobiol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"e1002251","DOI":"10.1371\/journal.pmed.1002251","article-title":"Association of lifelong exposure to cognitive reserve-enhancing factors with dementia risk: a community-based cohort study","volume":"14","author":"Wang","year":"2017","journal-title":"PLoS Med."},{"key":"B84","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1042\/bj20091861","article-title":"Mechanisms involved in the developmental programming of adulthood disease","volume":"427","author":"Warner","year":"2010","journal-title":"Biochem. J."},{"key":"B85","doi-asserted-by":"publisher","first-page":"e0147733","DOI":"10.1371\/journal.pone.0147733","article-title":"A comprehensive behavioral test battery to assess learning and memory in 129S6\/Tg2576 mice","volume":"11","author":"Wolf","year":"2016","journal-title":"PLoS One"},{"key":"B86","doi-asserted-by":"publisher","first-page":"2111.e6","DOI":"10.1016\/j.celrep.2019.07.060","article-title":"Complement C3 is activated in human AD brain and is required for neurodegeneration in mouse models of amyloidosis and tauopathy","volume":"28","author":"Wu","year":"2019","journal-title":"Cell Rep."},{"key":"B87","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.yjmcc.2016.01.003","article-title":"Antenatal hypoxia induces epigenetic repression of glucocorticoid receptor and promotes ischemic-sensitive phenotype in the developing heart","volume":"91","author":"Xiong","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.neurobiolaging.2012.06.012","article-title":"Prenatal hypoxia may aggravate the cognitive impairment and Alzheimer\u2019s disease neuropathology in APPSwe\/PS1A246E transgenic mice","volume":"34","author":"Zhang","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"B89","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1001\/jamaneurol.2013.2152","article-title":"Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease","volume":"70","author":"Zlokovic","year":"2013","journal-title":"JAMA Neurol."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnagi.2020.00251\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T12:09:35Z","timestamp":1598011775000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnagi.2020.00251\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,21]]},"references-count":89,"alternative-id":["10.3389\/fnagi.2020.00251"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2020.00251","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,21]]},"article-number":"251"}}