{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:05:21Z","timestamp":1782299121351,"version":"3.54.5"},"reference-count":75,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012619","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fragilidad y Envejecimiento Saludable","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> The role of the central nervous system in the pathophysiology of frailty is controversial. We used magnetoencephalography (MEG) to search for abnormalities in the ongoing oscillatory neural activity of frail individuals without global cognitive impairment.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Fifty four older (\u226570 years) and cognitively healthy (Mini-Mental State Examination \u226524) participants were classified as robust (0 criterion, <jats:italic>n<\/jats:italic> = 34) or frail (\u2265 3 criteria, <jats:italic>n<\/jats:italic> = 20) following Fried's phenotype. Memory, language, attention, and executive function were assessed through well-validated neuropsychological tests. Every participant underwent a resting-state MEG and a T1-weighted magnetic resonance imaging scan. We performed MEG power spectral analyses to compare the electrophysiological profiles of frail and robust individuals. We used an ensemble learner to investigate the ability of MEG spectral power to discriminate frail from robust participants.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> We identified increased relative power in the frail group in the mu (<jats:italic>p<\/jats:italic> &amp;lt; 0.05) and sensorimotor (<jats:italic>p<\/jats:italic> &amp;lt; 0.05) frequencies across right sensorimotor, posterior parietal, and frontal regions. The ensemble learner discriminated frail from robust participants [area under the curve = 0.73 (95% CI = 0.49\u20130.98)]. Frail individuals performed significantly worse in the Trail Making Test, Digit Span Test (forward), Rey-Osterrieth Complex Figure, and Semantic Fluency Test.<\/jats:p><jats:p><jats:bold>Interpretation:<\/jats:bold> Frail individuals without global cognitive impairment showed ongoing oscillatory alterations within brain regions associated with aspects of motor control, jointly to failures in executive function. Our results suggest that some physical manifestations of frailty might partly arise from failures in central structures relevant to sensorimotor and executive processing.<\/jats:p>","DOI":"10.3389\/fnagi.2021.609043","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T14:07:50Z","timestamp":1613830070000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Ongoing Oscillatory Electrophysiological Alterations in Frail Older Adults: A MEG Study"],"prefix":"10.3389","volume":"13","author":[{"given":"Isabel","family":"Su\u00e1rez-M\u00e9ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"L\u00f3pez-Sanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Pasqu\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Bernab\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Castillo Gallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Vald\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"del Pozo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Maest\u00fa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leocadio","family":"Rodr\u00edguez-Ma\u00f1as","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1111\/j.1532-5415.2008.02136.x","article-title":"Cognitive impairment improves the predictive validity of the phenotype of frailty for adverse health outcomes: the three-city study","volume":"57","author":"\u00c1vila-Funes","year":"2009","journal-title":"J. Am. Geriatr. Soc."},{"key":"B2","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1093\/gerona\/glw347","article-title":"Vascular cerebral damage in frail older adults: the AMImage study","volume":"72","author":"Avila-Funes","year":"2017","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.conb.2016.07.003","article-title":"How the prefrontal executive got its stripes","volume":"40","author":"Barbas","year":"2016","journal-title":"Curr. Opin. Neurobiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1002\/gps.646","article-title":"Standard measures of executive function in predicting instrumental activities of daily living in older adults","volume":"17","author":"Bell-McGinty","year":"2002","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"B5","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc."},{"key":"B6","doi-asserted-by":"publisher","first-page":"248","DOI":"10.3389\/fneur.2015.00248","article-title":"The right supramarginal gyrus is important for proprioception in healthy and stroke-affected participants: a functional MRI study","volume":"6","author":"Ben-Shabat","year":"2015","journal-title":"Front. Neurol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1093\/brain\/awf211","article-title":"Spatial neglect in near and far space investigated by repetitive transcranial magnetic stimulation","volume":"125","author":"Bjoertomt","year":"2002","journal-title":"Brain"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1093\/gerona\/glu117","article-title":"Brain pathology contributes to simultaneous change in physical frailty and cognition in old age","volume":"69","author":"Buchman","year":"2014","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2594","DOI":"10.1016\/j.neuropsychologia.2005.10.011","article-title":"The posterior parietal cortex: sensorimotor interface for the planning and online control of visually guided movements","volume":"44","author":"Buneo","year":"2006","journal-title":"Neuropsychologia"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1111\/j.1532-5415.2012.04054.x","article-title":"Prevalence of frailty in community-dwelling older persons: a systematic review","volume":"60","author":"Collard","year":"2012","journal-title":"J. Am. Geriatr. Soc."},{"key":"B11","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1111\/ggi.12708","article-title":"Neuroimaging signatures of frailty: a population-based study in community-dwelling older adults (the atahualpa project)","volume":"17","author":"Del Brutto","year":"2017","journal-title":"Geriatr. Gerontol. Int."},{"key":"B12","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.neuropsychologia.2013.10.015","article-title":"On the role of the supramarginal gyrus in phonological processing and verbal working memory: evidence from rTMS studies","volume":"53","author":"Deschamps","year":"2014","journal-title":"Neuropsychologia"},{"key":"B13","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1093\/cercor\/bhm050","article-title":"The angular gyrus computes action awareness representations","volume":"18","author":"Farrer","year":"2008","journal-title":"Cereb. Cortex"},{"key":"B14","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/j.nicl.2018.10.003","article-title":"Lesion locations associated with persistent proprioceptive impairment in the upper limbs after stroke","volume":"20","author":"Findlater","year":"2018","journal-title":"NeuroImage Clin."},{"key":"B15","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: evidence for a phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v033.i01","article-title":"regularization paths for generalized linear models via coordinate descent","volume":"33","author":"Friedman","year":"2010","journal-title":"J. Stat. Softw."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/s17122926","article-title":"Choice of magnetometers and gradiometers after signal space separation","volume":"17","author":"Garc\u00e9s","year":"2017","journal-title":"Sensors"},{"key":"B18","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1007\/s12603-011-0075-8","article-title":"The prevalence of frailty syndrome in an older population from Spain. The toledo study for healthy aging","volume":"15","author":"Garc\u00eda-Garc\u00eda","year":"2011","journal-title":"J. Nutr. Heal. Aging"},{"key":"B19","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1007\/s00221-007-0890-7","article-title":"Task-dependent asymmetries in the utilization of proprioceptive feedback for goal-directed movement","volume":"180","author":"Goble","year":"2007","journal-title":"Exp. Brain Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1002\/hbm.21257","article-title":"The neural basis of central proprioceptive processing in older versus younger adults: an important sensory role for right putamen","volume":"33","author":"Goble","year":"2012","journal-title":"Hum. Brain Mapp."},{"key":"B21","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s00221-005-0280-y","article-title":"Upper limb asymmetries in the utilization of proprioceptive feedback","volume":"168","author":"Goble","year":"2006","journal-title":"Exp. Brain Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1002\/hbm.23067","article-title":"Structural and functional connectivity in healthy aging: associations for cognition and motor behavior","volume":"37","author":"Hirsiger","year":"2016","journal-title":"Hum. Brain Mapp."