{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:19:39Z","timestamp":1792120779667,"version":"4.4.0"},"reference-count":325,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1136913"],"award-info":[{"award-number":["APP1136913"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>Acetylation is a key post-translational modification (PTM) involved in the regulation of both histone and non-histone proteins. It controls cellular processes such as DNA transcription, RNA modifications, proteostasis, aging, autophagy, regulation of cytoskeletal structures, and metabolism. Acetylation is essential to maintain neuronal plasticity and therefore essential for memory and learning. Homeostasis of acetylation is maintained through the activities of histone acetyltransferases (HAT) and histone deacetylase (HDAC) enzymes, with alterations to these tightly regulated processes reported in several neurodegenerative diseases including Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD), Huntington\u2019s disease (HD), and amyotrophic lateral sclerosis (ALS). Both hyperacetylation and hypoacetylation can impair neuronal physiological homeostasis and increase the accumulation of pathophysiological proteins such as tau, \u03b1-synuclein, and Huntingtin protein implicated in AD, PD, and HD, respectively. Additionally, dysregulation of acetylation is linked to impaired axonal transport, a key pathological mechanism in ALS. This review article will discuss the physiological roles of protein acetylation and examine the current literature that describes altered protein acetylation in neurodegenerative disorders.<\/jats:p>","DOI":"10.3389\/fnagi.2022.1025473","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T14:24:40Z","timestamp":1672842280000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":69,"title":["The role of altered protein acetylation in neurodegenerative disease"],"prefix":"10.3389","volume":"14","author":[{"given":"Fariha","family":"Kabir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony L.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew James","family":"Phipps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Elizabeth","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1021\/acschemneuro.0c00069","article-title":"Acetylation of A\u03b242 at lysine 16 disrupts amyloid formation","volume":"11","author":"Adhikari","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3233\/JAD-2012-121009","article-title":"Loss of HDAC5 impairs memory function: implications for Alzheimer's disease","volume":"33","author":"Agis-Balboa","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"4180","DOI":"10.3390\/ijms22084180","article-title":"A comprehensive analysis into the therapeutic application of natural products as SIRT6 modulators in Alzheimer\u2019s disease, aging, cancer, inflammation, and diabetes","volume":"22","author":"Akter","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"435","DOI":"10.3233\/JAD-2004-6412","article-title":"Demonstration of a role for \u03b1-synuclein as a functional microtubule-associated protein","volume":"6","author":"Alim","year":"2004","journal-title":"J. Alzheimers Dis."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0165-3806(99)00113-3","article-title":"Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain","volume":"117","author":"Alliot","year":"1999","journal-title":"Dev. Brain Res."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1002\/onco.13673","article-title":"First-in-class selective HDAC6 inhibitor (ACY-1215) has a highly favorable safety profile in patients with relapsed and refractory lymphoma","volume":"26","author":"Amengual","year":"2021","journal-title":"Oncologist"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"12969","DOI":"10.1073\/pnas.93.23.12969","article-title":"An essential role for p 300\/CBP in the cellular response to hypoxia","volume":"93","author":"Arany","year":"1996","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1002\/cbic.201000292","article-title":"Lysine acetylation: the tale of a modification from transcription regulation to metabolism","volume":"11","author":"Arif","year":"2010","journal-title":"Chembiochem"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1128\/MCB.01199-09","article-title":"The chaperone-like protein HYPK acts together with Nat a in cotranslational N-terminal acetylation and prevention of huntingtin aggregation","volume":"30","author":"Arnesen","year":"2010","journal-title":"Mol. Cell. Biol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.devcel.2007.02.004","article-title":"MEF2C transcription factor controls chondrocyte hypertrophy and bone development","volume":"12","author":"Arnold","year":"2007","journal-title":"Dev. Cell"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s11673-019-09921-5","article-title":"Dementia: Unwelcome Change Has Arrived and We Are Not Ready!","volume":"16","author":"Ashby","year":"2019","journal-title":"J. Bioeth. Inq."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s12017-021-08660-4","article-title":"Repurposing Vorinostat for the treatment of disorders affecting brain","volume":"23","author":"Athira","year":"2021","journal-title":"NeuroMolecular Med."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/1-4020-5466-1_13","article-title":"Functions of myst family histone acetyltransferases and their link to disease","volume":"41","author":"Avvakumov","year":"2007","journal-title":"Chrom. Dis."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.tibs.2015.12.006","article-title":"Mechanisms and dynamics of protein acetylation in mitochondria","volume":"41","author":"Baeza","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"101270","DOI":"10.1016\/j.redox.2019.101270","article-title":"Mechanisms of SOD1 regulation by post-translational modifications","volume":"26","author":"Banks","year":"2019","journal-title":"Redox Biol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"819","DOI":"10.4161\/auto.23908","article-title":"The emerging role of acetylation in the regulation of autophagy","volume":"9","author":"B\u00e1nr\u00e9ti","year":"2013","journal-title":"Autophagy"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1016\/j.bbadis.2006.03.008","article-title":"Oxidative stress in ALS: a mechanism of neurodegeneration and a therapeutic target","volume":"1762","author":"Barber","year":"2006","journal-title":"BBA Mol. Basis Dis."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s13311-016-0501-z","article-title":"Development of improved HDAC6 inhibitors as pharmacological therapy for axonal Charcot\u2013Marie\u2013tooth disease","volume":"14","author":"Benoy","year":"2017","journal-title":"Neurotherapeutics"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1146\/annurev.biochem.73.011303.073651","article-title":"The sir 2 family of protein deacetylases","volume":"73","author":"Blander","year":"2004","journal-title":"Annu. Rev. Biochem."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1002\/pro.4029","article-title":"N-terminal acetylation modestly enhances phase separation and reduces aggregation of the low-complexity domain of RNA-binding protein fused in sarcoma","volume":"30","author":"Bock","year":"2021","journal-title":"Protein Sci."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1159\/000330505","article-title":"Pcaf modulates polyglutamine pathology in a drosophila model of Huntington\u2019s disease","volume":"9","author":"Bodai","year":"2012","journal-title":"Neurodegener. Dis."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/S1474-4422(11)70013-8","article-title":"The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations","volume":"10","author":"Bonda","year":"2011","journal-title":"Lancet Neurol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"6194","DOI":"10.1007\/s12035-015-9509-3","article-title":"Rotenone induces the formation of 4-hydroxynonenal aggresomes. Role of ROS-mediated tubulin hyperacetylation and autophagic flux disruption","volume":"53","author":"Bonet-Ponce","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"S23","DOI":"10.1016\/S1353-8020(13)70009-9","article-title":"Genetics of Parkinson's disease\u2013state of the art, (2013)","volume":"20","author":"Bonifati","year":"2014","journal-title":"Parkinsonism Relat. Disord."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1046\/j.1471-4159.2003.01581.x","article-title":"Selective E2F-dependent gene transcription is controlled by histone deacetylase activity during neuronal apoptosis","volume":"84","author":"Boutillier","year":"2003","journal-title":"J. Neurochem."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/BF02686117","article-title":"Distribution of histone deacetylases 1\u201311 in the rat brain","volume":"31","author":"Broide","year":"2007","journal-title":"J. Mol. Neurosci."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1021\/acscentsci.1c00585","article-title":"A structural ensemble of a tau-microtubule complex reveals regulatory tau phosphorylation and acetylation mechanisms","volume":"7","author":"Brotzakis","year":"2021","journal-title":"ACS Centr. Sci."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.nbd.2016.12.021","article-title":"Altered microtubule dynamics in neurodegenerative disease: therapeutic potential of microtubule-stabilizing drugs","volume":"105","author":"Brunden","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1080\/14728222.2018.1439923","article-title":"TDP-43 post-translational modifications in health and disease","volume":"22","author":"Buratti","year":"2018","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"22687","DOI":"10.1073\/pnas.1012851108","article-title":"CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease","volume":"107","author":"Caccamo","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1002\/path.1650","article-title":"The cytoskeleton in neurodegenerative diseases","volume":"204","author":"Cairns","year":"2004","journal-title":"J. Pathol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/j.1471-4159.2010.06924.x","article-title":"Microtubule dysfunction precedes transport impairment and mitochondria damage in MPP+-induced neurodegeneration","volume":"115","author":"Cartelli","year":"2010","journal-title":"J. Neurochem."