{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T21:17:18Z","timestamp":1793654238793,"version":"4.5.1"},"reference-count":434,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T00:00:00Z","timestamp":1634688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>Structural and functional integrity of the cerebral vasculature ensures proper brain development and function, as well as healthy aging. The inability of the brain to store energy makes it exceptionally dependent on an adequate supply of oxygen and nutrients from the blood stream for matching colossal demands of neural and glial cells. Key vascular features including a dense vasculature, a tightly controlled environment, and the regulation of cerebral blood flow (CBF) all take part in brain health throughout life. As such, healthy brain development and aging are both ensured by the anatomical and functional interaction between the vascular and nervous systems that are established during brain development and maintained throughout the lifespan. During critical periods of brain development, vascular networks remodel until they can actively respond to increases in neural activity through neurovascular coupling, which makes the brain particularly vulnerable to neurovascular alterations. The brain vasculature has been strongly associated with the onset and\/or progression of conditions associated with aging, and more recently with neurodevelopmental disorders. Our understanding of cerebrovascular contributions to neurological disorders is rapidly evolving, and increasing evidence shows that deficits in angiogenesis, CBF and the blood-brain barrier (BBB) are causally linked to cognitive impairment. Moreover, it is of utmost curiosity that although neurodevelopmental and neurodegenerative disorders express different clinical features at different stages of life, they share similar vascular abnormalities. In this review, we present an overview of vascular dysfunctions associated with neurodevelopmental (autism spectrum disorders, schizophrenia, Down Syndrome) and neurodegenerative (multiple sclerosis, Huntington\u2019s, Parkinson\u2019s, and Alzheimer\u2019s diseases) disorders, with a focus on impairments in angiogenesis, CBF and the BBB. Finally, we discuss the impact of early vascular impairments on the expression of neurodegenerative diseases.<\/jats:p>","DOI":"10.3389\/fnagi.2021.749026","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T18:51:51Z","timestamp":1634755911000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":86,"title":["From Neurodevelopmental to Neurodegenerative Disorders: The Vascular Continuum"],"prefix":"10.3389","volume":"13","author":[{"given":"Julie","family":"Ouellette","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baptiste","family":"Lacoste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte-endothelial interactions at the blood-brain barrier.","volume":"7","author":"Abbott","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201600322","article-title":"Optically derived metabolic and hemodynamic parameters predict hippocampal neurogenesis in the BTBR mouse model of autism.","volume":"11","author":"Abookasis","year":"2018","journal-title":"J. Biophotonics"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/j.neuroimage.2006.08.008","article-title":"Pattern of hemodynamic impairment in multiple sclerosis: dynamic susceptibility contrast perfusion MR imaging at 3.0 T.","volume":"33","author":"Adhya","year":"2006","journal-title":"Neuroimage"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.593026","article-title":"Blood-Brain Barrier Leakage Is Increased in Parkinson\u2019s Disease.","volume":"11","author":"Al-Bachari","year":"2020","journal-title":"Front. Physiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/jcbfm.2014.172","article-title":"Human apolipoprotein E varepsilon4 expression impairs cerebral vascularization and blood-brain barrier function in mice.","volume":"35","author":"Alata","year":"2015","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/1531-8249(200001)47:1<93::AID-ANA15>3.0.CO;2-8","article-title":"Assessment of cerebral blood flow in Alzheimer\u2019s disease by spin-labeled magnetic resonance imaging.","volume":"47","author":"Alsop","year":"2000","journal-title":"Ann. Neurol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/alz.12328","article-title":"2021 Alzheimer\u2019s disease facts and figures.","volume":"17","year":"2021","journal-title":"Alzheimers Dement."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1016\/s0140-6736(96)08258-x","article-title":"Hypofrontality in schizophrenia: distributed dysfunctional circuits in neuroleptic-na\u00efve patients.","volume":"349","author":"Andreasen","year":"1997","journal-title":"Lancet"},{"key":"B9","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1146\/annurev-neuro-071714-033835","article-title":"Neuronal and vascular interactions.","volume":"38","author":"Andreone","year":"2015","journal-title":"Annu. Rev. Neurosci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"5981","DOI":"10.1111\/febs.12335","article-title":"The hallmarks of Parkinson\u2019s disease.","volume":"280","author":"Antony","year":"2013","journal-title":"FEBS J."},{"key":"B11","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s00401-003-0796-9","article-title":"Only cerebral capillary amyloid angiopathy correlates with Alzheimer pathology\u2013a pilot study.","volume":"107","author":"Attems","year":"2004","journal-title":"Acta Neuropathol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/nature09613","article-title":"Glial and neuronal control of brain blood flow.","volume":"468","author":"Attwell","year":"2010","journal-title":"Nature"},{"key":"B13","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1177\/0271678X15610340","article-title":"What is a pericyte?","volume":"36","author":"Attwell","year":"2016","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B14","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1097\/00004647-200110000-00001","article-title":"An energy budget for signaling in the grey matter of the brain.","volume":"21","author":"Attwell","year":"2001","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B15","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.neuroscience.2004.11.047","article-title":"Selective cholinergic denervation, independent from oxidative stress, in a mouse model of Alzheimer\u2019s disease.","volume":"132","author":"Aucoin","year":"2005","journal-title":"Neuroscience"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1007\/s10803-015-2672-6","article-title":"Persistent angiogenesis in the autism brain: an immunocytochemical study of postmortem cortex, brainstem and cerebellum.","volume":"46","author":"Azmitia","year":"2016","journal-title":"J. Autism Dev. Disord."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00218","article-title":"Parkinson\u2019s disease and the environment.","volume":"10","author":"Ball","year":"2019","journal-title":"Front. Neurol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/s1474-4422(16)00063-6","article-title":"Dementia in Down\u2019s syndrome.","volume":"15","author":"Ballard","year":"2016","journal-title":"Lancet Neurol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/s43587-021-00043-5","article-title":"Healthy aging and the blood-brain barrier.","volume":"1","author":"Banks","year":"2021","journal-title":"Nat. Aging"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2011.112","article-title":"Neurodegenerative processes in Huntington\u2019s disease [Review].","volume":"2","author":"Bano","year":"2011","journal-title":"Cell Death Dis."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1007\/s00702-004-0256-2","article-title":"Changes in vascularization in substantia nigra pars compacta of monkeys rendered parkinsonian.","volume":"112","author":"Barcia","year":"2005","journal-title":"J Neural Transm. (Vienna)"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1073\/pnas.87.4.1620","article-title":"Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.","volume":"87","author":"Beckman","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B23","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.neuron.2010.09.043","article-title":"Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging.","volume":"68","author":"Bell","year":"2010","journal-title":"Neuron"},{"key":"B24","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s00401-009-0522-3","article-title":"Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer\u2019s disease.","volume":"118","author":"Bell","year":"2009","journal-title":"Acta Neuropathol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1007\/s00330-016-4450-z","article-title":"Lower cerebral blood flow is associated with faster cognitive decline in Alzheimer\u2019s disease.","volume":"27","author":"Benedictus","year":"2017","journal-title":"Eur. Radiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1111\/j.1471-4159.2006.03937.x","article-title":"Gene-environment interactions in sporadic Parkinson\u2019s disease.","volume":"97","author":"Benmoyal-Segal","year":"2006","journal-title":"J. Neurochem."},{"key":"B27","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.jneuroim.2010.08.011","article-title":"Blood-brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE.","volume":"229","author":"Bennett","year":"2010","journal-title":"J. Neuroimmunol."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119356","article-title":"Increased perfusion in normal appearing white matter in high inflammatory multiple sclerosis patients.","volume":"10","author":"Bester","year":"2015","journal-title":"PLoS One"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.1177\/0271678X19895432","article-title":"Reduced cerebral blood flow in an alpha-synuclein transgenic mouse model of Parkinson\u2019s disease.","volume":"40","author":"Biju","year":"2020","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1242\/dev.182279","article-title":"Neuronal and glial regulation of CNS angiogenesis and barriergenesis.","volume":"147","author":"Biswas","year":"2020","journal-title":"Development"},{"key":"B31","doi-asserted-by":"publisher","first-page":"21","DOI":"10.21307\/ane-2018-005","article-title":"Cerebral hypoperfusion in autism spectrum disorder.","volume":"78","author":"Bj\u00f8rklund","year":"2018","journal-title":"Acta Neurobiol. Exp."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-015-0186-2","article-title":"Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy.","volume":"3","author":"Blair","year":"2015","journal-title":"Acta Neuropathol. Commun."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.611761","article-title":"Alpha-Synuclein in the regulation of brain endothelial and perivascular cells: gaps and future perspectives.","volume":"12","author":"Bogale","year":"2021","journal-title":"Front. Immunol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1177\/0271678X19873658","article-title":"Increasing cerebral blood flow improves cognition into late stages in Alzheimer\u2019s disease mice.","volume":"40","author":"Bracko","year":"2020","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B35","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1159\/000106990","article-title":"Transcranial doppler sonography in the early phase of Alzheimer\u2019s disease.","volume":"3","author":"Bressi","year":"1992","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2021.05.025","article-title":"Traumatic brain injury and risk of neurodegenerative disorder.","author":"Brett","year":"2021","journal-title":"Biol. Psychiatry"},{"key":"B37","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/BF00294173","article-title":"Pathological alterations of the cerebral microvasculature in Alzheimer\u2019s disease and related dementing disorders [Research Support, Non-U.S. Gov\u2019t Research Support, U.S. Gov\u2019t, P.H.S.].","volume":"87","author":"Buee","year":"1994","journal-title":"Acta Neuropathol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1177\/0269881113516200","article-title":"Endothelial nitric oxide synthetase genetic variants, metabolic syndrome and endothelial function in schizophrenia.","volume":"28","author":"Burghardt","year":"2014","journal-title":"J. Psychopharmacol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1097\/MNM.0b013e3282f1bb8e","article-title":"Regional cerebral blood flow in childhood autism: a SPET study with SPM evaluation.","volume":"29","author":"Burroni","year":"2008","journal-title":"Nucl. Med. Commun."},{"key":"B40","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1038\/s41380-018-0235-x","article-title":"Increased macrophages and changed brain endothelial cell gene expression in the frontal cortex of people with schizophrenia displaying inflammation.","volume":"25","author":"Cai","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"B41","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nature10144REVIEWDLL4","article-title":"Molecular mechanisms and clinical applications of angiogenesis.","volume":"473","author":"Carmeliet","year":"2011","journal-title":"Nat. Review"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1089\/ars.2011.3895","article-title":"Amyloid beta induces oxidative stress-mediated blood\u2013brain barrier changes in capillary amyloid angiopathy.","volume":"15","author":"Carrano","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.595002","article-title":"Structural and functional features of developing brain capillaries, and their alteration in schizophrenia.","volume":"14","author":"Carrier","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1176\/appi.ajp.158.9.1423","article-title":"Anterior cingulate cortex activity and impaired self-monitoring of performance in patients with schizophrenia: an event-related fMRI study.","volume":"158","author":"Carter","year":"2001","journal-title":"Am. J. Psychiatry"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0095-9","article-title":"hiPSC-derived neural stem cells from patients with schizophrenia induce an impaired angiogenesis.","volume":"8","author":"Casas","year":"2018","journal-title":"Transl. Psychiatry"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1016\/S0140-6736(04)15900-X","article-title":"Convergence of atherosclerosis and Alzheimer\u2019s disease: inflammation, cholesterol, and misfolded proteins [Review].","volume":"363","author":"Casserly","year":"2004","journal-title":"Lancet"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fnene.2010.00009","article-title":"Revisiting the role of neurons in neurovascular coupling.","volume":"2","author":"Cauli","year":"2010","journal-title":"Front. Neuroenergetics"},{"key":"B48","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jneuroim.2009.09.003","article-title":"Mesenchymal stem cell transplantation attenuates blood brain barrier damage and neuroinflammation and protects dopaminergic neurons against MPTP toxicity in the substantia nigra in a model of Parkinson\u2019s disease.","volume":"216","author":"Chao","year":"2009","journal-title":"J. Neuroimmunol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1111\/j.1469-8749.1995.tb11938.x","article-title":"SPECT of the Brain in childhood autism: evidence for a lack of normal hemispheric asymmetry.","volume":"37","author":"Chiron","year":"1995","journal-title":"Dev. Med. Child Neurol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1016\/j.neurobiolaging.2015.05.020","article-title":"P-glycoprotein expression and amyloid accumulation in human aging and Alzheimer\u2019s disease: preliminary observations.","volume":"36","author":"Chiu","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"B51","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.tins.2015.08.003","article-title":"The molecular constituents of the blood-brain barrier.","volume":"38","author":"Chow","year":"2015","journal-title":"Trends Neurosci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S2215-0366(20)30431-4","article-title":"Neuropsychiatric symptoms associated with cerebral small vessel disease: a systematic review and meta-analysis.","volume":"8","author":"Clancy","year":"2021","journal-title":"Lancet Psychiatry"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0405-x","article-title":"Dynamic expression of genes associated with schizophrenia and bipolar disorder across development.","volume":"9","author":"Clifton","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1002\/wdev.363","article-title":"Postnatal development of cerebrovascular structure and the neurogliovascular unit.","volume":"9","author":"Coelho-Santos","year":"2020","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/s0022-3476(99)70248-9","article-title":"Serum autoantibodies to brain in Landau-Kleffner variant, autism, and other neurologic disorders.","volume":"134","author":"Connolly","year":"1999","journal-title":"J. Pediatr."