{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:15:12Z","timestamp":1788498912282,"version":"build-2803163510"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG049722"],"award-info":[{"award-number":["R01AG049722"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R21AG051004"],"award-info":[{"award-number":["R21AG051004"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["F31AG058455"],"award-info":[{"award-number":["F31AG058455"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"DOI":"10.3389\/fnagi.2020.588297","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T02:01:41Z","timestamp":1603850501000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Age-Related Alterations in Prelimbic Cortical Neuron Arc Expression Vary by Behavioral State and Cortical Layer"],"prefix":"10.3389","volume":"12","author":[{"given":"Abbi R.","family":"Hernandez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah M.","family":"Truckenbrod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya E.","family":"Barrett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katelyn N.","family":"Lubke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara N.","family":"Burke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/nn.3648","article-title":"A solution to dependency: using multilevel analysis to accommodate nested data.","volume":"17","author":"Aarts","year":"2014","journal-title":"Nat. Neurosci."},{"key":"B2","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1523\/JNEUROSCI.1852-07.2008","article-title":"Age-related regional network of magnetic resonance imaging gray matter in the rhesus macaque.","volume":"28","author":"Alexander","year":"2008","journal-title":"J. Neurosci."},{"key":"B3","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1523\/JNEUROSCI.5192-13.2014","article-title":"Prefrontal cortical GABAergic dysfunction contributes to age-related working memory impairment.","volume":"34","author":"Banuelos","year":"2014","journal-title":"J. Neurosci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1101\/lm.48602","article-title":"Aged rats are impaired on an attentional set-shifting task sensitive to medial frontal cortex damage in young rats.","volume":"9","author":"Barense","year":"2002","journal-title":"Learn. Mem."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2948","DOI":"10.1523\/JNEUROSCI.5289-06.2007","article-title":"Recognition memory for objects, place, and temporal order: a disconnection analysis of the role of the medial prefrontal cortex and perirhinal cortex.","volume":"27","author":"Barker","year":"2007","journal-title":"J. Neurosci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1093\/cercor\/bht245","article-title":"Object-in-place associative recognition memory depends on glutamate receptor neurotransmission within two defined Hippocampal-cortical circuits: a critical role for AMPA and NMDA receptors in the Hippocampus, perirhinal, and prefrontal cortices.","volume":"25","author":"Barker","year":"2015","journal-title":"Cereb. Cortex"},{"key":"B7","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.tics.2013.08.012","article-title":"Efficiency, capacity, compensation, maintenance, plasticity: emerging concepts in cognitive reserve.","volume":"17","author":"Barulli","year":"2013","journal-title":"Trends Cogn. Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/0197-4580(96)00011-5","article-title":"Neurobiological substrates of behavioral decline: models and data analytic strategies for individual differences in aging.","volume":"17","author":"Baxter","year":"1996","journal-title":"Neurobiol. Aging"},{"key":"B9","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.neuroscience.2016.02.014","article-title":"Prefrontal cortical GABAergic signaling and impaired behavioral flexibility in aged F344 rats.","volume":"345","author":"Beas","year":"2016","journal-title":"Neuroscience"},{"key":"B10","doi-asserted-by":"publisher","first-page":"2988","DOI":"10.1093\/cercor\/bhu093","article-title":"Limbic tract integrity contributes to pattern separation performance across the lifespan.","volume":"25","author":"Bennett","year":"2015","journal-title":"Cereb. Cortex"},{"key":"B11","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.nlm.2015.06.014","article-title":"Mnemonic discrimination relates to perforant path integrity: an ultra-high resolution diffusion tensor imaging study.","volume":"129","author":"Bennett","year":"2016","journal-title":"Neurobiol. Learn. Mem."},{"key":"B12","author":"Blazer","year":"2015","journal-title":"Cognitive Aging: Progress in Understanding and Opportunities For Action."