{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T01:41:16Z","timestamp":1779327676627,"version":"3.51.4"},"reference-count":237,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"DOI":"10.3389\/fnagi.2020.00268","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T04:30:33Z","timestamp":1598502633000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":55,"title":["Secreted Chaperones in Neurodegeneration"],"prefix":"10.3389","volume":"12","author":[{"given":"Kriti","family":"Chaplot","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy S.","family":"Jarvela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Lindberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,8,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"293","DOI":"10.3233\/JAD-2006-9309","article-title":"Detection of biomarkers with a multiplex quantitative proteomic platform in cerebrospinal fluid of patients with neurodegenerative disorders.","volume":"9","author":"Abdi","year":"2006","journal-title":"J. Alzheimers Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/nsmb.1799","article-title":"Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils.","volume":"17","author":"Ahmed","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s00401-003-0783-1","article-title":"Expression of BRI, the normal precursor of the amyloid protein of familial British dementia, in human brain.","volume":"107","author":"Akiyama","year":"2004","journal-title":"Acta Neuropathol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"3033","DOI":"10.1016\/j.jmb.2020.02.003","article-title":"Conditional disorder in small heat-shock proteins.","volume":"432","author":"Alderson","year":"2020","journal-title":"J. Mol. Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.ymthe.2018.11.013","article-title":"AAV-mediated progranulin delivery to a mouse model of progranulin deficiency causes T cell-mediated toxicity.","volume":"27","author":"Amado","year":"2019","journal-title":"Mol. Ther."},{"key":"B6","doi-asserted-by":"publisher","first-page":"13287","DOI":"10.1073\/pnas.1107368108","article-title":"Systemic augmentation of alphaB-crystallin provides therapeutic benefit twelve hours post-stroke onset via immune modulation.","volume":"108","author":"Arac","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B7","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1073\/pnas.90.2.725","article-title":"Apolipoprotein J expression at fluid-tissue interfaces: potential role in barrier cytoprotection.","volume":"90","author":"Aronow","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2341","DOI":"10.1523\/JNEUROSCI.3081-17.2018","article-title":"Progranulin gene therapy improves lysosomal dysfunction and microglial pathology associated with frontotemporal dementia and neuronal ceroid lipofuscinosis.","volume":"38","author":"Arrant","year":"2018","journal-title":"J. Neurosci."},{"key":"B9","doi-asserted-by":"crossref","first-page":"15644","DOI":"10.1016\/S0021-9258(18)55446-6","article-title":"The neuroendocrine polypeptide 7B2 is a precursor protein.","volume":"265","author":"Ayoubi","year":"1990","journal-title":"J. Biol. Chem."},{"key":"B10","doi-asserted-by":"publisher","first-page":"11828","DOI":"10.1021\/bi010135x","article-title":"Clusterin, a binding protein with a molten globule-like region.","volume":"40","author":"Bailey","year":"2001","journal-title":"Biochemistry"},{"key":"B11","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1038\/nature05016","article-title":"Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17.","volume":"442","author":"Baker","year":"2006","journal-title":"Nature"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac4354","article-title":"In vivo aspects of protein folding and quality control.","volume":"353","author":"Balchin","year":"2016","journal-title":"Science"},{"key":"B13","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1006\/excr.2001.5358","article-title":"Multiple receptors mediate apoJ-dependent clearance of cellular debris into nonprofessional phagocytes.","volume":"271","author":"Bartl","year":"2001","journal-title":"Exp. Cell Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-1-4939-8559-3_1","article-title":"A brief overview of progranulin in health and disease.","volume":"1806","author":"Bateman","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"2850","DOI":"10.1093\/hmg\/ddx162","article-title":"Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.","volume":"26","author":"Beel","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"B16","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.bbrc.2020.04.091","article-title":"Interaction of the chaperones alpha B-crystallin and CHIP with fibrillar alpha-synuclein: effects on internalization by cells and identification of interacting interfaces.","volume":"527","author":"Bendifallah","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-015-0024-9","article-title":"Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations.","volume":"10","author":"Bettens","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"B18","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1042\/BCJ20180916","article-title":"Cysteine-rich granulin-3 rapidly promotes amyloid-\u03b2 fibrils in both redox states.","volume":"476","author":"Bhopatkar","year":"2019","journal-title":"Biochem. J."},{"key":"B19","doi-asserted-by":"publisher","first-page":"2506","DOI":"10.1074\/jbc.RA119.011501","article-title":"Granulins modulate liquid-liquid phase separation and aggregation of the prion-like C-terminal domain of the neurodegeneration-associated protein TDP-43.","volume":"295","author":"Bhopatkar","year":"2020","journal-title":"J. Biol. Chem."},{"key":"B20","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.bbapap.2015.04.005","article-title":"Dissociation of a BRICHOS trimer into monomers leads to increased inhibitory effect on Abeta42 fibril formation.","volume":"1854","author":"Biverstal","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"B21","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s12192-020-01093-1","article-title":"Structural aspects of the human small heat shock proteins related to their functional activities.","volume":"25","author":"Boelens","year":"2020","journal-title":"Cell Stress Chaperones"},{"key":"B22","doi-asserted-by":"publisher","first-page":"2670","DOI":"10.1021\/acs.biochem.9b00275","article-title":"Multi-granulin domain peptides bind to pro-cathepsin D and stimulate its enzymatic activity more effectively than progranulin in vitro.","volume":"58","author":"Butler","year":"2019","journal-title":"Biochemistry"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00119","article-title":"Transthyretin and BRICHOS: the paradox of amyloidogenic proteins with anti-amyloidogenic activity for abeta in the central nervous system.","volume":"11","author":"Buxbaum","year":"2017","journal-title":"Front. Neurosci."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5410657","article-title":"Alpha-2-macroglobulin, a hypochlorite-regulated chaperone and immune system modulator.","volume":"2019","author":"Cater","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"B25","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1111\/j.1600-0404.2010.01475.x","article-title":"Elevated HSP27 levels during attacks in patients with multiple sclerosis.","volume":"124","author":"Ce","year":"2011","journal-title":"Acta Neurol. Scand."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1002\/pmic.201300558","article-title":"MALDI imaging mass spectrometry to investigate endogenous peptides in an animal model of Usher\u2019s disease.","volume":"14","author":"Chatterji","year":"2014","journal-title":"Proteomics"},{"key":"B27","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1006\/bbrc.1995.1830","article-title":"The neuroendocrine protein 7B2 acts as a molecular chaperone in the in vitro folding of human insulin-like growth factor-1 secreted from yeast.","volume":"211","author":"Chaudhuri","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02056-4","article-title":"Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state.","volume":"8","author":"Chen","year":"2017","journal-title":"Nat. Commun."