{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:43:47Z","timestamp":1792701827871,"version":"4.5.0"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603112"],"award-info":[{"award-number":["81603112"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2018225089"],"award-info":[{"award-number":["2018225089"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2020-MS-161"],"award-info":[{"award-number":["2020-MS-161"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","award":["LJKZ0775"],"award-info":[{"award-number":["LJKZ0775"]}],"id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>Alzheimer's disease (AD) remains a medical and social challenge worldwide. Magnesium (Mg) is one of the most frequently evaluated essential minerals with diverse biological functions in human body. However, the association between circulating Mg levels and AD remains controversial. We conducted a meta-analysis of 21 studies published between 1991 and 2021 to determine whether the Mg levels in the blood and cerebrospinal fluid (CSF) are abnormal in AD. Literatures were searched in PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang Data without language limitations. A pooled subject sample including 1,112 AD patients and 1,001 healthy controls (HCs) was available to assess Mg levels in serum and plasma; 284 AD patients and 117 HCs were included for Mg levels in CSF. It was found that serum and plasma levels of Mg were significantly reduced in AD patients compared with HCs (standardized mean difference [SMD] = \u22120.89; 95% confidence interval [CI] [\u22121.36, \u22120.43];<jats:italic>P<\/jats:italic>= 0.000). There was statistically non-significant for Mg level in CSF between AD and HCs, whereas a decreased tendency were detected (SMD = \u22120.16; 95% CI [\u22120.50, 0.18];<jats:italic>P<\/jats:italic>= 0.364). .In addition, when we analyzed the Mg levels of serum, plasma and CSF together, the circulating Mg levels in AD patients was significantly lower (SMD = \u22120.74, 95% CI [\u22121.13; \u22120.35];<jats:italic>P<\/jats:italic>= 0.000). These results indicate that Mg deficiency may be a risk factor of AD and Mg supplementation may be a potentially valuable adjunctive treatment for AD.<\/jats:p><jats:p><jats:bold>Systematic Review Registration:<\/jats:bold><jats:ext-link>www.crd.york.ac.uk\/PROSPERO\/<\/jats:ext-link>, registration number CRD42021254557.<\/jats:p>","DOI":"10.3389\/fnagi.2021.799824","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T05:45:29Z","timestamp":1641793529000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Association of Circulating Magnesium Levels in Patients With Alzheimer's Disease From 1991 to 2021: A Systematic Review and Meta-Analysis"],"prefix":"10.3389","volume":"13","author":[{"given":"Ke","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Tai","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Ya","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Juan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"186","DOI":"10.4103\/njcp.njcp_252_18","article-title":"Serum magnesium in adult patients with idiopathic and symptomatic epilepsy in Maiduguri, Northeast Nigeria","volume":"22","author":"Abdullahi","year":"2019","journal-title":"Niger J. Clin. Pract."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1177\/1535370217711440","article-title":"Ameliorating effect of anti-Alzheimer's drugs on the bidirectional association between type 2 diabetes mellitus and Alzheimer's disease","volume":"242","author":"Ahmed","year":"2017","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"B3","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/S0197-4580(00)00124-X","article-title":"Inflammation and Alzheimer's disease","volume":"21","author":"Akiyama","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"B4","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.neuro.2006.12.001","article-title":"Serum chemical elements and oxidative status in Alzheimer's disease, Parkinson disease and multiple sclerosis","volume":"28","author":"Alimonti","year":"2007","journal-title":"Neurotoxicology"},{"key":"B5","first-page":"189","article-title":"Disturbances of magnesium concentrations in various brain areas in Alzheimer's disease","volume":"13","author":"Andrasi","year":"2000","journal-title":"Magnes. Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"273","DOI":"10.3233\/JAD-2005-7402","article-title":"Brain aluminum, magnesium and phosphorus contents of control and Alzheimer-diseased patients","volume":"7","author":"Andrasi","year":"2005","journal-title":"J. Alzheimers Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"7156928","DOI":"10.1155\/2017\/7156928","article-title":"Preliminary data on the interaction between some biometals and oxidative stress status in mild cognitive impairment and Alzheimer's disease patients","volume":"2017","author":"Balmus","year":"2017","journal-title":"Oxid. Med. Cell Longev."},{"key":"B8","doi-asserted-by":"publisher","first-page":"S115","DOI":"10.1684\/mrh.2011.0287","article-title":"Altered ionized magnesium levels in mild-to-moderate Alzheimer's disease","volume":"24","author":"Barbagallo","year":"2011","journal-title":"Magnes. Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1111\/jnc.13425","article-title":"Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics","volume":"139","author":"Belaidi","year":"2016","journal-title":"J. Neurochem"},{"key":"B10","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1159\/000249145","article-title":"Cerebrospinal fluid total tau is associated with shorter survival in dementia with Lewy bodies","volume":"28","author":"Bostrom","year":"","journal-title":"Dement. Geriatr. Cogn. Disord"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1016\/j.neurobiolaging.2007.10.018","article-title":"CSF Mg and Ca as diagnostic markers for dementia with Lewy bodies","volume":"30","author":"Bostrom","year":"","journal-title":"Neurobiol. Aging"},{"key":"B12","first-page":"467","article-title":"Study on calcium, magnesium, zinc and aluminum content in serum of senile dementia patients","volume":"15","author":"Cheng","year":"1999","journal-title":"Bull. Sci. Technol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3389\/fnagi.2014.00004","article-title":"Dietary mineral intake and risk of mild cognitive impairment: the PATH through life project","volume":"6","author":"Cherbuin","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"E97","DOI":"10.36076\/ppj\/2016.19.E97","article-title":"Effects of intravenous and oral magnesium on reducing migraine: a meta-analysis of randomized controlled trials","volume":"19","author":"Chiu","year":"2016","journal-title":"Pain Phys."},{"key":"B15","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.psc.2014.09.001","article-title":"The role of nutrient-based epigenetic changes in buffering against stress, aging, and Alzheimer's disease","volume":"37","author":"Chiu","year":"2014","journal-title":"Psychiatr. Clin. North Am."},{"key":"B16","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1159\/000110873","article-title":"Serum magnesium level and clinical deterioration in Alzheimer's disease","volume":"53","author":"Cilliler","year":"2007","journal-title":"Gerontology"},{"key":"B17","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s12011-019-01931-z","article-title":"The role of magnesium in pathophysiology and migraine treatment","volume":"196","author":"Dolati","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.cbpa.2007.01.678","article-title":"Copper and Alzheimer's disease","volume":"11","author":"Donnelly","year":"2007","journal-title":"Curr. Opin. Chem. Biol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3390\/nu9030231","article-title":"Association of serum manganese levels with Alzheimer's disease and mild cognitive impairment: a systematic review and meta-analysis","volume":"9","author":"Du","year":"2017","journal-title":"Nutrients"},{"key":"B20","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.mehy.2016.04.007","article-title":"A multipronged, nutritional-based strategy for managing Alzheimer's disease","volume":"91","author":"Glick","year":"2016","journal-title":"Med. Hypotheses"},{"key":"B21","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1039\/C3MT00301A","article-title":"Characterization of metal profiles in serum during the progression of Alzheimer's disease","volume":"6","author":"Gonzalez-Dominguez","year":"2014","journal-title":"Metallomics"},{"key":"B22","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1111\/j.1447-0594.2009.00571.x","article-title":"Lipids' peroxidation markers in Alzheimer's disease and vascular dementia","volume":"10","author":"Gustaw-Rothenberg","year":"2010","journal-title":"Geriatr. Gerontol. Int."},{"key":"B23","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1471-2288-5-13","article-title":"Estimating the mean and variance from the median, range, and the size of a sample","volume":"5","author":"Hozo","year":"2005","journal-title":"BMC Med. Res. Methodol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jns.2011.01.003","article-title":"Patterns of levels of biological metals in CSF differ among neurodegenerative diseases","volume":"303","author":"Hozumi","year":"2011","journal-title":"J. Neurol. Sci"},{"key":"B25","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1111\/cns.12775","article-title":"Magnesium boosts the memory restorative effect of environmental enrichment in Alzheimer's disease mice","volume":"24","author":"Huang","year":"2018","journal-title":"CNS Neurosci. Ther."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.3233\/JAD-201250","article-title":"Impacts of iron metabolism dysregulation on Alzheimer's disease","volume":"80","author":"Jouini","year":"2021","journal-title":"J. Alzheimers Dis."},{"key":"B27","doi-asserted-by":"publisher","first-page":"147","DOI":"10.3390\/nu10020147","article-title":"Zinc, carnosine, and neurodegenerative diseases","volume":"10","author":"Kawahara","year":"2018","journal-title":"Nutrients"},{"key":"B28","doi-asserted-by":"publisher","first-page":"730","DOI":"10.3390\/nu10060730","article-title":"The role of magnesium in neurological disorders","volume":"10","author":"Kirkland","year":"2018","journal-title":"Nutrients"},{"key":"B29","first-page":"1095","article-title":"Hair aluminium in normal aged and senile dementia of Alzheimer type","volume":"317","author":"Kobayashi","year":"1989","journal-title":"Prog. Clin. Biol. Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.3906\/sag-1407-67","article-title":"A comparison of hair and serum trace elements in patients with Alzheimer disease and healthy participants","volume":"45","author":"Koc","year":"2015","journal-title":"Turk. J. Med. Sci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1080\/00207450390162146","article-title":"Hypothalamic digoxin, hemispheric chemical dominance, and Alzheimer's disease","volume":"113","author":"Kurup","year":"2003","journal-title":"Int. J. Neurosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/0006-8993(84)91199-5","article-title":"Chronically elevating plasma Mg2+ improves hippocampal frequency potentiation and reversal learning in aged and young rats","volume":"322","author":"Landfield","year":"1984","journal-title":"Brain Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"S379","DOI":"10.3233\/JAD-179944","article-title":"Iron and Alzheimer's disease: an update on emerging mechanisms","volume":"64","author":"Lane","year":"2018","journal-title":"J. Alzheimers Dis"},{"key":"B34","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/0006-3223(94)00241-T","article-title":"Plasma magnesium decrease and altered calcium\/magnesium ratio in severe dementia of the Alzheimer type","volume":"37","author":"Lemke","year":"1995","journal-title":"Biol. Psychiatry"},{"key":"B35","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/nature04533","article-title":"A specific amyloid-beta protein assembly in the brain impairs memory","volume":"440","author":"Lesne","year":"2006","journal-title":"Nature"},{"key":"B36","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s13041-014-0065-y","article-title":"Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer's disease mouse model","volume":"7","author":"Li","year":"2014","journal-title":"Mol. Brain"},{"key":"B37","doi-asserted-by":"publisher","first-page":"735","DOI":"10.3389\/fnhum.2013.00735","article-title":"The role of iron-induced fibrin in the pathogenesis of Alzheimer's disease and the protective role of magnesium","volume":"7","author":"Lipinski","year":"2013","journal-title":"Front. Hum. Neurosci."},{"key":"B38","volume-title":"The Study of the Association Between Trace Element and Senile Dementia\/Depressive Disorder","author":"Liu","year":"2008"},{"key":"B39","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.neuro.2019.07.007","article-title":"The role of zinc, copper, manganese and iron in neurodegenerative diseases","author":"Mezzaroba","year":"2019","journal-title":"Neurotoxicology 74"},{"key":"B40","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.ijsu.2010.02.007","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"8","author":"Moher","year":"2010","journal-title":"Int. J. Surg."},{"key":"B41","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1017\/UPO9780987073051.018","article-title":"\u201cMagnesium in Parkinson's disease: an update in clinical and basic aspects,\u201d","volume-title":"Magnesium in the Central Nervous System","author":"Oyanagi","year":"2011"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/j.tips.2018.10.001","article-title":"Copper and zinc dysregulation in Alzheimer's Disease","volume":"39","author":"Sensi","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.3892\/mmr.2019.10374","article-title":"Cholinesterase inhibitors as Alzheimer's therapeutics (Review)","volume":"20","author":"Sharma","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"B44","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1016\/j.jada.2007.09.008","article-title":"Poor nutrient intakes during 1-year follow-up with community-dwelling older adults with early-stage Alzheimer dementia compared to cognitively intact matched controls","volume":"107","author":"Shatenstein","year":"2007","journal-title":"J. Am. Diet Assoc."},{"key":"B45","doi-asserted-by":"publisher","first-page":"3143","DOI":"10.2147\/NDT.S230688","article-title":"Treatment of magnesium-L-threonate elevates the magnesium level in the cerebrospinal fluid and attenuates motor deficits and dopamine neuron loss in a mouse model Of Parkinson's disease","volume":"15","author":"Shen","year":"2019","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"B46","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3945\/an.116.013474","article-title":"Nutritional considerations for healthy aging and reduction in age-related chronic disease","volume":"8","author":"Shlisky","year":"2017","journal-title":"Adv. Nutr."},{"key":"B47","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1177\/0891988714522698","article-title":"Polymorphism in cytochrome P450 2D6, glutathione S-transferases Pi 1 genes, and organochlorine pesticides in alzheimer disease: a case-control study in North Indian population","volume":"27","author":"Singh","year":"2014","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.neuron.2009.12.026","article-title":"Enhancement of learning and memory by elevating brain magnesium","volume":"65","author":"Slutsky","year":"2010","journal-title":"Neuron"},{"key":"B49","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1177\/1757975917743533","article-title":"Healthy China 2030, a breakthrough for improving health","volume":"26","author":"Tan","year":"2019","journal-title":"Glob. Health Promot."