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"6599","DOI":"10.1038\/s41388-019-0897-0","article-title":"HDAC7 regulates histone 3 lysine 27 acetylation and transcriptional activity at super-enhancer-associated genes in breast cancer stem cells","volume":"38","author":"Caslini","year":"2019","journal-title":"Oncogene"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"471","DOI":"10.2174\/187152710791556140","article-title":"The role of phosphorylation in synucleinopathies: focus on Parkinson's disease","volume":"9","author":"Cavallarin","year":"2010","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"9310","DOI":"10.1073\/pnas.152101299","article-title":"Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis","volume":"99","author":"Chai","year":"2002","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.tips.2015.04.013","article-title":"HDAC8: a multifaceted target for therapeutic interventions","volume":"36","author":"Chakrabarti","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"8467","DOI":"10.1128\/MCB.24.19.8467-8476.2004","article-title":"Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development","volume":"24","author":"Chang","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.cell.2006.05.040","article-title":"Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10","volume":"126","author":"Chang","year":"2006","journal-title":"Cells"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1093\/hmg\/ddr474","article-title":"Gcn 5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model","volume":"21","author":"Chen","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"4259","DOI":"10.1002\/cncr.28356","article-title":"Histone modification patterns correlate with patient outcome in oral squamous cell carcinoma","volume":"119","author":"Chen","year":"2013","journal-title":"Cancer"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13024-019-0354-0","article-title":"Promoting tau secretion and propagation by hyperactive p 300\/CBP via autophagy-lysosomal pathway in tauopathy","volume":"15","author":"Chen","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"ref42","author":"Chen","year":"2020"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1038\/sj.mp.4001893","article-title":"Valproate protects dopaminergic neurons in midbrain neuron\/glia cultures by stimulating the release of neurotrophic factors from astrocytes","volume":"11","author":"Chen","year":"2006","journal-title":"Mol. Psychiatry"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"5202","DOI":"10.1002\/anie.201611750","article-title":"Mutant exon 1 huntingtin aggregation is regulated by T3 phosphorylation-induced structural changes and crosstalk between T3 phosphorylation and acetylation at K6","volume":"56","author":"Chiki","year":"2017","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"3063","DOI":"10.1038\/emboj.2012.160","article-title":"HDAC5 is a novel injury-regulated tubulin deacetylase controlling axon regeneration","volume":"31","author":"Cho","year":"2012","journal-title":"EMBO J."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"13187","DOI":"10.1038\/s41598-019-49784-9","article-title":"Design, synthesis and biological evaluation of a series of CNS penetrant HDAC inhibitors structurally derived from amyloid-\u03b2 probes","volume":"9","author":"Choi","year":"2019","journal-title":"Sci. Rep."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1126\/science.1175371","article-title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions","volume":"325","author":"Choudhary","year":"2009","journal-title":"Science"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1038\/nrm3841","article-title":"The growing landscape of lysine acetylation links metabolism and cell signalling","volume":"15","author":"Choudhary","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/ncomms1255","article-title":"The acetylation of tau inhibits its function and promotes pathological tau aggregation","volume":"2","author":"Cohen","year":"2011","journal-title":"Nat. Commun."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"5845","DOI":"10.1038\/ncomms6845","article-title":"An acetylation switch controls TDP-43 function and aggregation propensity","volume":"6","author":"Cohen","year":"2015","journal-title":"Nat. Commun."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"2646","DOI":"10.1002\/ajmg.a.31368","article-title":"The new bone biology: pathologic, molecular, and clinical correlates","volume":"140","author":"Cohen","year":"2006","journal-title":"Am. J. Med. Genet. A"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"M111.009829","DOI":"10.1074\/mcp.M111.009829","article-title":"Mass spectrometric identification of novel lysine acetylation sites in huntingtin","volume":"10","author":"Cong","year":"2011","journal-title":"Mol. Cell. Proteomics"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.mcn.2005.05.003","article-title":"Mutant huntingtin represses CBP, but not p 300, by binding and protein degradation","volume":"30","author":"Cong","year":"2005","journal-title":"Mol. Cell. Neurosci."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1093\/hmg\/ddt402","article-title":"Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance","volume":"23","author":"Cook","year":"","journal-title":"Hum. Mol. Genet."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/alzrt259","article-title":"Acetylation: a new key to unlock tau\u2019s role in neurodegeneration","volume":"6","author":"Cook","year":"","journal-title":"Alzheimers Res. Ther."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"2983","DOI":"10.1242\/dev.01166","article-title":"Histone deacetylase 1 is required to repress notch target gene expression during zebrafish neurogenesis and to maintain the production of motoneurones in response to hedgehog signalling","volume":"131","author":"Cunliffe","year":"2004","journal-title":"Development"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.immuni.2018.02.016","article-title":"Histone deacetylases 1 and 2 regulate microglia function during development, homeostasis, and neurodegeneration in a context-dependent manner","volume":"48","author":"Datta","year":"2018","journal-title":"Immunity"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s00401-021-02323-1","article-title":"Identification of retinoblastoma binding protein 7 (Rbbp 7) as a mediator against tau acetylation and subsequent neuronal loss in Alzheimer\u2019s disease and related tauopathies","volume":"142","author":"Dave","year":"2021","journal-title":"Acta Neuropathol."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"e2000374","DOI":"10.1371\/journal.pbio.2000374","article-title":"The mechanism of sirtuin 2\u2013mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease","volume":"15","author":"De Oliveira","year":"2017","journal-title":"PLoS Biol."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.tibs.2020.08.005","article-title":"Protein N-terminal acetylation: structural basis, mechanism, versatility, and regulation","volume":"46","author":"Deng","year":"2021","journal-title":"Trends Biochem. Sci."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"e57491","DOI":"10.7554\/eLife.57491","article-title":"Molecular basis for N-terminal alpha-synuclein acetylation by human Nat B","volume":"9","author":"Deng","year":"2020","journal-title":"elife"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"9659","DOI":"10.1038\/srep09659","article-title":"Role of the tau N-terminal region in microtubule stabilization revealed by newendogenous truncated forms","volume":"5","author":"Derisbourg","year":"2015","journal-title":"Sci. Rep."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3934\/biophy.2016.1.27","article-title":"Post-translational modifications in neurodegeneration","volume":"3","author":"Didonna","year":"2016","journal-title":"Aims Biophys."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1002\/acn3.147","article-title":"The promise and perils of HDAC inhibitors in neurodegeneration","volume":"2","author":"Didonna","year":"2015","journal-title":"Ann. Clin. Trans. Neurol."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/0896-6273(95)90346-1","article-title":"Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons","volume":"14","author":"DiFiglia","year":"1995","journal-title":"Neuron"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"3571","DOI":"10.1523\/JNEUROSCI.0037-07.2007","article-title":"Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation","volume":"27","author":"Dompierre","year":"2007","journal-title":"J. Neurosci."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"8242","DOI":"10.1073\/pnas.1000478107","article-title":"Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation","volume":"107","author":"Dovey","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1021\/pr8006396","article-title":"Application of high-content analysis to the study of post-translational modifications of the cytoskeleton","volume":"8","author":"Drake","year":"2009","journal-title":"J. Proteome Res."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1016\/j.bbapap.2016.06.007","article-title":"The world of protein acetylation","volume":"1864","author":"Drazic","year":"2016","journal-title":"Biochim. Biophys. Acta Proteins Proteom."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"e1004049","DOI":"10.1371\/journal.pcbi.1004049","article-title":"The roles of post-translational modifications in the context of protein interaction networks","volume":"11","author":"Duan","year":"2015","journal-title":"PLoS Comput. Biol."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1038\/nm.2396","article-title":"HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1\u2013induced Charcot-Marie-tooth disease","volume":"17","author":"d'Ydewalle","year":"2011","journal-title":"Nat. Med."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.3390\/ijms18071414","article-title":"Histone deacetylase inhibitors as anticancer drugs","volume":"18","author":"Eckschlager","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"a033118","DOI":"10.1101\/cshperspect.a033118","article-title":"Clinical neurology and epidemiology of the major neurodegenerative diseases","volume":"10","author":"Erkkinen","year":"2018","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1177\/1073858415616558","article-title":"LRRK2 at the crossroad between autophagy and microtubule trafficking: insights into Parkinson\u2019s disease","volume":"23","author":"Esteves","year":"2017","journal-title":"Neuroscientist"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.bbadis.2013.10.003","article-title":"The rescue of microtubule-dependent traffic recovers mitochondrial function in Parkinson's disease","volume":"1842","author":"Esteves","year":"2014","journal-title":"BBA Mol. Basis Dis."},{"key":"ref76","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1016\/j.bbadis.2018.11.014","article-title":"Acetylation as a major determinant to microtubule-dependent autophagy: relevance to Alzheimer's and Parkinson disease pathology","volume":"1865","author":"Esteves","year":"2019","journal-title":"BBA Mol. Basis Dis."},{"key":"ref77","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.neuint.2015.01.007","article-title":"Acetylation and phosphorylation of STAT3 are involved in the responsiveness of microglia to beta amyloid","volume":"81","author":"Eufemi","year":"2015","journal-title":"Neurochem. Int."},{"key":"ref78","doi-asserted-by":"publisher","first-page":"9461","DOI":"10.18632\/aging.103219","article-title":"Regulation of PGC-1\u03b1 mediated by acetylation and phosphorylation in MPP+ induced cell model of Parkinson\u2019s disease","volume":"12","author":"Fan","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"585","DOI":"10.3389\/fmolb.2021.693325","article-title":"Post-translational modifications modulate proteinopathies of TDP-43, FUS and hn RNP-A\/B in amyotrophic lateral sclerosis","volume":"8","author":"Farina","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"ref80","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1177\/1073858406293853","article-title":"Microtubule: a common target for parkin and Parkinson\u2019s disease toxins","volume":"12","author":"Feng","year":"2006","journal-title":"Neuroscientist"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/emboj.2009.324","article-title":"Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6","volume":"29","author":"Fiesel","year":"2010","journal-title":"EMBO J."