{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:18:17Z","timestamp":1792081097625,"version":"4.4.0"},"reference-count":345,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>Aging is associated with a broad range of visual impairments that can have dramatic consequences on the quality of life of those impacted. These changes are driven by a complex series of alterations affecting interactions between multiple cellular and extracellular elements. The resilience of many of these interactions may be key to minimal loss of visual function in aging; yet many of them remain poorly understood. In this review, we focus on the relation between retinal neurons and their respective mass transport systems. These metabolite delivery systems include the retinal vasculature, which lies within the inner portion of the retina, and the choroidal vasculature located externally to the retinal tissue. A framework for investigation is proposed and applied to identify the structures and processes determining retinal mass transport at the cellular and tissue levels. Spatial variability in the structure of the retina and changes observed in aging are then harnessed to explore the relation between variations in neuron populations and those seen among retinal metabolite delivery systems. Existing data demonstrate that the relation between inner retinal neurons and their mass transport systems is different in nature from that observed between the outer retina and choroid. The most prominent structural changes observed across the eye and in aging are seen in Bruch\u2019s membrane, which forms a selective barrier to mass transfers at the interface between the choroidal vasculature and the outer retina.<\/jats:p>","DOI":"10.3389\/fnagi.2022.778404","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T02:13:05Z","timestamp":1645755185000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Variability in Retinal Neuron Populations and Associated Variations in Mass Transport Systems of the Retina in Health and Aging"],"prefix":"10.3389","volume":"14","author":[{"given":"Moussa A.","family":"Zouache","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/j.1748-1716.2011.02320.x","article-title":"Vasomotion - what is currently thought?","volume":"202","author":"Aalkj\u00e6r","year":"2011","journal-title":"Acta Physiol."},{"key":"B2","first-page":"451","article-title":"Modulation of retinal capillary endothelial cells by M\u00fcller glial cell-derived factors.","volume":"15","author":"Abukawa","year":"2009","journal-title":"Mol. Vis."},{"key":"B3","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s12038-007-0029-9","article-title":"Age-related decrease in rod bipolar cell density of the human retina: an immunohistochemical study.","volume":"32","author":"Aggarwal","year":"2007","journal-title":"J. Biosci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1002\/cne.902550103","article-title":"Identification of a subtype of cone photoreceptor, likely to be blue sensitive, in the human retina.","volume":"255","author":"Ahnelt","year":"1987","journal-title":"J. Comp. Neurol."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1201\/9780203833445","author":"Alberts","year":"2014","journal-title":"Molecular biology of the cell"},{"key":"B6","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/j.1748-1716.1972.tb05182.x","article-title":"The Oxygen Supply to the Retina, II. Effects of High Intraocular Pressure and of Increased Arterial Carbon Dioxide Tension on Uveal and Retinal Blood Flow in Cats.","volume":"84","author":"Alm","year":"1972","journal-title":"Acta Physiol. Scand."},{"key":"B7","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1136\/bjo.52.1.26","article-title":"Radial peripapillary capillaries of the retina. II. Possible role in Bjerrum scotoma.","volume":"52","author":"Alterman","year":"1968","journal-title":"Br. J. Ophthalmol."},{"key":"B8","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/BF00127643","article-title":"The Choriocapillaris in the Macular Area: Clinical and Angiographic Study.","volume":"6","author":"Amalric","year":"1983","journal-title":"Int. Ophthalmol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.exer.2018.02.006","article-title":"Quantitative comparisons between optical coherence tomography angiography and matched histology in the human eye.","volume":"170","author":"An","year":"2018","journal-title":"Exp. Eye Res."},{"key":"B10","first-page":"675","article-title":"[Observations on the corrosion casts of the choriocapillaries of enzyme-induced glaucomatous eye of rhesus monkey (author\u2019s transl)].","volume":"80","author":"Araki","year":"1976","journal-title":"Nihon. Ganka Gakkai Zasshi"},{"key":"B11","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.preteyeres.2013.07.003","article-title":"Aging is not a disease: distinguishing age-related macular degeneration from aging.","volume":"37","author":"Ardeljan","year":"2013","journal-title":"Prog. Retin Eye Res."},{"key":"B12","first-page":"584","article-title":"Effect of ocular pressure on choroidal circulation in the cat and Rhesus monkey.","volume":"14","author":"Armaly","year":"1975","journal-title":"Invest. Ophthalmol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.ajo.2018.02.007","article-title":"Comparisons Between Histology and Optical Coherence Tomography Angiography of the Periarterial Capillary-Free Zone.","volume":"189","author":"Balaratnasingam","year":"2018","journal-title":"Am. J. Ophthalmol."},{"key":"B14","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511800955","author":"Batchelor","year":"2000","journal-title":"An Introduction to Fluid Dynamics (Cambridge Mathematical Library)."},{"key":"B15","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1093\/cvr\/cvq105","article-title":"Vascular endothelial growth factors and vascular permeability.","volume":"87","author":"Bates","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"B16","first-page":"853","article-title":"TGF-\u03b2 increases retinal endothelial cell permeability by increasing MMP-9: possible role of glial cells in endothelial barrier function.","volume":"42","author":"Behzadian","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B17","first-page":"1016","article-title":"Fine structure of the choriocappillaris and retinal capillaries.","volume":"4","author":"Bernstein","year":"1965","journal-title":"Invest. Ophthalmol."},{"key":"B18","first-page":"898","article-title":"Analysis of RPE morphometry in human eyes.","volume":"22","author":"Bhatia","year":"2016","journal-title":"Mol. Vis."},{"key":"B19","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.1681\/ASN.2011080865","article-title":"Body fluid dynamics: back to the future.","volume":"22","author":"Bhave","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1001\/archopht.1962.00960020338010","article-title":"Intraocular pressure and blood flow through the uvea.","volume":"67","author":"Bill","year":"1962","journal-title":"Arch. Ophthalmol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/BF00127638","article-title":"Physiology of the choroidal vascular bed.","volume":"6","author":"Bill","year":"1983","journal-title":"Int. Ophthalmol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"H1696","DOI":"10.1152\/ajpheart.00221.2007","article-title":"Oxygen distribution and consumption in the macaque retina.","volume":"293","author":"Birol","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/S0002-9440(10)65138-3","article-title":"Polarized vascular endothelial growth factor secretion by human retinal pigment epithelium and localization of vascular endothelial growth factor receptors on the inner choriocapillaris. Evidence for a trophic paracrine relation.","volume":"155","author":"Blaauwgeers","year":"1999","journal-title":"Am. J. Pathol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2009.08.003","article-title":"The dynamic nature of Bruch\u2019s membrane.","volume":"29","author":"Booij","year":"2010","journal-title":"Prog. Retin Eye Res."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-018-0109-2","article-title":"The role of plasmalemma vesicle-associated protein in pathological breakdown of blood-brain and blood-retinal barriers: potential novel therapeutic target for cerebral edema and diabetic macular edema.","volume":"15","author":"Bosma","year":"2018","journal-title":"Fluids Barriers CNS"},{"key":"B26","first-page":"434","article-title":"Age-related physiological changes and their clinical significance.","volume":"135","author":"Boss","year":"1981","journal-title":"West J. Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.preteyeres.2006.05.003","article-title":"M\u00fcller cells in the healthy and diseased retina.","volume":"25","author":"Bringmann","year":"2006","journal-title":"Prog. Retin. Eye Res."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2021.100994","article-title":"Exploring the choroidal vascular labyrinth and its molecular and structural roles in health and disease.","volume":"2021","author":"Brinks","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/BF00237966","article-title":"The astrocytes in the retina and optic nerve head of mammals: a special glia for the ganglion cell axons.","volume":"206","author":"B\u00fcssow","year":"1980","journal-title":"Cell Tissue Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/0042-6989(91)90110-q","article-title":"How thick should a retina be? A comparative study of mammalian species with and without intraretinal vasculature.","volume":"31","author":"Buttery","year":"1991","journal-title":"Vision Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"ORSF37","DOI":"10.1167\/iovs.13-12784","article-title":"Age-related changes in the visual pathways: blame it on the axon.","volume":"54","author":"Calkins","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/srep42201","article-title":"Detailed Vascular Anatomy of the Human Retina by Projection-Resolved Optical Coherence Tomography Angiography.","volume":"7","author":"Campbell","year":"2017","journal-title":"Sci. Rep."},{"key":"B33","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1007\/978-1-4614-4711-5_3","article-title":"The blood-retina barrier: tight junctions and barrier modulation.","volume":"763","author":"Campbell","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-vision-100419-114940","article-title":"Aging of the retina: molecular and metabolic turbulences and potential interventions.","volume":"2021","author":"Campello","year":"2021","journal-title":"Annu. Rev. Vis. Sci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s10237-015-0708-7","article-title":"Blood flow mechanics and oxygen transport and delivery in the retinal microcirculation: multiscale mathematical modeling and numerical simulation.","volume":"15","author":"Causin","year":"2016","journal-title":"Biomech. Model Mechanobiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.mvr.2015.04.006","article-title":"In vivo optical imaging of human retinal capillary networks using speckle variance optical coherence tomography with quantitative clinico-histological correlation.","volume":"100","author":"Chan","year":"2015","journal-title":"Microvasc. Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"5502","DOI":"10.1167\/iovs.12-10265","article-title":"Quantitative morphometry of perifoveal capillary networks in the human retina.","volume":"53","author":"Chan","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1167\/iovs.10-5403","article-title":"Role of CD44+ stem cells in mural cell formation in the human choroid: evidence of vascular instability due to limited pericyte ensheathment.","volume":"52","author":"Chan-Ling","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1016\/s0161-6420(82)34608-4","article-title":"The evolution of retinal vascularization in mammals. A comparison of vascular and avascular retinae.","volume":"89","author":"Chase","year":"1982","journal-title":"Ophthalmology"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.25946","article-title":"Glycolytic reliance promotes anabolism in photoreceptors.","volume":"6","author":"Chinchore","year":"2017","journal-title":"Elife"},{"key":"B41","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/S0002-9440(10)62248-1","article-title":"Decreased thickness and integrity of the macular elastic layer of Bruch\u2019s membrane correspond to the distribution of lesions associated with age-related macular degeneration.","volume":"166","author":"Chong","year":"2005","journal-title":"Am. J. Pathol."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1186\/s40942-016-0037-8","article-title":"Human retinal microvascular imaging using adaptive optics scanning light ophthalmoscopy.","volume":"2","author":"Chui","year":"2016","journal-title":"Int. J. Retina Vitreous"},{"key":"B43","doi-asserted-by":"publisher","first-page":"3545","DOI":"10.1167\/iovs.11-8694","article-title":"Cone photoreceptor packing density and the outer nuclear layer thickness in healthy subjects.","volume":"53","author":"Chui","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B44","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1364\/JOSAA.25.003021","article-title":"Adaptive-optics imaging of human cone photoreceptor distribution.","volume":"25","author":"Chui","year":"","journal-title":"J. Opt. Soc. Am. A Opt. Image Sci. Vis."},{"key":"B45","doi-asserted-by":"publisher","first-page":"4679","DOI":"10.1167\/iovs.08-2135","article-title":"Individual variations in human cone photoreceptor packing density: variations with refractive error.","volume":"49","author":"Chui","year":"","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053386","article-title":"Perivascular mural cells of the mouse choroid demonstrate morphological diversity that is correlated to vasoregulatory function.","volume":"8","author":"Condren","year":"2013","journal-title":"PLoS One"},{"key":"B47","author":"Conn","year":"2006","journal-title":"Handbook of Models for Human Aging"},{"key":"B48","doi-asserted-by":"publisher","first-page":"OCT211","DOI":"10.1167\/iovs.15-18793","article-title":"Normative data for vascular density in superficial and deep capillary plexuses of healthy adults assessed by optical coherence tomography angiography.","volume":"57","author":"Coscas","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B49","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF00146764","article-title":"The blood-retinal barriers.","volume":"41","author":"Cunha-Vaz","year":"1976","journal-title":"Doc. Ophthalmol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1002\/cne.903120411","article-title":"Distribution and morphology of human cone photoreceptors stained with anti-blue opsin.","volume":"312","author":"Curcio","year":"1991","journal-title":"J. Comp. Neurol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/cne.903000103","article-title":"Topography of ganglion cells in human retina.","volume":"300","author":"Curcio","year":"1990","journal-title":"J. Comp. Neurol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1002\/ana.410330305","article-title":"Retinal ganglion cells in Alzheimer\u2019s disease and aging.","volume":"33","author":"Curcio","year":"1993","journal-title":"Ann. Neurol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1136\/bjophthalmol-2011-300344","article-title":"The oil spill in ageing Bruch membrane.","volume":"95","author":"Curcio","year":"2011","journal-title":"Br. J. Ophthalmol."},{"key":"B54","first-page":"3278","article-title":"Aging of the human photoreceptor mosaic: evidence for selective vulnerability of rods in central retina.","volume":"34","author":"Curcio","year":"1993","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1002\/cne.902920402","article-title":"Human photoreceptor topography.","volume":"292","author":"Curcio","year":"1990","journal-title":"J. Comp. Neurol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1126\/science.3576186","article-title":"Distribution of cones in human and monkey retina: individual variability and radial asymmetry.","volume":"236","author":"Curcio","year":"1987","journal-title":"Science"},{"key":"B57","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1002\/cne.903010310","article-title":"The dopaminergic amacrine cell.","volume":"301","author":"Dacey","year":"1990","journal-title":"J. Comp. Neurol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"2381","DOI":"10.1016\/0042-6989(96)00005-3","article-title":"Glia cells of the monkey retina\u2013II. M\u00fcller cells.","volume":"36","author":"Distler","year":"1996","journal-title":"Vis. Res."},{"key":"B59","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1002\/cne.903330111","article-title":"Glia cells of the monkey retina. I. Astrocytes.","volume":"333","author":"Distler","year":"1993","journal-title":"J. Comp. Neurol."