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Aging Neurosci."],"abstract":"<jats:p>Adult-onset neuronal ceroid lipofuscinosis (ANCL) is a rare neurodegenerative disease characterized by epilepsy, cognitive degeneration, and motor disorders caused by mutations in the <jats:italic>DNAJC5<\/jats:italic> gene. In addition to being associated with ANCL disease, the cysteine string proteins \u03b1 (CSP\u03b1) encoded by the <jats:italic>DNAJC5<\/jats:italic> gene have been implicated in several neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease. However, the pathogenic mechanism responsible for these neurodegenerative diseases has not yet been elucidated. 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