},{"key":"ref82","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S1097-2765(01)00429-4","article-title":"Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT\/N-CoR","volume":"9","author":"Fischle","year":"2002","journal-title":"Mol. Cell"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"BSR20181345","DOI":"10.1042\/BSR20181345","article-title":"Autophagy induced by SAHA affects mutant P 53 degradation and cancer cell survival","volume":"39","author":"Foggetti","year":"2019","journal-title":"Biosci. Rep."},{"key":"ref84","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1111\/bjh.13222","article-title":"A phase II trial of Belinostat (PXD 101) in patients with relapsed or refractory peripheral or cutaneous T-cell lymphoma","volume":"168","author":"Foss","year":"2015","journal-title":"Br. J. Haematol."},{"key":"ref85","doi-asserted-by":"publisher","first-page":"301","DOI":"10.3389\/fnmol.2019.00301","article-title":"Structural insights into TDP-43 and effects of post-translational modifications","volume":"12","author":"Fran\u00e7ois-Moutal","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"ref86","doi-asserted-by":"publisher","first-page":"e10270","DOI":"10.15252\/emmm.201910270","article-title":"MECP2 mutations affect ciliogenesis: a novel perspective for Rett syndrome and related disorders","volume":"12","author":"Frasca","year":"2020","journal-title":"EMBO Mol. Med."},{"key":"ref87","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1006\/bbrc.2000.3000","article-title":"Phylogenetic classification of prokaryotic and eukaryotic sir 2-like proteins","volume":"273","author":"Frye","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref88","doi-asserted-by":"publisher","first-page":"15035","DOI":"10.1074\/jbc.M112.431957","article-title":"HDAC6 regulates mutant SOD1 aggregation through two SMIR motifs and tubulin acetylation","volume":"288","author":"Gal","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref89","doi-asserted-by":"publisher","first-page":"8637","DOI":"10.1128\/MCB.00393-07","article-title":"Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis","volume":"27","author":"Gao","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"ref90","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1038\/s41467-022-28822-7","article-title":"Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43","volume":"13","author":"Garcia Morato","year":"2022","journal-title":"Nat. Commun."},{"key":"ref91","doi-asserted-by":"publisher","first-page":"747989","DOI":"10.3389\/fnagi.2021.747989","article-title":"SIRT6 through the brain evolution, development, and aging","volume":"13","author":"Garcia-Venzor","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"ref92","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.cell.2004.06.018","article-title":"Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules","volume":"118","author":"Gauthier","year":"2004","journal-title":"Cells"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1093\/hmg\/ddr108","article-title":"Partial loss of tip 60 slows mid-stage neurodegeneration in a spinocerebellar ataxia type 1 (SCA1) mouse model","volume":"20","author":"Gehrking","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"ref94","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1002\/dneu.20895","article-title":"The role of Pax 6 in forebrain development","volume":"71","author":"Georgala","year":"2011","journal-title":"Dev. Neurobiol."},{"key":"ref95","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.gene.2005.09.010","article-title":"Acetylation and deacetylation of non-histone proteins","volume":"363","author":"Glozak","year":"2005","journal-title":"Gene"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/0896-6273(89)90210-9","article-title":"Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease","volume":"3","author":"Goedert","year":"1989","journal-title":"Neuron"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"101363","DOI":"10.1016\/j.jbc.2021.101363","article-title":"N-alpha-acetylation of huntingtin protein increases its propensity to aggregate","volume":"297","author":"Gottlieb","year":"2021","journal-title":"J. Biol. Chem."},{"key":"ref98","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nature07925","article-title":"HDAC2 negatively regulates memory formation and synaptic plasticity","volume":"459","author":"Guan","year":"2009","journal-title":"Nature"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.cmet.2011.07.007","article-title":"The logic linking protein acetylation and metabolism","volume":"14","author":"Guarente","year":"2011","journal-title":"Cell Metab."},{"key":"ref100","doi-asserted-by":"publisher","first-page":"2484","DOI":"10.1016\/j.bbadis.2015.08.012","article-title":"HDAC6 inhibition induces mitochondrial fusion, autophagic flux and reduces diffuse mutant huntingtin in striatal neurons","volume":"1852","author":"Guedes-Dias","year":"2015","journal-title":"BBA Mol. Basis Dis."},{"key":"ref101","doi-asserted-by":"publisher","first-page":"9","DOI":"10.53388\/life2021-0121-305","article-title":"Amyloid beta peptides, tau protein acetylation and therapeutic strategies for treating Alzheimer\u2019s disease: a review","volume":"4","author":"Guha","year":"2021","journal-title":"Life Res."},{"key":"ref102","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/emboj.2009.324","article-title":"HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients","volume":"8","author":"Guo","year":"2017","journal-title":"Nat. Commun."},{"key":"ref103","doi-asserted-by":"publisher","first-page":"14","DOI":"10.15698\/cst2018.01.120","article-title":"Therapeutic potential of HDAC6 in amyotrophic lateral sclerosis","volume":"2","author":"Guo","year":"2018","journal-title":"Cell Stress"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1101\/gad.1809209","article-title":"Epigenetic control of skull morphogenesis by histone deacetylase 8","volume":"23","author":"Haberland","year":"","journal-title":"Genes Dev."},{"key":"ref105","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/nrg2485","article-title":"The many roles of histone deacetylases in development and physiology: implications for disease and therapy","volume":"10","author":"Haberland","year":"","journal-title":"Nat. Rev. Genet."},{"key":"ref106","first-page":"1","article-title":"What is the link between protein aggregation and interneuronal lesion propagation in neurodegenerative disease","volume-title":"Neurodegenerative Diseases\u2013Processes, Prevention, Protection and Monitoring Rijeka","author":"Hall","year":"2011"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.molmed.2009.01.003","article-title":"Tau phosphorylation: the therapeutic challenge for neurodegenerative disease","volume":"15","author":"Hanger","year":"2009","journal-title":"Trends Mol. Med."},{"key":"ref108","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1083\/jcb.201709069","article-title":"Microglia in Alzheimer\u2019s disease","volume":"217","author":"Hansen","year":"2018","journal-title":"J. Cell Biol."},{"key":"ref109","doi-asserted-by":"publisher","first-page":"7084","DOI":"10.1096\/fj.201802752R","article-title":"Enhanced SIRT6 activity abrogates the neurotoxic phenotype of astrocytes expressing ALS-linked mutant SOD1","volume":"33","author":"Harlan","year":"2019","journal-title":"FASEB J."},{"key":"ref110","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2164-12-24","article-title":"The epigenetic regulator histone deacetylase 1 promotes transcription of a core neurogenic programme in zebrafish embryos","volume":"12","author":"Harrison","year":"2011","journal-title":"BMC Genomics"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1159\/000351444","article-title":"Expression of acetylated and dimethylated histone H3 in colorectal cancer","volume":"30","author":"Hashimoto","year":"2013","journal-title":"Dig. Surg."},{"key":"ref112","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1038\/nbt.3199","article-title":"Epigenome editing by a CRISPR-Cas 9-based acetyltransferase activates genes from promoters and enhancers","volume":"33","author":"Hilton","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"ref113","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1073\/pnas.0437870100","article-title":"Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease","volume":"100","author":"Hockly","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref114","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/8363245","article-title":"Common protective strategies in neurodegenerative disease: focusing on risk factors to target the cellular redox system","volume":"2020","author":"Hrelia","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref115","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/417455a","article-title":"HDAC6 is a microtubule-associated deacetylase","volume":"417","author":"Hubbert","year":"2002","journal-title":"Nature"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"21110","DOI":"10.1074\/jbc.M116.726612","article-title":"The impact of N-terminal acetylation of \u03b1-synuclein on phospholipid membrane binding and fibril structure","volume":"291","author":"Iyer","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref117","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1083\/jcb.201406055","article-title":"The tubulin code: molecular components, readout mechanisms, and functions","volume":"206","author":"Janke","year":"2014","journal-title":"J. Cell Biol."},{"key":"ref118","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1097\/NEN.0b013e3181ddd404","article-title":"Differential histone deacetylase mRNA expression patterns in amyotrophic lateral sclerosis","volume":"69","author":"Janssen","year":"2010","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref119","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.cell.2009.03.018","article-title":"Acetylation targets mutant huntingtin to autophagosomes for degradation","volume":"137","author":"Jeong","year":"2009","journal-title":"Cells"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1007\/s11064-016-2110-y","article-title":"Sirtuins and their roles in brain aging and neurodegenerative disorders","volume":"42","author":"J\u0119\u015bko","year":"2017","journal-title":"Neurochem. Res."},{"key":"ref121","doi-asserted-by":"publisher","first-page":"5280","DOI":"10.1093\/hmg\/dds379","article-title":"Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: implications for the ubiquitin\u2013proteasomal and autophagy systems","volume":"21","author":"Jia","year":"","journal-title":"Hum. Mol. Genet."