},{"key":"B60","first-page":"1691","article-title":"Cell loss in the aging retina. Relationship to lipofuscin accumulation and macular degeneration.","volume":"30","author":"Dorey","year":"1989","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1002\/cne.903230106","article-title":"M\u00fcller cells in vascular and avascular retinae: a survey of seven mammals.","volume":"323","author":"Dreher","year":"1992","journal-title":"J. Comp. Neurol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"4698","DOI":"10.1074\/jbc.M115.698985","article-title":"Phototransduction influences metabolic flux and nucleotide metabolism in mouse retina.","volume":"291","author":"Du","year":"","journal-title":"J. Biol. Chem."},{"key":"B63","doi-asserted-by":"publisher","first-page":"14710","DOI":"10.1073\/pnas.1604572113","article-title":"Reductive carboxylation is a major metabolic pathway in the retinal pigment epithelium.","volume":"113","author":"Du","year":"","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1364\/BOE.2.001864","article-title":"Noninvasive imaging of the human rod photoreceptor mosaic using a confocal adaptive optics scanning ophthalmoscope.","volume":"2","author":"Dubra","year":"2011","journal-title":"Biomed. Opt. Express"},{"key":"B65","doi-asserted-by":"publisher","first-page":"2824","DOI":"10.1167\/iovs.06-1228","article-title":"Cellular reorganization in the human retina during normal aging.","volume":"48","author":"Eliasieh","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B66","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.visres.2016.06.015","article-title":"Distribution differences of macular cones measured by AOSLO: Variation in slope from fovea to periphery more pronounced than differences in total cones.","volume":"132","author":"Elsner","year":"2017","journal-title":"Vis. Res."},{"key":"B67","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/s0034-5687(01)00306-1","article-title":"Tissue oxygen tension and brain sensitivity to hypoxia.","volume":"128","author":"Ereci\u0144ska","year":"2001","journal-title":"Respir. Physiol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1136\/bjo.2007.131094","article-title":"Macular thickness decreases with age in normal eyes: a study on the macular thickness map protocol in the Stratus OCT.","volume":"93","author":"Eriksson","year":"2009","journal-title":"Br. J. Ophthalmol."},{"key":"B69","first-page":"1558","article-title":"Distribution patterns of photoreceptors, protein, and cyclic nucleotides in the human retina.","volume":"26","author":"Farber","year":"1985","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B70","doi-asserted-by":"publisher","first-page":"C456","DOI":"10.1152\/ajpcell.00259.2017","article-title":"PEDF expression affects the oxidative and inflammatory state of choroidal endothelial cells.","volume":"314","author":"Farnoodian","year":"2018","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B71","first-page":"498","article-title":"The fenestrations of the choriocapillaris in the presence of choroidal melanoma.","volume":"80","author":"Federman","year":"1982","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"B72","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/0002-9394(85)90625-7","article-title":"Age-related changes in the ultrastructure of Bruch\u2019s membrane.","volume":"100","author":"Feeney-Burns","year":"1985","journal-title":"Am. J. Ophthalmol."},{"key":"B73","first-page":"58","article-title":"Blood flow in the normal human retina.","volume":"30","author":"Feke","year":"1989","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1084\/jem.183.5.1981","article-title":"Vesiculo-vacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor, histamine, and serotonin.","volume":"183","author":"Feng","year":"1996","journal-title":"J. Exp. Med."},{"key":"B75","first-page":"2720","article-title":"Extraction of choriocapillaris hemodynamic data from ICG fluorescence angiograms.","volume":"34","author":"Flower","year":"1993","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B76","first-page":"1247","article-title":"Variability in choriocapillaris blood flow distribution.","volume":"36","author":"Flower","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B77","doi-asserted-by":"publisher","first-page":"5754","DOI":"10.1167\/iovs.17-22097","article-title":"The 3D retinal capillary circulation in pigs reveals a predominant serial organization.","volume":"58","author":"Fouquet","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B78","first-page":"999","article-title":"Pericyte coverage of retinal and cerebral capillaries.","volume":"31","author":"Frank","year":"1990","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B79","doi-asserted-by":"publisher","first-page":"305.e","DOI":"10.1016\/j.cell.2017.12.023","article-title":"Transmembrane Pickets Connect Cyto- and Pericellular Skeletons Forming Barriers to Receptor Engagement.","volume":"172","author":"Freeman","year":"2018","journal-title":"Cell"},{"key":"B80","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1111\/j.1432-1033.1991.tb16391.x","article-title":"Pericytes of the brain microvasculature express gamma-glutamyl transpeptidase.","volume":"202","author":"Frey","year":"1991","journal-title":"Eur. J. Biochem."},{"key":"B81","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0092-8240(78)80011-1","article-title":"A mathematical model of transmural transport of oxygen to the retina.","volume":"40","author":"Friedland","year":"1978","journal-title":"Bull. Math. Biol."},{"key":"B82","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1001\/archopht.1970.00990030097018","article-title":"Choroidal blood flow. Pressure-flow relationships.","volume":"83","author":"Friedman","year":"1970","journal-title":"Arch. Ophthalmol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/ng.3448","article-title":"A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.","volume":"48","author":"Fritsche","year":"2016","journal-title":"Nat. Genet."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mbs.2018.08.005","article-title":"Predicting retinal tissue oxygenation using an image-based theoretical model.","volume":"305","author":"Fry","year":"2018","journal-title":"Math. Biosci."},{"key":"B85","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/BF00915961","article-title":"Anatomical and functional choroidal lobuli.","volume":"18","author":"Fryczkowski","year":"1994","journal-title":"Int. Ophthalmol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1159\/000146586","article-title":"Scanning electron microscopy of human ocular vascular casts: the submacular choriocapillaris.","volume":"132","author":"Fryczkowski","year":"1988","journal-title":"Acta Anatomica"},{"key":"B87","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/BF00224463","article-title":"Observations on the lobular organization of the human choriocapillaris.","volume":"15","author":"Fryczkowski","year":"1991","journal-title":"Int. Ophthalmol."},{"key":"B88","first-page":"1","article-title":"Aging of the human retina. Differential loss of neurons and retinal pigment epithelial cells.","volume":"33","author":"Gao","year":"1992","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1097\/IAE.0000000000001784","article-title":"Considerations in the understanding of venous outflow in the retinal capillary plexus.","volume":"37","author":"Garrity","year":"2017","journal-title":"Retina"},{"key":"B90","first-page":"545","article-title":"The Ultrastructure of the Retinal Pigment Epithelium with Observations on the Choriocapillaris and Bruch\u2019s Membrane.","volume":"61","author":"Garron","year":"1963","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"B91","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1136\/bjo.65.1.23","article-title":"Aging and degeneration of the human macula. 1. Outer nuclear layer and photoreceptors.","volume":"65","author":"Gartner","year":"1981","journal-title":"Br. J. Ophthalmol."},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093485","article-title":"A comparison of spatial analysis methods for the construction of topographic maps of retinal cell density.","volume":"9","author":"Garza-Gisholt","year":"2014","journal-title":"PLoS One"},{"key":"B93","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0014-4835(91)90068-P","article-title":"Choroidal and Ciliary Body Blood Flow Analysis: Application of Laser Doppler Flowmetry in Experimental Animals.","volume":"53","author":"Gherezguiher","year":"1991","journal-title":"Exp. Eye Res."