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.1016\/j.jacc.2019.07.081","article-title":"Long-Term dabigatran treatment delays Alzheimer\u2019s disease pathogenesis in the tgcrnd8 mouse model.","volume":"74","author":"Cortes-Canteli","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.nicl.2013.12.001","article-title":"Abnormal blood-brain barrier permeability in normal appearing white matter in multiple sclerosis investigated by MRI.","volume":"4","author":"Cramer","year":"2014","journal-title":"Neuroimage Clin."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1093\/brain\/awab055","article-title":"Disruption of the blood-brain barrier in 22q11.2 deletion syndrome.","volume":"144","author":"Crockett","year":"2021","journal-title":"Brain"},{"key":"B59","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/s41593-018-0329-4","article-title":"Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer\u2019s disease mouse models.","volume":"22","author":"Cruz Hernandez","year":"2019","journal-title":"Nat. Neurosci."},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1101\/2021.02.04.429741","article-title":"Microglia control cerebral blood flow and neurovascular coupling via P2Y12R-mediated actions.","author":"Cs\u00e1sz\u00e1r","year":"2021","journal-title":"bioRXiv"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1038\/nm.2494","article-title":"Vascular endothelial growth factor ameliorates the ataxic phenotype in a mouse model of spinocerebellar ataxia type 1 [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov\u2019t].","volume":"17","author":"Cvetanovic","year":"2011","journal-title":"Nat. Med."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1007\/s11357-020-00252-7","article-title":"Retinal biomarkers for Alzheimer\u2019s disease and vascular cognitive impairment and dementia (VCID): implication for early diagnosis and prognosis.","volume":"42","author":"Czako","year":"2020","journal-title":"Geroscience"},{"key":"B63","doi-asserted-by":"publisher","first-page":"5654","DOI":"10.1073\/pnas.1222560110","article-title":"Cerebral hypoperfusion in multiple sclerosis is reversible and mediated by endothelin-1.","volume":"110","author":"D\u2019Haeseleer","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B64","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/s1474-4422(11)70105-3","article-title":"Vascular aspects of multiple sclerosis.","volume":"10","author":"D\u2019Haeseleer","year":"2011","journal-title":"Lancet Neurol."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2025998118","article-title":"PIP 2 corrects cerebral blood flow deficits in small vessel disease by rescuing capillary Kir2.1 activity.","volume":"118","author":"Dabertrand","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B66","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1002\/ana.23648","article-title":"The blood\u2013brain barrier in health and disease.","volume":"72","author":"Daneman","year":"2012","journal-title":"Ann. Neurol."},{"key":"B67","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1073\/pnas.0805165106","article-title":"Wnt\/ -catenin signaling is required for CNS, but not non-CNS, angiogenesis.","volume":"106","author":"Daneman","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020412","article-title":"The blood-brain barrier.","volume":"7","author":"Daneman","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B69","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1073\/pnas.1.5.283","article-title":"Huntington\u2019s Chorea in relation to heredity and eugenics.","volume":"1","author":"Davenport","year":"1915","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B70","doi-asserted-by":"publisher","first-page":"20296","DOI":"10.1074\/jbc.M312946200","article-title":"Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch\/Iowa mutant form of amyloid beta-protein precursor.","volume":"279","author":"Davis","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B71","doi-asserted-by":"publisher","first-page":"2831","DOI":"10.1007\/s00018-011-0723-5","article-title":"Hypoxia in the regulation of neural stem cells.","volume":"68","author":"De Filippis","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"B72","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1212\/WNL.53.8.1628","article-title":"Astrocytes in multiple sclerosis lack beta-2 adrenergic receptors.","volume":"53","author":"De Keyser","year":"1999","journal-title":"Neurology"},{"key":"B73","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s10571-015-0308-1","article-title":"Microvascular dysfunction and cognitive impairment.","volume":"36","author":"De Silva","year":"2016","journal-title":"Cell. Mol. Neurobiol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.neuron.2004.07.017","article-title":"LRP\/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.","volume":"43","author":"Deane","year":"2004","journal-title":"Neuron"},{"key":"B75","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/S0006-8993(00)02506-3","article-title":"Vasomotor hyporeactivity in the anterior cerebral artery during motor activation in Huntington\u2019s disease patients.","volume":"872","author":"Deckel","year":"2000","journal-title":"Brain Res."},{"key":"B76","first-page":"773","article-title":"Altered patterns of regional cerebral blood flow in patients with Huntington\u2019s disease: a SPECT study during rest and cognitive or motor activation.","volume":"41","author":"Deckel","year":"2000","journal-title":"J. Nucl. Med."},{"key":"B77","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/j.neuron.2014.06.015","article-title":"Endothelial NT-3 delivered by vasculature and CSF promotes quiescence of subependymal neural stem cells through nitric oxide induction.","volume":"83","author":"Delgado","year":"2014","journal-title":"Neuron"},{"key":"B78","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1097\/01.mnm.0000243370.18883.62","article-title":"Regional cerebral blood flow in Parkinson\u2019s disease as an indicator of cognitive impairment.","volume":"27","author":"Derejko","year":"2006","journal-title":"Nucl. Med. Commun."},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1038\/srep41316","article-title":"Impairment of blood-brain barrier is an early event in R6\/2 mouse model of Huntington Disease.","volume":"7","author":"Di Pardo","year":"2017","journal-title":"Sci. Rep."},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-5-15","article-title":"Soluble amyloid-beta, effect on cerebral arteriolar regulation and vascular cells.","volume":"5","author":"Dietrich","year":"2010","journal-title":"Mol. Neurodegener."},{"key":"B81","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/ene.13819","article-title":"Multiple sclerosis \u2013 a review.","volume":"26","author":"Dobson","year":"2019","journal-title":"Eur. J. Neurol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s00401-006-0115-3","article-title":"RAGE, LRP-1, and amyloid-beta protein in Alzheimer\u2019s disease.","volume":"112","author":"Donahue","year":"2006","journal-title":"Acta Neuropathol."},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-42532-z","article-title":"Different effects of prenatal MAM vs. perinatal THC exposure on regional cerebral blood perfusion detected by Arterial Spin Labelling MRI in rats.","volume":"9","author":"Drazanova","year":"2019","journal-title":"Sci. Rep."},{"key":"B84","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1002\/ana.24406","article-title":"Cerebrovascular and blood-brain barrier impairments in Huntington\u2019s disease: potential implications for its pathophysiology.","volume":"78","author":"Drouin-Ouellet","year":"2015","journal-title":"Ann. Neurol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"3326","DOI":"10.1073\/pnas.1914655117","article-title":"Molecular adaptations of the blood-brain barrier promote stress resilience vs. depression.","volume":"117","author":"Dudek","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B86","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1002\/ana.23566","article-title":"Functional magnetic resonance imaging detection of vascular reactivity in cerebral amyloid angiopathy.","volume":"72","author":"Dumas","year":"2012","journal-title":"Ann. Neurol."},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-80889-8","article-title":"Human alpha-synuclein overexpression in a mouse model of Parkinson\u2019s disease leads to vascular pathology, blood brain barrier leakage and pericyte activation.","volume":"11","author":"Elabi","year":"2021","journal-title":"Sci. Rep."},{"key":"B88","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.schres.2011.03.031","article-title":"Dietary, lifestyle and pharmacogenetic factors associated with arteriole endothelial-dependent vasodilatation in schizophrenia patients treated with atypical antipsychotics (AAPs).","volume":"130","author":"Ellingrod","year":"2011","journal-title":"Schizophr. Res."},{"key":"B89","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s12640-009-9079-0","article-title":"Injectable hydrogels providing sustained delivery of vascular endothelial growth factor are neuroprotective in a rat model of Huntington\u2019s disease.","volume":"17","author":"Emerich","year":"2010","journal-title":"Neurotox. Res."},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aag2882","article-title":"Functional neuroimaging of high-risk 6-month-old infants predicts a diagnosis of autism at 24 months of age.","volume":"9","author":"Emerson","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"B91","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s004010000195","article-title":"Pathological features of cerebral cortical capillaries are doubled in Alzheimer\u2019s disease and Parkinson\u2019s disease.","volume":"100","author":"Farkas","year":"2000","journal-title":"Acta Neuropathol."},{"key":"B92","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0301-0082(00)00068-X","article-title":"Cerebral microvascular pathology in aging and Alzheimer\u2019s disease [Review].","volume":"64","author":"Farkas","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/s0140-6736(99)00641-8","article-title":"Blood vessels change in the mesencephalon of patients with Parkinson\u2019s disease.","volume":"353","author":"Faucheux","year":"1999","journal-title":"Lancet"},{"key":"B94","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/ana.20684","article-title":"Preclinical Huntington\u2019s disease: compensatory brain responses during learning.","volume":"59","author":"Feigin","year":"2006","journal-title":"Ann. Neurol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1038\/jcbfm.2015.60","article-title":"Diverse functions of pericytes in cerebral blood flow regulation and ischemia.","volume":"35","author":"Fernandez-Klett","year":"2015","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B96","doi-asserted-by":"publisher","first-page":"2743","DOI":"10.1016\/j.neuroimage.2011.10.033","article-title":"Cortical hypoperfusion in Parkinson\u2019s disease assessed using arterial spin labeled perfusion MRI.","volume":"59","author":"Fernandez-Seara","year":"2012","journal-title":"Neuroimage"},{"key":"B97","doi-asserted-by":"publisher","first-page":"H609","DOI":"10.1152\/ajpheart.00359.2013","article-title":"Astrocyte regulation of cerebral vascular tone.","volume":"305","author":"Filosa","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1021\/cn4000567","article-title":"An investigation of hypofrontality in an animal model of schizophrenia using real-time microelectrochemical sensors for glucose, oxygen, and nitric oxide.","volume":"4","author":"Finnerty","year":"2013","journal-title":"ACS Chem. Neurosci."},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-016-0110-z","article-title":"Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders.","volume":"7","author":"Fiorentino","year":"2016","journal-title":"Mol. Autism"},{"key":"B100","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1016\/j.neuroimage.2005.03.001","article-title":"Delayed hemodynamic responses in schizophrenia.","volume":"26","author":"Ford","year":"2005","journal-title":"Neuroimage"},{"key":"B101","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/s0920-9964(98)00148-0","article-title":"Failures of automatic and strategic processing in schizophrenia: comparisons of event-related brain potential and startle blink modification.","volume":"37","author":"Ford","year":"1999","journal-title":"Schizophr. Res."},{"key":"B102","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1212\/wnl.41.1.10","article-title":"Roy and Sherrington (1890): a centennial reexamination of \u201dOn the regulation of the blood-supply of the brain\u201d.","volume":"41","author":"Friedland","year":"1991","journal-title":"Neurology"},{"key":"B103","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1093\/cvr\/cvy002","article-title":"Smooth muscle cells of intracranial vessels: from development to disease.","volume":"114","author":"Frosen","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"B104","doi-asserted-by":"publisher","first-page":"675","DOI":"10.2147\/NDT.S43137","article-title":"Reduced prefrontal cortex activation using the Trail Making Test in schizophrenia.","volume":"9","author":"Fujiki","year":"2013","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"B105","first-page":"1539","article-title":"Dynamic susceptibility contrast perfusion MR imaging of multiple sclerosis lesions: characterizing hemodynamic impairment and inflammatory activity.","volume":"26","author":"Ge","year":"2005","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"2998","DOI":"10.1093\/brain\/awaa255","article-title":"Vascular disease and multiple sclerosis: a post-mortem study exploring their relationships.","volume":"143","author":"Geraldes","year":"2020","journal-title":"Brain"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1177\/1073858420954811","article-title":"Cerebral amyloid angiopathy and blood-brain barrier dysfunction.","author":"Gireud-Goss","year":"2020","journal-title":"Neuroscientist"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-014-0084-z","article-title":"Angiogenesis in multiple sclerosis and experimental autoimmune encephalomyelitis.","volume":"2","author":"Girolamo","year":"2014","journal-title":"Acta Neuropathol. Commun."