{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:59:33Z","timestamp":1793383173224,"version":"4.5.0"},"reference-count":114,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001582","name":"Centre for Ageing Research and Development in Ireland","doi-asserted-by":"publisher","award":["13533"],"award-info":[{"award-number":["13533"]}],"id":[{"id":"10.13039\/501100001582","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p><jats:bold>Background<\/jats:bold>: Increasing efforts have focused on the establishment of novel biomarkers for the early detection of Alzheimer\u2019s disease (AD) and prediction of Mild Cognitive Impairment (MCI)-to-AD conversion. Behavioral changes over the course of healthy ageing, at disease onset and during disease progression, have been recently put forward as promising markers for the detection of MCI and AD. The present study examines whether the temporal characteristics of speech in a collaborative referencing task are associated with cognitive function and the volumes of brain regions involved in speech production and known to be reduced in MCI and AD pathology. We then explore the discriminative ability of the temporal speech measures for the classification of MCI and AD.<\/jats:p><jats:p><jats:bold>Method<\/jats:bold>: Individuals with MCI, mild-to-moderate AD and healthy controls (HCs) underwent a structural MRI scan and a battery of neuropsychological tests. They also engaged in a collaborative referencing task with a caregiver. The associations between the conversational speech timing features, cognitive function (domain-specific) and regional brain volumes were examined by means of linear mixed-effect modeling. Genetic programming was used to explore the discriminative ability of the conversational speech features.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold>: MCI and mild-to-moderate AD are characterized by a general slowness of speech, attributed to slower speech rate and slower turn-taking in conversational settings. The speech characteristics appear to be reflective of episodic, lexico-semantic, executive functioning and visuospatial deficits and underlying volume reductions in frontal, temporal and cerebellar areas.<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold>: The implementation of conversational speech timing-based technologies in clinical and community settings may provide additional markers for the early detection of cognitive deficits and structural changes associated with MCI and AD.<\/jats:p>","DOI":"10.3389\/fnagi.2021.637404","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T04:13:11Z","timestamp":1619496791000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Cognitive and Structural Correlates of Conversational Speech Timing in Mild Cognitive Impairment and Mild-to-Moderate Alzheimer\u2019s Disease: Relevance for Early Detection Approaches"],"prefix":"10.3389","volume":"13","author":[{"given":"C\u00e9line","family":"De Looze","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Dehsarvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Crosby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisling","family":"Vourdanou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Coen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Lawlor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,4,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.neucom.2016.08.041","article-title":"Recognition of Alzheimer\u2019s disease and mild cognitive impairment with multimodal image-derived biomarkers and multiple kernel learning","volume":"220","author":"Ahmed","year":"2017","journal-title":"Neurocomputing"},{"key":"B2","doi-asserted-by":"publisher","first-page":"3727","DOI":"10.1093\/brain\/awt269","article-title":"Connected speech as a marker of disease progression in autopsy-proven Alzheimer\u2019s disease","volume":"136","author":"Ahmed","year":"2013","journal-title":"Brain Lang."},{"key":"B3","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The diagnosis of mild cognitive impairment due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Albert","year":"2011","journal-title":"Alzheimers Dement."},{"key":"B4","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.trci.2017.01.006","article-title":"Predicting mild cognitive impairment from spontaneous spoken utterances","volume":"3","author":"Asgari","year":"2017","journal-title":"Alzheimers Dement."},{"key":"B5","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.bandl.2011.05.006","article-title":"The organization of narrative discourse in Lewy body spectrum disorder","volume":"119","author":"Ash","year":"2011","journal-title":"Brain Lang."},{"key":"B6","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1037\/a0027115","article-title":"The organization and anatomy of narrative comprehension and expression in Lewy body spectrum disorders","volume":"26","author":"Ash","year":"2012","journal-title":"Neuropsychology"},{"key":"B7","doi-asserted-by":"publisher","first-page":"12881","DOI":"10.1038\/srep12881","article-title":"Neural signatures of response planning occur midway through an incoming question in conversation","volume":"5","author":"B\u00f6gels","year":"2015","journal-title":"Sci. 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