},{"key":"ref122","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.nbd.2012.01.016","article-title":"Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease","volume":"46","author":"Jia","year":"","journal-title":"Neurobiol. Dis."},{"key":"ref123","doi-asserted-by":"publisher","first-page":"34743","DOI":"10.1074\/jbc.M114.576702","article-title":"Histone hyperacetylation up-regulates protein kinase C\u03b4 in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease","volume":"289","author":"Jin","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref124","author":"Kaliszewski","year":"2016"},{"key":"ref125","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3389\/fncel.2016.00287","article-title":"SOD1 lysine 123 acetylation in the adult central nervous system","volume":"10","author":"Kaliszewski","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"ref126","doi-asserted-by":"publisher","first-page":"3052","DOI":"10.1016\/j.celrep.2017.03.008","article-title":"Neuroprotective functions for the histone deacetylase SIRT6","volume":"18","author":"Kaluski","year":"2017","journal-title":"Cell Rep."},{"key":"ref127","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/s0092-8674(00)81118-6","article-title":"A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors","volume":"85","author":"Kamei","year":"1996","journal-title":"Cells"},{"key":"ref128","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep23281","article-title":"Mass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains","volume":"6","author":"Kametani","year":"2016","journal-title":"Sci. Rep."},{"key":"ref129","doi-asserted-by":"publisher","first-page":"4368","DOI":"10.1242\/jcs.145912","article-title":"Histone acetylation in astrocytes suppresses GFAP and stimulates a reorganization of the intermediate filament network","volume":"127","author":"Kanski","year":"2014","journal-title":"J. Cell Sci."},{"key":"ref130","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.neuron.2015.05.046","article-title":"Building the neuronal microtubule cytoskeleton","volume":"87","author":"Kapitein","year":"2015","journal-title":"Neuron"},{"key":"ref131","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.bbrc.2018.02.195","article-title":"HDAC8 regulates neural differentiation through embryoid body formation in P 19 cells","volume":"498","author":"Katayama","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref132","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1101\/gad.1393106","article-title":"MOZ is essential for maintenance of hematopoietic stem cells","volume":"20","author":"Katsumoto","year":"2006","journal-title":"Genes Dev."},{"key":"ref133","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/srep00090","article-title":"Proteome-wide post-translational modification statistics: frequency analysis and curation of the swiss-prot database","volume":"1","author":"Khoury","year":"2011","journal-title":"Sci. Rep."},{"key":"ref134","doi-asserted-by":"publisher","first-page":"10879","DOI":"10.1523\/JNEUROSCI.2089-12.2012","article-title":"An essential role for histone deacetylase 4 in synaptic plasticity and memory formation","volume":"32","author":"Kim","year":"2012","journal-title":"J. Neurosci."},{"key":"ref135","first-page":"e42983","volume-title":"HDAC6 inhibitor blocks amyloid beta-induced impairment of mitochondrial transport in hippocampal neurons","author":"Kim","year":"2012"},{"key":"ref136","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s13041-020-00644-y","article-title":"Cortactin deacetylation by HDAC6 and SIRT2 regulates neuronal migration and dendrite morphogenesis during cerebral cortex development","volume":"13","author":"Kim","year":"2020","journal-title":"Mol. Brain"},{"key":"ref137","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.bbrc.2012.06.126","article-title":"Transcriptional activity of paired homeobox Pax 6 is enhanced by histone acetyltransferase tip 60 during mouse retina development","volume":"424","author":"Kim","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref138","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.cell.2008.11.050","article-title":"A centrosomal Cdc 20-APC pathway controls dendrite morphogenesis in postmitotic neurons","volume":"136","author":"Kim","year":"2009","journal-title":"Cells"},{"key":"ref139","doi-asserted-by":"publisher","first-page":"2766","DOI":"10.1101\/gad.1979710","article-title":"Gcn 5 regulates the dissociation of SWI\/SNF from chromatin by acetylation of SWI 2\/SNF 2","volume":"24","author":"Kim","year":"2010","journal-title":"Genes Dev."},{"key":"ref140","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.molcel.2006.06.026","article-title":"Substrate and functional diversity of lysine acetylation revealed by a proteomics survey","volume":"23","author":"Kim","year":"2006","journal-title":"Mol. Cell"},{"key":"ref141","article-title":"Molecular components of the neuronal cytoskeleton","volume-title":"Basic Neurochemistry: Molecular, Cellular and Medical Aspects","author":"Kirkpatrick","year":"1999"},{"key":"ref142","doi-asserted-by":"publisher","first-page":"29","DOI":"10.32607\/20758251-2009-1-3-29-51","article-title":"Chemical and functional aspects of posttranslational modification of proteins","volume":"1","author":"Knorre","year":"2009","journal-title":"Acta Theriol."},{"key":"ref143","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1038\/emboj.2008.51","article-title":"Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks","volume":"27","author":"Knutson","year":"2008","journal-title":"EMBO J."},{"key":"ref144","doi-asserted-by":"publisher","first-page":"3012","DOI":"10.1093\/hmg\/ddl243","article-title":"\u03b1-Synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity","volume":"15","author":"Kontopoulos","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"ref145","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1159\/000338048","article-title":"Differential sirtuin expression patterns in amyotrophic lateral sclerosis (ALS) postmortem tissue: neuroprotective or neurotoxic properties of sirtuins in ALS?","volume":"11","author":"K\u00f6rner","year":"2013","journal-title":"Neurodegener. Dis."},{"key":"ref146","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.neuron.2004.06.002","article-title":"CBP histone acetyltransferase activity is a critical component of memory consolidation","volume":"42","author":"Korzus","year":"2004","journal-title":"Neuron"},{"key":"ref147","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1128\/MCB.00159-10","article-title":"HBO1 is required for H3K14 acetylation and normal transcriptional activity during embryonic development","volume":"31","author":"Kueh","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"ref148","doi-asserted-by":"publisher","first-page":"647","DOI":"10.17179\/excli2022-4741","article-title":"HDAC11: a novel inflammatory biomarker in Huntington's disease","volume":"21","author":"Kumar","year":"2022","journal-title":"EXCLI J."},{"key":"ref149","doi-asserted-by":"publisher","first-page":"6310","DOI":"10.1093\/emboj\/cdg601","article-title":"NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function","volume":"22","author":"Kuwahara","year":"2003","journal-title":"EMBO J."},{"key":"ref150","doi-asserted-by":"publisher","first-page":"7187","DOI":"10.1074\/jbc.M109.061861","article-title":"Histone deacetylase 10 relieves repression on the melanogenic program by maintaining the deacetylation status of repressors","volume":"285","author":"Lai","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref151","doi-asserted-by":"publisher","first-page":"e202006151","DOI":"10.1083\/jcb.202006151","article-title":"Lysine acetylation of cytoskeletal proteins: emergence of an actin code","volume":"219","author":"Latario","year":"2020","journal-title":"J. Cell Biol."},{"key":"ref152","author":"Le Guen","year":"2021"},{"key":"ref153","doi-asserted-by":"publisher","first-page":"147670","DOI":"10.1016\/j.brainres.2021.147670","article-title":"HDAC inhibitor ameliorates behavioral deficits in Mecp 2308\/y mouse model of Rett syndrome","volume":"1772","author":"Lebrun","year":"2021","journal-title":"Brain Res."},{"key":"ref154","doi-asserted-by":"publisher","first-page":"3224","DOI":"10.1073\/pnas.0400243101","article-title":"Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a drosophila model of Huntington's disease","volume":"101","author":"Lee","year":"2004","journal-title":"PNAS Nexus"},{"key":"ref155","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1002\/pmic.200700404","article-title":"Proteomic analyses of intermediate filaments reveals cytokeratin 8 is highly acetylated\u2013implications for colorectal epithelial homeostasis","volume":"8","author":"Leech","year":"2008","journal-title":"Proteomics"},{"key":"ref156","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1007\/s12035-013-8437-3","article-title":"Sirt 1 promotes axonogenesis by deacetylation of Akt and inactivation of GSK3","volume":"48","author":"Li","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"ref157","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.14336\/AD.2020.0216","article-title":"The critical role of SIRT1 in Parkinson\u2019s disease: mechanism and therapeutic considerations","volume":"11","author":"Li","year":"2020","journal-title":"Aging Dis."},{"key":"ref158","doi-asserted-by":"publisher","first-page":"132","DOI":"10.14336\/AD.2020.0329","article-title":"Roles of the MYST family in the pathogenesis of Alzheimer\u2019s disease via histone or non-histone acetylation","volume":"12","author":"Li","year":"2021","journal-title":"Aging Dis."},{"key":"ref159","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1111\/febs.12079","article-title":"Histone deacetylase 6 plays a role as a distinct regulator of diverse cellular processes","volume":"280","author":"Li","year":"2013","journal-title":"FEBS J."},{"key":"ref160","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.3389\/fcell.2020.576946","article-title":"The roles of histone deacetylases and their inhibitors in cancer therapy","volume":"8","author":"Li","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref161","doi-asserted-by":"publisher","first-page":"B93","DOI":"10.1093\/gerona\/57.3.B93","article-title":"Histone acetyltransferase activities of cAMP-regulated enhancer-binding protein and p 300 in tissues of fetal, young, and old mice","volume":"57","author":"Li","year":"2002","journal-title":"J. Gerontol. Ser. A Biol. Med. Sci."},{"key":"ref162","first-page":"85","volume-title":"Analysis of expression and functions of histone deacetylase 6 (hdac 6). Histone deacetylasesMethods Mol. Biol.","author":"Li","year":"2016"},{"key":"ref163","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/nature05292","article-title":"Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases","volume":"443","author":"Lin","year":"2006","journal-title":"Nature"},{"key":"ref164","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/glia.20729","article-title":"Histone deacetylase 11 regulates oligodendrocyte-specific gene expression and cell development in OL-1 oligodendroglia cells","volume":"57","author":"Liu","year":"2009","journal-title":"Glia"},{"key":"ref165","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1002\/jnr.21521","article-title":"Developmental expression of histone deacetylase 11 in the murine brain","volume":"86","author":"Liu","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"ref166","doi-asserted-by":"publisher","first-page":"355","DOI":"10.2478\/s13380-012-0044-7","article-title":"Pathologies of axonal transport in neurodegenerative diseases","volume":"3","author":"Liu","year":"2012","journal-title":"Transl. Neurosci."