},{"key":"B94","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1080\/10739680801938289","article-title":"Theoretical models of microvascular oxygen transport to tissue.","volume":"15","author":"Goldman","year":"2008","journal-title":"Microcirculation"},{"key":"B95","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/nrn3723","article-title":"M\u00fcller glial cell reprogramming and retina regeneration.","volume":"15","author":"Goldman","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"B96","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1111\/j.1365-2796.2006.01625.x","article-title":"Vasculoprotective properties of the endothelial glycocalyx: effects of fluid shear stress.","volume":"259","author":"Gouverneur","year":"2006","journal-title":"J. Intern. Med."},{"key":"B97","doi-asserted-by":"publisher","first-page":"5705","DOI":"10.1167\/iovs.18-24677","article-title":"Human retinal pigment epithelium: in vivo cell morphometry, multispectral autofluorescence, and relationship to cone mosaic.","volume":"59","author":"Granger","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B98","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.exer.2019.02.018","article-title":"Ultrastructural analysis of submacular choriocapillaris and its transport systems in AMD and aged control eyes.","volume":"181","author":"Grebe","year":"2019","journal-title":"Exp. Eye Res."},{"key":"B99","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.shpsc.2016.12.003","article-title":"Biology meets physics: Reductionism and multi-scale modeling of morphogenesis.","volume":"61","author":"Green","year":"2017","journal-title":"Stud. Hist. Philos. Biol. Biomed. Sci."},{"key":"B100","doi-asserted-by":"publisher","first-page":"ORSF23","DOI":"10.1167\/iovs.13-12711","article-title":"Anatomic alterations in aging and age-related diseases of the eye.","volume":"54","author":"Grossniklaus","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B101","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1002\/cne.903480410","article-title":"Immunocytochemical analysis of bipolar cells in the macaque monkey retina.","volume":"348","author":"Gr\u00fcnert","year":"1994","journal-title":"J. Comp. Neurol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1001\/archopht.116.2.150","article-title":"Effect of aging on foveolar choroidal circulation.","volume":"116","author":"Grunwald","year":"1998","journal-title":"Arch. Ophthalmol."},{"key":"B103","first-page":"991","article-title":"Relaxation of retinal pericyte contractile tone through the nitric oxide-cyclic guanosine monophosphate pathway.","volume":"35","author":"Haefliger","year":"1994","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B104","doi-asserted-by":"publisher","first-page":"30661","DOI":"10.1073\/pnas.2010943117","article-title":"Label-free adaptive optics imaging of human retinal macrophage distribution and dynamics.","volume":"117","author":"Hammer","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B105","first-page":"775","article-title":"Increase in the advanced glycation end product pentosidine in Bruch\u2019s membrane with age.","volume":"40","author":"Handa","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B106","first-page":"2016","article-title":"Development and aging of cell topography in the human retinal pigment epithelium.","volume":"38","author":"Harman","year":"1997","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B107","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1002\/1097-0185(20001001)260:2<124::AID-AR20<3.0.CO;2-D","article-title":"Neuronal density in the human retinal ganglion cell layer from 16-77 years.","volume":"260","author":"Harman","year":"2000","journal-title":"Anat. Rec."},{"key":"B108","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/BF02368415","article-title":"Mathematical models of the spatial distribution of retinal oxygen tension and consumption, including changes upon illumination.","volume":"18","author":"Haugh","year":"1990","journal-title":"Ann. Biomed. Eng."},{"key":"B109","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1136\/bjo.46.4.212","article-title":"The ophthalmic artery: iii. branches.","volume":"46","author":"Hayreh","year":"1962","journal-title":"Br. J. Ophthalmol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1002\/bjs.18005022708","article-title":"Arteries of the orbit in the human being.","volume":"50","author":"Hayreh","year":"1963","journal-title":"Br. J. Surg."},{"key":"B111","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/BF00416866","article-title":"The long posterior ciliary arteries. An experimental study.","volume":"192","author":"Hayreh","year":"","journal-title":"Albrecht Von Graefes Arch. Klin. Exp. Ophthalmol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/BF00416865","article-title":"Submacular choroidal vascular pattern. Experimental fluorescein fundus angiographic studies.","volume":"192","author":"Hayreh","year":"","journal-title":"Albrecht Von Graefes Arch. Klin. Exp. Ophthalmol."},{"key":"B113","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF00416864","article-title":"The choriocapillaris.","volume":"192","author":"Hayreh","year":"","journal-title":"Albrecht Von Graefes Arch. Klin. Exp. Ophthalmol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1136\/bjo.59.11.631","article-title":"Segmental nature of the choroidal vasculature.","volume":"59","author":"Hayreh","year":"1975","journal-title":"Br. J. Ophthalmol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/eye.1990.39","article-title":"In vivo choroidal circulation and its watershed zones.","volume":"4","author":"Hayreh","year":"1990","journal-title":"Eye"},{"key":"B116","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1136\/bjo.46.3.165","article-title":"The ophthalmic artery: ii. intra-orbital course.","volume":"46","author":"Hayreh","year":"1962","journal-title":"Br. J. Ophthalmol."},{"key":"B117","first-page":"103","article-title":"Symposium on glaucoma: joint meeting with the National Society for the Prevention of Blindness. New observations on the radial peripapillary capillaries.","volume":"6","author":"Henkind","year":"1967","journal-title":"Invest. Ophthalmol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/0042-6989(89)90058-8","article-title":"The spatial resolution capacity of human foveal retina.","volume":"29","author":"Hirsch","year":"1989","journal-title":"Vision Res."},{"key":"B119","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/0042-6989(84)90060-9","article-title":"Quality of the primate photoreceptor lattice and limits of spatial vision.","volume":"24","author":"Hirsch","year":"1984","journal-title":"Vision Res."},{"key":"B120","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/978-3-642-68976-5_15","article-title":"\u201cThe eye in the elderly: lens,\u201d in","author":"Hockwin","year":"1984","journal-title":"Geriatrics 3"},{"key":"B121","first-page":"61","article-title":"Ultrastructure of the choroid. Its role in the pathogenesis of chorioretinal disease.","volume":"42","author":"Hogan","year":"1961","journal-title":"Trans. Pac. Coast Otoophthalmol. Soc. Annu. Meet."},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1967.00980020412022","article-title":"Studies on the human macula. IV. Aging changes in Bruch\u2019s Membrane.","volume":"77","author":"Hogan","year":"1967","journal-title":"Arch. Ophthalmol."},{"key":"B123","author":"Hogan","year":"1971","journal-title":"Histology of the human eye;: An atlas and textbook."},{"key":"B124","doi-asserted-by":"publisher","first-page":"1084\/212","DOI":"10.1016\/0002-9394(61)91797-4","article-title":"Electron microscopy of the human choroid. III. The blood vessels.","volume":"51","author":"Hogan","year":"1961","journal-title":"Am. J. Ophthalmol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/S0022-5320(63)80033-7","article-title":"The ultrastructure of the retinal blood vessels. I. The large vessels.","volume":"9","author":"Hogan","year":"","journal-title":"J. Ultrastruct. Res."},{"key":"B126","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0022-5320(63)80034-9","article-title":"The ultrastructure of the retinal vessels: II. The small vessels.","volume":"9","author":"Hogan","year":"","journal-title":"J. Ultrastruct. Res."},{"key":"B127","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0022-5320(63)80035-0","article-title":"The ultrastructure of the retinal vessels. III. Vascular-glial relationships.","volume":"9","author":"Hogan","year":"","journal-title":"J. Ultrastruct. Res."},{"key":"B128","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1001\/archopht.1994.01090150132035","article-title":"Analysis of lipid deposits extracted from human macular and peripheral Bruch\u2019s membrane.","volume":"112","author":"Holz","year":"1994","journal-title":"Arch. Ophthalmol."