{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T16:13:03Z","timestamp":1782058383565,"version":"3.54.5"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Migraine is a common disabling disorder, and its substantial burden is associated with a considerable negative impact on the patients\u2019 quality of life. Moreover, aging patients with migraine have more cognitive complaints. Additionally, the elderly are more likely to have sleep disturbances, which may also predict the risk of incident dementia. Migraines are reported to be closely associated with sleep and circadian rhythms. Sleep disturbance is a well-known trigger for migraine episodes; moreover, shift work or jet lag reportedly triggers some migraines. The hypothalamus is thought to be the migraine generator; sleep and circadian activity rhythm are also controlled by the hypothalamus. Evidence suggests an influence of both sleep and circadian system on migraine. Previously, light therapy has been show to stabilize sleep architecture and further improve insomnia related to circadian rhythm disorders. However, the beneficial effect of light therapy on migraine with sleep disturbance has not yet been determined. We aim to explore the effects of light therapy for migraine combined with sleep disturbance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and analysis<\/jats:title><jats:p>This project is a 2-year, randomized, double-blind, placebo-controlled clinical trial. The study design includes a 4-week monitoring period (baseline and pretest), a 4-week treatment period, and a posttest. The study participants will undergo assessments on headache frequency and severity and subjective and objective (wrist actigraphy and polysomnography) sleep disturbances, and quality of life and a series of blood tests for serum biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This study will establish evidence-based alternative medicine for the preventive effect of bright light therapy in migraine patients with sleep disturbances. Moreover, our data will be useful to comprehend the biochemical mechanism of light therapy in migraine prevention.<\/jats:p><jats:p><jats:bold>Clinical Trial Registration<\/jats:bold>: <jats:ext-link>ClinicalTrials.gov<\/jats:ext-link>, identifier NCT04890691.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnagi.2022.1041076","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T07:28:39Z","timestamp":1674113319000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["The effect of bright light therapy in migraine patients with sleep disturbance: A prospective, observational cohort study protocol"],"prefix":"10.3389","volume":"14","author":[{"given":"Tsung-Hsing","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Chia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Yu","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Mao","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Ju","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Yu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Pai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/head.13456.","article-title":"The American headache society position statement on integrating new migraine treatments into clinical practice","volume":"59","year":"2019","journal-title":"Headache"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1212\/WNL.0000000000002261","article-title":"Change in brain network connectivity during PACAP38-induced migraine attacks: a resting-state functional MRI study","volume":"86","author":"Amin","year":"2016","journal-title":"Neurology"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1093\/sleep\/20.1.24","article-title":"Use of wrist activity for monitoring sleep\/wake in demented nursing-home patients","volume":"20","author":"Ancoli-Israel","year":"1997","journal-title":"Sleep"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/head.14250","article-title":"Migraine and light: a narrative review","volume":"62","author":"Artemenko","year":"2022","journal-title":"Headache"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"647","DOI":"10.2217\/pmt-2021-0015","article-title":"PEARL study protocol: a real-world study of fremanezumab effectiveness in patients with chronic or episodic migraine","volume":"11","author":"Ashina","year":"","journal-title":"Pain Manage."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1016\/S0140-6736(20)32160-7","article-title":"Migraine: epidemiology and systems of care","volume":"17","author":"Ashina","year":"","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"4616417","DOI":"10.1155\/2019\/4616417","article-title":"Circadian variation of migraine attack onset: a review of clinical studies","volume":"2019","author":"Baksa","year":"2019","journal-title":"Biomed. 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