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1523\/JNEUROSCI.3258-12.2013","article-title":"Differential balance of prefrontal synaptic activity in successful versus unsuccessful cognitive aging.","volume":"33","author":"Bories","year":"2013","journal-title":"J. Neurosci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.neubiorev.2018.05.008","article-title":"The cingulum bundle: anatomy, function, and dysfunction.","volume":"92","author":"Bubb","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B15","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/nrn3214","article-title":"The economy of brain network organization.","volume":"13","author":"Bullmore","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"B16","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.tins.2018.03.001","article-title":"Shared functions of perirhinal and parahippocampal cortices: implications for cognitive aging.","volume":"41","author":"Burke","year":"2018","journal-title":"Trends Neurosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2080","DOI":"10.1002\/hipo.22066","article-title":"Layer V perirhinal cortical ensemble activity during object exploration: a comparison between young and aged rats.","volume":"22","author":"Burke","year":"2012","journal-title":"Hippocampus"},{"key":"B18","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1523\/JNEUROSCI.2875-13.2014","article-title":"Advanced age dissociates dual functions of the perirhinal cortex.","volume":"34","author":"Burke","year":"2014","journal-title":"J. Neurosci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1002\/(SICI)1096-9861(19980824)398:2<179::AID-CNE3>3.0.CO;2-Y","article-title":"Cortical afferents of the perirhinal, postrhinal, and entorhinal cortices of the rat.","volume":"398","author":"Burwell","year":"1998","journal-title":"J. Comp. Neurol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/nrn3687","article-title":"The log-dynamic brain: how skewed distributions affect network operations.","volume":"15","author":"Buzs\u00e1ki","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.neurobiolaging.2016.05.015","article-title":"Age-related changes in tonic activation of presynaptic versus extrasynaptic \u03b3-amniobutyric acid type B receptors in rat medial prefrontal cortex.","volume":"45","author":"Carpenter","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"B22","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1126\/science.274.5287.484","article-title":"Hippocampal neurodegeneration in aging.","volume":"274","author":"Gallagher","year":"1996","journal-title":"Science"},{"key":"B23","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/nrn3256","article-title":"The cognitive neuroscience of ageing.","volume":"13","author":"Grady","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1038\/16046","article-title":"Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles.","volume":"2","author":"Guzowski","year":"1999","journal-title":"Nat. Neurosci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/S0959-4388(00)00252-X","article-title":"Imaging neural activity with temporal and cellular resolution using FISH.","volume":"11","author":"Guzowski","year":"2001","journal-title":"Curr. Opin. Neurobiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"3424","DOI":"10.1523\/JNEUROSCI.4727-12.2013","article-title":"Transcription of the immediate-early gene Arc in CA1 of the hippocampus reveals activity differences along the proximodistal axis that are attenuated by advanced age.","volume":"33","author":"Hartzell","year":"2013","journal-title":"J. Neurosci."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00391","article-title":"A ketogenic diet improves cognition and has biochemical effects in prefrontal cortex that are dissociable from hippocampus.","volume":"10","author":"Hernandez","year":"","journal-title":"Front. Aging Neurosci."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2019.00239","article-title":"Age and ketogenic diet have dissociable effects on synapse-related gene expression between hippocampal subregions.","volume":"11","author":"Hernandez","year":"","journal-title":"Front Aging Neurosci"},{"key":"B29","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1037\/bne0000093","article-title":"Age-related impairments in object-place associations are not due to hippocampal dysfunction.","volume":"129","author":"Hernandez","year":"2015","journal-title":"Behav. Neurosci."},{"key":"B30","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.neurobiolaging.2018.06.028","article-title":"Dissociable effects of advanced age on prefrontal cortical and medial temporal lobe ensemble activity.","volume":"70","author":"Hernandez","year":"","journal-title":"Neurobiol. Aging"},{"key":"B31","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.nlm.2016.10.012","article-title":"Medial prefrontal-perirhinal cortical communication is necessary for flexible response selection.","volume":"137","author":"Hernandez","year":"2017","journal-title":"Neurobiol. Learn. Mem."},{"key":"B32","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1037\/bne0000352","article-title":"Sex differences in age-related impairments vary across cognitive and physical assessments in rats.","volume":"134","author":"Hernandez","year":"","journal-title":"Behav. Neurosci."