},{"key":"B129","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.preteyeres.2014.06.003","article-title":"Functional architecture of the retina: development and disease.","volume":"42","author":"Hoon","year":"2014","journal-title":"Prog. Retin. Eye Res."},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2020.100878","article-title":"Plexus-specific retinal vascular anatomy and pathologies as seen by projection-resolved optical coherence tomographic angiography.","volume":"2020","author":"Hormel","year":"2020","journal-title":"Prog. Retin. Eye Res."},{"key":"B131","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/978-1-4614-4711-5_4","article-title":"The inner blood-retinal barrier: molecular structure and transport biology.","volume":"763","author":"Hosoya","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"B132","doi-asserted-by":"publisher","first-page":"21745","DOI":"10.1016\/S0021-9258(18)54699-8","article-title":"Glycolytic enzymes and a GLUT-1 glucose transporter in the outer segments of rod and cone photoreceptor cells.","volume":"266","author":"Hsu","year":"1991","journal-title":"J. Biol. Chem."},{"key":"B133","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1126\/science.1957169","article-title":"Optical coherence tomography.","volume":"254","author":"Huang","year":"1991","journal-title":"Science"},{"key":"B134","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1097\/BOR.0b013e32835b137b","article-title":"The biology of the extracellular matrix: novel insights.","volume":"25","author":"Hubmacher","year":"2013","journal-title":"Curr. Opin. Rheumatol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/978-3-642-66468-7_11","article-title":"\u201cThe topography of vision in mammals of contrasting life style: comparative optics and retinal organisation,\u201d in","author":"Hughes","year":"1977","journal-title":"The visual system in vertebrates"},{"key":"B136","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1364\/josaa.19.000166","article-title":"Age-related alterations in the diffusional transport of amino acids across the human Bruch\u2019s-choroid complex.","volume":"19","author":"Hussain","year":"2002","journal-title":"J. Opt. Soc. Am. A Opt. Image Sci. Vis."},{"key":"B137","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.exer.2010.02.013","article-title":"Macromolecular diffusion characteristics of ageing human Bruch\u2019s membrane: implications for age-related macular degeneration (AMD).","volume":"90","author":"Hussain","year":"2010","journal-title":"Exp. Eye Res."},{"key":"B138","doi-asserted-by":"publisher","first-page":"5780","DOI":"10.1167\/iovs.16-20045","article-title":"Retinal Capillary Density and Foveal Avascular Zone Area Are Age-Dependent: Quantitative Analysis Using Optical Coherence Tomography Angiography.","volume":"57","author":"Iafe","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00024","article-title":"Glial Cells and Their Function in the Adult Brain: A Journey through the History of Their Ablation.","volume":"11","author":"J\u00e4kel","year":"2017","journal-title":"Front. Cell Neurosci."},{"key":"B140","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1016\/j.ophtha.2014.01.021","article-title":"Optical coherence tomography angiography of optic disc perfusion in glaucoma.","volume":"121","author":"Jia","year":"2014","journal-title":"Ophthalmology"},{"key":"B141","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1080\/02713680701550660","article-title":"Comparison of morphology of human macular and peripheral Bruch\u2019s membrane in older eyes.","volume":"32","author":"Johnson","year":"2007","journal-title":"Curr. Eye Res."},{"key":"B142","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1007\/BF00181769","article-title":"Count and density of human retinal photoreceptors.","volume":"230","author":"Jonas","year":"1992","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49121-0","article-title":"Fundamental differences in patterns of retinal ageing between primates and mice.","volume":"9","author":"Kam","year":"2019","journal-title":"Sci. Rep."},{"key":"B144","doi-asserted-by":"publisher","first-page":"H560","DOI":"10.1152\/ajpheart.00133.2005","article-title":"VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature.","volume":"290","author":"Kamba","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.28899","article-title":"Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye.","volume":"6","author":"Kanow","year":"2017","journal-title":"Elife"},{"key":"B146","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1136\/bjophthalmol-2013-303219","article-title":"Evaluation of retinal pigment epithelium-Bruch\u2019s membrane complex thickness in dry age-related macular degeneration using optical coherence tomography.","volume":"97","author":"Karampelas","year":"2013","journal-title":"Br. J. Ophthalmol."},{"key":"B147","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1097\/IAE.0000000000002037","article-title":"Three-dimensional analysis of retinal microaneurysms with adaptive optics optical coherence tomography.","volume":"39","author":"Karst","year":"2019","journal-title":"Retina"},{"key":"B148","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1136\/bjo.79.10.944","article-title":"Preparation of Bruch\u2019s membrane and analysis of the age-related changes in the structural collagens.","volume":"79","author":"Karwatowski","year":"1995","journal-title":"Br. J. Ophthalmol."},{"key":"B149","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.preteyeres.2017.07.002","article-title":"Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications.","volume":"60","author":"Kashani","year":"2017","journal-title":"Prog. Retin. Eye Res."},{"key":"B150","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-75847-3","author":"Keener","year":"2009","journal-title":"Mathematical Physiology"},{"key":"B151","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1006\/exer.1994.1047","article-title":"Choroidal myogenic autoregulation and intraocular pressure.","volume":"58","author":"Kiel","year":"1994","journal-title":"Exp. Eye Res."},{"key":"B152","first-page":"2399","article-title":"Autoregulation of choroidal blood flow in the rabbit.","volume":"33","author":"Kiel","year":"1992","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B153","first-page":"579","article-title":"Ocular perfusion pressure and choroidal blood flow in the rabbit.","volume":"36","author":"Kiel","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.11.085","article-title":"Retinal VEGFA maintains the ultrastructure and function of choriocapillaris by preserving the endothelial PLVAP.","volume":"2019","author":"Kim","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B155","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1097\/OPX.0000000000001031","article-title":"SD-OCT and Adaptive Optics Imaging of Outer Retinal Tubulation.","volume":"94","author":"King","year":"2017","journal-title":"Optom. Vis. Sci."},{"key":"B156","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/0002-9394(66)90243-1","article-title":"Regional and aging characteristics of the normal choriocapillaris in flat preparations. Preliminary remarks.","volume":"61","author":"Klien","year":"1966","journal-title":"Am. J. Ophthalmol."},{"key":"B157","first-page":"116","article-title":"Retinal vasculature in the aged.","volume":"40","author":"Kornzweig","year":"1964","journal-title":"Bull. N. Y. Acad. Med."},{"key":"B158","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1113\/jphysiol.1919.sp001844","article-title":"The supply of oxygen to the tissues and the regulation of the capillary circulation.","volume":"52","author":"Krogh","year":"1919","journal-title":"J. Physiol."},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.8.001803","article-title":"Adaptive optics optical coherence tomography angiography for morphometric analysis of choriocapillaris [Invited].","volume":"8","author":"Kurokawa","year":"2017","journal-title":"Biomed. Opt. Express"},{"key":"B160","doi-asserted-by":"publisher","first-page":"22796","DOI":"10.1364\/OE.20.022796","article-title":"Three-dimensional retinal and choroidal capillary imaging by power Doppler optical coherence angiography with adaptive optics.","volume":"20","author":"Kurokawa","year":"2012","journal-title":"Opt. Express"},{"key":"B161","first-page":"1049","article-title":"Retinal vascular patterns. VII. Acellular change.","volume":"4","author":"Kuwabara","year":"1965","journal-title":"Invest. Ophthalmol."