},{"key":"ref167","doi-asserted-by":"publisher","first-page":"485","DOI":"10.3389\/fonc.2020.00485","article-title":"HDAC10 is positively associated with PD-L1 expression and poor prognosis in patients with NSCLC","volume":"10","author":"Liu","year":"2020","journal-title":"Front. Oncol."},{"key":"ref168","doi-asserted-by":"publisher","first-page":"519","DOI":"10.3389\/fneur.2019.00519","article-title":"The selective HDAC6 inhibitor ACY-738 impacts memory and disease regulation in an animal model of multiple sclerosis","volume":"10","author":"LoPresti","year":"2019","journal-title":"Front. Neurol."},{"key":"ref169","doi-asserted-by":"publisher","first-page":"e103067","DOI":"10.1371\/journal.pone.0103067","article-title":"Histone acetyltransferase p 300 mediates histone acetylation of PS1 and BACE1 in a cellular model of Alzheimer's disease","volume":"9","author":"Lu","year":"2014","journal-title":"PLoS One"},{"key":"ref170","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1007\/s12264-019-00361-0","article-title":"Circular HDAC9\/micro RNA-138\/Sirtuin-1 pathway mediates synaptic and amyloid precursor protein processing deficits in Alzheimer\u2019s disease","volume":"35","author":"Lu","year":"2019","journal-title":"Neurosci. Bull."},{"key":"ref171","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1146\/annurev.cellbio.18.031802.150501","article-title":"Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticity","volume":"18","author":"Luo","year":"2002","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref172","doi-asserted-by":"publisher","first-page":"5369","DOI":"10.1242\/jcs.106336","article-title":"Depletion of histone deacetylase 3 antagonizes PI3K-mediated overgrowth of drosophila organs through the acetylation of histone H4 at lysine 16","volume":"125","author":"Lv","year":"2012","journal-title":"J. Cell Sci."},{"key":"ref173","doi-asserted-by":"publisher","first-page":"4819","DOI":"10.1074\/jbc.M110.146860","article-title":"Neuroprotection by histone deacetylase-7 (HDAC7) occurs by inhibition of c-Jun expression through a deacetylase-independent mechanism","volume":"286","author":"Ma","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref174","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.ydbio.2008.04.011","article-title":"Histone deacetylase 1 (HDAC1) regulates histone acetylation, development, and gene expression in preimplantation mouse embryos","volume":"319","author":"Ma","year":"2008","journal-title":"Dev. Biol."},{"key":"ref175","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1385\/NMM:4:1-2:7","article-title":"Huntington\u2019s disease","volume":"4","author":"Mac Donald","year":"2003","journal-title":"NeuroMolecular Med."},{"key":"ref176","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.immuni.2019.12.003","article-title":"Microglia, lifestyle stress, and neurodegeneration","volume":"52","author":"Madore","year":"2020","journal-title":"Immunity"},{"key":"ref177","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1002\/dneu.20637","article-title":"HDAC4 inhibits cell-cycle progression and protects neurons from cell death","volume":"68","author":"Majdzadeh","year":"2008","journal-title":"Dev. Neurobiol."},{"key":"ref178","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.trci.2015.08.001","article-title":"Pharmocologic treatment with histone deacetylase 6 inhibitor (ACY-738) recovers Alzheimer's disease phenotype in amyloid precursor protein\/presenilin 1 (APP\/PS1) mice","volume":"1","author":"Majid","year":"2015","journal-title":"Alzheimer's Dement."},{"key":"ref179","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/nbt0303-255","article-title":"Proteomic analysis of post-translational modifications","volume":"21","author":"Mann","year":"2003","journal-title":"Nat. Biotechnol."},{"key":"ref180","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1242\/dmm.028316","article-title":"Increased acetylation of microtubules rescues human tau-induced microtubule defects and neuromuscular junction abnormalities in drosophila","volume":"10","author":"Mao","year":"2017","journal-title":"Dis. Model. Mech."},{"key":"ref181","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/nbt1272","article-title":"Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug","volume":"25","author":"Marks","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"ref182","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1006\/jmbi.2001.4859","article-title":"Structure of histone acetyltransferases","volume":"311","author":"Marmorstein","year":"2001","journal-title":"J. Mol. Biol."},{"key":"ref183","doi-asserted-by":"publisher","first-page":"164","DOI":"10.4161\/epi.3.3.6253","article-title":"A work in progress: the clinical development of histone deacetylase inhibitor","volume":"3","author":"Marsoni","year":"2008","journal-title":"Epigenetics"},{"key":"ref184","doi-asserted-by":"publisher","first-page":"e39456","DOI":"10.1371\/journal.pone.0039456","article-title":"N-Myc and GCN5 regulate significantly overlapping transcriptional programs in neural stem cells","volume":"7","author":"Mart\u00ednez-Cerde\u00f1o","year":"2012","journal-title":"PLoS One"},{"key":"ref185","doi-asserted-by":"publisher","first-page":"10677","DOI":"10.1038\/s41598-021-90059-z","article-title":"Gene variants and expression changes of SIRT1 and SIRT6 in peripheral blood are associated with Parkinson\u2019s disease","volume":"11","author":"Maszlag-T\u00f6r\u00f6k","year":"2021","journal-title":"Sci. Rep."},{"key":"ref186","author":"Mazzocchi","year":"2021"},{"key":"ref187","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1523\/JNEUROSCI.5052-10.2011","article-title":"HDAC3 is a critical negative regulator of long-term memory formation","volume":"31","author":"McQuown","year":"2011","journal-title":"J. Neurosci."},{"key":"ref188","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/nn1408","article-title":"Histone deacetylase 9 couples neuronal activity to muscle chromatin acetylation and gene expression","volume":"8","author":"M\u00e9jat","year":"2005","journal-title":"Nat. Neurosci."},{"key":"ref189","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1515\/CCLM.2001.172","article-title":"Protein aggregation","volume":"39","author":"Merlini","year":"2001","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref190","doi-asserted-by":"publisher","first-page":"4623","DOI":"10.1091\/mbc.e05-01-0033","article-title":"Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins","volume":"16","author":"Michishita","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"ref191","doi-asserted-by":"publisher","first-page":"e27746","DOI":"10.1371\/journal.pone.0027746","article-title":"SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6\/2 mouse model of Huntington's disease","volume":"6","author":"Mielcarek","year":"2011","journal-title":"PLoS One"},{"key":"ref192","doi-asserted-by":"publisher","first-page":"e1001717","DOI":"10.1371\/journal.pbio.1001717","article-title":"HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration","volume":"11","author":"Mielcarek","year":"2013","journal-title":"PLoS Biol."},{"key":"ref193","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1038\/nm.3951","article-title":"Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits","volume":"21","author":"Min","year":"2015","journal-title":"Nat. Med."},{"key":"ref194","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/j.neuron.2010.08.044","article-title":"Acetylation of tau inhibits its degradation and contributes to tauopathy","volume":"67","author":"Min","year":"2010","journal-title":"Neuron"},{"key":"ref195","doi-asserted-by":"publisher","first-page":"3680","DOI":"10.1523\/JNEUROSCI.2369-17.2018","article-title":"SIRT1 deacetylates tau and reduces pathogenic tau spread in a mouse model of tauopathy","volume":"38","author":"Min","year":"2018","journal-title":"J. Neurosci."},{"key":"ref196","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1111\/j.1464-410X.2006.06704.x","article-title":"Epigenetic events, remodelling enzymes and their relationship to chromatin organization in prostatic intraepithelial neoplasia and prostatic adenocarcinoma","volume":"99","author":"Mohamed","year":"2007","journal-title":"BJU Int."},{"key":"ref197","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1101\/gad.1563807","article-title":"Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility","volume":"21","author":"Montgomery","year":"2007","journal-title":"Genes Dev."},{"key":"ref198","doi-asserted-by":"publisher","first-page":"7876","DOI":"10.1073\/pnas.0902750106","article-title":"Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development","volume":"106","author":"Montgomery","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref199","first-page":"296","article-title":"Panobinostat (Farydak): a novel option for the treatment of relapsed or relapsed and refractory multiple myeloma","volume":"41","author":"Moore","year":"2016","journal-title":"Pharm. Therap."},{"key":"ref200","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.ijdevneu.2013.02.005","article-title":"Unique functional roles for class I and class II histone deacetylases in central nervous system development and function","volume":"31","author":"Morris","year":"2013","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref201","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.pneurobio.2008.05.002","article-title":"The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics\u2014relevance for Alzheimer's disease","volume":"85","author":"M\u00fcller","year":"2008","journal-title":"Prog. Neurobiol."},{"key":"ref202","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1016\/j.yjmcc.2006.08.010","article-title":"Class II HDACs mediate CaMK-dependent signaling to NRSF in ventricular myocytes","volume":"41","author":"Nakagawa","year":"2006","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref203","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/s41467-017-02299-1","article-title":"Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation","volume":"9","author":"Naumann","year":"2018","journal-title":"Nat. Commun."},{"key":"ref204","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.bbadis.2017.11.004","article-title":"Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration","volume":"1864","author":"Neal","year":"2018","journal-title":"BBA Mol. Basis Dis."},{"key":"ref205","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3389\/fneur.2013.00083","article-title":"The importance of tau phosphorylation for neurodegenerative diseases","volume":"4","author":"Noble","year":"2013","journal-title":"Front. Neurol."