},{"key":"B33","article-title":"Age-Related Declines in prefrontal cortical expression of metabotropic glutamate receptors that support working memory.","volume":"5","author":"Hernandez","year":"","journal-title":"eNeuro"},{"key":"B34","first-page":"155","article-title":"Use of a body condition score technique to assess health status in a rat model of polycystic kidney disease.","volume":"49","author":"Hickman","year":"2010","journal-title":"J. Am. Assoc. Lab. Anim. Sci."},{"key":"B35","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/hbm.23067","article-title":"Structural and functional connectivity in healthy aging: associations for cognition and motor behavior.","volume":"37","author":"Hirsiger","year":"2016","journal-title":"Hum. Brain Mapp."},{"key":"B36","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.bbr.2017.07.032","article-title":"Prefrontal connections of the perirhinal and postrhinal cortices in the rat.","volume":"354","author":"Hwang","year":"2018","journal-title":"Behav. Brain Res."},{"key":"B37","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.celrep.2019.06.053","article-title":"Prefrontal pathways provide top-down control of memory for sequences of events.","volume":"28","author":"Jayachandran","year":"2019","journal-title":"Cell Rep."},{"key":"B38","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.neurobiolaging.2017.08.027","article-title":"Dynamic range in BOLD modulation: lifespan aging trajectories and association with performance.","volume":"60","author":"Kennedy","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"B39","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/hipo.20448","article-title":"Effects of aging on agmatine levels in memory-associated brain structures.","volume":"18","author":"Liu","year":"","journal-title":"Hippocampus"},{"key":"B40","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.neuroscience.2008.06.033","article-title":"Age-related changes in polyamines in memory-associated brain structures in rats.","volume":"155","author":"Liu","year":"","journal-title":"Neuroscience"},{"key":"B41","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.neuroscience.2009.08.029","article-title":"Age-related changes in arginine and its metabolites in memory-associated brain structures.","volume":"164","author":"Liu","year":"2009","journal-title":"Neuroscience"},{"key":"B42","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/0896-6273(95)90299-6","article-title":"Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites.","volume":"14","author":"Lyford","year":"1995","journal-title":"Neuron"},{"key":"B43","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/j.neurobiolaging.2006.07.005","article-title":"Frontal connections and cognitive changes in normal aging rhesus monkeys: a DTI study.","volume":"28","author":"Makris","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2010.00011","article-title":"Selective vulnerabilities of N-methyl-D-aspartate (NMDA) receptors during brain aging.","author":"Magnusson","year":"2010","journal-title":"Front. Aging Neurosci"},{"key":"B45","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/S0169-328X(01)00344-8","article-title":"Age-related changes in the protein expression of subunits of the NMDA receptor.","author":"Magnusson","year":"2002","journal-title":"Mol. Brain Res"},{"key":"B46","doi-asserted-by":"publisher","first-page":"8965","DOI":"10.1523\/JNEUROSCI.0531-17.2017","article-title":"Attenuated activity across multiple cell types and reduced monosynaptic connectivity in the aged perirhinal cortex.","volume":"37","author":"Maurer","year":"","journal-title":"J Neurosci."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2017.00049","article-title":"Age-related changes in lateral entorhinal and CA3 neuron allocation predict poor performance on object discrimination.","volume":"11","author":"Maurer","year":"","journal-title":"Front. Syst. Neurosci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"12537","DOI":"10.1523\/JNEUROSCI.2332-16.2016","article-title":"NR2A-containing NMDARs in the prefrontal cortex are required for working memory and associated with age-related cognitive decline.","author":"McQuail","year":"2016","journal-title":"J. Neurosci"},{"key":"B49","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.molmed.2015.05.002","article-title":"Molecular aspects of age-related cognitive decline: the role of GABA signaling.","volume":"21","author":"McQuail","year":"2015","journal-title":"Trends Mol. Med."},{"key":"B50","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.neurobiolaging.2014.06.030","article-title":"Spatial reference memory in normal aging Fischer 344 x Brown Norway F1 hybrid rats.","volume":"36","author":"McQuail","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1016\/j.celrep.2013.07.039","article-title":"Preconfigured, skewed distribution of firing rates in the hippocampus and entorhinal cortex.","volume":"4","author":"Mizuseki","year":"2013","journal-title":"Cell Rep."