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-0757-z","article-title":"Augmentation of Bri2 molecular chaperone activity against amyloid-beta reduces neurotoxicity in mouse hippocampus in vitro.","volume":"3","author":"Chen","year":"2020","journal-title":"Commun. Biol."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2020.05.005","article-title":"Regulation of SPARC family proteins in disorders of the central nervous system","author":"Chen","year":"2020","journal-title":"Brain Res. Bull."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.4049\/jimmunol.182.3.1449","article-title":"Heat shock protein 70, released from heat-stressed tumor cells, initiates antitumor immunity by inducing tumor cell chemokine production and activating dendritic cells via TLR4 pathway.","volume":"182","author":"Chen","year":"2009","journal-title":"J. Immunol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1007\/s00415-014-7630-2","article-title":"Association of progranulin polymorphism rs5848 with neurodegenerative diseases: a meta-analysis.","volume":"262","author":"Chen","year":"2015","journal-title":"J. Neurol."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023880","article-title":"Secreted protein acidic and rich in cysteine is a matrix scavenger chaperone.","volume":"6","author":"Chlenski","year":"2011","journal-title":"PLoS ONE"},{"key":"B34","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.jchromb.2013.05.003","article-title":"Targeted human cerebrospinal fluid proteomics for the validation of multiple Alzheimer\u2019s disease biomarker candidates.","volume":"930","author":"Choi","year":"2013","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/nsmb.2971","article-title":"A molecular chaperone breaks the catalytic cycle that generates toxic Abeta oligomers.","volume":"22","author":"Cohen","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1111\/nan.12248","article-title":"Clusterin\/apolipoprotein J immunoreactivity is associated with white matter damage in cerebral small vessel diseases.","volume":"42","author":"Craggs","year":"2016","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"485","DOI":"10.2174\/156720506779025251","article-title":"Progranulin mutations in ubiquitin-positive frontotemporal dementia linked to chromosome 17q21.","volume":"3","author":"Cruts","year":"2006","journal-title":"Curr. Alzheimer Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.cytogfr.2019.01.002","article-title":"Progranulin: a conductor of receptors orchestra, a chaperone of lysosomal enzymes and a therapeutic target for multiple diseases.","volume":"45","author":"Cui","year":"2019","journal-title":"Cytokine Growth. Factor. Rev."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1007\/s00109-010-0651-0","article-title":"alpha-Melanocyte stimulating hormone: production and degradation.","volume":"88","author":"D\u2019Agostino","year":"2010","journal-title":"J. Mol. Med. (Berlin, Germany)"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-53226-x","article-title":"Unconventional secretion of alpha-Crystallin B requires the autophagic pathway and is controlled by phosphorylation of its serine 59 residue.","volume":"9","author":"D\u2019Agostino","year":"2019","journal-title":"Sci. Rep."},{"key":"B41","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1177\/002215540004800713","article-title":"Cellular localization of gene expression for progranulin.","volume":"48","author":"Daniel","year":"2000","journal-title":"J. Histochem. Cytochem."},{"key":"B42","doi-asserted-by":"publisher","first-page":"7456","DOI":"10.1021\/bi300871k","article-title":"The neuroendocrine protein 7B2 is intrinsically disordered.","volume":"51","author":"Dasgupta","year":"2012","journal-title":"Biochemistry"},{"key":"B43","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/S0169-328X(02)00549-1","article-title":"Studies of the pathophysiological mechanisms in frontotemporal dementia by proteome analysis of CSF proteins.","volume":"109","author":"Davidsson","year":"2002","journal-title":"Brain Res. Mol. Brain Res."},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-019-0498-8","article-title":"Peripheral administration of human recombinant ApoJ\/clusterin modulates brain beta-amyloid levels in APP23 mice.","volume":"11","author":"de Retana","year":"2019","journal-title":"Alzheimers Res. Ther."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1016\/j.neurobiolaging.2014.01.007","article-title":"BRI2-BRICHOS is increased in human amyloid plaques in early stages of Alzheimer\u2019s disease.","volume":"35","author":"Del Campo","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"B46","doi-asserted-by":"publisher","first-page":"10843","DOI":"10.1073\/pnas.162228299","article-title":"Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer\u2019s disease.","volume":"99","author":"DeMattos","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B47","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3233\/ADR-170051","article-title":"The Bri2 and Bri3 BRICHOS domains interact differently with Abeta42 and alzheimer amyloid plaques.","volume":"2","author":"Dolfe","year":"2018","journal-title":"J. Alzheimers Dis. Rep."},{"key":"B48","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1042\/BJ20150920","article-title":"BRICHOS binds to a designed amyloid-forming beta-protein and reduces proteasomal inhibition and aggresome formation.","volume":"473","author":"Dolfe","year":"2016","journal-title":"Biochem. J."},{"key":"B49","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.exger.2017.01.025","article-title":"CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN\/PGRN.","volume":"90","author":"Fardo","year":"2017","journal-title":"Exp. Gerontol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1002\/ana.21038","article-title":"Cerebrospinal fluid proteomic biomarkers for Alzheimer\u2019s disease.","volume":"61","author":"Finehout","year":"2007","journal-title":"Ann. Neurol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.exer.2016.04.019","article-title":"Clusterin in the eye: an old dog with new tricks at the ocular surface.","volume":"147","author":"Fini","year":"2016","journal-title":"Exp. Eye Res."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00164","article-title":"Clusterin in Alzheimer\u2019s disease: mechanisms, genetics, and lessons from other pathologies.","volume":"13","author":"Foster","year":"2019","journal-title":"Front. Neurosci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s00401-004-0891-6","article-title":"Clusterin solubility and aggregation in Creutzfeldt-Jakob disease.","volume":"108","author":"Freixes","year":"2004","journal-title":"Acta Neuropathol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1523\/JNEUROSCI.20-02-00639.2000","article-title":"Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing.","volume":"20","author":"Fricker","year":"2000","journal-title":"J. Neurosci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"12930","DOI":"10.1074\/jbc.M115.698530","article-title":"Inhibition of the expression of the small heat shock protein alphab-crystallin inhibits exosome secretion in human retinal pigment epithelial cells in culture.","volume":"291","author":"Gangalum","year":"2016","journal-title":"J. Biol. Chem."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024211","article-title":"An exploratory study on CLU, CR1 and PICALM and Parkinson disease.","volume":"6","author":"Gao","year":"2011","journal-title":"PLoS ONE"},{"key":"B57","doi-asserted-by":"publisher","first-page":"612","DOI":"10.2174\/1389203718666170918155247","article-title":"Regulation of clusterin gene expression.","volume":"19","author":"Garcia-Aranda","year":"2018","journal-title":"Curr. Protein Pept. Sci"},{"key":"B58","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.brainres.2012.01.047","article-title":"Progranulin: an emerging target for FTLD therapies.","volume":"1462","author":"Gass","year":"2012","journal-title":"Brain Res."},{"key":"B59","doi-asserted-by":"publisher","first-page":"4","DOI":"10.15252\/embj.201488896","article-title":"Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis.","volume":"34","author":"Genereux","year":"","journal-title":"EMBO J."