},{"key":"B109","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1152\/japplphysiol.00966.2005","article-title":"Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease.","volume":"100","author":"Girouard","year":"2006","journal-title":"J. Appl. Physiol. (1985)"},{"key":"B110","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1242\/dmm.030205","article-title":"Neurodegenerative disease: models, mechanisms, and a new hope.","volume":"10","author":"Gitler","year":"2017","journal-title":"Dis. Model. Mech."},{"key":"B111","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1093\/schbul\/sbr030","article-title":"Age of onset of schizophrenia: perspectives from structural neuroimaging studies.","volume":"37","author":"Gogtay","year":"2011","journal-title":"Schizophr. Bull."},{"key":"B112","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1038\/nn.2963","article-title":"Perivascular instruction of cell genesis and fate in the adult brain.","volume":"14","author":"Goldman","year":"2011","journal-title":"Nat. Neurosci."},{"key":"B113","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1161\/01.STR.0000143318.70292.47","article-title":"Risk factors for vascular dementia and Alzheimer disease.","author":"Gorelick","year":"2004","journal-title":"Stroke"},{"key":"B114","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nrn2420","article-title":"Animal models of Alzheimer\u2019s disease and frontotemporal dementia.","volume":"9","author":"Gotz","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"B115","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1136\/jnnp-2017-317557","article-title":"Understanding neurodegeneration after traumatic brain injury: from mechanisms to clinical trials in dementia.","volume":"90","author":"Graham","year":"2019","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-26","article-title":"Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer\u2019s disease.","volume":"8","author":"Grammas","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"B117","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1177\/0271678X17732229","article-title":"Organizational hierarchy and structural diversity of microvascular pericytes in adult mouse cortex.","volume":"39","author":"Grant","year":"2019","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B118","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/jcbfm.2015.32","article-title":"Striatal blood-brain barrier permeability in Parkinson\u2019s disease.","volume":"35","author":"Gray","year":"2015","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B119","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1038\/mp.2017.156","article-title":"Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia.","volume":"23","author":"Greene","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"B120","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.schres.2015.02.006","article-title":"Endothelial function, folate pharmacogenomics, and neurocognition in psychotic disorders.","volume":"164","author":"Grove","year":"2015","journal-title":"Schizophr. Res."},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2020.110893","article-title":"Brain capillary pericytes and neurovascular coupling.","volume":"254","author":"Grubb","year":"2021","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc8479","article-title":"Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span.","volume":"373","author":"Grunewald","year":"2021","journal-title":"Science"},{"key":"B123","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1126\/science.1105416","article-title":"Semaphorin 3E and Plexin-D1 control vascular pattern independently of neuropilins.","volume":"307","author":"Gu","year":"2005","journal-title":"Science"},{"key":"B124","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/j.1750-3639.2012.00628.x","article-title":"Vascular degeneration in Parkinson\u2019s disease.","volume":"23","author":"Guan","year":"2013","journal-title":"Brain Pathol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"3045","DOI":"10.3892\/mmr.2019.9950","article-title":"Age and brain regionassociated alterations of cerebral blood flow in early Alzheimer\u2019s disease assessed in AbetaPPSWE\/PS1DeltaE9 transgenic mice using arterial spin labeling.","volume":"19","author":"Guo","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"B126","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.schres.2019.09.014","article-title":"Association of a functional Claudin-5 variant with schizophrenia in female patients with the 22q11.2 deletion syndrome.","volume":"215","author":"Guo","year":"2020","journal-title":"Schizophr. Res."},{"key":"B127","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1038\/mp.2017.161","article-title":"A neurogenetic model for the study of schizophrenia spectrum disorders: the International 22q11.2 Deletion Syndrome Brain Behavior Consortium.","volume":"22","author":"Gur","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"B128","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1097\/WCO.0b013e3283550c97","article-title":"Huntington\u2019s disease.","volume":"25","author":"Ha","year":"2012","journal-title":"Curr. Opin. Neurol."},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109405","article-title":"Astrocytes regulate ultra-slow arteriole oscillations via stretch-mediated TRPV4-COX-1 feedback.","volume":"36","author":"Haidey","year":"2021","journal-title":"Cell Rep."},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.01020","article-title":"Small vessel disease.","volume":"10","author":"Hakim","year":"2019","journal-title":"Front. Neurol."},{"key":"B131","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/jcbfm.2015.44","article-title":"Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer\u2019s disease.","volume":"36","author":"Halliday","year":"2016","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B132","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1152\/japplphysiol.00954.2005","article-title":"Perivascular nerves and the regulation of cerebrovascular tone.","volume":"100","author":"Hamel","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"B133","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1097\/FJC.0000000000000177","article-title":"Cerebral circulation function and dysfunction in Alzheimer\u2019s disease.","volume":"65","author":"Hamel","year":"2015","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1002\/hbm.23063","article-title":"Hemodynamic response function abnormalities in schizophrenia during a multisensory detection task.","volume":"37","author":"Hanlon","year":"2016","journal-title":"Hum. Brain Mapp."},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00499","article-title":"Gliotransmitter release from astrocytes: functional, developmental, and pathological implications in the brain.","volume":"9","author":"Harada","year":"2015","journal-title":"Front. Neurosci."},{"key":"B136","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1177\/1756285613488434","article-title":"Sex and gender issues in multiple sclerosis.","volume":"6","author":"Harbo","year":"2013","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"B137","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1093\/brain\/122.9.1667","article-title":"Reduced basal ganglia blood flow and volume in pre-sympotmatic, gene-tested persons at-risk for Huntington\u2019s disease.","volume":"122","author":"Harris","year":"1999","journal-title":"Brain"},{"key":"B138","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/s41593-020-00793-2","article-title":"Brain capillary pericytes exert a substantial but slow influence on blood flow.","volume":"24","author":"Hartmann","year":"2021","journal-title":"Nat. Neurosci."},{"key":"B139","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1161\/STROKEAHA.111.627562","article-title":"Amyloid-beta contributes to blood-brain barrier leakage in transgenic human amyloid precursor protein mice and in humans with cerebral amyloid angiopathy.","volume":"43","author":"Hartz","year":"2012","journal-title":"Stroke"},{"key":"B140","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1136\/jnnp.55.11.1018","article-title":"Reduced regional cerebral blood flow in Huntington\u2019s disease studied by SPECT.","volume":"55","author":"Hasselbalch","year":"1992","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B141","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s10571-015-0261-z","article-title":"The utility of cerebral blood flow as a biomarker of preclinical Alzheimer\u2019s disease.","volume":"36","author":"Hays","year":"2016","journal-title":"Cell. Mol. Neurobiol."},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-020-00368-6","article-title":"Initiation and propagation of alpha-synuclein aggregation in the nervous system.","volume":"15","author":"Hijaz","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"B143","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1146\/annurev-neuro-071013-014111","article-title":"Coupling mechanism and significance of the BOLD signal: a status report.","volume":"37","author":"Hillman","year":"2014","journal-title":"Annu. Rev. Neurosci."},{"key":"B144","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1093\/ageing\/afp223","article-title":"Ageing, neurodegeneration and Parkinson\u2019s disease.","volume":"39","author":"Hindle","year":"2010","journal-title":"Age Ageing"},{"key":"B145","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.jpsychires.2016.07.018","article-title":"Decreased VEGFR2 expression and increased phosphorylated Akt1 in the prefrontal cortex of individuals with schizophrenia.","volume":"82","author":"Hino","year":"2016","journal-title":"J. Psychiatry Res."},{"key":"B146","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1242\/dev.01039","article-title":"The neural tube patterns vessels developmentally using the VEGF signaling pathway.","volume":"131","author":"Hogan","year":"2004","journal-title":"Development"},{"key":"B147","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.neulet.2009.12.059","article-title":"Increased blood vessel density and endothelial cell proliferation in multiple sclerosis cerebral white matter.","volume":"470","author":"Holley","year":"2010","journal-title":"Neurosci. Lett."},{"key":"B148","doi-asserted-by":"publisher","first-page":"17076","DOI":"10.1073\/pnas.1114042108","article-title":"Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism.","volume":"108","author":"Horev","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B149","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1192\/bjp.bp.107.045633","article-title":"Structural and metabolic changes in language areas linked to formal thought disorder.","volume":"194","author":"Horn","year":"2009","journal-title":"Br. J. Psychiatry"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-019-3252-4","article-title":"Role of cerebral hypoperfusion in multiple sclerosis (ROCHIMS): study protocol for a proof-of-concept randomized controlled trial with bosentan.","volume":"20","author":"Hostenbach","year":"2019","journal-title":"Trials"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00103","article-title":"The contribution of astrocytes to the regulation of cerebral blood flow.","volume":"8","author":"Howarth","year":"2014","journal-title":"Front. Neurosci."},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2019.0630","article-title":"More than just summed neuronal activity: how multiple cell types shape the BOLD response.","volume":"376","author":"Howarth","year":"2021","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.601320","article-title":"The role of basement membranes in cerebral amyloid angiopathy.","volume":"11","author":"Howe","year":"2020","journal-title":"Front. Physiol."},{"key":"B154","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1073\/pnas.96.6.3228","article-title":"Plaque-independent disruption of neural circuits in Alzheimer\u2019s disease mouse models [Research Support, Non-U.S. Gov\u2019t Research Support, U.S. Gov\u2019t, P.H.S.].","volume":"96","author":"Hsia","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B155","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1002\/ana.24428","article-title":"Aberrant astrocytes impair vascular reactivity in Huntington disease.","volume":"78","author":"Hsiao","year":"2015","journal-title":"Ann. Neurol."},{"key":"B156","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1002\/mds.25591","article-title":"Elevated arteriolar cerebral blood volume in prodromal Huntington\u2019s disease.","volume":"29","author":"Hua","year":"2014","journal-title":"Mov. Disord."},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2020.100857","article-title":"Blood-brain barrier integrity in the pathogenesis of Alzheimer\u2019s disease.","volume":"59","author":"Huang","year":"2020","journal-title":"Front. Neuroendocrinol."},{"key":"B158","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1038\/jcbfm.2013.76","article-title":"The APOE varepsilon4\/varepsilon4 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of Alzheimer\u2019s disease patients.","volume":"33","author":"Hultman","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B159","doi-asserted-by":"crossref","first-page":"341","DOI":"10.2174\/156720205774322610","article-title":"Cerebrovascular damage as a cause for Alzheimer\u2019s disease [Research Support, Non-U.S. Gov\u2019t Review].","volume":"2","author":"Humpel","year":"2005","journal-title":"Curr. Neurovasc. Res."},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00467","article-title":"Investigating human neurovascular coupling using functional neuroimaging: a critical review of dynamic models.","volume":"9","author":"Huneau","year":"2015","journal-title":"Front. Neurosci."},{"key":"B161","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/nrn1387","article-title":"Neurovascular regulation in the normal brain and in Alzheimer\u2019s disease.","volume":"5","author":"Iadecola","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"B162","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.neuron.2013.10.008","article-title":"The pathobiology of vascular dementia.","volume":"80","author":"Iadecola","year":"2013","journal-title":"Neuron"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00458","article-title":"Traumatic brain injury leads to development of Parkinson\u2019s disease related pathology in mice.","volume":"10","author":"Impellizzeri","year":"2016","journal-title":"Front. Neurosci."