},{"key":"B23","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.cortex.2016.03.019","article-title":"Mu suppression - a good measure of the human mirror neuron system?","volume":"82","author":"Hobson","year":"2016","journal-title":"Cortex"},{"key":"B24","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1093\/gerona\/glr068","article-title":"fNIRS study of walking and walking while talking in young and old individuals","volume":"66","author":"Holtzer","year":"2011","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci"},{"key":"B25","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1002\/ana.20799","article-title":"Brain imaging evidence of preclinical Alzheimer's disease in normal aging","volume":"54","author":"Jagust","year":"2006","journal-title":"Ann. Neurol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1093\/gerona\/glz006","article-title":"Diminished locomotor control is associated with reduced neurovascular coupling in older adults","volume":"75","author":"Jor'dan","year":"2020","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1093\/gerona\/glx063","article-title":"Executive network activation is linked to walking speed in older adults: functional MRI and TCD ultrasound evidence from the MOBILIZE boston study","volume":"72","author":"Jor'dan","year":"2017","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci"},{"key":"B28","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1111\/jgs.13114","article-title":"Associations between frailty, retinal microvascular changes, and cerebral white matter abnormalities in Korean older adults","volume":"62","author":"Jung","year":"2014","journal-title":"J. Am. Geriatr. Soc."},{"key":"B29","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.neurobiolaging.2018.06.032","article-title":"The association between brain volume, cortical brain infarcts, and physical frailty","volume":"70","author":"Kant","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"B30","doi-asserted-by":"publisher","first-page":"11343","DOI":"10.1038\/s41598-019-47731-2","article-title":"The association between frailty and MRI features of cerebral small vessel disease","volume":"9","author":"Kant","year":"2019","journal-title":"Sci. Rep."},{"key":"B31","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1007\/s12603-013-0367-2","article-title":"Cognitive frailty: rational and definition from an (I.A.N.A.\/I.A.G.G.) international consensus group","volume":"17","author":"Kelaiditi","year":"2013","journal-title":"J. Nutr. Heal. Aging"},{"key":"B32","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.neuroimage.2013.04.070","article-title":"Cortical control of normal gait and precision stepping: an fNIRS study","author":"Koenraadt","year":"2014","journal-title":"Neuroimage"},{"key":"B33","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1093\/gerona\/glz297","article-title":"Functional connectivity of the supplementary motor network is associated with Fried's modified frailty score in the elderly","volume":"75","author":"Lammers","year":"2020","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"284","DOI":"10.3389\/fmed.2018.00284","article-title":"Scoping review of neuroimaging studies investigating frailty and frailty components","volume":"5","author":"L\u00f3pez-Sanz","year":"2018","journal-title":"Front. Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1111\/jgs.16343","article-title":"Prospective associations between diffusion tensor imaging parameters and frailty in older adults","volume":"68","author":"Maltais","year":"2020","journal-title":"J. Am. Geriatr. Soc."},{"key":"B36","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1177\/1545968318792616","article-title":"Transcranial direct current stimulation may improve cognitive-motor function in functionally limited older adults","volume":"32","author":"Manor","year":"2018","journal-title":"Neurorehabil. Neural Repair"},{"key":"B37","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.jneumeth.2007.03.024","article-title":"Nonparametric statistical testing of EEG- and MEG-data","volume":"164","author":"Maris","year":"2007","journal-title":"J. Neurosci. Methods"},{"key":"B38","author":"Meyer","year":"2015","journal-title":"e1071: Misc Functions of the Department of Statistics (e1071), TU Wien, 2014"},{"key":"B39","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.neuroimage.2008.07.029","article-title":"Role of the prefrontal cortex in human balance control","volume":"43","author":"Mihara","year":"2008","journal-title":"Neuroimage"},{"key":"B40","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.bandc.2017.04.002","article-title":"Effects of aging on prefrontal brain activation during challenging walking conditions","volume":"115","author":"Mirelman","year":"2017","journal-title":"Brain Cogn."