},{"key":"B60","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1080\/19336896.2015.1011887","article-title":"Regulating extracellular proteostasis capacity through the unfolded protein response.","volume":"9","author":"Genereux","year":"","journal-title":"Prion"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1002\/pro.3212","article-title":"Disulfide bonds and disorder in granulin-3: an unusual handshake between structural stability and plasticity.","volume":"26","author":"Ghag","year":"2017","journal-title":"Protein Sci."},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21062075","article-title":"Undiscovered roles for transthyretin: from a transporter protein to a new therapeutic target for Alzheimer\u2019s disease.","volume":"21","author":"Giao","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1177\/1533317509346209","article-title":"Progranulin and beta-amyloid distribution: a case report of the brain from preclinical PS-1 mutation carrier.","volume":"24","author":"Gliebus","year":"2009","journal-title":"Am. J. Alzheimers Dis. Other Demen."},{"key":"B64","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/ki.1995.54","article-title":"Clusterin expression and apoptosis in tissue remodeling associated with renal regeneration.","volume":"47","author":"Gob\u00e9","year":"1995","journal-title":"Kid. Int."},{"key":"B65","doi-asserted-by":"publisher","first-page":"4050","DOI":"10.2174\/1381612822666160519113339","article-title":"The impact of small heat shock proteins (HspBs) in Alzheimer\u2019s and other neurological diseases.","volume":"22","author":"Golenhofen","year":"2016","journal-title":"Curr. Pharm. Des"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-018-0281-5","article-title":"Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice.","volume":"13","author":"G\u00f6tzl","year":"2018","journal-title":"Mol. Neurodegener."},{"key":"B67","doi-asserted-by":"publisher","first-page":"E3699","DOI":"10.1073\/pnas.1510329112","article-title":"Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer\u2019s disease amyloid plaques.","volume":"112","author":"Gowrishankar","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B68","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/nan.12575","article-title":"Neuronal clusterin expression is associated with cognitive protection in amyotrophic lateral sclerosis.","volume":"46","author":"Gregory","year":"2020","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-017-0481-1","article-title":"Clusterin protects neurons against intracellular proteotoxicity.","volume":"5","author":"Gregory","year":"2017","journal-title":"Acta Neuropathol. Commun."},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-29450-2","article-title":"Analyzing 74,248 samples confirms the association between CLU rs11136000 polymorphism and Alzheimer\u2019s disease in caucasian but not chinese population.","volume":"8","author":"Han","year":"2018","journal-title":"Sci. Rep."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/ng.440","article-title":"Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer\u2019s disease.","volume":"41","author":"Harold","year":"2009","journal-title":"Nat. Genet."},{"key":"B72","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1038\/nature10317","article-title":"Molecular chaperones in protein folding and proteostasis.","volume":"475","author":"Hartl","year":"2011","journal-title":"Nature"},{"key":"B73","doi-asserted-by":"publisher","first-page":"12527","DOI":"10.1073\/pnas.0804340105","article-title":"Mass spectrometry-based discovery of circadian peptides.","volume":"105","author":"Hatcher","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1074\/jbc.M112.417071","article-title":"The neuroendocrine protein 7B2 suppresses the aggregation of neurodegenerative disease-related proteins.","volume":"288","author":"Helwig","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B75","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1242\/dmm.014787","article-title":"The chaperone domain BRICHOS prevents CNS toxicity of amyloid-beta peptide in Drosophila melanogaster.","volume":"7","author":"Hermansson","year":"2014","journal-title":"Dis. Model. Mech."},{"key":"B76","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/128_2012_324","article-title":"Small heat-shock proteins: paramedics of the cell.","volume":"328","author":"Hilton","year":"2013","journal-title":"Top. Curr. Chem."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1021\/bi991581b","article-title":"pH-dependent changes in the in vitro ligand-binding properties and structure of human clusterin.","volume":"39","author":"Hochgrebe","year":"2000","journal-title":"Biochemistry"},{"key":"B78","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1515\/hsz-2014-0125","article-title":"Functional aspects of extracellular cyclophilins.","volume":"395","author":"Hoffmann","year":"2014","journal-title":"Biol. Chem."},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-016-0114-3","article-title":"Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.","volume":"11","author":"Holler","year":"2016","journal-title":"Mol. Neurodegener."},{"key":"B80","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1021\/pr501076j","article-title":"An integrated workflow for multiplex CSF proteomics and peptidomics-identification of candidate cerebrospinal fluid biomarkers of Alzheimer\u2019s disease.","volume":"14","author":"Holtta","year":"2015","journal-title":"J. Proteome Res."},{"key":"B81","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1111\/jnc.12454","article-title":"A novel function for proSAAS as an amyloid anti-aggregant in Alzheimer\u2019s disease.","volume":"128","author":"Hoshino","year":"2014","journal-title":"J. Neurochem."},{"key":"B82","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1111\/bpa.12057","article-title":"Clusterin associates specifically with A\u03b240 in Alzheimer\u2019s disease brain tissue.","volume":"23","author":"Howlett","year":"2013","journal-title":"Brain Pathol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/0014-5793(82)81055-7","article-title":"Isolation and NH2-terminal sequence of a novel porcine anterior pituitary polypeptide. Homology to proinsulin, secretin and Rous sarcoma virus transforming protein TVFV60.","volume":"147","author":"Hsi","year":"1982","journal-title":"FEBS Lett."},{"key":"B84","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.neuron.2010.09.034","article-title":"Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.","volume":"68","author":"Hu","year":"2010","journal-title":"Neuron"},{"key":"B85","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s00401-018-1907-y","article-title":"Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson\u2019s disease pathogenesis.","volume":"137","author":"Hughes","year":"2019","journal-title":"Acta Neuropathol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"6875","DOI":"10.1074\/jbc.274.11.6875","article-title":"Clusterin has chaperone-like activity similar to that of small heat shock proteins.","volume":"274","author":"Humphreys","year":"1999","journal-title":"J. Biol. Chem."},{"key":"B87","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/0006-8993(85)90251-3","article-title":"Regional distribution of a novel pituitary protein (7B2) in the rat brain.","volume":"338","author":"Iguchi","year":"1985","journal-title":"Brain Res."},{"key":"B88","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/0196-9781(87)90030-1","article-title":"Evidence for a novel pituitary protein (7B2) in human brain, cerebrospinal fluid and plasma: brain concentrations in controls and patients with Alzheimer\u2019s disease.","volume":"8","author":"Iguchi","year":"","journal-title":"Peptides"},{"key":"B89","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1111\/j.1471-4159.1987.tb02440.x","article-title":"Presence of the novel pituitary protein \u201c7B2\u201d in bovine chromaffin granules: possible co-release of 7B2 and catecholamine as induced by nicotine.","volume":"49","author":"Iguchi","year":"","journal-title":"J. Neurochem."