},{"key":"B164","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.vph.2017.05.005","article-title":"Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases.","volume":"100","author":"Incalza","year":"2018","journal-title":"Vascul. Pharmacol."},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11934","article-title":"Early role of vascular dysregulation on late-onset Alzheimer\u2019s disease based on multifactorial data-driven analysis.","volume":"7","author":"Iturria-Medina","year":"2016","journal-title":"Nat. Commun."},{"key":"B166","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1242\/dev.028845","article-title":"Neurovascular development uses VEGF-A signaling to regulate blood vessel ingression into the neural tube.","volume":"136","author":"James","year":"2009","journal-title":"Development"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.358","article-title":"Altered resting perfusion and functional connectivity of default mode network in youth with autism spectrum disorder.","volume":"5","author":"Jann","year":"2015","journal-title":"Brain Behav."},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/598093","article-title":"The evidence for hypoperfusion as a factor in multiple sclerosis lesion development.","volume":"2013","author":"Juurlink","year":"2013","journal-title":"Mult. Scler. Int."},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-020-00230-3","article-title":"A blood-brain barrier overview on structure, function, impairment, and biomarkers of integrity.","volume":"17","author":"Kadry","year":"2020","journal-title":"Fluids Barriers CNS"},{"key":"B170","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0163-7258(96)00116-7","article-title":"Cerebral vessels in ageing and Alzheimer\u2019s disease [Research Support, Non-U.S. Gov\u2019t Research Support, U.S. Gov\u2019t, P.H.S. Review].","volume":"72","author":"Kalaria","year":"1996","journal-title":"Pharmacol. Ther."},{"key":"B171","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1111\/j.1471-4159.1989.tb07399.x","article-title":"Reduced glucose transporter at the blood-brain barrier and in cerebral cortex in Alzheimer disease.","volume":"53","author":"Kalaria","year":"1989","journal-title":"J. Neurochem."},{"key":"B172","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1111\/ane.12563","article-title":"The genetic background of Parkinson\u2019s disease: current progress and future prospects.","volume":"134","author":"Kalinderi","year":"2016","journal-title":"Acta Neurol. Scand."},{"key":"B173","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1002\/jmri.22515","article-title":"Posterior hypoperfusion in Parkinson\u2019s disease with and without dementia measured with arterial spin labeling MRI.","volume":"33","author":"Kamagata","year":"2011","journal-title":"J. Magn. Reson. Imaging"},{"key":"B174","doi-asserted-by":"publisher","first-page":"157","DOI":"10.2174\/1871527314666150116125246","article-title":"The blood-brain barrier in multiple sclerosis: microRNAs as key regulators.","volume":"14","author":"Kamphuis","year":"2015","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"B175","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1038\/s41583-020-0322-2","article-title":"Neuronal regulation of the blood-brain barrier and neurovascular coupling.","volume":"21","author":"Kaplan","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"key":"B176","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1159\/000358840","article-title":"The effects of aging on changes in regional cerebral blood flow in schizophrenia.","volume":"69","author":"Kawakami","year":"2014","journal-title":"Neuropsychobiology"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006881","article-title":"Impaired prefrontal hemodynamic maturation in autism and unaffected siblings.","volume":"4","author":"Kawakubo","year":"2009","journal-title":"PLoS One"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.06.033","article-title":"Blood-brain barrier regulation in psychiatric disorders.","volume":"726","author":"Kealy","year":"2020","journal-title":"Neurosci. Lett."},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-25758-2_2","author":"Keefe","year":"2012","journal-title":"Cognitive Impairment in Schizophrenia"},{"key":"B180","first-page":"197","article-title":"Evidence of endothelial dysfunction in the development of Alzheimer\u2019s disease: Is Alzheimer\u2019s a vascular disorder?","volume":"3","author":"Kelleher","year":"2013","journal-title":"Am. J. Cardiovasc. Dis."},{"key":"B181","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/s2215-0366(14)00122-9","article-title":"Inflammation and immunity in schizophrenia: implications for pathophysiology and treatment.","volume":"2","author":"Khandaker","year":"2015","journal-title":"Lancet Psychiatry"},{"key":"B182","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1002\/path.1434","article-title":"Tight junctional abnormality in multiple sclerosis white matter affects all calibres of vessel and is associated with blood\u2013brain barrier leakage and active demyelination.","volume":"201","author":"Kirk","year":"2003","journal-title":"J. Pathol."},{"key":"B183","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1038\/nrn.2017.48","article-title":"Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease.","volume":"18","author":"Kisler","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"B184","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/nn.4489A","article-title":"Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain.","volume":"20","author":"Kisler","year":"2016","journal-title":"Nat. Neurosci."},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a008888","article-title":"Genetics of Parkinson\u2019s disease.","volume":"2","author":"Klein","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"B186","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1177\/0271678X20949286","article-title":"Impaired response of cerebral oxygen metabolism to visual stimulation in Huntington\u2019s disease.","volume":"41","author":"Klinkmueller","year":"2021","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2017.00280","article-title":"Psychosocial dysfunction in major depressive disorder-rationale, design, and characteristics of the cognitive and emotional recovery training program for depression (CERT-D).","volume":"8","author":"Knight","year":"2017","journal-title":"Front. Psychiatry"},{"key":"B188","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1093\/schbul\/sbaa078","article-title":"A white matter connection of schizophrenia and Alzheimer\u2019s disease.","volume":"47","author":"Kochunov","year":"2021","journal-title":"Schizophr. Bull."},{"key":"B189","doi-asserted-by":"publisher","first-page":"8845","DOI":"10.1523\/JNEUROSCI.6102-11.2012","article-title":"Abeta(1)(-)(4)(2)-RAGE interaction disrupts tight junctions of the blood-brain barrier via Ca(2)(+)-calcineurin signaling.","volume":"32","author":"Kook","year":"2012","journal-title":"J. Neurosci."},{"key":"B190","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1007\/s00401-020-02215-w","article-title":"Cerebral blood flow decrease as an early pathological mechanism in Alzheimer\u2019s disease.","volume":"140","author":"Korte","year":"2020","journal-title":"Acta Neuropathol."},{"key":"B191","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1002\/ana.20369","article-title":"Blood\u2013brain barrier dysfunction in parkinsonian midbrain in vivo.","volume":"57","author":"Kortekaas","year":"2005","journal-title":"Ann. Neurol."},{"key":"B192","first-page":"15","article-title":"The effectiveness of hyperbaric oxygen therapy (HBOT) in children with autism spectrum disorders.","volume":"48","author":"Kostiukow","year":"2020","journal-title":"Pol. Merkur. Lekarski."},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10505-w","article-title":"The known burden of Huntington disease in the North of Scotland: prevalence of manifest and identified pre-symptomatic gene expansion carriers in the molecular era.","author":"Kounidas","year":"2021","journal-title":"J. Neurol."},{"key":"B194","doi-asserted-by":"publisher","first-page":"6704","DOI":"10.1523\/JNEUROSCI.2363-15.2016","article-title":"Rapid postnatal expansion of neural networks occurs in an environment of altered neurovascular and neurometabolic coupling.","volume":"36","author":"Kozberg","year":"2016","journal-title":"J. Neurosci."},{"key":"B195","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.expneurol.2016.09.003","article-title":"\u03b1-Synuclein pre-formed fibrils impair tight junction protein expression without affecting cerebral endothelial cell function.","author":"Kuan","year":"2016","journal-title":"Exp. Neurol."},{"key":"B196","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.brainresbull.2016.03.013","article-title":"Memantine ameliorates autistic behavior, biochemistry & blood brain barrier impairments in rats.","volume":"124","author":"Kumar","year":"2016","journal-title":"Brain Res. Bull."},{"key":"B197","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.neuint.2015.10.007","article-title":"Benefits of agomelatine in behavioral, neurochemical and blood brain barrier alterations in prenatal valproic acid induced autism spectrum disorder.","volume":"91","author":"Kumar","year":"2015","journal-title":"Neurochem. Int."},{"key":"B198","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/S0002-9440(10)62995-1","article-title":"Dense-Core plaques in Tg2576 and PSAPP mouse models of Alzheimer\u2019s disease are centered on vessel walls.","volume":"167","author":"Kumar-Singh","year":"2005","journal-title":"Am. J. Pathol."},{"key":"B199","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1002\/mds.28484","article-title":"Increased risk of Parkinson\u2019s disease in patients with schizophrenia spectrum disorders.","volume":"36","author":"Kuusimaki","year":"2021","journal-title":"Mov. Disord."},{"key":"B200","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1007\/s11064-016-2052-4","article-title":"Disease-Toxicant interactions in Parkinson\u2019s disease neuropathology.","volume":"42","author":"Kwakye","year":"2017","journal-title":"Neurochem. Res."},{"key":"B201","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/jcbfm.2013.241","article-title":"Cerebral blood flow is an earlier indicator of perfusion abnormalities than cerebral blood volume in Alzheimer\u2019s disease.","volume":"34","author":"Lacalle-Aurioles","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B202","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/j.neuron.2014.07.034","article-title":"Sensory-Related neural activity regulates the structure of vascular networks in the cerebral cortex.","volume":"83","author":"Lacoste","year":"2014","journal-title":"Neuron"},{"key":"B203","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.mod.2015.06.003","article-title":"Control of cerebrovascular patterning by neural activity during postnatal development.","author":"Lacoste","year":"2015","journal-title":"Mech. Dev."},{"key":"B204","doi-asserted-by":"crossref","DOI":"10.1186\/1742-2094-10-57","article-title":"Cognitive and cerebrovascular improvements following kinin B1 receptor blockade in Alzheimer\u2019s disease mice.","volume":"10","author":"Lacoste","year":"2013","journal-title":"J. Neuroinflammation"},{"key":"B205","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.2174\/1568026614666140329230311","article-title":"Recent advances in delivery through the blood-brain barrier.","volume":"14","author":"Larsen","year":"2014","journal-title":"Curr. Top. Med. Chem."},{"key":"B206","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1148\/radiol.2313030996","article-title":"Microvascular abnormality in relapsing-remitting multiple sclerosis: perfusion MR imaging findings in normal-appearing white matter.","volume":"231","author":"Law","year":"2004","journal-title":"Radiology"},{"key":"B207","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/j.1748-1716.2011.02256.x","article-title":"The neurovascular unit in brain function and disease.","volume":"203","author":"Lecrux","year":"2011","journal-title":"Acta Physiol. (Oxf.)"},{"key":"B208","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1111\/j.1365-2990.2006.00781.x","article-title":"Persistent endothelial abnormalities and blood-brain barrier leak in primary and secondary progressive multiple sclerosis.","volume":"33","author":"Leech","year":"2007","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"B209","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.jalz.2016.08.013","article-title":"Lower cerebral blood flow is associated with impairment in multiple cognitive domains in Alzheimer\u2019s disease.","volume":"13","author":"Leeuwis","year":"2017","journal-title":"Alzheimers Dement."},{"key":"B210","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1093\/schbul\/sbv036","article-title":"Matrix Metalloproteinase-9 as a Novel Player in Synaptic Plasticity and Schizophrenia.","volume":"41","author":"Lepeta","year":"2015","journal-title":"Schizophr. Bull."},{"key":"B211","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1602\/neurorx.2.3.447","article-title":"The use of the R6 transgenic mouse models of Huntington\u2019s disease in attempts to develop novel therapeutic strategies.","volume":"2","author":"Li","year":"2005","journal-title":"NeuroTherapeutics"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1038\/srep29514","article-title":"The HSA21 gene EURL\/C21ORF91 controls neurogenesis within the cerebral cortex and is implicated in the pathogenesis of Down Syndrome.","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"B213","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.mod.2015.06.001","article-title":"The vascular niche in adult neurogenesis.","author":"Licht","year":"2015","journal-title":"Mech. Dev."},{"key":"B214","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1016\/j.celrep.2017.04.021","article-title":"Huntington\u2019s disease iPSC-derived brain microvascular endothelial cells reveal WNT-mediated angiogenic and blood-brain barrier deficits.","volume":"19","author":"Lim","year":"2017","journal-title":"Cell Rep."},{"key":"B215","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1177\/0271678X15621575","article-title":"Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer\u2019s disease.","volume":"37","author":"Lin","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B216","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.expneurol.2013.08.019","article-title":"Neurovascular abnormalities in humans and mice with Huntington\u2019s disease.","volume":"250","author":"Lin","year":"2013","journal-title":"Exp. Neurol."