{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:07:59Z","timestamp":1753891679398,"version":"3.41.2"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:00:00Z","timestamp":1643846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This is a cross-sectional study to evaluate whether \u03b2-amyloid-(A\u03b2)-PET positivity and cortical superficial siderosis (cSS) in patients with cerebral amyloid angiopathy (CAA) are regionally colocalized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten patients with probable or possible CAA (73.3 \u00b1 10.9 years, 40% women) underwent MRI examination with a gradient-echo-T2*-weighted-imaging sequence to detect cSS and<jats:sup>18<\/jats:sup>F-florbetaben PET examination to detect fibrillar A\u03b2. In all cortical regions of the Hammers Atlas, cSS positivity (MRI: ITK-SNAP segmentation) and A\u03b2-PET positivity (PET: \u2265 mean value + 2 standard deviations of 14 healthy controls) were defined. Regional agreement of cSS- and A\u03b2-PET positivity was evaluated. A\u03b2-PET quantification was compared between cSS-positive and corresponding contralateral cSS-negative atlas regions. Furthermore, the A\u03b2-PET quantification of cSS-positive regions was evaluated in voxels close to cSS and in direct cSS voxels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>cSS- and A\u03b2-PET positivity did not indicate similarity of their regional patterns, despite a minor association between the frequency of A\u03b2-positive patients and the frequency of cSS-positive patients within individual regions (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>= 0.277,<jats:italic>p<\/jats:italic>= 0.032). However, this association was driven by temporal regions lacking cSS- and A\u03b2-PET positivity. When analyzing all composite brain regions, A\u03b2-PET values in regions close to cSS were significantly higher than in regions directly affected with cSS (<jats:italic>p<\/jats:italic>&amp;lt; 0.0001). However, A\u03b2-PET values in regions close to cSS were not different when compared to corresponding contralateral cSS-negative regions (<jats:italic>p<\/jats:italic>= 0.603).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this cross-sectional study, cSS and A\u03b2-PET positivity did not show regional association in patients with CAA and deserve further exploitation in longitudinal designs. In clinical routine, a specific cross-sectional evaluation of A\u03b2-PET in cSS-positive regions is probably not useful for visual reading of A\u03b2-PETs in patients with CAA.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnagi.2021.786143","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T08:58:43Z","timestamp":1643878723000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Regional Associations of Cortical Superficial Siderosis and \u03b2-Amyloid-Positron-Emission-Tomography Positivity in Patients With Cerebral Amyloid Angiopathy"],"prefix":"10.3389","volume":"13","author":[{"given":"Anika","family":"Finze","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannes","family":"Wahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Janowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Buerger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Linn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Rominger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"St\u00f6cklein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Bartenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank Arne","family":"Wollenweber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cihan","family":"Catak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Brendel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e1809","DOI":"10.1212\/WNL.0000000000012778","article-title":"Spontaneous ARIA-like Events in Cerebral Amyloid Angiopathy-Related Inflammation: a Multicenter Prospective Longitudinal Cohort Study.","volume":"97","author":"Antolini","year":"2021","journal-title":"Neurology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1111\/opo.12131","article-title":"Review: when to use the Bonferroni correction.","volume":"34","author":"Armstrong","year":"2014","journal-title":"Ophthalmic. 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