},{"key":"B90","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1159\/000124020","article-title":"Tissue distribution and molecular forms of a novel pituitary protein in the rat.","volume":"39","author":"Iguchi","year":"1984","journal-title":"Neuroendocrinology"},{"key":"B91","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1007\/s00401-017-1720-z","article-title":"Sushi repeat-containing protein 1: a novel disease-associated molecule in cerebral amyloid angiopathy.","volume":"134","author":"Inoue","year":"2017","journal-title":"Acta Neuropathol."},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201911126","article-title":"Heparan sulfate is a clearance receptor for aberrant extracellular proteins.","volume":"219","author":"Itakura","year":"2020","journal-title":"J. Cell Biol."},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcz003","article-title":"Clusterin accumulates in synapses in Alzheimer\u2019s disease and is increased in apolipoprotein E4 carriers.","volume":"1","author":"Jackson","year":"2019","journal-title":"Brain Commun."},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026540","article-title":"Peptide fingerprinting of Alzheimer\u2019s disease in cerebrospinal fluid: identification and prospective evaluation of new synaptic biomarkers.","volume":"6","author":"Jahn","year":"2011","journal-title":"PLoS ONE"},{"key":"B95","doi-asserted-by":"publisher","first-page":"E4708","DOI":"10.1073\/pnas.1601091113","article-title":"The neural chaperone proSAAS blocks alpha-synuclein fibrillation and neurotoxicity.","volume":"113","author":"Jarvela","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28031-7","article-title":"7B2 chaperone knockout in APP model mice results in reduced plaque burden.","volume":"8","author":"Jarvela","year":"2018","journal-title":"Sci. Rep."},{"key":"B97","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.ebiom.2016.10.010","article-title":"Progranulin recruits HSP70 to \u03b2-glucocerebrosidase and is therapeutic against gaucher disease.","volume":"13","author":"Jian","year":"2016","journal-title":"EBioMedicine"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-40483-z","article-title":"Conservation of the amyloid interactome across diverse fibrillar structures.","volume":"9","author":"Juhl","year":"2019","journal-title":"Sci. Rep."},{"key":"B99","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1523\/JNEUROSCI.5491-10.2011","article-title":"Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake.","volume":"31","author":"Kanekiyo","year":"2011","journal-title":"J. Neurosci."},{"key":"B100","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/nrn.2017.36","article-title":"Progranulin, lysosomal regulation and neurodegenerative disease.","volume":"18","author":"Kao","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"B101","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1002\/pro.5560061007","article-title":"Identification and characterization of glycosylation sites in human serum clusterin.","volume":"6","author":"Kapron","year":"1997","journal-title":"Protein Sci."},{"key":"B102","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/S0006-291X(03)01391-3","article-title":"An N-terminal fragment of ProSAAS (a granin-like neuroendocrine peptide precursor) is associated with tau inclusions in Pick\u2019s disease.","volume":"308","author":"Kikuchi","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B103","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/mp.2012.163","article-title":"Clusterin regulates \u03b2-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway.","volume":"19","author":"Killick","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-8-15","article-title":"Normal cognition in transgenic BRI2-Abeta mice.","volume":"8","author":"Kim","year":"2013","journal-title":"Mol. Neurodegener."},{"key":"B105","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1146\/annurev-biochem-060208-092442","article-title":"Molecular chaperone functions in protein folding and proteostasis.","volume":"82","author":"Kim","year":"2013","journal-title":"Annu. Rev. Biochem."},{"key":"B106","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/29106","article-title":"Crystal structure of a small heat-shock protein.","volume":"394","author":"Kim","year":"1998","journal-title":"Nature"},{"key":"B107","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1038\/14783","article-title":"Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia.","volume":"2","author":"Kim","year":"1999","journal-title":"Nat. Neurosci."},{"key":"B108","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1002\/jnr.22536","article-title":"Differential expression and induction of small heat shock proteins in rat brain and cultured hippocampal neurons.","volume":"89","author":"Kirbach","year":"2011","journal-title":"J. Neurosci. Res."},{"key":"B109","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1083\/jcb.201709072","article-title":"Pathways of cellular proteostasis in aging and disease.","volume":"217","author":"Klaips","year":"2018","journal-title":"J. Cell Biol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1007\/978-3-642-79850-4_8","article-title":"Clusterin: a role in cell survival in the face of apoptosis?","volume":"16","author":"Koch-Brandt","year":"1996","journal-title":"Prog. Mol. Subcell. Biol."},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1101\/2020.05.17.099465","article-title":"Alzheimer cells on their way to derailment show selective changes in protein quality control network.","author":"Koopman","year":"2020","journal-title":"bioRxiv"},{"key":"B112","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1515\/bmc-2018-0009","article-title":"Small heat shock proteins and neurodegeneration: recent developments.","volume":"9","author":"Kourtis","year":"2018","journal-title":"Biomol. Concepts"},{"key":"B113","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1210\/en.2008-1301","article-title":"Identification of proSAAS homologs in lower vertebrates: conservation of hydrophobic helices and convertase-inhibiting sequences.","volume":"150","author":"Kudo","year":"2009","journal-title":"Endocrinology"},{"key":"B114","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1038\/ng.439","article-title":"Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer\u2019s disease.","volume":"41","author":"Lambert","year":"2009","journal-title":"Nat. Genet."},{"key":"B115","doi-asserted-by":"publisher","first-page":"4141","DOI":"10.1210\/endo.142.9.8386","article-title":"Coexpression of proprotein convertase SPC3 and the neuroendocrine precursor proSAAS.","volume":"142","author":"Lanoue","year":"2001","journal-title":"Endocrinology"},{"key":"B116","doi-asserted-by":"publisher","first-page":"3087","DOI":"10.1073\/pnas.261715099","article-title":"Mortality in 7B2 null mice can be rescued by adrenalectomy: involvement of dopamine in ACTH hypersecretion.","volume":"99","author":"Laurent","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-2-11","article-title":"Novel rat Alzheimer\u2019s disease models based on AAV-mediated gene transfer to selectively increase hippocampal Abeta levels.","volume":"2","author":"Lawlor","year":"2007","journal-title":"Mol. Neurodegener."},{"key":"B118","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.bbrc.2009.07.166","article-title":"Clusterin regulates transthyretin amyloidosis.","volume":"388","author":"Lee","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B119","doi-asserted-by":"publisher","first-page":"4116","DOI":"10.1210\/en.2008-0064","article-title":"7B2 prevents unfolding and aggregation of prohormone convertase 2.","volume":"149","author":"Lee","year":"2008","journal-title":"Endocrinology"},{"key":"B120","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1080\/15384101.2015.1041686","article-title":"Administration of progranulin (PGRN) triggers ER stress and impairs insulin sensitivity via PERK-eIF2\u03b1-dependent manner.","volume":"14","author":"Li","year":"2015","journal-title":"Cell Cycle"},{"key":"B121","article-title":"Intranigral overexpression of the neural\/endocrine chaperone ProSAAS attenuates Parkinson\u2019s symptoms in a rat PD model.","volume":"131","author":"Lindberg","year":"2018","journal-title":"Cold Spring Harb. Labor. Proteost."