},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.1101\/2020.11.17.386631","article-title":"HTT silencing delays onset and slows progression of Huntington\u2019s disease like phenotype: monitoring with a novel neurovascular biomarker.","author":"Liu","year":"2020","journal-title":"bioRXiv"},{"key":"B218","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.arr.2018.06.002","article-title":"Cerebral small vessel disease and the risk of Alzheimer\u2019s disease: a systematic review.","volume":"47","author":"Liu","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"B219","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1158\/1535-7163.MCT-12-0131","article-title":"A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo.","volume":"11","author":"Liu","year":"2012","journal-title":"Mol. Cancer Ther."},{"key":"B220","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1111\/bpa.12401","article-title":"Cerebral Hypoperfusion and the Energy Deficit in Alzheimer\u2019s Disease.","volume":"26","author":"Love","year":"2016","journal-title":"Brain Pathol."},{"key":"B221","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1212\/01.wnl.0000172914.08967.dc","article-title":"Aggregation of vascular risk factors and risk of incident Alzheimer disease [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov\u2019t Research Support, U.S. Gov\u2019t, P.H.S.].","volume":"65","author":"Luchsinger","year":"2005","journal-title":"Neurology"},{"key":"B222","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1097\/01.jnen.0000225024.12074.80","article-title":"The pathogenesis of multiple sclerosis: relating human pathology to experimental studies.","volume":"65","author":"Ludwin","year":"2006","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B223","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020388","article-title":"Astrocyte regulation of blood flow in the brain.","volume":"7","author":"MacVicar","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B224","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1002\/mds.26128","article-title":"Cerebral perfusion and cortical thickness indicate cortical involvement in mild Parkinson\u2019s disease.","volume":"30","author":"Madhyastha","year":"2015","journal-title":"Mov. Disord."},{"key":"B225","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.neurobiolaging.2018.06.004","article-title":"The effects of cerebral amyloid angiopathy on integrity of the blood-brain barrier.","volume":"70","author":"Magaki","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"B226","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/j.biopsych.2004.09.013","article-title":"Resting neural activity distinguishes subgroups of schizophrenia patients.","volume":"56","author":"Malaspina","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"B227","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/s0006-3223(98)00306-0","article-title":"SPECT study of visual fixation in schizophrenia and comparison subjects.","volume":"46","author":"Malaspina","year":"1999","journal-title":"Soc. Biol. Psychiatry"},{"key":"B228","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1093\/hmg\/ddw050","article-title":"Motor deficits associated with Huntington\u2019s disease occur in the absence of striatal degeneration in BACHD transgenic mice.","volume":"25","author":"Mantovani","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"B229","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.neulet.2006.03.047","article-title":"Amyloid beta-peptide1-42 alters tight junction protein distribution and expression in brain microvessel endothelial cells.","volume":"401","author":"Marco","year":"2006","journal-title":"Neurosci. Lett."},{"key":"B230","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1001\/jamaneurol.2014.1668","article-title":"Impaired cerebrovascular reactivity in multiple sclerosis.","volume":"71","author":"Marshall","year":"2014","journal-title":"JAMA Neurol."},{"key":"B231","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1093\/brain\/124.6.1208","article-title":"Recovery of brain function during induced cerebral hypoperfusion.","volume":"124","author":"Marshall","year":"2001","journal-title":"Brain"},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.1186\/s13036-019-0145-8","article-title":"Current trends in biomarker discovery and analysis tools for traumatic brain injury.","volume":"13","author":"Martinez","year":"2019","journal-title":"J. Biol. Eng."},{"key":"B233","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/s0006-3223(99)00277-2","article-title":"Trait and state aspects of P300 amplitude reduction in schizophrenia: a retrospective longitudinal study.","volume":"47","author":"Mathalon","year":"2000","journal-title":"Biol. Psychiatry"},{"key":"B234","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1093\/brain\/awu043","article-title":"Association of brain amyloid-beta with cerebral perfusion and structure in Alzheimer\u2019s disease and mild cognitive impairment.","author":"Mattsson","year":"2014","journal-title":"Brain"},{"key":"B235","doi-asserted-by":"publisher","first-page":"C1148","DOI":"10.1152\/ajpcell.1999.276.5.C1148","article-title":"VEGF increases permeability of the blood-brain barrier via a nitric oxide synthase\/cGMP-dependent pathway.","volume":"276","author":"Mayhan","year":"1999","journal-title":"Am. J. Physiol."},{"key":"B236","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/ene.13413","article-title":"Huntington\u2019s disease: a clinical review.","volume":"25","author":"McColgan","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"B237","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.neuint.2019.04.005","article-title":"Astrocyte dysfunction and neurovascular impairment in neurological disorders: correlation or causation?","volume":"128","author":"McConnell","year":"2019","journal-title":"Neurochem. Int."},{"key":"B238","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.neuron.2005.06.030","article-title":"A\u03b242 is essential for parenchymal and vascular amyloid deposition in mice.","volume":"47","author":"McGowan","year":"2005","journal-title":"Neuron"},{"key":"B239","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1042\/BST0370329","article-title":"The effects of blood\u2013brain barrier disruption on glial cell function in multiple sclerosis.","author":"McQuaid","year":"2009","journal-title":"Biochem. Soc. Trans."},{"key":"B240","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1093\/brain\/awq377","article-title":"Arterial spin labelling reveals an abnormal cerebral perfusion pattern in Parkinson\u2019s disease.","author":"Melzer","year":"2011","journal-title":"Brain"},{"key":"B241","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1038\/s41593-017-0010-3","article-title":"Social stress induces neurovascular pathology promoting depression.","volume":"20","author":"Menard","year":"2017","journal-title":"Nat. Neurosci."},{"key":"B242","doi-asserted-by":"publisher","first-page":"667","DOI":"10.3233\/JAD-161002","article-title":"What is the relationship of traumatic brain injury to dementia?","volume":"57","author":"Mendez","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"B243","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1177\/0271678X15605847","article-title":"Arterial spin labeling imaging reveals widespread and Abeta-independent reductions in cerebral blood flow in elderly apolipoprotein epsilon-4 carriers.","volume":"36","author":"Michels","year":"2016","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B244","doi-asserted-by":"publisher","first-page":"37","DOI":"10.2147\/CLEP.S37929","article-title":"Clinical epidemiology of Alzheimer\u2019s disease: assessing sex and gender differences.","volume":"6","author":"Mielke","year":"2014","journal-title":"Clin. Epidemiol."},{"key":"B245","doi-asserted-by":"publisher","first-page":"3064","DOI":"10.1161\/STROKEAHA.114.006078","article-title":"Cerebral amyloid angiopathy increases susceptibility to infarction after focal cerebral ischemia in Tg2576 mice.","volume":"45","author":"Milner","year":"2014","journal-title":"Stroke"},{"key":"B246","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1080\/713714452","article-title":"Drug transport into the mammalian brain: the nasal pathway and its specific metabolic barrier.","volume":"10","author":"Minn","year":"2002","journal-title":"J. Drug Target"},{"key":"B247","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/ana.410420114","article-title":"Metabolic reduction in the posterior cingulate cortex in very early Alzheimer\u2019s disease.","volume":"42","author":"Minoshima","year":"1997","journal-title":"Ann. Neurol."},{"key":"B248","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1113\/JP270979","article-title":"Binaural blood flow control by astrocytes: listening to synapses and the vasculature.","volume":"595","author":"Mishra","year":"2017","journal-title":"J. Physiol."},{"key":"B249","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2012.00145","article-title":"Putative role of prostaglandin receptor in intracerebral hemorrhage.","volume":"3","author":"Mohan","year":"2012","journal-title":"Front. Neurol."},{"key":"B250","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1007\/s00401-016-1570-0","article-title":"Brain imaging of neurovascular dysfunction in Alzheimer\u2019s disease.","volume":"131","author":"Montagne","year":"2016","journal-title":"Acta Neuropathol."},{"key":"B251","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/s43587-021-00073-z","article-title":"APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer\u2019s mice via cyclophilin A independently of amyloid-\u03b2.","volume":"1","author":"Montagne","year":"2021","journal-title":"Nat. Aging"},{"key":"B252","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1136\/jnnp.53.1.33","article-title":"Measurement of regional cerebral blood flow and cognitive performance in Alzheimer\u2019s disease.","volume":"53","author":"Montaldi","year":"1990","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B253","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/1177271918774800","article-title":"Impaired cerebral perfusion in multiple sclerosis: relevance of endothelial factors.","volume":"13","author":"Monti","year":"2018","journal-title":"Biomark. Insights"},{"key":"B254","doi-asserted-by":"publisher","first-page":"4053","DOI":"10.1093\/cercor\/bhab068","article-title":"Contribution of excitatory and inhibitory neuronal activity to BOLD fMRI.","volume":"31","author":"Moon","year":"2021","journal-title":"Cereb. Cortex"},{"key":"B255","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/s0197-4580(97)00111-5","article-title":"GLUT-1 expression in the cerebra of patients with Alzheimer\u2019s disease.","volume":"18","author":"Mooradian","year":"1997","journal-title":"Neurobiol. Aging"},{"key":"B256","doi-asserted-by":"publisher","first-page":"e329","DOI":"10.1212\/WNL.0000000000012257","article-title":"Association of aortic stiffness with biomarkers of neuroinflammation, synaptic dysfunction, and neurodegeneration.","volume":"97","author":"Moore","year":"2021","journal-title":"Neurology"},{"key":"B257","doi-asserted-by":"publisher","first-page":"65","DOI":"10.31887\/DCNS.2020.22.1\/macrocq","article-title":"Neurodevelopmental disorders-the history and future of a diagnostic concept.","volume":"22","author":"Morris-Rosendahl","year":"2020","journal-title":"Dialogues Clin. Neurosci."},{"key":"B258","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1523\/JNEUROSCI.20-11-04050.2000","article-title":"High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation.","volume":"20","author":"Mucke","year":"2000","journal-title":"J. Neurosci."},{"key":"B259","doi-asserted-by":"publisher","DOI":"10.1093\/function\/zqab010","article-title":"PIP2 improves cerebral blood flow in a mouse model of Alzheimer\u2019s disease.","volume":"2","author":"Mughal","year":"2021","journal-title":"Function (Oxf)"},{"key":"B260","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/0920-9964(94)00045-a","article-title":"Immunoglobulin and albumin content of cerebrospinal fluid in schizophrenic patients: relationship to negative symptomatology.","volume":"14","author":"M\u00fcller","year":"1995","journal-title":"Schizophr. Res."},{"key":"B261","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1097\/00004728-200211000-00007","article-title":"Age-dependent change in metabolic re- sponse to photic stimulation of the primary visual cortex in infants: functional mag- netic resonance imaging study.","volume":"26","author":"Muramuto","year":"2002","journal-title":"J. Comput. Assist. Tomogr."},{"key":"B262","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/j.bbadis.2015.12.016","article-title":"Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer\u2019s disease.","volume":"1862","author":"Nelson","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"B263","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1089\/ars.2009.2800","article-title":"HIF prolyl hydroxylase inhibitors prevent neuronal death induced by mitochondrial toxins: therapeutic implications for Huntington\u2019s disease and Alzheimer\u2019s disease [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov\u2019t].","volume":"12","author":"Niatsetskaya","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"B264","doi-asserted-by":"crossref","first-page":"9287","DOI":"10.1523\/JNEUROSCI.3348-08.2008","article-title":"Complete rescue of cerebrovascular function in aged Alzheimer\u2019s disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist.","volume":"28","author":"Nicolakakis","year":"2008","journal-title":"J. Neurosci."},{"key":"B265","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1038\/jcbfm.2011.43","article-title":"Neurovascular function in Alzheimer\u2019s disease patients and experimental models.","volume":"31","author":"Nicolakakis","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B266","doi-asserted-by":"publisher","first-page":"93382","DOI":"10.18632\/oncotarget.21850","article-title":"PKA activation and endothelial claudin-5 breakdown in the schizophrenic prefrontal cortex.","volume":"7","author":"Nishiura","year":"2017","journal-title":"Oncotarget"},{"key":"B267","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1097\/00004647-200012000-00005","article-title":"Exogenous Ab1-40 reproduces cerebrovascular alterations resulting from amyloid precursor protein overexpression in mice.","volume":"20","author":"Niwa","year":"2000","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B268","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1006\/nbdi.2001.0460","article-title":"Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein.","volume":"9","author":"Niwa","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"B269","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1126\/science.1224631","article-title":"Mutations in BCKD-kinase lead to a potentially treatable form of autism with epilepsy.","volume":"338","author":"Novarino","year":"2012","journal-title":"Science"},{"key":"B270","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1136\/jnnp.55.12.1182","article-title":"A study of regional cerebral blood flow and cognitive performance in Alzheimer\u2019s disease.","volume":"55","author":"O\u2019Brien","year":"1992","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B271","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/916198","article-title":"Gender differences in schizophrenia and first-episode psychosis: a comprehensive literature review.","volume":"2012","author":"Ochoa","year":"2012","journal-title":"Schizophr. Res. Treat."