},{"key":"B52","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/nrn3200","article-title":"The ageing cortical synapse: hallmarks and implications for cognitive decline.","volume":"13","author":"Morrison","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1016\/j.neurobiolaging.2009.10.001","article-title":"Aging-related changes in calcium-binding proteins in rat perirhinal cortex.","volume":"32","author":"Moyer","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"B54","doi-asserted-by":"publisher","first-page":"2727","DOI":"10.1007\/s12035-020-01915-4","article-title":"Survey of the arc epigenetic landscape in normal cognitive aging.","author":"Myrum","year":"2020","journal-title":"Mol Neurobiol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"6542","DOI":"10.1523\/JNEUROSCI.1077-07.2007","article-title":"Learning-related facilitation of rhinal interactions by medial prefrontal inputs.","volume":"27","author":"Paz","year":"2007","journal-title":"J. Neurosci."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2010.00009","article-title":"An epigenetic hypothesis of aging-related cognitive dysfunction.","author":"Penner","year":"2010","journal-title":"Front. Aging Neurosci"},{"key":"B57","doi-asserted-by":"publisher","first-page":"3067","DOI":"10.1016\/j.neurobiolaging.2015.07.024","article-title":"Head west or left, east or right: interactions between memory systems in neurocognitive aging.","volume":"36","author":"Pereira","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"B58","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/0197-4580(91)90077-W","article-title":"Recognition memory deficits in a subpopulation of aged monkeys resemble the effects of medial temporal lobe damage.","volume":"12","author":"Rapp","year":"1991","journal-title":"Neurobiol. Aging"},{"key":"B59","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/j.1467-8721.2008.00570.x","article-title":"Neurocognitive aging and the compensation hypothesis.","volume":"17","author":"Reuter-Lorenz","year":"2008","journal-title":"Curr. Dir. Psychol. Sci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.neuroimage.2016.12.022","article-title":"Age-related reduction of BOLD modulation to cognitive difficulty predicts poorer task accuracy and poorer fluid reasoning ability.","volume":"147","author":"Rieck","year":"2017","journal-title":"Neuroimage"},{"key":"B61","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S0301-0082(02)00126-0","article-title":"Impact of aging on hippocampal function: plasticity, network dynamics, and cognition.","volume":"69","author":"Rosenzweig","year":"2003","journal-title":"Prog. Neurobiol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1002\/hipo.22069","article-title":"Age-related impairment in a complex object discrimination task that engages perirhinal cortex.","volume":"22","author":"Ryan","year":"2012","journal-title":"Hippocampus"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1111\/ejn.12183","article-title":"Impact of aging brain circuits on cognition.","volume":"37","author":"Samson","year":"2013","journal-title":"Eur. J. Neurosci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/S0896-6273(00)80591-7","article-title":"Synaptic activation causes the mRNA for the IEG Arc to localize selectively near activated postsynaptic sites on dendrites.","volume":"21","author":"Steward","year":"1998","journal-title":"Neuron"},{"key":"B65","doi-asserted-by":"crossref","first-page":"B492","DOI":"10.1093\/gerona\/54.11.B492","article-title":"Growth curves and survival characteristics of the animals used in the biomarkers of aging program.","volume":"54","author":"Turturro","year":"1999","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"B66","doi-asserted-by":"publisher","first-page":"6489","DOI":"10.1523\/JNEUROSCI.0350-04.2004","article-title":"Differences in hippocampal neuronal population responses to modifications of an environmental context: evidence for distinct, yet complementary, functions of CA3 and CA1 ensembles.","author":"Vazdarjanova","year":"2004","journal-title":"J. Neurosci"},{"key":"B67","author":"Vespa","year":"2018","journal-title":"Demographic Turning Points for the United States: Population projections for 2020 to 2060."},{"key":"B68","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/30918","article-title":"Collective dynamics of \u2018small-world\u2019networks.","volume":"393","author":"Watts","year":"1998","journal-title":"Nature"},{"key":"B69","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.neuron.2016.11.045","article-title":"AAV-mediated anterograde transsynaptic tagging: mapping corticocollicular input-defined neural pathways for defense behaviors.","volume":"93","author":"Zingg","year":"2017","journal-title":"Neuron"}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2020.588297\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T02:01:45Z","timestamp":1603850505000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2020.588297\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,28]]},"references-count":69,"alternative-id":["10.3389\/fnagi.2020.588297"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2020.588297","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.08.11.247262","asserted-by":"object"}]},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,28]]},"article-number":"588297"}}