},{"key":"ref206","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/S1097-2765(03)00038-8","article-title":"The human sir 2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase","volume":"11","author":"North","year":"2003","journal-title":"Mol. Cell"},{"key":"ref207","doi-asserted-by":"publisher","first-page":"34569","DOI":"10.1074\/jbc.M114.576397","article-title":"Histone deacetylase 3 is necessary for proper brain development","volume":"289","author":"Norwood","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref208","doi-asserted-by":"publisher","first-page":"2771","DOI":"10.1111\/febs.15895","article-title":"HDAC11: a multifaceted histone deacetylase with proficient fatty deacylase activity and its roles in physiological processes","volume":"289","author":"N\u00fa\u00f1ez-\u00c1lvarez","year":"2022","journal-title":"FEBS J."},{"key":"ref209","doi-asserted-by":"publisher","first-page":"3741","DOI":"10.1091\/mbc.e06-12-1125","article-title":"P 180 is involved in the interaction between the endoplasmic reticulum and microtubules through a novel microtubule-binding and bundling domain","volume":"18","author":"Ogawa-Goto","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"ref210","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1080\/14789450.2017.1304216","article-title":"Role of the microtubule-associated TPPP\/p 25 in Parkinson\u2019s and related diseases and its therapeutic potential","volume":"14","author":"Ol\u00e1h","year":"2017","journal-title":"Expert Rev. Proteomics"},{"key":"ref211","doi-asserted-by":"publisher","first-page":"e201901099","DOI":"10.1083\/jcb.201901099","article-title":"HDAC6 regulates microtubule stability and clustering of AChRs at neuromuscular junctions","volume":"219","author":"Osseni","year":"2020","journal-title":"J. Cell Biol."},{"key":"ref212","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1126\/science.1143780","article-title":"Sirtuin 2 inhibitors rescue \u03b1-synuclein-mediated toxicity in models of Parkinson's disease","volume":"317","author":"Outeiro","year":"2007","journal-title":"Science"},{"key":"ref213","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.bbadis.2008.02.010","article-title":"Therapeutic role of sirtuins in neurodegenerative disease","volume":"1782","author":"Outeiro","year":"2008","journal-title":"Biochim Biophys Acta Proteins Proteom."},{"key":"ref214","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1083\/jcb.200707126","article-title":"The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility","volume":"180","author":"Pandithage","year":"2008","journal-title":"J. Cell Biol."},{"key":"ref215","doi-asserted-by":"publisher","first-page":"2484","DOI":"10.1038\/s41467-020-16361-y","article-title":"HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer\u2019s disease","volume":"11","author":"Pao","year":"2020","journal-title":"Nat. Commun."},{"key":"ref216","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/s12276-020-0382-4","article-title":"A short guide to histone deacetylases including recent progress on class II enzymes","volume":"52","author":"Park","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"ref217","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.3892\/ijmm.2015.2099","article-title":"Selective PCAF inhibitor ameliorates cognitive and behavioral deficits by suppressing NF-\u03baB-mediated neuroinflammation induced by A\u03b2 in a model of Alzheimer's disease","volume":"35","author":"Park","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"ref218","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1111\/febs.13061","article-title":"Class II a HDAC s\u2013new insights into their functions in physiology and pathology","volume":"282","author":"Parra","year":"2015","journal-title":"FEBS J."},{"key":"ref219","doi-asserted-by":"publisher","first-page":"105","DOI":"10.5414\/NP301233","article-title":"Micro RNAs and HDAC4 protein expression in the skeletal muscle of ALS patients","volume":"39","author":"Pegoraro","year":"2020","journal-title":"Clin. Neuropathol."},{"key":"ref220","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.bbamcr.2012.12.004","article-title":"Lysine acetylation in the lumen of the ER: a novel and essential function under the control of the UPR","volume":"1833","author":"Pehar","year":"2013","journal-title":"Biochim. Biophys. Acta, Mol. Cell Res."},{"key":"ref221","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.tibs.2016.05.008","article-title":"The metabolic impact on histone acetylation and transcription in ageing","volume":"41","author":"Peleg","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"ref222","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1002\/stem.1606","article-title":"MOZ-mediated repression of p16INK4a is critical for the self-renewal of neural and hematopoietic stem cells","volume":"32","author":"Perez-Campo","year":"2014","journal-title":"Stem Cells"},{"key":"ref223","doi-asserted-by":"publisher","first-page":"371832","DOI":"10.1155\/2011\/371832","article-title":"Physical and functional HAT\/HDAC interplay regulates protein acetylation balance","volume":"2011","author":"Peserico","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"ref224","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1172\/JCI71601","article-title":"Emerging mechanisms of molecular pathology in ALS","volume":"125","author":"Peters","year":"2015","journal-title":"J. Clin. Invest."},{"key":"ref225","doi-asserted-by":"publisher","first-page":"113281","DOI":"10.1016\/j.expneurol.2020.113281","article-title":"HDAC6 inhibition promotes \u03b1-tubulin acetylation and ameliorates CMT2A peripheral neuropathy in mice","volume":"328","author":"Picci","year":"2020","journal-title":"Exp. Neurol."},{"key":"ref226","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1021\/acschemneuro.9b00483","article-title":"Acetylation of A\u03b240 alters aggregation in the presence and absence of lipid membranes","volume":"11","author":"Pilkington","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"ref227","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/B0-12-475570-4\/00003-2","volume-title":"Encyclopedia of Endocrine Diseases","author":"Portaleone","year":"2004"},{"key":"ref228","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1002\/jnr.23170","article-title":"Conditional deletion of histone deacetylase-4 in the central nervous system has no major effect on brain architecture or neuronal viability","volume":"91","author":"Price","year":"2013","journal-title":"J. Neurosci. Res."},{"key":"ref229","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/j.cell.2013.04.032","article-title":"Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis","volume":"153","author":"Qian","year":"2013","journal-title":"Cells"},{"key":"ref230","doi-asserted-by":"publisher","first-page":"13154","DOI":"10.1038\/s41598-021-92701-2","article-title":"Integrated network analysis identifying potential novel drug candidates and targets for Parkinson's disease","volume":"11","author":"Quan","year":"2021","journal-title":"Sci. Rep."},{"key":"ref231","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/nm1205","article-title":"Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model","volume":"11","author":"Ralph","year":"2005","journal-title":"Nat. Med."},{"key":"ref232","doi-asserted-by":"publisher","first-page":"9989","DOI":"10.1523\/JNEUROSCI.3257-08.2008","article-title":"Brain SIRT1: anatomical distribution and regulation by energy availability","volume":"28","author":"Ramadori","year":"2008","journal-title":"J. Neurosci."},{"key":"ref233","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.1016\/j.cub.2006.09.014","article-title":"Microtubule acetylation promotes kinesin-1 binding and transport","volume":"16","author":"Reed","year":"2006","journal-title":"Curr. Biol."},{"key":"ref234","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.intimp.2015.10.006","article-title":"HDAC expression and activity is upregulated in diseased lupus-prone mice","volume":"29","author":"Regna","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"ref235","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1002\/med.21701","article-title":"Histone deacetylases as targets for the treatment of neurodegenerative disorders: challenges and future opportunities","volume":"40","author":"Rodrigues","year":"2020","journal-title":"Med. Res. Rev."},{"key":"ref236","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s40478-019-0750-2","article-title":"Restoration of histone acetylation ameliorates disease and metabolic abnormalities in a FUS mouse model","volume":"7","author":"Rossaert","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"key":"ref237","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1146\/annurev.biochem.70.1.81","article-title":"Histone acetyltransferases","volume":"70","author":"Roth","year":"2001","journal-title":"Annu. Rev. Biochem."},{"key":"ref238","doi-asserted-by":"publisher","first-page":"6537","DOI":"10.1093\/emboj\/cdg615","article-title":"Critical loss of CBP\/p 300 histone acetylase activity by caspase-6 during neurodegeneration","volume":"22","author":"Rouaux","year":"2003","journal-title":"EMBO J."},{"key":"ref239","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1016\/j.bcp.2004.05.035","article-title":"Targeting CREB-binding protein (CBP) loss of function as a therapeutic strategy in neurological disorders","volume":"68","author":"Rouaux","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"ref240","doi-asserted-by":"publisher","first-page":"671","DOI":"10.3233\/JAD-130794","article-title":"Regulation of neuronal cytoskeletal protein phosphorylation in neurodegenerative diseases","volume":"41","author":"Rudrabhatla","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"ref241","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1042\/bj20021321","article-title":"Histone deacetylases (HDACs): characterization of the classical HDAC family","volume":"370","author":"Ruijter","year":"2003","journal-title":"Biochem. J."},{"key":"ref242","doi-asserted-by":"publisher","first-page":"970382","DOI":"10.1155\/2011\/970382","article-title":"The tale of protein lysine acetylation in the cytoplasm","volume":"2011","author":"Sadoul","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"ref243","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1038\/sj.cdd.4401769","article-title":"HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis","volume":"13","author":"Saha","year":"2006","journal-title":"Cell Death Differ."},{"key":"ref244","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.neuint.2017.04.012","article-title":"SIRT3 and mitochondrial metabolism in neurodegenerative diseases","volume":"109","author":"Salvatori","year":"2017","journal-title":"Neurochem. Int."},{"key":"ref245","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3389\/fnmol.2017.00082","article-title":"Post-translational modifications and protein quality control in motor neuron and polyglutamine diseases","volume":"10","author":"Sambataro","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"ref246","doi-asserted-by":"publisher","first-page":"2579","DOI":"10.1182\/blood-2011-10-387365","article-title":"Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma","volume":"119","author":"Santo","year":"2012","journal-title":"Blood"},{"key":"ref247","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.cub.2021.12.012","article-title":"Acetylated \u03b1-tubulin K394 regulates microtubule stability to shape the growth of axon terminals","volume":"32","author":"Saunders","year":"2022","journal-title":"Curr. Biol."