},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033923","article-title":"Genetics of clusterin isoform expression and Alzheimer\u2019s disease risk.","volume":"7","author":"Ling","year":"2012","journal-title":"PLoS ONE"},{"key":"B123","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1007\/s12017-013-8250-1","article-title":"The CLU gene rs11136000 variant is significantly associated with Alzheimer\u2019s disease in Caucasian and Asian populations.","volume":"16","author":"Liu","year":"2014","journal-title":"Neuromol. Med."},{"key":"B124","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1097\/NEN.0b013e31823a44f4","article-title":"Clusterin overexpression and its possible protective role in transthyretin deposition in familial amyloidotic polyneuropathy.","volume":"70","author":"Magalh\u00e3es","year":"2011","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"507","DOI":"10.3233\/JAD-170110","article-title":"Changes of cerebrospinal fluid peptides due to tauopathy.","volume":"58","author":"Majerova","year":"2017","journal-title":"J. Alzheimers. Dis."},{"key":"B126","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/0014-5793(88)81324-3","article-title":"Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2.","volume":"234","author":"Martens","year":"1988","journal-title":"FEBS Lett."},{"key":"B127","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1074\/jbc.M706661200","article-title":"Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a\/SPPL2b.","volume":"283","author":"Martin","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21453-3","article-title":"Identification and characterization of the BRI2 interactome in the brain.","volume":"8","author":"Martins","year":"2018","journal-title":"Sci. Rep."},{"key":"B129","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.cellsig.2015.10.012","article-title":"BRI2 and BRI3 are functionally distinct phosphoproteins.","volume":"28","author":"Martins","year":"2016","journal-title":"Cell. Signal."},{"key":"B130","doi-asserted-by":"publisher","first-page":"2752","DOI":"10.1002\/jcb.25925","article-title":"BRI2 processing and its neuritogenic role are modulated by protein phosphatase 1 complexing.","volume":"118","author":"Martins","year":"2017","journal-title":"J. Cell. Biochem."},{"key":"B131","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/s41586-019-1195-2","article-title":"Single-cell transcriptomic analysis of Alzheimer\u2019s disease.","volume":"570","author":"Mathys","year":"2019","journal-title":"Nature"},{"key":"B132","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1042\/bj3160671","article-title":"Apolipoprotein J and Alzheimer\u2019s amyloid beta solubility.","author":"Matsubara","year":"1996","journal-title":"Biochem. J."},{"key":"B133","doi-asserted-by":"publisher","first-page":"28912","DOI":"10.1074\/jbc.C500217200","article-title":"The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production.","volume":"280","author":"Matsuda","year":"2005","journal-title":"J. Biol. Chem."},{"key":"B134","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1016\/j.neurobiolaging.2009.08.005","article-title":"Maturation of BRI2 generates a specific inhibitor that reduces APP processing at the plasma membrane and in endocytic vesicles.","volume":"32","author":"Matsuda","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"B135","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1093\/brain\/awu367","article-title":"Independent information from cerebrospinal fluid amyloid-\u03b2 and florbetapir imaging in Alzheimer\u2019s disease.","volume":"138","author":"Mattsson","year":"2015","journal-title":"Brain"},{"key":"B136","doi-asserted-by":"publisher","first-page":"757","DOI":"10.3892\/mmr_00000025","article-title":"Novel cerebrospinal fluid biomarkers of axonal degeneration in frontotemporal dementia.","volume":"1","author":"Mattsson","year":"2008","journal-title":"Mol. Med. Rep."},{"key":"B137","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1042\/bj3570329","article-title":"Neuroendocrine secretory protein 7B2: structure, expression and functions.","volume":"357","author":"Mbikay","year":"2001","journal-title":"Biochem. J."},{"key":"B138","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1111\/evj.12543","article-title":"Equine grass sickness, but not botulism, causes autonomic and enteric neurodegeneration and increases soluble N-ethylmaleimide-sensitive factor attachment receptor protein expression within neuronal perikarya.","volume":"48","author":"McGorum","year":"2016","journal-title":"Equine Vet. J."},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-019-0862-8","article-title":"Characterization of lysosomal proteins progranulin and prosaposin and their interactions in Alzheimer\u2019s disease and aged brains: increased levels correlate with neuropathology.","volume":"7","author":"Mendsaikhan","year":"","journal-title":"Acta Neuropathol. Commun."},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.3390\/cells8030230","article-title":"Microglial progranulin: involvement in Alzheimer\u2019s disease and neurodegenerative diseases.","volume":"8","author":"Mendsaikhan","year":"","journal-title":"Cells"},{"key":"B141","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1038\/nm.3672","article-title":"Progranulin protects against amyloid beta deposition and toxicity in Alzheimer\u2019s disease mouse models.","volume":"20","author":"Minami","year":"2014","journal-title":"Nat. Med."},{"key":"B142","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1111\/bpa.12392","article-title":"Clusterin levels are increased in Alzheimer\u2019s disease and influence the regional distribution of Abeta.","volume":"27","author":"Miners","year":"2017","journal-title":"Brain Pathol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1146\/annurev-micro-020518-115515","article-title":"Cellular functions and mechanisms of action of small heat shock proteins.","volume":"73","author":"Mogk","year":"2019","journal-title":"Annu. Rev. Microbiol."},{"key":"B144","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.bcp.2018.07.012","article-title":"Differential effects of apoE and apoJ mimetic peptides on the action of an anti-A\u03b2 scFv in 3xTg-AD mice.","volume":"155","author":"Montoliu-Gaya","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"B145","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1111\/j.1471-4159.2005.03138.x","article-title":"Embryonic gene expression and pro-protein processing of proSAAS during rodent development.","volume":"93","author":"Morgan","year":"2005","journal-title":"J. Neurochem."},{"key":"B146","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1111\/j.1471-4159.2010.06706.x","article-title":"The propeptide precursor proSAAS is involved in fetal neuropeptide processing and body weight regulation.","volume":"113","author":"Morgan","year":"2010","journal-title":"J. Neurochem."},{"key":"B147","doi-asserted-by":"publisher","first-page":"21471","DOI":"10.1074\/jbc.274.30.21471","article-title":"A 36-residue peptide contains all of the information required for 7B2-mediated activation of prohormone convertase 2.","volume":"274","author":"Muller","year":"1999","journal-title":"J. Biol. Chem."},{"key":"B148","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1134\/S000629791911004X","article-title":"Small heat shock proteins and human neurodegenerative diseases.","volume":"84","author":"Muranova","year":"2019","journal-title":"Biochemistry (Mosc)"},{"key":"B149","doi-asserted-by":"publisher","first-page":"6207","DOI":"10.1074\/jbc.M009067200","article-title":"ProSAAS processing in mouse brain and pituitary.","volume":"276","author":"Mzhavia","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B150","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1042\/bj3610067","article-title":"Processing of proSAAS in neuroendocrine cell lines.","volume":"361","author":"Mzhavia","year":"2002","journal-title":"Biochem. J."},{"key":"B151","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3233\/JAD-150317","article-title":"Astrocytes release HspB1 in response to amyloid-beta exposure in vitro.","volume":"49","author":"Nafar","year":"2016","journal-title":"J. Alzheimers. Dis."