},{"key":"B272","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","article-title":"Triple-transgenic model of Alzheimer\u2019s disease with plaques and tangles: intracellular Abeta and synaptic dysfunction [Comparative Study Research Support, Non-U.S. Gov\u2019t Research Support, U.S. Gov\u2019t, P.H.S.].","volume":"39","author":"Oddo","year":"2003","journal-title":"Neuron"},{"key":"B273","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1093\/brain\/123.9.1838","article-title":"Abnormal regional cerebral blood flow in childhood autism.","author":"Ohnishi","year":"2000","journal-title":"Brain"},{"key":"B274","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.ydbio.2019.11.016","article-title":"Neuron-derived VEGF contributes to cortical and hippocampal development independently of VEGFR1\/2-mediated neurotrophism.","volume":"459","author":"Okabe","year":"2020","journal-title":"Dev. Biol."},{"key":"B275","doi-asserted-by":"publisher","first-page":"3071","DOI":"10.2353\/ajpath.2010.100339","article-title":"Transgenic mice overexpressing APP and transforming growth factor-beta1 feature cognitive and vascular hallmarks of Alzheimer\u2019s disease.","volume":"177","author":"Ongali","year":"2010","journal-title":"Am. J. Pathol."},{"key":"B276","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.bbi.2011.08.007","article-title":"The role of immune dysfunction in the pathophysiology of autism.","volume":"26","author":"Onore","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"B277","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.arcmed.2014.11.013","article-title":"Role of the blood-brain barrier in multiple sclerosis.","volume":"45","author":"Ortiz","year":"2014","journal-title":"Arch. Med. Res."},{"key":"B278","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1016\/j.mri.2013.03.016","article-title":"Abnormalities of cerebral blood flow in multiple sclerosis: a pseudocontinuous arterial spin labeling MRI study.","volume":"31","author":"Ota","year":"2013","journal-title":"Magn. Reson. Imaging"},{"key":"B279","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1038\/s41593-020-0663-1","article-title":"Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice.","volume":"23","author":"Ouellette","year":"2020","journal-title":"Nat. Neurosci."},{"key":"B280","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s00401-006-0145-x","article-title":"Differences in expression of junctional adhesion molecule-A and beta-catenin in multiple sclerosis brain tissue: increasing evidence for the role of tight junction pathology.","volume":"113","author":"Padden","year":"2007","journal-title":"Acta Neuropathol."},{"key":"B281","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1212\/WNL.0000000000002461","article-title":"Age at onset and Parkinson disease phenotype.","volume":"86","author":"Pagano","year":"2016","journal-title":"Neurology"},{"key":"B282","doi-asserted-by":"crossref","first-page":"9572","DOI":"10.1073\/pnas.1133381100","article-title":"Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer\u2019s disease-related cognitive deficits.","volume":"100","author":"Palop","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B283","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/252419","article-title":"Regional MRI perfusion measures predict motor\/executive function in patients with clinically isolated syndrome.","volume":"2014","author":"Papadaki","year":"2014","journal-title":"Behav. Neurol."},{"key":"B284","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1038\/jcbfm.2012.126","article-title":"Drug transport across the blood-brain barrier.","volume":"32","author":"Pardridge","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B285","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1006\/exnr.1998.6828","article-title":"Role of peroxynitrite in the vasoactive and cytotoxic effects of Alzheimer\u2019s beta-amyloid1-40 peptide.","volume":"152","author":"Paris","year":"1998","journal-title":"Exp. Neurol."},{"key":"B286","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5607\/en.2016.25.1.1","article-title":"A short review on the current understanding of autism spectrum disorders.","volume":"25","author":"Park","year":"2016","journal-title":"Exp. Neurobiol."},{"key":"B287","doi-asserted-by":"publisher","first-page":"5063","DOI":"10.1073\/pnas.1015413108","article-title":"Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-beta.","volume":"108","author":"Park","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B288","year":"2010","journal-title":"A Manual for People Living with Parkinson\u2019s Disease."},{"key":"B289","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13258","article-title":"Alzheimer\u2019s amyloid beta heterogeneous species differentially affect brain endothelial cell viability, blood-brain barrier integrity, and angiogenesis.","volume":"19","author":"Parodi-Rullan","year":"2020","journal-title":"Aging Cell"},{"key":"B290","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.expneurol.2011.06.004","article-title":"An angiogenic inhibitor, cyclic RGDfV, attenuates MPTP-induced dopamine neuron toxicity.","volume":"231","author":"Patel","year":"2011","journal-title":"Exp. Neurol."},{"key":"B291","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1111\/j.1471-4159.2009.06426.x","article-title":"Alzheimer\u2019s beta-amyloid peptide blocks vascular endothelial growth factor mediated signaling via direct interaction with VEGFR-2.","volume":"112","author":"Patel","year":"2010","journal-title":"J. Neurochem."},{"key":"B292","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1007\/s11910-011-0215-x","article-title":"Cognitive impairment in Huntington disease: diagnosis and treatment [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov\u2019t Review].","volume":"11","author":"Paulsen","year":"2011","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"B293","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.conb.2021.04.005","article-title":"Neurovascular crosstalk coordinates the central nervous system development.","volume":"69","author":"Peguera","year":"2021","journal-title":"Curr. Opin. Neurobiol."},{"key":"B294","doi-asserted-by":"publisher","first-page":"511","DOI":"10.3171\/2015.2.JNS14503","article-title":"Association of traumatic brain injury with subsequent neurological and psychiatric disease: a meta-analysis.","volume":"124","author":"Perry","year":"2016","journal-title":"J. Neurosurg."},{"key":"B295","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/jcbfm.2012.192","article-title":"Heterogeneity of cortical lesions in multiple sclerosis: an MRI perfusion study.","volume":"33","author":"Peruzzo","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B296","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.biopsych.2018.11.026","article-title":"Hyperperfusion of frontal white and subcortical gray matter in autism spectrum disorder.","volume":"85","author":"Peterson","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"B297","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.pscychresns.2011.06.013","article-title":"Resting quantitative cerebral blood flow in schizophrenia measured by pulsed arterial spin labeling perfusion MRI.","volume":"194","author":"Pinkham","year":"2011","journal-title":"Psychiatry Res."},{"key":"B298","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1001\/jamapsychiatry.2018.3658","article-title":"Exploring comorbidity within mental disorders among a danish national population.","volume":"76","author":"Plana-Ripoll","year":"2019","journal-title":"JAMA Psychiatry"},{"key":"B299","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190062","article-title":"The blood-brain barrier in health and disease: important unanswered questions.","volume":"217","author":"Profaci","year":"2020","journal-title":"J. Exp. Med."},{"key":"B300","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1212\/WNL.38.6.931","article-title":"Cerebral perfusion as a diagnostic marker of early Alzheimer\u2019s disease.","volume":"38","author":"Prohovnik","year":"1988","journal-title":"Neurology"},{"key":"B301","doi-asserted-by":"publisher","DOI":"10.1038\/srep22500","article-title":"Social cognition and prefrontal hemodynamic responses during a working memory task in schizophrenia.","volume":"6","author":"Pu","year":"2016","journal-title":"Sci. Rep."},{"key":"B302","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.neuron.2011.07.013","article-title":"The neurovascular link in health and disease: molecular mechanisms and therapeutic implications.","volume":"71","author":"Quaegebeur","year":"2011","journal-title":"Neuron"},{"key":"B303","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","article-title":"Alzheimer\u2019s disease.","volume":"362","author":"Querfurth","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"B304","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ebiom.2018.01.021","article-title":"Traumatic brain injury and Alzheimer\u2019s disease: the cerebrovascular link.","volume":"28","author":"Ramos-Cejudo","year":"2018","journal-title":"EBioMedicine"},{"key":"B305","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1159\/000443738","article-title":"The prevalence of Huntington\u2019s disease.","volume":"46","author":"Rawlins","year":"2016","journal-title":"Neuroepidemiology"},{"key":"B306","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1083\/jcb.34.1.207","article-title":"Fine structural localization of a blood-brain barrier to exogenous peroxidase.","volume":"34","author":"Reese","year":"1967","journal-title":"J. Cell Biol."},{"key":"B307","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1136\/jnnp.51.10.1264","article-title":"Imaging of cerebral blood flow markers in Huntington\u2019s disease using single photon emission computed tomography.","volume":"51","author":"Reid","year":"1988","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B308","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/jcbfm.2015.88","article-title":"Ischemic brain injury in cerebral amyloid angiopathy.","volume":"36","author":"Reijmer","year":"2016","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B309","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.dcn.2013.07.003","article-title":"The BOLD signal and neurovascular coupling in autism.","volume":"6","author":"Reynell","year":"2013","journal-title":"Dev. Cogn. Neurosci."},{"key":"B310","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1001\/jamapsychiatry.2015.1546","article-title":"Long-term Risk of dementia in persons with Schizophrenia: a Danish population-based cohort study.","volume":"72","author":"Ribe","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"B311","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1111\/j.1471-4159.2007.04567.x","article-title":"Blood-brain barrier disruption induces in vivo degeneration of nigral dopaminergic neurons.","volume":"101","author":"Rite","year":"2007","journal-title":"J. Neurochem."},{"key":"B312","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1007\/s12035-010-8132-6","article-title":"Brain endothelial cell death: modes, signaling pathways, and relevance to neural development, homeostasis, and disease.","volume":"42","author":"Rizzo","year":"2010","journal-title":"Mol. Neurobiol."},{"key":"B313","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1161\/01.ATV.0000095973.42032.44","article-title":"Circle of willis atherosclerosis is a risk factor for sporadic Alzheimer\u2019s disease.","volume":"23","author":"Roher","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B314","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S1474-4422(10)70245-3","article-title":"Huntington\u2019s disease: from molecular pathogenesis to clinical treatment.","volume":"10","author":"Ross","year":"2011","journal-title":"Lancet Neurol."},{"key":"B315","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.jneuroim.2004.02.011","article-title":"Intranasal administration of interferon beta bypasses the blood\u2013brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy for multiple sclerosis.","volume":"151","author":"Ross","year":"2004","journal-title":"J. Neuroinflammation"},{"key":"B316","doi-asserted-by":"crossref","DOI":"10.1186\/2045-9912-2-16","article-title":"Hyperbaric oxygen treatment in autism spectrum disorders.","volume":"2","author":"Rossignol","year":"2012","journal-title":"Med. Gas Res."},{"key":"B317","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/nrn3381","article-title":"The brain reward circuitry in mood disorders.","volume":"14","author":"Russo","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"B318","doi-asserted-by":"publisher","first-page":"2911","DOI":"10.1111\/j.1582-4934.2008.00434.x","article-title":"A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer\u2019s disease brain.","volume":"13","author":"Ryu","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"B319","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.3174\/ajnr.A5773","article-title":"Gadolinium and multiple sclerosis: vessels, barriers of the brain, and glymphatics.","volume":"39","author":"Saade","year":"2018","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"B320","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1016\/s0140-6736(96)08380-8","article-title":"Correlation of positive symptoms exclusively to hyperperfusion or hypoperfusion of cerebral cortex in never-treated schizophrenics.","volume":"349","author":"Sabri","year":"1997","journal-title":"Lancet"},{"key":"B321","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3932","article-title":"Pericyte loss influences Alzheimer-like neurodegeneration in mice.","volume":"4","author":"Sagare","year":"2013","journal-title":"Nat. Commun."},{"key":"B322","first-page":"767","article-title":"Correlation of diffusion tensor and dynamic perfusion MR imaging metrics in normal- appearing corpus callosum: support for primary hypoperfusion in multiple sclerosis.","volume":"28","author":"Saindane","year":"2007","journal-title":"Am. J. Neuroradiol."},{"key":"B323","first-page":"446","article-title":"Hyperbaric oxygen therapy for children with autism spectrum disorder.","volume":"63","author":"Sakulchit","year":"2017","journal-title":"Can. Fam. Physician"},{"key":"B324","doi-asserted-by":"publisher","first-page":"2","DOI":"10.2174\/1567205012999151021102914","article-title":"The link between Alzheimer\u2019s disease and down syndrome. a historical perspective.","volume":"13","author":"Salehi","year":"2016","journal-title":"Curr. Alzheimer Res."},{"key":"B325","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1097\/NNR.0000000000000068","article-title":"Reactive oxygen and nitrogen species: impact on endothelial dysfunction.","volume":"64","author":"Salisbury","year":"2015","journal-title":"Nurs. Res."},{"key":"B326","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/s0022-510x(02)00288-5","article-title":"Effect of APOE genotype on microvascular basement membrane in Alzheimer\u2019s disease.","author":"Salloway","year":"2002","journal-title":"J. Neurol. Sci."