},{"key":"B50","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.neuint.2019.03.014","article-title":"Can magnesium reduce central neurodegeneration in Alzheimer's disease? Basic evidences and research needs","volume":"126","author":"Toffa","year":"2019","journal-title":"Neurochem. Int."},{"key":"B51","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3233\/JAD-141296","article-title":"Zinc in Alzheimer's disease: A meta-analysis of serum, plasma, and cerebrospinal fluid studies","volume":"46","author":"Ventriglia","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"B52","doi-asserted-by":"publisher","first-page":"981","DOI":"10.3233\/JAD-2012-120244","article-title":"Copper in Alzheimer's disease: a meta-analysis of serum, plasma, and cerebrospinal fluid studies","volume":"30","author":"Ventriglia","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"B53","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1177\/1533317515602674","article-title":"Magnesium status in Alzheimer's disease: a systematic review","volume":"31","author":"Veronese","year":"2016","journal-title":"Am. J. Alzheimers Dis. Other Dement."},{"key":"B54","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.jtemb.2010.02.002","article-title":"Alterations of plasma magnesium, copper, zinc, iron and selenium concentrations and some related erythrocyte antioxidant enzyme activities in patients with Alzheimer's disease","volume":"24","author":"Vural","year":"2010","journal-title":"J. Trace Elem. Med. Biol."},{"key":"B55","volume-title":"A Case-Control Study for Relevant Factors of Alzheimer's Disease","author":"Wang","year":"2015"},{"key":"B56","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/cmi.2015.93","article-title":"Magnesium ion influx reduces neuroinflammation in Abeta precursor protein\/Presenilin 1 transgenic mice by suppressing the expression of interleukin-1beta","volume":"14","author":"Wang","year":"2017","journal-title":"Cell Mol. Immunol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"565","DOI":"10.3233\/JAD-143108","article-title":"Serum iron, zinc, and copper levels in patients with alzheimer's disease: a replication study and meta-analyses","volume":"47","author":"Wang","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"B58","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s10534-018-0089-3","article-title":"Plasma metals as potential biomarkers in dementia: a case-control study in patients with sporadic Alzheimer's disease","volume":"31","author":"Xu","year":"2018","journal-title":"Biometals"},{"key":"B59","doi-asserted-by":"publisher","first-page":"e108645","DOI":"10.1371\/journal.pone.0108645","article-title":"Magnesium protects cognitive functions and synaptic plasticity in streptozotocin-induced sporadic Alzheimer's model","volume":"9","author":"Xu","year":"2014","journal-title":"PLoS ONE"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.3390\/ijms18091965","article-title":"Blood-brain barrier dysfunction and the pathogenesis of Alzheimer's disease","volume":"18","author":"Yamazaki","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.nut.2018.06.019","article-title":"Dietary intake of magnesium and the risk of epilepsy in middle-aged and older Finnish men: a 22-year follow-up study in a general population","volume":"58","author":"Yary","year":"2019","journal-title":"Nutrition"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.3233\/JAD-2010-091444","article-title":"Magnesium modulates amyloid-beta protein precursor trafficking and processing","volume":"20","author":"Yu","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"B63","doi-asserted-by":"publisher","first-page":"172","DOI":"10.3389\/fnmol.2018.00172","article-title":"Magnesium ions inhibit the expression of tumor necrosis factor alpha and the activity of gamma-secretase in a beta-amyloid protein-dependent mechanism in APP\/PS1 transgenic mice","volume":"11","author":"Yu","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"B64","volume-title":"A case-control study on related influence factors of Alzheimer's disease","author":"Zheng","year":"2015"},{"key":"B65","doi-asserted-by":"publisher","first-page":"7118","DOI":"10.1007\/s12035-018-0896-0","article-title":"Magnesium reduces blood-brain barrier permeability and regulates amyloid-beta transcytosis","volume":"55","author":"Zhu","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"B66","first-page":"18","article-title":"Determination of trace elements in serum of senile dementia","volume":"14","author":"Zhu","year":"1997","journal-title":"Stud. Trace Elem. Health"}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2021.799824\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,22]],"date-time":"2023-01-22T10:59:06Z","timestamp":1674385146000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2021.799824\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,10]]},"references-count":66,"alternative-id":["10.3389\/fnagi.2021.799824"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2021.799824","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,10]]},"article-number":"799824"}}