},{"key":"B152","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/nsmb.2191","article-title":"The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-beta(1-40) peptide.","volume":"19","author":"Narayan","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B153","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/0024-3205(87)90685-0","article-title":"Age-related change in plasma concentration of 7B2 (a novel pituitary polypeptide) in normal humans.","volume":"41","author":"Natori","year":"1987","journal-title":"Life Sci."},{"key":"B154","doi-asserted-by":"publisher","first-page":"8627","DOI":"10.1074\/jbc.M112.441949","article-title":"Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL).","volume":"288","author":"Nguyen","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B155","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1111\/j.1600-0854.2007.00549.x","article-title":"Stress-induced retrotranslocation of clusterin\/ApoJ into the cytosol.","volume":"8","author":"Nizard","year":"2007","journal-title":"Traffic"},{"key":"B156","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/bpa.12660","article-title":"Clusterin contributes to early stage of Alzheimer\u2019s disease pathogenesis.","volume":"29","author":"Oh","year":"2019","journal-title":"Brain Pathol."},{"key":"B157","doi-asserted-by":"publisher","first-page":"3146","DOI":"10.1128\/MCB.01187-10","article-title":"Sequestration of toxic oligomers by HspB1 as a cytoprotective mechanism.","volume":"31","author":"Ojha","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"B158","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s00702-015-1477-2","article-title":"Antibodies against small heat-shock proteins in Alzheimer\u2019s disease as a part of natural human immune repertoire or activation of humoral response?","volume":"123","author":"Papuc","year":"2016","journal-title":"J. Neural Transm. (Vienna)"},{"key":"B159","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s11154-013-9275-3","article-title":"The physiological roles of apolipoprotein J\/clusterin in metabolic and cardiovascular diseases.","volume":"15","author":"Park","year":"2014","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1186\/s12014-020-09276-9","article-title":"A comprehensive sytematic review of CSF proteins and peptides that define Alzheimer\u2019s disease.","volume":"17","author":"Pedrero-Prieto","year":"2020","journal-title":"Clin. Proteom."},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1101\/2020.04.15.039578","article-title":"Phase separation of proSAAS into spheres results in core sequestration of TDP-43216\u2013414 aggregates.","author":"Peinado","year":"2020","journal-title":"bioRxiv"},{"key":"B162","doi-asserted-by":"publisher","first-page":"3406","DOI":"10.1016\/j.febslet.2013.09.006","article-title":"Blockade of islet amyloid polypeptide fibrillation and cytotoxicity by the secretory chaperones 7B2 and proSAAS.","volume":"587","author":"Peinado","year":"2013","journal-title":"FEBS Lett."},{"key":"B163","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/s41582-020-0333-7","article-title":"Protein transmission in neurodegenerative disease.","volume":"16","author":"Peng","year":"2020","journal-title":"Nat. Rev. Neurol."},{"key":"B164","doi-asserted-by":"publisher","first-page":"2405","DOI":"10.2147\/CMAR.S196273","article-title":"The role of clusterin in cancer metastasis.","volume":"11","author":"Peng","year":"2019","journal-title":"Cancer Manage. Res."},{"key":"B165","doi-asserted-by":"publisher","first-page":"5412","DOI":"10.1242\/jcs.132076","article-title":"Activity-dependent secretion of progranulin from synapses.","volume":"126","author":"Petoukhov","year":"2013","journal-title":"J. Cell Sci."},{"key":"B166","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1074\/jbc.REV118.002804","article-title":"The endoplasmic reticulum (ER) chaperone BiP is a master regulator of ER functions: getting by with a little help from ERdj friends.","volume":"294","author":"Pobre","year":"2019","journal-title":"J. Biol. Chem."},{"key":"B167","doi-asserted-by":"publisher","first-page":"15953","DOI":"10.1021\/bi002189x","article-title":"Clusterin is an ATP-independent chaperone with very broad substrate specificity that stabilizes stressed proteins in a folding-competent state.","volume":"39","author":"Poon","year":"2000","journal-title":"Biochemistry"},{"key":"B168","doi-asserted-by":"publisher","first-page":"39532","DOI":"10.1074\/jbc.M204855200","article-title":"Mildly acidic pH activates the extracellular molecular chaperone clusterin.","volume":"277","author":"Poon","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B169","doi-asserted-by":"publisher","first-page":"3683","DOI":"10.1042\/BCJ20160277","article-title":"Dementia-related Bri2 BRICHOS is a versatile molecular chaperone that efficiently inhibits Abeta42 toxicity in Drosophila.","volume":"473","author":"Poska","year":"2016","journal-title":"Biochem. J."},{"key":"B170","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.jns.2015.12.023","article-title":"Clusterin CSF levels in differential diagnosis of neurodegenerative disorders.","volume":"361","author":"P\u0159ikrylov\u00e1 Vranov\u00e1","year":"2016","journal-title":"J. Neurol. Sci."},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075303","article-title":"Non-secreted clusterin isoforms are translated in rare amounts from distinct human mRNA variants and do not affect Bax-mediated apoptosis or the NF-\u03baB signaling pathway.","volume":"8","author":"Prochnow","year":"2013","journal-title":"PLoS ONE"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1186\/s12868-018-0402-7","article-title":"Intraventricular infusion of clusterin ameliorated cognition and pathology in Tg6799 model of Alzheimer\u2019s disease.","volume":"19","author":"Qi","year":"2018","journal-title":"BMC Neurosci."},{"key":"B173","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.neuroscience.2008.01.058","article-title":"Expression of the small heat shock protein family in the mouse CNS: differential anatomical and biochemical compartmentalization.","volume":"153","author":"Quraishe","year":"2008","journal-title":"Neuroscience"},{"key":"B174","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1111\/j.1471-4159.2005.03478.x","article-title":"Proteomic profiling of cerebrospinal fluid identifies biomarkers for amyotrophic lateral sclerosis.","volume":"95","author":"Ranganathan","year":"2005","journal-title":"J. Neurochem."},{"key":"B175","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1007\/s12192-017-0856-z","article-title":"Extracellular small heat shock proteins: exosomal biogenesis and function.","volume":"23","author":"Reddy","year":"2018","journal-title":"Cell Stress Chaperones"},{"key":"B176","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1097\/00001756-199908020-00009","article-title":"Dementia, gliosis and expression of the small heat shock proteins hsp27 and alpha B-crystallin in Parkinson\u2019s disease.","volume":"10","author":"Renkawek","year":"1999","journal-title":"Neuroreport"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00504","article-title":"Clusterin is required for \u03b2-Amyloid toxicity in human iPSC-derived neurons.","volume":"12","author":"Robbins","year":"2018","journal-title":"Front. Neurosci."},{"key":"B178","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1515\/bmc-2015-0026","article-title":"The CLU-files: disentanglement of a mystery.","volume":"7","author":"Rohne","year":"2016","journal-title":"Biomol. Concepts"},{"key":"B179","doi-asserted-by":"publisher","first-page":"1814","DOI":"10.1007\/s00018-005-5092-5","article-title":"Chromosome 13 dementias.","volume":"62","author":"Rostagno","year":"2005","journal-title":"Cell Mol. Life. Sci"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a034223","article-title":"Small heat shock proteins, amyloid fibrils, and nicotine stimulate a common immune suppressive pathway with implications for future therapies.","volume":"9","author":"Rothbard","year":"2019","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-59414-4","article-title":"Cerebrospinal fluid proteomics implicates the granin family in Parkinson\u2019s disease.","volume":"10","author":"Rotunno","year":"2020","journal-title":"Sci. Rep."