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Aging Neurosci."],"abstract":"<jats:p>Physical activity (PA) and Alzheimer's disease are associated. However, how PA influences the cerebral \u03b2-amyloid (A\u03b2) burden remains unclear. The aim of this study was to determine if PA levels and\/or functional capacity (FC) are associated with A\u03b2 plaque deposition, and whether these associations differed according to APOE-\u03b54 genotype. A total of 117 women (69.7 \u00b1 2.6 years; 33.3% APOE-\u03b54-carriers) from the Women's Healthy Ageing Project cohort (WHAP) were analyzed. PA was measured using the International Physical Activity Questionnaire and, FC was evaluated using the Timed Up and Go test (TUGt). Positron emission tomography with F-18 Florbetaben was carried out to assess cerebral A\u03b2 burden, and quantified using standardized uptake value rations. The sample was split into PA and TUGt tertiles (T1, T2 and T3), and compared according to APOE-\u03b54 genotype (positive\/negative). There were no significant differences in A\u03b2 accumulation according to PA tertiles and APOE-\u03b54 genotype. Regarding FC, APOE-\u03b54+ participants in the first TUGt tertile (high performance) obtained significant lower A\u03b2 accumulations compared with the other two tertiles (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). Comparing between genotypes, greater A\u03b2 depositions were found between T2 and T3 in APOE-\u03b54+ compared with those who were APOE-\u03b54\u2013 (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). Values of TUGt \u2265 6.5 s (APOE-\u03b54+) and 8.5 s (APOE-\u03b54\u2013) were associated with an increased risk of having higher A\u03b2 retention. In conclusion, low performance in TUGt is associated with a negative effect on brain pathology with increasing cerebral A\u03b2 depositions in older women who are APOE-\u03b54+. In physically active older women (&amp;gt; 600 METs\u00b7min\/week), higher PA levels are not associated with reduction in A\u03b2 depositions.<\/jats:p>","DOI":"10.3389\/fnagi.2021.697528","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T15:40:27Z","timestamp":1625845227000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Influence of Physical Activity Levels and Functional Capacity on Brain \u03b2-Amyloid Deposition in Older Women"],"prefix":"10.3389","volume":"13","author":[{"given":"Raquel","family":"Pedrero-Chamizo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassandra","family":"Szoeke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorraine","family":"Dennerstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,7,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1007\/s12603-009-0246-z","article-title":"Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an International Academy on Nutrition and Aging (IANA) task force","volume":"13","author":"Abellan van Kan","year":"2009","journal-title":"J. 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