},{"key":"B162","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1001\/archopht.1961.01840020710019","article-title":"Retinal vascular patterns. III. Age, hypertension, absolute glaucoma, injury.","volume":"65","author":"Kuwabara","year":"1961","journal-title":"Arch. Ophthalmol."},{"key":"B163","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.1093\/brain\/awq155","article-title":"Melanopsin retinal ganglion cells are resistant to neurodegeneration in mitochondrial optic neuropathies.","volume":"133","author":"La Morgia","year":"2010","journal-title":"Brain"},{"key":"B164","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1126\/science.2396104","article-title":"Principles of design of fluid transport systems in zoology.","volume":"249","author":"LaBarbera","year":"1990","journal-title":"Science"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2021.100951","article-title":"Retinal applications of swept source optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA).","volume":"84","author":"La\u00edns","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"B166","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1097\/IAE.0b013e3182a2f50c","article-title":"A lensing effect of inner retinal cysts on images of the photoreceptor mosaic.","volume":"34","author":"Langlo","year":"2014","journal-title":"Retina"},{"key":"B167","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1002\/ar.1091560403","article-title":"A comparative study of the autonomic innervation of the eye in monkey, cat, and rabbit.","volume":"156","author":"Laties","year":"1966","journal-title":"Anat. Rec."},{"key":"B168","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1097\/IAE.0000000000002413","article-title":"Vessel density of superficial, intermediate, and deep capillary plexuses using optical coherence tomography angiography.","volume":"39","author":"Lavia","year":"2019","journal-title":"Retina"},{"key":"B169","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s12551-013-0122-2","article-title":"Stochastic chemical kinetics: A review of the modelling and simulation approaches.","volume":"5","author":"Lecca","year":"2013","journal-title":"Biophys. Rev."},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0191141","article-title":"Distribution of cone density, spacing and arrangement in adult healthy retinas with adaptive optics flood illumination.","volume":"13","author":"Legras","year":"2018","journal-title":"PLoS One"},{"key":"B171","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1038\/s41591-019-0673-2","article-title":"Undulating changes in human plasma proteome profiles across the lifespan.","volume":"25","author":"Lehallier","year":"2019","journal-title":"Nat. Med."},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.47381","article-title":"The challenges of big data biology.","volume":"8","author":"Leonelli","year":"2019","journal-title":"Elife"},{"key":"B173","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1017\/S0960129507005944","article-title":"The discrete versus continuous controversy in physics.","volume":"17","author":"Lesne","year":"2007","journal-title":"Math. Struct. Comp. Sci."},{"key":"B174","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s10441-013-9170-z","article-title":"Multiscale analysis of biological systems.","volume":"61","author":"Lesne","year":"2013","journal-title":"Acta Biotheor."},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20030762","article-title":"Is Retinal Metabolic Dysfunction at the Center of the Pathogenesis of Age-related Macular Degeneration?","volume":"20","author":"L\u00e9veillard","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1016\/C2013-0-06523-1","author":"Levick","year":"2018","journal-title":"Levick\u2019s introduction to cardiovascular physiology"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12917-9","article-title":"Single-nuclei RNA-seq on human retinal tissue provides improved transcriptome profiling.","volume":"10","author":"Liang","year":"2019","journal-title":"Nat. Commun."},{"key":"B178","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1017\/S0022112072001557","article-title":"Physiological fluid dynamics: a survey?","volume":"52","author":"Lighthill","year":"1972","journal-title":"J. Fluid Mech."},{"key":"B179","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1167\/iovs.18-25864","article-title":"Age-Related Alterations in Retinal Tissue Perfusion and Volumetric Vessel Density.","volume":"60","author":"Lin","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B180","doi-asserted-by":"publisher","first-page":"15579","DOI":"10.1073\/pnas.1412441111","article-title":"Pyruvate kinase and aspartate-glutamate carrier distributions reveal key metabolic links between neurons and glia in retina.","volume":"111","author":"Lindsay","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B181","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1085\/jgp.99.2.177","article-title":"Oxygen distribution and consumption in the cat retina during normoxia and hypoxemia.","volume":"99","author":"Linsenmeier","year":"1992","journal-title":"J. Gen. Physiol."},{"key":"B182","first-page":"3117","article-title":"Metabolic dependence of photoreceptors on the choroid in the normal and detached retina.","volume":"41","author":"Linsenmeier","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B183","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.preteyeres.2017.01.003","article-title":"Retinal oxygen: from animals to humans.","volume":"58","author":"Linsenmeier","year":"2017","journal-title":"Prog. Retin. Eye Res."},{"key":"B184","doi-asserted-by":"publisher","first-page":"OCT533","DOI":"10.1167\/iovs.16-19106","article-title":"3D imaging of retinal pigment epithelial cells in the living human retina.","volume":"57","author":"Liu","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B185","doi-asserted-by":"publisher","first-page":"12803","DOI":"10.1073\/pnas.1711734114","article-title":"Imaging and quantifying ganglion cells and other transparent neurons in the living human retina.","volume":"114","author":"Liu","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B186","doi-asserted-by":"publisher","first-page":"H921","DOI":"10.1152\/ajpheart.01268.2005","article-title":"A novel mechanism for regulation of retinal blood flow by lactate: gap junctions, hypoxia, and pericytes.","volume":"290","author":"Lombard","year":"2006","journal-title":"Am. J. Physiol. Heart Circulat. Physiol."},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2018100811","article-title":"A single-cell transcriptome atlas of the adult human retina.","volume":"38","author":"Lukowski","year":"2019","journal-title":"EMBO J."},{"key":"B188","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1210\/endo.133.2.8344201","article-title":"Characterization of glucose transporter isoforms in the adult and developing human eye.","volume":"133","author":"Mantych","year":"1993","journal-title":"Endocrinology"},{"key":"B189","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.visres.2017.01.006","article-title":"Vision science and adaptive optics, the state of the field.","volume":"132","author":"Marcos","year":"2017","journal-title":"Vision Res."},{"key":"B190","author":"Marmor","year":"1998","journal-title":"The retinal pigment epithelium."},{"key":"B191","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1016\/S0002-9440(10)61231-X","article-title":"Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function.","volume":"167","author":"Marneros","year":"2005","journal-title":"Am. J. Pathol."},{"key":"B192","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/eye.1987.47","article-title":"The ageing retina: physiology or pathology.","volume":"1","author":"Marshall","year":"1987","journal-title":"Eye"},{"key":"B193","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1002\/cne.903230210","article-title":"Spatial density and immunoreactivity of bipolar cells in the macaque monkey retina.","volume":"323","author":"Martin","year":"1992","journal-title":"J. Comp. Neurol."},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-34102-6","article-title":"Visualizing large choroidal blood flow by subtraction of the choriocapillaris projection artifacts in swept source optical coherence tomography angiography in normal eyes.","volume":"8","author":"Maruko","year":"2018","journal-title":"Sci. Rep."