{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:08:07Z","timestamp":1753891687815,"version":"3.41.2"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2019TX320002"],"award-info":[{"award-number":["2019TX320002"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Carotid artery stenting (CAS) performed perioperatively with high-dose atorvastatin may reduce the incidence of new ischemic brain lesions, but more high-level evidence is needed. Furthermore, the optimal dose and course of perioperative statin therapy remain uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single-center, prospective, parallel controlled, pilot randomized clinical trial was conducted at Beijing Hospital. The study includes a total of 130 patients with CAS. The patients were randomly assigned to receive a high-dose of 80\u2009mg\/day atorvastatin (<jats:italic>n<\/jats:italic>\u2009=\u200965) or a standard-dose of 20\u2009mg\/day atorvastatin (<jats:italic>n<\/jats:italic>\u2009=\u200965) 3\u2009days before and 3\u2009days after planned CAS. The primary endpoint event was the cumulative incidence of silent new ischemic cerebral lesions (sNICL) on post-CAS cerebral diffusion-weighted magnetic resonance imaging (DW-MRI), transient ischemic attack (TIA), or ischemic stroke within 30\u2009days after CAS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 130 patients, 123 completed the study, of which 63 were in the high-dose group and 60 were in the standard-dose group. The incidence of major endpoint events was 69.8% (44 cases) and 78.3% (46 cases) in the high-dose and standard-dose groups, respectively. There was no significant difference between the two groups (HR, 0.705; 95% CI, 0.315\u20131.576; <jats:italic>p<\/jats:italic>\u2009=\u20090.393). According to the stratified analysis results, the sNICL incidence was significantly different between the two groups in the symptomatic patients (HR, 0.263; 95% CI, 0.70\u20130.984; <jats:italic>p<\/jats:italic>\u2009=\u20090.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among patients with CAS, a periprocedural high-dose of atorvastatin did not reduce the rate of periprocedural ischemic brain damage. However, high-dose statins can reduce the incidence of sNICL after CAS in patients with symptomatic carotid stenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Trial Registration<\/jats:title><jats:p><jats:ext-link>Clinicaltrials.gov<\/jats:ext-link>, identifier NCT03079115.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnagi.2022.1066316","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T05:33:10Z","timestamp":1671773590000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A single-center pilot randomized controlled trial of atorvastatin loading for preventing ischemic brain damage after carotid artery stenting"],"prefix":"10.3389","volume":"14","author":[{"given":"Haipeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ximeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunpeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erteng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"314","DOI":"10.29271\/jcpsp.2021.03.314","article-title":"Incidence of silent ischemic infarct after diagnostic conventional cerebral angiogram","volume":"31","author":"Al-Hussain","year":"2021","journal-title":"J. Coll. Physicians Surg. Pak."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1056\/NEJMoa1910355","article-title":"A comparison of two LDL cholesterol targets after ischemic stroke","volume":"382","author":"Amarenco","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1016\/S0140-6736(10)61350-5","article-title":"Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170\u2008000 participants in 26 randomised trials","volume":"376","author":"Baigent","year":"2010","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1016\/j.jacc.2011.11.035","article-title":"The PROFI study (prevention of cerebral embolization by proximal balloon occlusion compared to filter protection during carotid artery stenting)","volume":"59","author":"Bijuklic","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.jcin.2012.10.019","article-title":"Impact of asymptomatic cerebral lesions in diffusion-weighted magnetic resonance imaging after carotid artery stenting","volume":"6","author":"Bijuklic","year":"","journal-title":"J. Am. Coll. Cardiol. Intv."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1161\/CIRCINTERVENTIONS.112.000093","article-title":"Risk factors for cerebral embolization after carotid artery stenting with embolic protection: a diffusion-weighted magnetic resonance imaging study in 837 consecutive patients","volume":"6","author":"Bijuklic","year":"","journal-title":"Circ. Cardiovasc. 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Cardiol."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1177\/159101991101700409","article-title":"Insight into the Periprocedural embolic events of internal carotid artery angioplasty: a report of four cases and literature review","volume":"17","author":"Jiang","year":"2011","journal-title":"Interv. Neuroradiol."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.jacc.2016.03.519","article-title":"2016 ACC expert consensus decision pathway on the role of non-statin therapies for LDL-cholesterol lowering in the Management of Atherosclerotic Cardiovascular Disease Risk","volume":"68","author":"Lloyd-Jones","year":"2016","journal-title":"J. Am. Coll. 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Cardiol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1583\/13-4354R.1","article-title":"Inflammatory mediators and cerebral embolism in carotid stenting: new markers of risk","volume":"20","author":"Pini","year":"2013","journal-title":"J. Endovasc. Ther."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1016\/j.jvs.2019.07.002","article-title":"Predictors of new Ischaemic brain lesions on diffusion weighted imaging after carotid stenting and endarterectomy: a systematic review","volume":"70","author":"Rots","year":"2019","journal-title":"J. Vasc. Surg."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1016\/j.jacc.2005.04.023","article-title":"Effect of two different neuroprotection systems on microembolization during carotid artery stenting","volume":"44","author":"Schmidt","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1007\/s00380-019-01552-5","article-title":"Effect of high-dose strong statin for preventing periprocedural ischemic complications of carotid artery stenting","volume":"35","author":"Shinozaki","year":"2020","journal-title":"Heart Vessels"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"2889","DOI":"10.1016\/j.jacc.2013.11.002","article-title":"2013 ACC\/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American college of cardiology\/American heart association task force on practice guidelines","volume":"63","author":"Stone","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1007\/s00270-013-0813-x","article-title":"Effect of Pitavastatin on preventing ischemic complications with carotid artery stenting: a multicenter prospective study\u2014EPOCH-CAS study","volume":"37","author":"Takayama","year":"2014","journal-title":"Cardiovasc. Intervent. 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Neurol."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1136\/neurintsurg-2017-013622","article-title":"Influence of stent design and use of protection devices on outcome of carotid artery stenting: a pooled analysis of individual patient data","volume":"10","author":"Wodarg","year":"2018","journal-title":"J. Neuro. Intervent. 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