},{"key":"ref248","doi-asserted-by":"publisher","first-page":"232","DOI":"10.3390\/brainsci10040232","article-title":"Do post-translational modifications influence protein aggregation in neurodegenerative diseases: a systematic review","volume":"10","author":"Schaffert","year":"2020","journal-title":"Brain Sci."},{"key":"ref249","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1038\/nchembio.95","article-title":"Small-molecule activation of neuronal cell fate","volume":"4","author":"Schneider","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"ref250","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1042\/bse0520135","article-title":"Lysine post-translational modifications and the cytoskeleton","volume":"52","author":"Scott","year":"2012","journal-title":"Essays Biochem."},{"key":"ref251","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3389\/fphar.2014.00089","article-title":"Sirtuin modulators control reactive gliosis in an in vitro model of Alzheimer\u2019s disease","volume":"5","author":"Scuderi","year":"2014","journal-title":"Front. Pharmacol."},{"key":"ref252","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/alzrt241","article-title":"Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition","volume":"6","author":"Selenica","year":"2014","journal-title":"Alzheimers Res. Ther."},{"key":"ref253","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1021\/cn500021p","article-title":"Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors","volume":"5","author":"Seo","year":"2014","journal-title":"ACS Chem. Neurosci."},{"key":"ref254","doi-asserted-by":"publisher","first-page":"6826","DOI":"10.1074\/jbc.M109.061846","article-title":"TDP-43 is a developmentally regulated protein essential for early embryonic development","volume":"285","author":"Sephton","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref255","doi-asserted-by":"publisher","first-page":"a018713","DOI":"10.1101\/cshperspect.a018713","article-title":"Erasers of histone acetylation: the histone deacetylase enzymes","volume":"6","author":"Seto","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref256","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-79649-5","article-title":"Structural characterization of a GNAT family acetyltransferase from Elizabethkingia anophelis bound to acetyl-CoA reveals a new dimeric interface","volume":"11","author":"Shirmast","year":"2021","journal-title":"Sci. Rep."},{"key":"ref257","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1002\/ar.20875","article-title":"Function of sirtuins in biological tissues","volume":"292","author":"Shoba","year":"2009","journal-title":"Anat. Rec. Adv. Integr. Anat. Evol. Biol."},{"key":"ref258","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1021\/acschembio.7b00883","article-title":"Chemical control of a CRISPR-Cas 9 acetyltransferase","volume":"13","author":"Shrimp","year":"2018","journal-title":"ACS Chem. Biol."},{"key":"ref259","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3389\/fncel.2018.00196","article-title":"The role of SIRT3 in the brain under physiological and pathological conditions","volume":"12","author":"Sidorova-Darmos","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"ref260","doi-asserted-by":"publisher","first-page":"333","DOI":"10.3389\/fnagi.2014.00333","article-title":"Differential expression of sirtuin family members in the developing, adult, and aged rat brain","volume":"6","author":"Sidorova-Darmos","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"ref261","doi-asserted-by":"publisher","first-page":"CT107-CT","DOI":"10.1158\/1538-7445.AM2020-CT107","article-title":"Abstract CT107: phase IB trial of ACY-1215 (ricolinostat) combined with nab-paclitaxel in metastatic breast cancer (MBC)","volume":"80","author":"Silva","year":"2020","journal-title":"Cancer Res."},{"key":"ref262","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1750-1326-8-7","article-title":"HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?","volume":"8","author":"Sim\u00f5es-Pires","year":"2013","journal-title":"Mol. Neurodegener."},{"key":"ref263","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1093\/hmg\/ddn375","article-title":"Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration","volume":"18","author":"Simpson","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"ref264","doi-asserted-by":"publisher","first-page":"2101308","DOI":"10.1002\/adbi.202101308","article-title":"HDAC6 inhibition corrects electrophysiological and axonal transport deficits in a human stem cell-based model of Charcot-Marie-tooth disease (type 2D)","volume":"6","author":"Smith","year":"2022","journal-title":"Adv. Biol."},{"key":"ref265","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1002\/j.1460-2075.1991.tb08031.x","article-title":"Stepwise assembly of chromatin during DNA replication in vitro","volume":"10","author":"Smith","year":"1991","journal-title":"EMBO J."},{"key":"ref266","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s13024-016-0109-0","article-title":"Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment","volume":"11","author":"Sohn","year":"2016","journal-title":"Mol. Neurodegener."},{"key":"ref267","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s12276-021-00556-4","article-title":"Autophagy regulation by acetylation\u2014implications for neurodegenerative diseases","volume":"53","author":"Son","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"ref268","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1124\/mol.109.062174","article-title":"Environmental neurotoxic pesticide increases histone acetylation to promote apoptosis in dopaminergic neuronal cells: relevance to epigenetic mechanisms of neurodegeneration","volume":"77","author":"Song","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"ref269","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1007\/s00401-015-1468-2","article-title":"Rab 1-dependent ER\u2013Golgi transport dysfunction is a common pathogenic mechanism in SOD1, TDP-43 and FUS-associated ALS","volume":"130","author":"Soo","year":"2015","journal-title":"Acta Neuropathol."},{"key":"ref270","doi-asserted-by":"publisher","first-page":"e21056","DOI":"10.1371\/journal.pone.0021056","article-title":"In cortical neurons HDAC3 activity suppresses RD4-dependent SMRT export","volume":"6","author":"Soriano","year":"2011","journal-title":"PLoS One"},{"key":"ref271","doi-asserted-by":"publisher","first-page":"4274","DOI":"10.1073\/pnas.82.12.4274","article-title":"Aberrant neurofilament phosphorylation in Alzheimer disease","volume":"82","author":"Sternberger","year":"1985","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref272","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1006\/scdb.1999.0315","article-title":"Protein folding in the ER","volume":"10","author":"Stevens","year":"1999","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref273","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1111\/j.1460-9568.2010.07218.x","article-title":"Nucleocytoplasmic translocation of HDAC9 regulates gene expression and dendritic growth in developing cortical neurons","volume":"31","author":"Sugo","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"ref274","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1046\/j.1471-4159.2003.02004.x","article-title":"Regulation of microglial inflammatory response by histone deacetylase inhibitors","volume":"87","author":"Suuronen","year":"2003","journal-title":"J. Neurochem."},{"key":"ref275","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1083\/jcb.200803153","article-title":"Dynamic instability of microtubules requires dynamin 2 and is impaired in a Charcot-Marie-tooth mutant","volume":"185","author":"Tanabe","year":"2009","journal-title":"J. Cell Biol."},{"key":"ref276","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.gpb.2016.09.002","article-title":"Lysine acetylation and deacetylation in brain development and neuropathies","volume":"15","author":"Tapias","year":"2017","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"ref277","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1126\/science.1067122","article-title":"Toxic proteins in neurodegenerative disease","volume":"296","author":"Taylor","year":"2002","journal-title":"Science"},{"key":"ref278","doi-asserted-by":"publisher","first-page":"9939","DOI":"10.1523\/JNEUROSCI.1643-10.2010","article-title":"Histone deacetylase Rpd 3 regulates olfactory projection neuron dendrite targeting via the transcription factor Prospero","volume":"30","author":"Tea","year":"2010","journal-title":"J. Neurosci."},{"key":"ref279","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3389\/fnmol.2014.00042","article-title":"Protein phosphorylation in neurodegeneration: friend or foe?","volume":"7","author":"Tenreiro","year":"2014","journal-title":"Front. Mol. Neurosci."},{"key":"ref280","doi-asserted-by":"publisher","first-page":"2537","DOI":"10.1242\/dev.127.12.2537","article-title":"Querkopf, a MYST family histone acetyltransferase, is required for normal cerebral cortex development","volume":"127","author":"Thomas","year":"2000","journal-title":"Development"},{"key":"ref281","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1038\/nn.3264","article-title":"BCL6 controls neurogenesis through Sirt 1-dependent epigenetic repression of selective notch targets","volume":"15","author":"Tiberi","year":"2012","journal-title":"Nat. Neurosci."},{"key":"ref282","doi-asserted-by":"publisher","first-page":"17896","DOI":"10.1074\/jbc.M109.096578","article-title":"TPPP\/p 25 promotes tubulin acetylation by inhibiting histone deacetylase 6","volume":"285","author":"T\u0151k\u00e9si","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref283","doi-asserted-by":"publisher","first-page":"26484","DOI":"10.1074\/jbc.M803686200","article-title":"Transgenic overexpression of Hdac 3 in the heart produces increased postnatal cardiac myocyte proliferation but does not induce hypertrophy","volume":"283","author":"Trivedi","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref284","doi-asserted-by":"publisher","first-page":"12171","DOI":"10.1073\/pnas.2034961100","article-title":"Microtubule destabilization and nuclear entry are sequential steps leading to toxicity in Huntington's disease","volume":"100","author":"Trushina","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref285","doi-asserted-by":"crossref","DOI":"10.5772\/54487","volume-title":"Role Of Protein Aggregation In Neurodegenerative Diseases","author":"Tutar","year":"2013"},{"key":"ref286","doi-asserted-by":"publisher","first-page":"1260419","DOI":"10.1126\/science.1260419","article-title":"Tissue-based map of the human proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science"},{"key":"ref287","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2147\/RRB.S35470","article-title":"The role of histone deacetylase 6 (HDAC6) in neurodegeneration","volume":"5","author":"Van Helleputte","year":"2014","journal-title":"Res. Rep. Biol."