},{"key":"B195","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.neuron.2012.10.002","article-title":"The neuronal organization of the retina.","volume":"76","author":"Masland","year":"2012","journal-title":"Neuron"},{"key":"B196","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/493473a","article-title":"Computing: A vision for data science.","volume":"493","author":"Mattmann","year":"2013","journal-title":"Nature"},{"key":"B197","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1152\/jappl.2001.91.5.2255","article-title":"A theoretical model for oxygen transport in skeletal muscle under conditions of high oxygen demand.","volume":"91","author":"McGuire","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"B198","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1152\/physrev.00012.2005","article-title":"Signaling mechanisms regulating endothelial permeability.","volume":"86","author":"Mehta","year":"2006","journal-title":"Physiol. Rev."},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12780-8","article-title":"Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration.","volume":"10","author":"Menon","year":"2019","journal-title":"Nat. Commun."},{"key":"B200","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.1364\/BOE.2.002189","article-title":"Observation of cone and rod photoreceptors in normal subjects and patients using a new generation adaptive optics scanning laser ophthalmoscope.","volume":"2","author":"Merino","year":"2011","journal-title":"Biomed. Opt. Express"},{"key":"B201","author":"Michaelson","year":"1956","journal-title":"Retinal Circulation in Man and Animals."},{"key":"B202","doi-asserted-by":"publisher","first-page":"16603","DOI":"10.1073\/pnas.1903336116","article-title":"In vivo imaging reveals transient microglia recruitment and functional recovery of photoreceptor signaling after injury.","volume":"116","author":"Miller","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B203","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/0014-4835(77)90090-2","article-title":"Active transport of ions across frog retinal pigment epithelium.","volume":"25","author":"Miller","year":"","journal-title":"Exp. Eye Res."},{"key":"B204","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/BF01868158","article-title":"Passive ionic properties of frog retinal pigment epithelium.","volume":"36","author":"Miller","year":"","journal-title":"J. Membr. Biol."},{"key":"B205","doi-asserted-by":"publisher","first-page":"L1179","DOI":"10.1152\/ajplung.00242.2003","article-title":"Caveolin regulation of endothelial function.","volume":"285","author":"Minshall","year":"2003","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"B206","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000304300","article-title":"Etude des capillaires de la r\u00e9tine et de la choriocapillaire au microscope \u00e9lectronique.","volume":"144","author":"Missotten","year":"1962","journal-title":"Ophthalmologica"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00253","article-title":"The emerging role of the mammalian glycocalyx in functional membrane organization and immune system regulation.","volume":"8","author":"M\u00f6ckl","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B208","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/360677a0","article-title":"The spatial arrangement of cones in the primate fovea.","volume":"360","author":"Mollon","year":"1992","journal-title":"Nature"},{"key":"B209","first-page":"2970","article-title":"The effect of age on the macromolecular permeability of human Bruch\u2019s membrane.","volume":"42","author":"Moore","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B210","first-page":"1290","article-title":"Age-related variation in the hydraulic conductivity of Bruch\u2019s membrane.","volume":"36","author":"Moore","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B211","doi-asserted-by":"publisher","first-page":"5847","DOI":"10.1167\/iovs.18-25301","article-title":"Segmentation of the Four-Layered Retinal Vasculature Using High-Resolution Optical Coherence Tomography Angiography Reveals the Microcirculation Unit.","volume":"59","author":"Muraoka","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.636330","article-title":"Intrinsically photosensitive retinal ganglion cells of the human retina.","volume":"12","author":"Mure","year":"2021","journal-title":"Front. Neurol."},{"key":"B213","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.micron.2012.01.011","article-title":"Ultrastructure of the human retina in aging and various pathological states.","volume":"43","author":"Nag","year":"2012","journal-title":"Micron"},{"key":"B214","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1001\/archopht.1964.00970020380016","article-title":"The ultrastructure of bruch\u2019s membrane. I. Human, Monkey, Rabbit, Guinea Pig, and Rat eyes.","volume":"72","author":"Nakaizumi","year":"1964","journal-title":"Arch. Ophthalmol."},{"key":"B215","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1001\/archopht.1964.00970020395018","article-title":"The ultrastructure of bruch\u2019s membrane. III. The macular area of the human eye.","volume":"72","author":"Nakaizumi","year":"1964","journal-title":"Arch. Ophthalmol."},{"key":"B216","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.1167\/iovs.15-17934","article-title":"Albumen transport to bruch\u2019s membrane and RPE by choriocapillaris caveolae.","volume":"57","author":"Nakanishi","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B217","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1111\/ceo.12952","article-title":"Glucose metabolism in mammalian photoreceptor inner and outer segments.","volume":"45","author":"Narayan","year":"2017","journal-title":"Clin. Exp. Ophthalmol."},{"key":"B218","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1002\/cne.24176","article-title":"Melanopsin-expressing ganglion cells in human retina: Morphology, distribution, and synaptic connections.","volume":"527","author":"Nasir-Ahmad","year":"2019","journal-title":"J. Comp. Neurol."},{"key":"B219","doi-asserted-by":"publisher","first-page":"3858","DOI":"10.1167\/iovs.18-24710","article-title":"Human parafoveal capillary vascular anatomy and connectivity revealed by optical coherence tomography angiography.","volume":"59","author":"Nesper","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B220","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1242\/jeb.017574","article-title":"Energy limitation as a selective pressure on the evolution of sensory systems.","volume":"211","author":"Niven","year":"2008","journal-title":"J. Exp. Biol."},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67829-2","article-title":"Normal aging changes in the choroidal angioarchitecture of the macula.","volume":"10","author":"Nivison-Smith","year":"2020","journal-title":"Sci. Rep."},{"key":"B222","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/eye.1990.38","article-title":"Functional anatomy of the choroidal circulation: methyl methacrylate casting of human choroid.","volume":"4","author":"Olver","year":"1990","journal-title":"Eye"},{"key":"B223","doi-asserted-by":"publisher","first-page":"1246.e","DOI":"10.1016\/j.celrep.2019.12.082","article-title":"Integration of eQTL and a Single-Cell Atlas in the Human Eye Identifies Causal Genes for Age-Related Macular Degeneration.","volume":"30","author":"Orozco","year":"2020","journal-title":"Cell Rep."},{"key":"B224","first-page":"1","article-title":"Topography of the layer of rods and cones in the human retina.","volume":"31","author":"Osterberg","year":"1935","journal-title":"Acta Ophthalmol."},{"key":"B225","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1016\/j.visres.2010.10.020","article-title":"Aging and vision.","volume":"51","author":"Owsley","year":"2011","journal-title":"Vision Res."},{"key":"B226","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/978-1-4615-3390-0_9","article-title":"\u201cAging and spatial contrast sensitivity: underlying mechanisms and implications for everyday life,\u201d in","author":"Owsley","year":"1991","journal-title":"The changing visual system"},{"key":"B227","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1001\/jama.279.14.1083","article-title":"Visual processing impairment and risk of motor vehicle crash among older adults.","volume":"279","author":"Owsley","year":"1998","journal-title":"JAMA"},{"key":"B228","author":"Oyster","year":"1999","journal-title":"The Human Eye: Structure and Function."