},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-10-130","article-title":"Progranulin is expressed within motor neurons and promotes neuronal cell survival.","volume":"10","author":"Ryan","year":"2009","journal-title":"BMC Neurosci."},{"key":"B183","doi-asserted-by":"publisher","first-page":"9315","DOI":"10.1523\/JNEUROSCI.4808-14.2015","article-title":"The progranulin cleavage products, granulins, exacerbate TDP-43 Toxicity and Increase TDP-43 Levels.","volume":"35","author":"Salazar","year":"2015","journal-title":"J. Neurosci."},{"key":"B184","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1002\/mds.27949","article-title":"CLU rs11136000 promotes early cognitive decline in Parkinson\u2019s disease.","volume":"35","author":"Sampedro","year":"2020","journal-title":"Mov. Disord."},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a004952","article-title":"Heparan sulfate proteoglycans.","volume":"3","author":"Sarrazin","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B186","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s00401-002-0546-4","article-title":"Clusterin\/apolipoprotein J is associated with cortical Lewy bodies: immunohistochemical study in cases with alpha-synucleinopathies.","volume":"104","author":"Sasaki","year":"2002","journal-title":"Acta Neuropathol."},{"key":"B187","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1046\/j.1471-4159.2001.00165.x","article-title":"Tissue distribution and processing of proSAAS by proprotein convertases.","volume":"76","author":"Sayah","year":"2001","journal-title":"J. Neurochem."},{"key":"B188","doi-asserted-by":"publisher","first-page":"9838","DOI":"10.1074\/jbc.RA120.012748","article-title":"N- and C-terminal regions of \u03b1B-crystallin and Hsp27 mediate inhibition of amyloid nucleation, fibril binding, and fibril disaggregation.","volume":"295","author":"Selig","year":"2020","journal-title":"J. Biol. Chem."},{"key":"B189","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1111\/j.1365-2826.1993.tb00518.x","article-title":"Depolarizing action of secretory granule protein 7B2 on rat supraoptic neurosecretory neurons.","volume":"5","author":"Senatorov","year":"1993","journal-title":"J. Neuroendocrinol."},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16305-6","article-title":"Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity.","volume":"11","author":"Seo","year":"2020","journal-title":"Nat. Commun."},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-020-01128-7","article-title":"Increased expression and retention of the secretory chaperone ProSAAS following cell stress.","author":"Shakya","year":"2020","journal-title":"Cell Stress Chaperones"},{"key":"B192","doi-asserted-by":"publisher","first-page":"l115","DOI":"10.1016\/S0024-3205(96)00685-6","article-title":"The putative blood-brain barrier transporter for the beta-amyloid binding protein apolipoprotein j is saturated at physiological concentrations.","volume":"60","author":"Shayo","year":"1997","journal-title":"Life Sci."},{"key":"B193","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1007\/s12035-019-01858-5","article-title":"Alzheimer\u2019s disease and diabetes: insulin signaling as the bridge linking two pathologies.","volume":"57","author":"Shieh","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"B194","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1007\/s11064-008-9588-x","article-title":"Structural and quantitative comparison of cerebrospinal fluid glycoproteins in Alzheimer\u2019s disease patients and healthy individuals.","volume":"33","author":"Sihlbom","year":"2008","journal-title":"Neurochem. Res."},{"key":"B195","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1016\/j.ajhg.2012.04.021","article-title":"Strikingly different clinicopathological phenotypes determined by progranulin-mutation dosage.","volume":"90","author":"Smith","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"B196","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1038\/s41593-018-0235-9","article-title":"Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases.","volume":"21","author":"Soto","year":"2018","journal-title":"Nat. Neurosci."},{"key":"B197","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1002\/prca.201400178","article-title":"Development and evaluation of a multiplexed mass spectrometry based assay for measuring candidate peptide biomarkers in Alzheimer\u2019s Disease neuroimaging initiative (ADNI) CSF.","volume":"9","author":"Spellman","year":"2015","journal-title":"Proteom. Clin. Appl."},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012578","article-title":"\u03b1B crystallin is apically secreted within exosomes by polarized human retinal pigment epithelium and provides neuroprotection to adjacent cells.","volume":"5","author":"Sreekumar","year":"2010","journal-title":"PLoS ONE"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201809712","article-title":"CSF progranulin increases in the course of Alzheimer\u2019s disease and is associated with sTREM2, neurodegeneration and cognitive decline.","volume":"10","author":"Su\u00e1rez-Calvet","year":"2018","journal-title":"EMBO Mol. Med."},{"key":"B200","doi-asserted-by":"publisher","first-page":"11265","DOI":"10.1073\/pnas.1918481117","article-title":"Ultrastructural evidence for self-replication of Alzheimer-associated Abeta42 amyloid along the sides of fibrils.","volume":"117","author":"Tornquist","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B201","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1159\/000351207","article-title":"The molecular chaperone apolipoprotein J\/clusterin as a sensor of oxidative stress: implications in therapeutic approaches \u2013 a mini-review.","volume":"59","author":"Trougakos","year":"2013","journal-title":"Gerontology"},{"key":"B202","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1016\/j.celrep.2018.10.055","article-title":"KDEL receptors are differentially regulated to maintain the ER proteome under calcium deficiency.","volume":"25","author":"Trychta","year":"2018","journal-title":"Cell Rep."},{"key":"B203","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1093\/glycob\/cwr097","article-title":"Glycosylation of BRI2 on asparagine 170 is involved in its trafficking to the cell surface but not in its processing by furin or ADAM10.","volume":"21","author":"Tsachaki","year":"2011","journal-title":"Glycobiology"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1002\/humu.9484","article-title":"Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia.","volume":"28","author":"van der Zee","year":"2007","journal-title":"Hum. Mutat."},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097032","article-title":"Progranulin gene delivery protects dopaminergic neurons in a mouse model of Parkinson\u2019s disease.","volume":"9","author":"Van Kampen","year":"2014","journal-title":"PLoS ONE"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182896","article-title":"Progranulin gene delivery reduces plaque burden and synaptic atrophy in a mouse model of Alzheimer\u2019s disease.","volume":"12","author":"Van Kampen","year":"2017","journal-title":"PLoS ONE"},{"key":"B207","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-020-00388-2","article-title":"Identification of novel cerebrospinal fluid biomarker candidates for dementia with Lewy bodies: a proteomic approach.","volume":"15","author":"Van Steenoven","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"B208","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1007\/s12192-020-01101-4","article-title":"Small heat shock proteins in neurodegenerative diseases.","volume":"25","author":"Vendredy","year":"2020","journal-title":"Cell Stress Chaper."},{"key":"B209","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1046\/j.1523-1747.1999.00531.x","article-title":"Clusterin gene expression mediates resistance to apoptotic cell death induced by heat shock and oxidative stress.","volume":"112","author":"Viard","year":"1999","journal-title":"J. Invest. Dermatol."