},{"key":"ref288","doi-asserted-by":"publisher","first-page":"9364","DOI":"10.1523\/JNEUROSCI.4787-13.2014","article-title":"Synucleins regulate the kinetics of synaptic vesicle endocytosis","volume":"34","author":"Vargas","year":"2014","journal-title":"J. Neurosci."},{"key":"ref289","doi-asserted-by":"publisher","first-page":"104781","DOI":"10.1016\/j.nbd.2020.104781","article-title":"N-terminal acetylation mutants affect alpha-synuclein stability, protein levels and neuronal toxicity","volume":"137","author":"Vinueza-Gavilanes","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"ref290","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.conb.2020.04.001","article-title":"Traffic signaling: new functions of huntingtin and axonal transport in neurological disease","volume":"63","author":"Vitet","year":"2020","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref291","doi-asserted-by":"publisher","first-page":"3307","DOI":"10.1158\/1078-0432.CCR-16-2526","article-title":"Ricolinostat, the first selective histone deacetylase 6 inhibitor, in combination with Bortezomib and dexamethasone for relapsed or refractory multiple myeloma Ricolinostat, Bortezomib, and dexamethasone for myeloma","volume":"23","author":"Vogl","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"ref292","doi-asserted-by":"publisher","first-page":"3561","DOI":"10.1182\/blood.V130.Suppl_1.3561.3561","article-title":"A novel role for histone deacetylase 10 (HDAC10) in the regulation of PD-L1 expression and immune tolerance mediated by antigen presenting cells (APCs)","volume":"130","author":"Wang","year":"2017","journal-title":"Blood"},{"key":"ref293","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1182\/blood.2020007401","article-title":"Impairment of human terminal erythroid differentiation by histone deacetylase 5 deficiency","volume":"138","author":"Wang","year":"2021","journal-title":"Blood"},{"key":"ref294","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/641979","article-title":"Dysregulation of histone acetyltransferases and deacetylases in cardiovascular diseases","volume":"2014","author":"Wang","year":"2014","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref295","doi-asserted-by":"publisher","first-page":"139","DOI":"10.2217\/epi.13.73","article-title":"HDAC4: mechanism of regulation and biological functions","volume":"6","author":"Wang","year":"2014","journal-title":"Epigenomics"},{"key":"ref296","doi-asserted-by":"publisher","first-page":"7182","DOI":"10.3390\/ijms21197182","article-title":"Imbalance of lysine acetylation contributes to the pathogenesis of Parkinson\u2019s disease","volume":"21","author":"Wang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"ref297","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.apsb.2012.06.005","article-title":"Histone deacetylases and their inhibitors: molecular mechanisms and therapeutic implications in diabetes mellitus","volume":"2","author":"Wang","year":"2012","journal-title":"Acta Pharm. Sin. B"},{"key":"ref298","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.canlet.2008.02.066","article-title":"Cortactin in tumor invasiveness","volume":"265","author":"Weaver","year":"2008","journal-title":"Cancer Lett."},{"key":"ref299","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1073\/pnas.72.5.1858","article-title":"A protein factor essential for microtubule assembly","volume":"72","author":"Weingarten","year":"1975","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref300","doi-asserted-by":"publisher","first-page":"351ra106","DOI":"10.1126\/scitranslmed.aaf7551","article-title":"Insights into neuroepigenetics through human histone deacetylase PET imaging","volume":"8","author":"Wey","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"ref301","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/nan.12153","article-title":"Histone deacetylases (HDACs) in frontotemporal lobar degeneration","volume":"41","author":"Whitehouse","year":"2015","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref302","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1083\/jcb.200707042","article-title":"Microtubule stabilization specifies initial neuronal polarization","volume":"180","author":"Witte","year":"2008","journal-title":"J. Cell Biol."},{"key":"ref303","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1017\/S1461145708009024","article-title":"Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons","volume":"11","author":"Wu","year":"2008","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref304","doi-asserted-by":"publisher","first-page":"560487","DOI":"10.3389\/fonc.2020.560487","article-title":"Small molecules targeting HATs, HDACs, and BRDs in cancer therapy","volume":"10","author":"Wu","year":"2020","journal-title":"Front. Oncol."},{"key":"ref305","doi-asserted-by":"publisher","first-page":"6970","DOI":"10.1007\/s12035-016-0199-2","article-title":"Nuclear accumulation of histone deacetylase 4 (HDAC4) exerts neurotoxicity in models of Parkinson\u2019s disease","volume":"54","author":"Wu","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref306","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/jnc.13234","article-title":"The phosphorylation of \u03b1-synuclein: development and implication for the mechanism and therapy of the Parkinson's disease","volume":"135","author":"Xu","year":"2015","journal-title":"J. Neurochem."},{"key":"ref307","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/79973","article-title":"Loss of Gcn 5l2 leads to increased apoptosis and mesodermal defects during mouse development","volume":"26","author":"Xu","year":"2000","journal-title":"Nat. Genet."},{"key":"ref308","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3389\/fncel.2014.00068","article-title":"A selective histone deacetylase-6 inhibitor improves BDNF trafficking in hippocampal neurons from Mecp 2 knockout mice: implications for Rett syndrome","volume":"8","author":"Xu","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"ref309","article-title":"Acetylation in the regulation of autophagy","volume-title":"Autophagy","author":"Xu","year":"2022"},{"key":"ref310","doi-asserted-by":"publisher","first-page":"9153","DOI":"10.2147\/CMAR.S219535","article-title":"Ras-ERK1\/2 signaling promotes the development of osteosarcoma by regulating H2BK12ac through CBP","volume":"11","author":"Xu","year":"2019","journal-title":"Cancer Manag. Res."},{"key":"ref311","first-page":"3027","article-title":"Histone deacetylase 1 regulates retinal neurogenesis in zebrafish by suppressing Wnt and notch signaling pathways","volume-title":"Development","author":"Yamaguchi","year":"2005"},{"key":"ref312","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1002\/bies.20104","article-title":"Lysine acetylation and the bromodomain: a new partnership for signaling","volume":"26","author":"Yang","year":"2004","journal-title":"BioEssays"},{"key":"ref313","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2011\/146493","article-title":"Beyond histone and deacetylase: an overview of cytoplasmic histone deacetylases and their nonhistone substrates","volume":"2011","author":"Yao","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"key":"ref314","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1038\/nn.2333","article-title":"HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the \u03b2-catenin\u2013TCF interaction","volume":"12","author":"Ye","year":"2009","journal-title":"Nat. Neurosci."},{"key":"ref315","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.brainres.2013.02.012","article-title":"Histone deacetylase class II and acetylated core histone immunohistochemistry in human brains with Huntington\u2019s disease","volume":"1504","author":"Yeh","year":"2013","journal-title":"Brain Res."},{"key":"ref316","doi-asserted-by":"publisher","first-page":"e1005034","DOI":"10.1371\/journal.pgen.1005034","article-title":"The lysine acetyltransferase activator Brpf 1 governs dentate gyrus development through neural stem cells and progenitors","volume":"11","author":"You","year":"2015","journal-title":"PLoS Genet."},{"key":"ref317","doi-asserted-by":"publisher","first-page":"5169","DOI":"10.1523\/JNEUROSCI.21-14-05169.2001","article-title":"Stages of synapse development defined by dependence on F-actin","volume":"21","author":"Zhang","year":"2001","journal-title":"J. Neurosci."},{"key":"ref318","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.devcel.2016.01.002","article-title":"Hdac 3 interaction with p 300 histone acetyltransferase regulates the oligodendrocyte and astrocyte lineage fate switch","volume":"36","author":"Zhang","year":"2016","journal-title":"Dev. Cell"},{"key":"ref319","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1128\/MCB.01154-06","article-title":"Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally","volume":"28","author":"Zhang","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"ref320","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1093\/emboj\/cdg115","article-title":"HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo","volume":"22","author":"Zhang","year":"2003","journal-title":"EMBO J."},{"key":"ref321","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.3233\/JAD-140066","article-title":"Tubastatin A\/ACY-1215 improves cognition in Alzheimer's disease transgenic mice","volume":"41","author":"Zhang","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"ref322","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.molcel.2007.05.033","article-title":"HDAC6 modulates cell motility by altering the acetylation level of cortactin","volume":"27","author":"Zhang","year":"2007","journal-title":"Mol. Cell"},{"key":"ref323","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/onc.2008.388","article-title":"Deacetylation of cortactin by SIRT1 promotes cell migration","volume":"28","author":"Zhang","year":"2009","journal-title":"Oncogene"},{"key":"ref324","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.bbrc.2008.08.137","article-title":"SIRTUIN 1: regulating the regulator","volume":"376","author":"Zschoernig","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref325","doi-asserted-by":"publisher","first-page":"7913","DOI":"10.1128\/MCB.01220-06","article-title":"Negative and positive regulation of gene expression by mouse histone deacetylase 1","volume":"26","author":"Zupkovitz","year":"2006","journal-title":"Mol. Cell. Biol."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2022.1025473\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T14:24:53Z","timestamp":1672842293000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2022.1025473\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,4]]},"references-count":325,"alternative-id":["10.3389\/fnagi.2022.1025473"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2022.1025473","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,4]]},"article-number":"1025473"}}