},{"key":"B327","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1186\/s13041-016-0193-7","article-title":"Endothelial progenitor cells in cerebral endothelium development and repair.","volume":"6","author":"Salmina","year":"2014","journal-title":"Curr. Technol. Med."},{"key":"B328","doi-asserted-by":"crossref","first-page":"302","DOI":"10.2174\/1874192401004010302","article-title":"The endothelium and its role in regulating vascular tone.","volume":"4","author":"Sandoo","year":"2010","journal-title":"Open Cardiovasc. Med. J."},{"key":"B329","doi-asserted-by":"publisher","DOI":"10.1101\/2021.08.06.21261566","article-title":"Association of VEGF and KDR polymorphisms with the development of schizophrenia.","author":"Saoud","year":"2021","journal-title":"medRxiv"},{"key":"B330","doi-asserted-by":"publisher","first-page":"48","DOI":"10.2174\/1567202610666131124234506","article-title":"Neurovascular changes in acute, sub-acute and chronic mouse models of Parkinson\u2019s disease.","volume":"11","author":"Sarkar","year":"2014","journal-title":"Curr. Neurovasc. Res."},{"key":"B331","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1002\/mds.870110612","article-title":"Evidence of cortical metabolic dysfunction in early Huntington\u2019s disease by single-photon-emission computed tomography.","volume":"11","author":"Sax","year":"1996","journal-title":"Mov. Disord."},{"key":"B332","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1038\/s41593-021-00904-7","article-title":"Revisiting the neurovascular unit.","volume":"24","author":"Schaeffer","year":"2021","journal-title":"Nat. Neurosci."},{"key":"B333","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1148\/radiol.10091224","article-title":"Resting-State perfusion in nonmedicated schizophrenic patients: a continuous arterial spin-labeling 3.0-T MR study.","volume":"256","author":"Scheef","year":"2010","journal-title":"Radiology"},{"key":"B334","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1177\/088307389400900210","article-title":"Neuroimaging in infantile autism.","volume":"9","author":"Schifter","year":"1994","journal-title":"J. Child Neurol."},{"key":"B335","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.bandc.2016.09.002","article-title":"Determinants of cerebral hemodynamics during the Trail Making Test in schizophrenia.","volume":"109","author":"Schuepbach","year":"2016","journal-title":"Brain Cogn."},{"key":"B336","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1176\/jnp.14.1.19","article-title":"Age and regional cerebral blood flow in schizophrenia: age effects in anterior cingulate, frontal, and parietal cortex.","volume":"14","author":"Schultz","year":"2002","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"B337","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.jns.2005.03.014","article-title":"Protective autoimmunity and neuroprotection in inflammatory and noninflammatory neurodegenerative diseases.","volume":"233","author":"Schwartz","year":"2005","journal-title":"J. Neurol. Sci."},{"key":"B338","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-7-95","article-title":"Angiogenesis is present in experimental autoimmune encephalomyelitis and pro- angiogenic factors are increased in multiple sclerosis lesions.","volume":"7","author":"Seabrook","year":"2010","journal-title":"J. Neuroinflammation"},{"key":"B339","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1126\/science.1074069","article-title":"Alzheimer\u2019s disease is a synaptic failure.","volume":"298","author":"Selkoe","year":"2002","journal-title":"Science"},{"key":"B340","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41591-020-01182-9","article-title":"The distribution of cellular turnover in the human body.","volume":"27","author":"Sender","year":"2021","journal-title":"Nat. Med."},{"key":"B341","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/bpa.12004","article-title":"Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer\u2019s disease.","volume":"23","author":"Sengillo","year":"2013","journal-title":"Brain Pathol."},{"key":"B342","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.107929","article-title":"Microvascular basis of cognitive impairment in type 1 diabetes.","volume":"107929","author":"Sharma","year":"2021","journal-title":"Pharmacol. Therap."},{"key":"B343","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/s0162-3109(99)00099-5","article-title":"The possible role of plasma kallikrein-kinin system and leukocyte elastase in pathogenesis of schizophrenia.","volume":"43","author":"Shcherbakova","year":"1999","journal-title":"Immunopharmacology"},{"key":"B344","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1126\/science.1095505","article-title":"Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells.","volume":"304","author":"Shen","year":"2004","journal-title":"Science"},{"key":"B345","first-page":"10","article-title":"On the regulation of the blood-supply of the brain.","volume":"41","author":"Sherrington","year":"1890","journal-title":"Neurology"},{"key":"B346","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1176\/jnp.4.4.406","article-title":"Regional cerebral glucose metabolism and attention in adults with a history of childhood autism.","volume":"4","author":"Siegel","year":"1992","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"B347","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.0305-1846.2001.00299.x","article-title":"The selective vulnerability of nerve cells in Huntington\u2019s disease [Review].","volume":"27","author":"Sieradzan","year":"2001","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"B348","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02135","article-title":"Wnt\/beta-Catenin signaling as a molecular target by pathogenic bacteria.","volume":"10","author":"Silva-Garcia","year":"2019","journal-title":"Front. Immunol."},{"key":"B349","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1002\/ana.410350507","article-title":"Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer\u2019s diseas.","volume":"35","author":"Simpson","year":"1994","journal-title":"Ann. Neurol."},{"key":"B350","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1096\/fj.201700999","article-title":"The \u201dglymphatic\u201d mechanism for solute clearance in Alzheimer\u2019s disease: game changer or unproven speculation?","volume":"32","author":"Smith","year":"2018","journal-title":"FASEB J."},{"key":"B351","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1212\/WNL.53.7.1391","article-title":"Altered brain activation in cognitively intact individuals at high risk for Alzheimer\u2019s disease.","volume":"53","author":"Smith","year":"1999","journal-title":"Neurology"},{"key":"B352","doi-asserted-by":"publisher","first-page":"2601","DOI":"10.1161\/STROKEAHA.108.536839","article-title":"Beta-amyloid, blood vessels, and brain function.","volume":"40","author":"Smith","year":"2009","journal-title":"Stroke"},{"key":"B353","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1212\/01.wnl.0000327887.64299.a4","article-title":"Impaired visual evoked flow velocity response in cerebral amyloid angiopathy.","volume":"71","author":"Smith","year":"2008","journal-title":"Neurology"},{"key":"B354","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1001\/archneur.1992.00530350056020","article-title":"Topography of cross-sectional and longitudinal glucose metabolic deficits in Alzheimer\u2019s disease.","volume":"49","author":"Smith","year":"1992","journal-title":"Arch. Neurol."},{"key":"B355","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1093\/arclin\/acx086","article-title":"The neuropsychology of Huntington\u2019s disease.","volume":"32","author":"Snowden","year":"2017","journal-title":"Arch. Clin. Neuropsychol."},{"key":"B356","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.3233\/JAD-200473","article-title":"Alzheimer\u2019s disease: the link between amyloid-beta and neurovascular dysfunction.","volume":"76","author":"Solis","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"B357","doi-asserted-by":"publisher","first-page":"18781","DOI":"10.1523\/JNEUROSCI.4201-12.2013","article-title":"Effective connectivity within human primary visual cortex predicts interindividual diversity in illusory perception.","volume":"33","author":"Song","year":"2013","journal-title":"J. Neurosci."},{"key":"B358","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22042022","article-title":"The neurovascular unit dysfunction in Alzheimer\u2019s disease.","volume":"22","author":"Soto-Rojas","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B359","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1212\/wnl.41.7.1117","article-title":"Morphometric analysis of the prefrontal cortex in Huntington\u2019s disease.","volume":"41","author":"Sotrel","year":"1991","journal-title":"Neurology"},{"key":"B360","doi-asserted-by":"publisher","first-page":"5608","DOI":"10.1016\/j.biomaterials.2010.03.042","article-title":"The effect of encapsulated VEGF-secreting cells on brain amyloid load and behavioral impairment in a mouse model of Alzheimer\u2019s disease [Research Support, Non-U.S. Gov\u2019t].","volume":"31","author":"Spuch","year":"2010","journal-title":"Biomaterials"},{"key":"B361","doi-asserted-by":"publisher","first-page":"389","DOI":"10.2217\/nmt.15.41","article-title":"Targeting cerebrovascular impairments in Huntington\u2019s disease: a novel treatment perspective.","volume":"5","author":"St-Amour","year":"2015","journal-title":"Future Med."},{"key":"B362","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.schres.2012.11.004","article-title":"Schizophrenia: a neurodevelopmental disorder \u2014 Integrative genomic hypothesis and therapeutic implications from a transgenic mouse model.","volume":"143","author":"Stachowiak","year":"2013","journal-title":"Schizophr. Res."},{"key":"B363","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.702832","article-title":"Neurovascular coupling in development and disease: focus on astrocytes.","volume":"9","author":"Stackhouse","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B364","doi-asserted-by":"publisher","first-page":"179","DOI":"10.2174\/157015908785777210","article-title":"Brain endothelial cell-cell junctions: how to \u201copen\u201d the blood brain barrier.","volume":"6","author":"Stamatovic","year":"2008","journal-title":"Curr. Neuropharmacol."},{"key":"B365","doi-asserted-by":"publisher","DOI":"10.1186\/s11689-015-9125-6","article-title":"High rates of parkinsonism in adults with autism.","volume":"7","author":"Starkstein","year":"2015","journal-title":"J. Neurodev. Disord."},{"key":"B366","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.schres.2017.03.018","article-title":"Specific cerebral perfusion patterns in three schizophrenia symptom dimensions.","volume":"190","author":"Stegmayer","year":"2017","journal-title":"Schizophr. Res."},{"key":"B367","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaa044","article-title":"Altered cerebrovascular response to acute exercise in patients with Huntington\u2019s disease.","volume":"2","author":"Steventon","year":"2020","journal-title":"Brain Commun."},{"key":"B368","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.1523\/JNEUROSCI.15-07-04738.1995","article-title":"Development of retinal vasculature is mediated by hypoxia- induced vascular endothelial growth factor (VEGF) expression by neuroglia.","volume":"15","author":"Stone","year":"1995","journal-title":"J. Neurosci."},{"key":"B369","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1172\/JCI81108","article-title":"Endothelial LRP1 transports amyloid-beta(1-42) across the blood-brain barrier.","volume":"126","author":"Storck","year":"2016","journal-title":"J. Clin. Invest."},{"key":"B370","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jns.2005.11.006","article-title":"Upregulation of vascular growth factors in multiple sclerosis: correlation with MRI findings.","volume":"243","author":"Su","year":"2006","journal-title":"J. Neurol. Sci."},{"key":"B371","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/s0304-3940(98)00814-3","article-title":"Soluble Alzheimers beta-amyloid constricts the cerebral vasculature in vivo.","volume":"257","author":"Suo","year":"1998","journal-title":"Neurosci. Lett."},{"key":"B372","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.jalz.2014.05.1755","article-title":"Reduced cerebrovascular reactivity in young adults carrying the APOE epsilon4 allele.","volume":"11","author":"Suri","year":"2015","journal-title":"Alzheimers Dement."},{"key":"B373","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1038\/s41593-018-0234-x","article-title":"The role of brain vasculature in neurodegenerative disorders.","volume":"21","author":"Sweeney","year":"2018","journal-title":"Nat. Neurosci."},{"key":"B374","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.jalz.2018.07.222","article-title":"Vascular dysfunction-The disregarded partner of Alzheimer\u2019s disease.","volume":"15","author":"Sweeney","year":"2019","journal-title":"Alzheimers Dement."},{"key":"B375","doi-asserted-by":"publisher","first-page":"e1333","DOI":"10.1212\/WNL.0000000000010201","article-title":"Cerebrovascular reactivity in cerebral amyloid angiopathy, Alzheimer disease, and mild cognitive impairment.","volume":"95","author":"Switzer","year":"2020","journal-title":"Neurology"},{"key":"B376","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s00702-017-1703-1","article-title":"Arterial spin labelling detects posterior cortical hypoperfusion in non-demented patients with Parkinson\u2019s disease.","volume":"124","author":"Syrimi","year":"2017","journal-title":"J. Neural Transm. (Vienna)"},{"key":"B377","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1177\/0271678X21992462","article-title":"Cerebrovascular phenotypes in mouse models of Alzheimer\u2019s disease.","volume":"41","author":"Szu","year":"2021","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B378","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1111\/j.1582-4934.2009.00717.x","article-title":"Amyloid-beta-induced occludin down-regulation and increased permeability in human brain endothelial cells is mediated by MAPK activation.","volume":"14","author":"Tai","year":"2010","journal-title":"J. Cell. Mol. Med."},{"key":"B379","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1023\/b:nere.0000014828.32200.bd","article-title":"Peroxynitrite mediates nitric oxide\u2013induced blood\u2013brain barrier damage.","volume":"29","author":"Tan","year":"2004","journal-title":"Neurochem. Res."},{"key":"B380","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.180138","article-title":"Synaptic dysfunction in neurodegenerative and neurodevelopmental diseases: an overview of induced pluripotent stem-cell-based disease models.","volume":"8","author":"Taoufik","year":"2018","journal-title":"Open Biol."},{"key":"B381","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1016\/j.cell.2016.11.013","article-title":"Impaired amino acid transport at the blood brain barrier is a cause of autism spectrum disorder.","volume":"167","author":"Tarlungeanu","year":"2016","journal-title":"Cell"},{"key":"B382","doi-asserted-by":"publisher","DOI":"10.1042\/NS20170139","article-title":"Cross-talk between blood vessels and neural progenitors in the developing brain.","volume":"2","author":"Tata","year":"2018","journal-title":"Neuronal Signal."