},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028152","article-title":"ProSAAS-derived peptides are colocalized with Neuropeptide Y and function as neuropeptides in the regulation of food intake.","volume":"6","author":"Wardman","year":"2011","journal-title":"PLoS ONE"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104232","article-title":"ProSAAS-derived peptides are differentially processed and sorted in mouse brain and AtT-20 cells.","volume":"9","author":"Wardman","year":"2014","journal-title":"PLoS ONE"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01047","article-title":"Small heat shock proteins, big impact on protein aggregation in neurodegenerative disease.","volume":"10","author":"Webster","year":"2019","journal-title":"Front. Pharmacol."},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1590\/1678-4685-gmb-2019-0052","article-title":"Comparative transcriptome analysis of the hippocampus from sleep-deprived and Alzheimer\u2019s disease mice.","volume":"43","author":"Wei","year":"2020","journal-title":"Genet. Mol. Biol."},{"key":"B214","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/S0092-8674(00)80579-6","article-title":"The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing\u2019s disease.","volume":"96","author":"Westphal","year":"1999","journal-title":"Cell"},{"key":"B215","doi-asserted-by":"publisher","first-page":"3492","DOI":"10.1016\/j.celrep.2018.05.074","article-title":"Single-molecule characterization of the interactions between extracellular chaperones and toxic alpha-synuclein oligomers.","volume":"23","author":"Whiten","year":"2018","journal-title":"Cell Rep."},{"key":"B216","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/j.1471-4159.2004.02840.x","article-title":"Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin.","volume":"92","author":"Wickham","year":"2005","journal-title":"J. Neurochem."},{"key":"B217","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.neurobiolaging.2007.06.001","article-title":"Small heat shock proteins associated with cerebral amyloid angiopathy of hereditary cerebral hemorrhage with amyloidosis (Dutch type) induce interleukin-6 secretion.","volume":"30","author":"Wilhelmus","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"B218","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1111\/j.1365-2990.2006.00689.x","article-title":"Specific association of small heat shock proteins with the pathological hallmarks of Alzheimer\u2019s disease brains.","volume":"32","author":"Wilhelmus","year":"2006","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"B219","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1159\/000448896","article-title":"Cerebrospinal fluid progranulin, but not serum progranulin, is reduced in GRN-negative frontotemporal dementia.","volume":"17","author":"Wilke","year":"2017","journal-title":"Neurodegener. Dis."},{"key":"B220","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1073\/pnas.1114740109","article-title":"High-resolution structure of a BRICHOS domain and its implications for anti-amyloid chaperone activity on lung surfactant protein C.","volume":"109","author":"Willander","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B221","doi-asserted-by":"publisher","first-page":"3893","DOI":"10.1111\/j.1742-4658.2011.08209.x","article-title":"BRICHOS domain associated with lung fibrosis, dementia and cancer\u2013a chaperone that prevents amyloid fibril formation?","volume":"278","author":"Willander","year":"2011","journal-title":"FEBS J."},{"key":"B222","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0968-0004(99)01534-0","article-title":"Clusterin is a secreted mammalian chaperone.","volume":"25","author":"Wilson","year":"2000","journal-title":"Trends Biochem. Sci."},{"key":"B223","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1080\/14728222.2017.1267142","article-title":"Clusterin as a therapeutic target.","volume":"21","author":"Wilson","year":"2017","journal-title":"Expert Opin. Ther. Targets"},{"key":"B224","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/S0306-4522(03)00560-8","article-title":"The proprotein convertase PC2 is involved in the maturation of prosomatostatin to somatostatin-14 but not in the somatostatin deficit in Alzheimer\u2019s disease.","volume":"122","author":"Winsky-Sommerer","year":"2003","journal-title":"Neuroscience"},{"key":"B225","doi-asserted-by":"publisher","first-page":"E6962","DOI":"10.1073\/pnas.1701137114","article-title":"Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways.","volume":"114","author":"Wojtas","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B226","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S0065-230X(09)04006-8","article-title":"Chapter 6: the chaperone action of clusterin and its putative role in quality control of extracellular protein folding.","volume":"104","author":"Wyatt","year":"2009","journal-title":"Adv. Cancer Res."},{"key":"B227","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1146\/annurev-biochem-072711-163904","article-title":"Extracellular chaperones and proteostasis.","volume":"82","author":"Wyatt","year":"2013","journal-title":"Annu. Rev. Biochem."},{"key":"B228","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1080\/21678421.2018.1433689","article-title":"Mass spectrometry analysis of plasma from amyotrophic lateral sclerosis and control subjects.","volume":"19","author":"Xu","year":"2018","journal-title":"Amyotroph. Lateral Scler. Frontotemporal Degener."},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.1101\/2020.03.30.015214","article-title":"A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation.","author":"Yao","year":"2020","journal-title":"bioRxiv"},{"key":"B230","doi-asserted-by":"publisher","first-page":"3478","DOI":"10.1016\/j.celrep.2020.02.059","article-title":"NRBP1-containing CRL2\/CRL4A regulates amyloid beta production by targeting BRI2 and BRI3 for degradation.","volume":"30","author":"Yasukawa","year":"2020","journal-title":"Cell Rep."},{"key":"B231","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.neuron.2016.06.015","article-title":"TREM2 binds to apolipoproteins, including APOE and CLU\/APOJ, and thereby facilitates uptake of amyloid-beta by microglia.","volume":"91","author":"Yeh","year":"2016","journal-title":"Neuron"},{"key":"B232","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1096\/fj.06-7986com","article-title":"The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures.","volume":"21","author":"Yerbury","year":"2007","journal-title":"FASEB J."},{"key":"B233","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1038\/sj.embor.7400586","article-title":"Quality control of protein folding in extracellular space.","volume":"6","author":"Yerbury","year":"2005","journal-title":"EMBO Rep."},{"key":"B234","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1007\/s10072-018-3259-8","article-title":"Association between CLU gene rs11136000 polymorphism and Alzheimer\u2019s disease: an updated meta-analysis.","volume":"39","author":"Zhu","year":"2018","journal-title":"Neurol. Sci."},{"key":"B235","doi-asserted-by":"publisher","first-page":"23582","DOI":"10.1074\/jbc.271.38.23582","article-title":"Involvement of a polyproline helix-like structure in the interaction of 7B2 with prohormone convertase 2.","volume":"271","author":"Zhu","year":"1996","journal-title":"J. Biol. Chem."},{"key":"B236","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1083\/jcb.129.6.1641","article-title":"7B2 facilitates the maturation of proPC2 in neuroendocrine cells and is required for the expression of enzymatic activity.","volume":"129","author":"Zhu","year":"1995","journal-title":"J. Cell Biol."},{"key":"B237","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1016\/0024-3205(96)00310-4","article-title":"Cerebrovascular transport of Alzheimer\u2019s amyloid beta and apolipoproteins J and E: possible anti-amyloidogenic role of the blood-brain barrier.","volume":"59","author":"Zlokovic","year":"1996","journal-title":"Life Sci."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnagi.2020.00268\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T13:38:08Z","timestamp":1617025088000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnagi.2020.00268\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,27]]},"references-count":237,"alternative-id":["10.3389\/fnagi.2020.00268"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2020.00268","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,27]]},"article-number":"268"}}