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1152\/jn.00637.2004","article-title":"Dominance of the right hemisphere and role of area 2 in human kinesthesia","volume":"93","author":"Naito","year":"","journal-title":"J. Neurophysiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1177\/1073858403259628","article-title":"Sensing limb movements in the motor cortex: how humans sense limb movement","volume":"10","author":"Naito","year":"","journal-title":"Neuroscientist"},{"key":"B43","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1016\/S0896-6273(02)00980-7","article-title":"I feel my hand moving: a new role of the primary motor cortex in somatic perception of limb movement","volume":"36","author":"Naito","year":"2002","journal-title":"Neuron"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1093\/brain\/awy044","article-title":"Electromagnetic signatures of the preclinical and prodromal stages of Alzheimer's disease","volume":"141","author":"Nakamura","year":"2018","journal-title":"Brain"},{"key":"B45","doi-asserted-by":"publisher","first-page":"M158","DOI":"10.1093\/gerona\/56.3.M158","article-title":"Associations of subclinical cardiovascular disease with frailty","volume":"56","author":"Newman","year":"2001","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"3637","DOI":"10.1088\/0031-9155\/48\/22\/002","article-title":"The magnetic lead field theorem in the quasi-static approximation and its use for magnetoenchephalography forward calculation in realistic volume conductors","volume":"48","author":"Nolte","year":"2003","journal-title":"Phys. Med. Biol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"156869","DOI":"10.1155\/2011\/156869","article-title":"FieldTrip: open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data","volume":"2011","author":"Oostenveld","year":"2011","journal-title":"Comput. Intell. Neurosci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1002\/1097-4679(198601)42:1<28::AID-JCLP2270420104>3.0.CO;2-T","article-title":"Factorial and discriminant validity of the center for epidemiological studies depression (CES-D) scale","volume":"42","author":"Orme","year":"1986","journal-title":"J. Clin. Psychol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"3228","DOI":"10.1016\/j.neuropsychologia.2010.06.039","article-title":"Parietal cortex coding of limb posture: in search of the body-schema","volume":"48","author":"Parkinson","year":"2010","journal-title":"Neuropsychologia"},{"key":"B50","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.gerinurse.2020.01.017","article-title":"A home-based exercise program focused on proprioception to reduce falls in frail and pre-frail community-dwelling older adults","volume":"41","author":"P\u00e9rez-Ros","year":"2020","journal-title":"Geriatr. Nurs."},{"key":"B51","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.brainresrev.2005.04.005","article-title":"The functional significance of mu rhythms: translating \u201cseeing\u201d and \u201chearing\u201d into \u201cdoing.\u201d","volume":"50","author":"Pineda","year":"2005","journal-title":"Brain Res. Rev."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1093\/english\/efy032","author":"Polley","year":"2018","journal-title":"Package \u201cSuperLearner\u201d."},{"key":"B53","unstructured":"R: A Language and Environment for Statistical Computing. Vienna: R Foundation Statistical Computing2017"},{"key":"B54","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1007\/s12603-013-0433-9","article-title":"Frailty: the quest for new domains, clinical definitions and subtypes. Is this justified on new evidence emerging?","volume":"18","author":"Rodr\u00edguez-Ma\u00f1as","year":"2014","journal-title":"J. Nutr. Health Aging"},{"key":"B55","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1007\/s12603-017-0895-2","article-title":"Global performance of executive function is predictor of risk of frailty and disability in older adults","volume":"21","author":"Rosado-Artalejo","year":"","journal-title":"J. Nutr. Health Aging"},{"key":"B56","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.jamda.2017.04.008","article-title":"Cognitive performance across 3 frailty phenotypes: toledo study for healthy aging","volume":"18","author":"Rosado-Artalejo","year":"","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/j.neurobiolaging.2008.08.004","article-title":"Magnetization transfer imaging, white matter hyperintensities, brain atrophy and slower gait in older men and women","volume":"31","author":"Rosano","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"B58","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1093\/gerona\/glv224","article-title":"Cerebral white matter and slow gait: contribution of hyperintensities and normal-appearing parenchyma","volume":"71","author":"Rosario","year":"2016","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"B59","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.neuroimage.2014.12.023","article-title":"Associations between age, motor function, and resting state sensorimotor network connectivity in healthy older adults","volume":"108","author":"Seidler","year":"2015","journal-title":"Neuroimage"},{"key":"B60","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1159\/000333407","article-title":"Executive dysfunctions and frontal syndromes","volume":"30","author":"Seni\u00f3w","year":"2012","journal-title":"Front. Neurol. Neurosci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"772","DOI":"10.3389\/fpsyg.2014.00772","article-title":"What do verbal fluency tasks measure? Predictors of verbal fluency performance in older adults","volume":"5","author":"Shao","year":"2014","journal-title":"Front. Psychol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"S693","DOI":"10.3233\/BME-151361","article-title":"Falls study: Proprioception, postural stability, and slips","volume":"26","author":"Sohn","year":"2015","journal-title":"Biomed. Mater. Eng."