},{"key":"B383","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.mod.2015.07.001","article-title":"Vascularisation of the central nervous system.","author":"Tata","year":"2015","journal-title":"Mech. Dev."},{"key":"B384","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.1016\/j.neurobiolaging.2008.01.017","article-title":"Capillary cerebral amyloid angiopathy is associated with vessel occlusion and cerebral blood flow disturbances.","volume":"30","author":"Thal","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"B385","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1001\/archneurol.2009.913","article-title":"APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging.","volume":"67","author":"Thambisetty","year":"2010","journal-title":"Arch. Neurol."},{"key":"B386","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/380168a0","article-title":"\u03b2-Amyloid-mediated vasoactivity and vascular endothelial damage.","volume":"380","author":"Thomas","year":"1996","journal-title":"Nature"},{"key":"B387","doi-asserted-by":"crossref","first-page":"11165","DOI":"10.1523\/JNEUROSCI.4031-05.2005","article-title":"Vascular remodeling versus amyloid beta-induced oxidative stress in the cerebrovascular dysfunctions associated with Alzheimer\u2019s disease.","volume":"25","author":"Tong","year":"2005","journal-title":"J. Neurosci"},{"key":"B388","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00787","article-title":"Low frequency systemic hemodynamic \u201dnoise\u201d in resting state BOLD fMRI: characteristics, causes, implications, mitigation strategies, and applications.","volume":"13","author":"Tong","year":"2019","journal-title":"Front. Neurosci."},{"key":"B389","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-85062-3","article-title":"Genetic dissection of down syndrome-associated alterations in APP\/amyloid-beta biology using mouse models.","volume":"11","author":"Tosh","year":"2021","journal-title":"Sci. Rep."},{"key":"B390","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/S1474-4422(09)70043-2","article-title":"Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis.","volume":"8","author":"Trapp","year":"2009","journal-title":"Lancet Neurol."},{"key":"B391","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.schres.2006.12.033","article-title":"Increased hemodynamic response in the hippocampus, thalamus and prefrontal cortex during abnormal sensory gating in schizophrenia.","volume":"92","author":"Tregellas","year":"2007","journal-title":"Schizophr. Res."},{"key":"B392","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2016.00056","article-title":"Implications of MMP9 for blood brain barrier disruption and hemorrhagic transformation following ischemic stroke.","volume":"10","author":"Turner","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"B393","doi-asserted-by":"publisher","first-page":"567","DOI":"10.3109\/15622970903414188","article-title":"Ultrastructural damage of capillaries in the neocortex in schizophrenia.","volume":"11","author":"Uranova","year":"2010","journal-title":"World J. Biol. Psychiatry"},{"key":"B394","doi-asserted-by":"publisher","DOI":"10.1186\/s13034-019-0289-9","article-title":"Reduced prefrontal hemodynamic response in pediatric autism spectrum disorder measured with near-infrared spectroscopy.","volume":"13","author":"Uratani","year":"2019","journal-title":"Child Adolesc. Psychiatry Ment. Health"},{"key":"B395","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1007\/s00406-020-01152-9","article-title":"Serum zonulin and claudin-5 levels in patients with schizophrenia.","volume":"271","author":"Usta","year":"2021","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"B396","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1148\/radiol.2016152244","article-title":"Blood-Brain barrier leakage in patients with early Alzheimer disease.","volume":"281","author":"van de Haar","year":"2016","journal-title":"Radiology"},{"key":"B397","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00930","article-title":"Impact of metabolic syndrome on neuroinflammation and the blood\u2013brain barrier.","volume":"12","author":"Van Dyken","year":"2018","journal-title":"Front. Neurosci."},{"key":"B398","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.jns.2008.12.036","article-title":"White matter hemodynamic abnormalities precede sub-cortical gray matter changes in multiple sclerosis.","volume":"282","author":"Varga","year":"2009","journal-title":"J. Neurol. Sci."},{"key":"B399","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.tig.2015.01.004","article-title":"Progress in unraveling the genetic etiology of Parkinson disease in a genomic era.","volume":"31","author":"Verstraeten","year":"2015","journal-title":"Trends Genet."},{"key":"B400","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.jns.2016.03.026","article-title":"Autism spectrum disorders: integration of the genome, transcriptome and the environment.","volume":"364","author":"Vijayakumar","year":"2016","journal-title":"J. Neurol. Sci."},{"key":"B401","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3109\/01913129409023202","article-title":"Microvasculature in brain biopsy specimens from patients with Alzheimer\u2019s disease: an immunohistochemical and ultrastructural study [Research Support, U.S. Gov\u2019t, P.H.S.].","volume":"18","author":"Vinters","year":"1994","journal-title":"Ultrastruct. Pathol."},{"key":"B402","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1080\/15622970701210247","article-title":"Deficit of pericapillary oligodendrocytes in the prefrontal cortex in schizophrenia.","volume":"9","author":"Vostrikov","year":"2008","journal-title":"World J. Biol. Psychiatry"},{"key":"B403","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1097\/01.wnr.0000215769.71657.65","article-title":"Expression levels of vascular endothelial growth factor and its receptors in Parkinson\u2019s disease.","volume":"17","author":"Wada","year":"2006","journal-title":"Neuroreport"},{"key":"B404","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.neuron.2015.06.038","article-title":"Wiring the vascular network with neural cues: a CNS perspective.","volume":"87","author":"Walchli","year":"2015","journal-title":"Neuron"},{"key":"B405","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/S0140-6736(07)60111-1","article-title":"Huntington\u2019s disease [Review].","volume":"369","author":"Walker","year":"2007","journal-title":"Lancet"},{"key":"B406","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1111\/jnc.13122","article-title":"Abeta(1-42) oligomer-induced leakage in an in vitro blood-brain barrier model is associated with up-regulation of RAGE and metalloproteinases, and down-regulation of tight junction scaffold proteins.","volume":"134","author":"Wan","year":"2015","journal-title":"J. Neurochem."},{"key":"B407","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1097\/WNR.0000000000000529","article-title":"Altered resting-state ascending\/descending pathways associated with the posterior thalamus in migraine without aura.","volume":"27","author":"Wang","year":"2016","journal-title":"Neuroreport"},{"key":"B408","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1161\/STROKEAHA.107.500124","article-title":"Changes in background blood-brain barrier integrity between lacunar and cortical ischemic stroke subtypes.","volume":"39","author":"Wardlaw","year":"2008","journal-title":"Stroke"},{"key":"B409","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1038\/332734a0","article-title":"A highly polymorphic locus very tightly linked to the Huntington\u2019s disease gene [Research Support, Non-U.S. Gov\u2019t Research Support, U.S. Gov\u2019t, P.H.S.].","volume":"332","author":"Wasmuth","year":"1988","journal-title":"Nature"},{"key":"B410","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.557384","article-title":"Aging of the vascular system and neural diseases.","volume":"12","author":"Watanabe","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"B411","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.1177\/0271678X19900543","article-title":"Mild pericyte deficiency is associated with aberrant brain microvascular flow in aged PDGFR\u03b2+\/- mice.","volume":"40","author":"Watson","year":"2020","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B412","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.bbamem.2008.10.022","article-title":"The blood-brain barrier in brain homeostasis and neurological diseases.","volume":"1788","author":"Weiss","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"B413","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nature12821","article-title":"Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical period.","volume":"505","author":"Whiteus","year":"2014","journal-title":"Nature"},{"key":"B414","doi-asserted-by":"publisher","first-page":"S691","DOI":"10.1002\/mds.22500","article-title":"Serial volumetric MRI in Parkinsonian disorders.","author":"Wild","year":"2009","journal-title":"Mov. Disord."},{"key":"B415","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2013.00013","article-title":"Stroke prevention and cognitive reserve: emerging approaches to modifying risk and delaying onset of dementia.","volume":"4","author":"Willis","year":"2013","journal-title":"Front. Neurol."},{"key":"B416","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.1093\/brain\/awy159","article-title":"Trisomy of human chromosome 21 enhances amyloid-beta deposition independently of an extra copy of APP.","volume":"141","author":"Wiseman","year":"2018","journal-title":"Brain"},{"key":"B417","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.1038\/jcbfm.2011.60","article-title":"Magnetic resonance perfusion imaging of resting-state cerebral blood flow in preclinical Huntington\u2019s disease.","volume":"31","author":"Wolf","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B418","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1038\/nm1287","article-title":"Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease.","volume":"11","author":"Wu","year":"2005","journal-title":"Nat. Med."},{"key":"B419","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1093\/brain\/awh007","article-title":"Changes in cerebral perfusion precede plaque formation in multiple sclerosis: a longitudinal perfusion MRI study.","author":"Wuerfel","year":"2004","journal-title":"Brain"},{"key":"B420","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00764","article-title":"Blood-Brain barrier: more contributor to disruption of central nervous system homeostasis than victim in neurological disorders.","volume":"14","author":"Xiao","year":"2020","journal-title":"Front. Neurosci."},{"key":"B421","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1212\/WNL.55.2.218","article-title":"A milestone for normal development of the infantile brain detected by functional MRI.","volume":"55","author":"Yamada","year":"2000","journal-title":"Neurology"},{"key":"B422","doi-asserted-by":"publisher","first-page":"821","DOI":"10.3233\/JPD-140454","article-title":"String vessel formation is increased in the brain of Parkinson disease.","volume":"5","author":"Yang","year":"2015","journal-title":"J. Parkinsons Dis."},{"key":"B423","doi-asserted-by":"publisher","DOI":"10.1186\/s11689-018-9250-0","article-title":"Arterial spin labeling provides a reliable neurobiological marker of autism spectrum disorder.","volume":"10","author":"Yerys","year":"2018","journal-title":"J. Neurodev. Disord."},{"key":"B424","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1749-6632.1997.tb48467.x","article-title":"Vascular basement membrane pathology and Alzheimer\u2019s disease.","volume":"826","author":"Zarow","year":"1997","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B425","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1172\/JCI9369","article-title":"VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain.","volume":"106","author":"Zhang","year":"2000","journal-title":"J. Clin. Invest."},{"key":"B426","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1038\/nn.4025","article-title":"Central role for PICALM in amyloid-beta blood-brain barrier transcytosis and clearance.","volume":"18","author":"Zhao","year":"2015","journal-title":"Nat. Neurosci."},{"key":"B427","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00738","article-title":"Disrupted regional cerebral blood flow, functional activity and connectivity in Alzheimer\u2019s disease: a combined ASL perfusion and resting state fMRI Study.","volume":"13","author":"Zheng","year":"2019","journal-title":"Front. Neurosci."},{"key":"B428","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/B978-0-12-385883-2.00010-2","article-title":"Huntington disease and the huntingtin protein [Review].","volume":"107","author":"Zheng","year":"2012","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"B429","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1093\/schbul\/sbx051","article-title":"Altered coupling between resting-state cerebral blood flow and functional connectivity in schizophrenia.","volume":"43","author":"Zhu","year":"2017","journal-title":"Schizophr. Bull."},{"key":"B430","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1192\/bjp.bp.115.174961","article-title":"Cerebral blood flow alterations specific to auditory verbal hallucinations in schizophrenia.","volume":"210","author":"Zhuo","year":"2017","journal-title":"Br. J. Psychiatry"},{"key":"B431","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1176\/appi.ajp.157.12.1988","article-title":"Temporal lobe dysfunction in childhood autism: a PET study.","volume":"157","author":"Zilbovicius","year":"2000","journal-title":"Am. J. Psychiatry"},{"key":"B432","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.tins.2005.02.001","article-title":"Neurovascular mechanisms of Alzheimer\u2019s neurodegeneration.","volume":"28","author":"Zlokovic","year":"2005","journal-title":"Trends Neurosci."},{"key":"B433","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.neuron.2008.01.003","article-title":"The blood-brain barrier in health and chronic neurodegenerative disorders.","volume":"57","author":"Zlokovic","year":"2008","journal-title":"Neuron"},{"key":"B434","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/nrn3114","article-title":"Neurovascular pathways to neurodegeneration in Alzheimer\u2019s disease and other disorders.","volume":"12","author":"Zlokovic","year":"2011","journal-title":"Nat. Rev. Neurosci."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2021.749026\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T18:52:26Z","timestamp":1634755946000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2021.749026\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,20]]},"references-count":434,"alternative-id":["10.3389\/fnagi.2021.749026"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2021.749026","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,20]]},"article-number":"749026"}}