},{"key":"B63","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s00221-013-3538-9","article-title":"Right but not left angular gyrus modulates the metric component of the mental body representation: A tDCS study","volume":"228","author":"Spitoni","year":"2013","journal-title":"Exp. Brain Res."},{"key":"B64","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/BF02214147","article-title":"Physiological origins and functional correlates of EEG rhythmic activities: implications for self-regulation","volume":"21","author":"Sterman","year":"1996","journal-title":"Biofeedback Self Regul."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/j.cortex.2008.12.004","article-title":"Supramarginal gyrus involvement in visual word recognition","volume":"45","author":"Stoeckel","year":"2009","journal-title":"Cortex"},{"key":"B66","doi-asserted-by":"publisher","first-page":"322","DOI":"10.3389\/fmed.2020.00322","article-title":"Functional connectivity disruption in frail older adults without global cognitive deficits","volume":"7","author":"Su\u00e1rez-M\u00e9ndez","year":"2020","journal-title":"Front. Med."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1016\/j.neuroimage.2004.07.002","article-title":"Prefrontal and premotor cortices are involved in adapting walking and running speed on the treadmill: an optical imaging study","volume":"23","author":"Suzuki","year":"2004","journal-title":"Neuroimage"},{"key":"B68","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.jamda.2016.01.019","article-title":"A multicomponent exercise intervention that reverses frailty and improves cognition, emotion, and social networking in the community-dwelling frail elderly: a randomized clinical trial","volume":"17","author":"Tarazona-Santabalbina","year":"2016","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1002\/hbm.20627","article-title":"Removal of magnetoencephalographic artifacts with temporal signal-space separation: demonstration with single-trial auditory-evoked responses","volume":"30","author":"Taulu","year":"2009","journal-title":"Hum. Brain Mapp."},{"key":"B70","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/0021-9681(78)90058-9","article-title":"A questionnaire for the assessment of leisure time physical activities","volume":"31","author":"Taylor","year":"1978","journal-title":"J. Chronic Dis."},{"key":"B71","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/0013-4694(78)90260-2","article-title":"Lack of bilateral coherence of mu rhythm","volume":"44","author":"Van Leeuwen","year":"1978","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1109\/10.623056","article-title":"Localization of brain electrical activity via linearly constrained minimum variance spatial filtering","volume":"44","author":"Van Veen","year":"1997","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"B73","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1111\/j.1532-5415.2010.02780.x","article-title":"Trail making test predicts physical impairment and mortality in older persons","volume":"58","author":"Vazzana","year":"2010","journal-title":"J. Am. Geriatr. Soc."},{"key":"B74","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/2245","article-title":"Maintaining internal representations: the role of the human superior parietal lobe","volume":"1","author":"Wolpert","year":"1998","journal-title":"Nat. Neurosci."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1002\/hbm.22717","article-title":"Functional connectivity associated with gait velocity during walking and walking-while-talking in aging: a resting-state fMRI study","volume":"36","author":"Yuan","year":"2015","journal-title":"Hum. Brain Mapp."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2021.609043\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T14:07:55Z","timestamp":1613830075000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2021.609043\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,18]]},"references-count":75,"alternative-id":["10.3389\/fnagi.2021.609043"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2021.609043","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,18]]},"article-number":"609043"}}