},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.1186\/s40246-021-00359-8","article-title":"Protective chromosome 1q32 haplotypes mitigate risk for age-related macular degeneration associated with the CFH-CFHR5 and ARMS2\/HTRA1 loci.","volume":"15","author":"Pappas","year":"2021","journal-title":"Hum. Genomics"},{"key":"B230","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.exer.2012.12.011","article-title":"A study of factors affecting the human cone photoreceptor density measured by adaptive optics scanning laser ophthalmoscope.","volume":"108","author":"Park","year":"2013","journal-title":"Exp. Eye Res."},{"key":"B231","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0161-6420(90)32619-2","article-title":"Aging changes in Bruch\u2019s membrane. A histochemical and morphologic study.","volume":"97","author":"Pauleikhoff","year":"1990","journal-title":"Ophthalmology"},{"key":"B232","doi-asserted-by":"publisher","first-page":"1222.e","DOI":"10.1016\/j.cell.2019.01.004","article-title":"Molecular classification and comparative taxonomics of foveal and peripheral cells in primate retina.","volume":"176","author":"Peng","year":"2019","journal-title":"Cell"},{"key":"B233","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1038\/nature05193","article-title":"Bidirectional control of CNS capillary diameter by pericytes.","volume":"443","author":"Peppiatt","year":"2006","journal-title":"Nature"},{"key":"B234","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1117\/12.230729","article-title":"Aging changes in the optical elements of the eye.","volume":"1","author":"Pierscionek","year":"1996","journal-title":"J. Biomed. Opt."},{"key":"B235","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/BF00234169","article-title":"Structure and permeability to ferritin of the choriocapillary endothelium of the rat eye.","volume":"208","author":"Pino","year":"1980","journal-title":"Cell Tissue Res."},{"key":"B236","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1177\/29.2.7252121","article-title":"Permeability of rat choriocapillaris to hemeproteins. Restriction of tracers by a fenestrated endothelium.","volume":"29","author":"Pino","year":"1981","journal-title":"J. Histochem. Cytochem."},{"key":"B237","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1177\/31.3.6827079","article-title":"Vascular permeability in the rat eye to endogenous albumin and immunoglobulin G (IgG) examined by immunohistochemical methods.","volume":"31","author":"Pino","year":"1983","journal-title":"J. Histochem. Cytochem."},{"key":"B238","author":"Polyak","year":"1941","journal-title":"The Retina."},{"key":"B239","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.preteyeres.2008.02.002","article-title":"Regulation of retinal blood flow in health and disease.","volume":"27","author":"Pournaras","year":"2008","journal-title":"Prog. Retin. Eye Res."},{"key":"B240","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1136\/bjo.2011.204222","article-title":"Basement membrane changes in capillaries of the ageing human retina.","volume":"95","author":"Powner","year":"2011","journal-title":"Br. J. Ophthalmol."},{"key":"B241","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/s1350-9462(01)00012-x","article-title":"Development of the primate retinal vasculature.","volume":"20","author":"Provis","year":"2001","journal-title":"Prog. Retin. Eye Res."},{"key":"B242","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1136\/bjophthalmol-2014-305455","article-title":"Appearance of medium-large drusen and reticular pseudodrusen on adaptive optics in age-related macular degeneration.","volume":"98","author":"Querques","year":"2014","journal-title":"Br. J. Ophthalmol."},{"key":"B243","first-page":"2857","article-title":"Morphometric analysis of Bruch\u2019s membrane, the choriocapillaris, and the choroid in aging.","volume":"35","author":"Ramrattan","year":"1994","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B244","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/s0014-4835(77)80009-2","article-title":"The structural basis of the blood-ocular barriers.","volume":"25","author":"Raviola","year":"1977","journal-title":"Exp. Eye Res."},{"key":"B245","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/1350-9462(95)00008-9","article-title":"Phylogenetic constraints on retinal organisation and development.","volume":"15","author":"Reichenbach","year":"1995","journal-title":"Prog. Retin. Eye Res."},{"key":"B246","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1007\/978-3-642-68976-5_12","article-title":"\u201cThe eye in the aging patient: cornea,\u201d in","author":"Reim","year":"1984","journal-title":"Geriatrics 3"},{"key":"B247","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.preteyeres.2017.12.001","article-title":"Neural control of choroidal blood flow.","volume":"64","author":"Reiner","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"B248","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1001\/archopht.1967.00980030433005","article-title":"Observations on the anatomy and pathology of the choroidal vasculature.","volume":"78","author":"Ring","year":"1967","journal-title":"Arch. Ophthalmol."},{"key":"B249","first-page":"1124","article-title":"Blood velocity and volumetric flow rate in human retinal vessels.","volume":"26","author":"Riva","year":"1985","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B250","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1002\/cne.903210106","article-title":"Spatial density and distribution of choline acetyltransferase immunoreactive cells in human, macaque, and baboon retinas.","volume":"321","author":"Rodieck","year":"1992","journal-title":"J. Comp. Neurol."},{"key":"B251","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1007\/978-3-642-68976-5_13","article-title":"\u201cAge-Related Changes in the Anterior Segment of the Eye,\u201d in","author":"Rohen","year":"1984","journal-title":"Geriatrics 3"},{"key":"B252","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1111\/j.1460-9568.1989.tb00349.x","article-title":"Horizontal Cells in the Monkey Retina: Immunocytochemical staining with antibodies against calcium binding proteins.","volume":"1","author":"R\u00f6hrenbeck","year":"1989","journal-title":"Eur. J. Neurosci."},{"key":"B253","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1038\/17383","article-title":"The arrangement of the three cone classes in the living human eye.","volume":"397","author":"Roorda","year":"1999","journal-title":"Nature"},{"key":"B254","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0209276","article-title":"Thickness of retina and choroid in the elderly population and its association with Complement Factor H polymorphism: KLoSHA Eye study.","volume":"13","author":"Ryoo","year":"2018","journal-title":"PLoS One"},{"key":"B255","author":"Salzman","year":"1912","journal-title":"The Anatomy and Histology of the Human Eyeball in the Normal State, Its Development and Senescence."},{"key":"B256","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1364\/BOE.9.001323","article-title":"Enhanced retinal vasculature imaging with a rapidly configurable aperture.","volume":"9","author":"Sapoznik","year":"2018","journal-title":"Biomed. Opt. Express"},{"key":"B257","doi-asserted-by":"publisher","DOI":"10.1186\/2040-2384-2-14","article-title":"Physiologic upper limits of pore size of different blood capillary types and another perspective on the dual pore theory of microvascular permeability.","volume":"2","author":"Sarin","year":"2010","journal-title":"J. Angiogenes Res."},{"key":"B258","doi-asserted-by":"publisher","first-page":"F947","DOI":"10.1152\/ajprenal.90601.2008","article-title":"Glomerular endothelial cell fenestrations: an integral component of the glomerular filtration barrier.","volume":"296","author":"Satchell","year":"2009","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"B259","doi-asserted-by":"publisher","first-page":"4244","DOI":"10.1167\/iovs.14-14542","article-title":"In vivo imaging of human cone photoreceptor inner segments.","volume":"55","author":"Scoles","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B260","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1093\/imammb\/dqv031","article-title":"A Green\u2019s function method for simulation of time-dependent solute transport and reaction in realistic microvascular geometries.","volume":"33","author":"Secomb","year":"2016","journal-title":"Math. Med. Biol."},{"key":"B261","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1114\/b:abme.0000049036.08817.44","article-title":"Green\u2019s function methods for analysis of oxygen delivery to tissue by microvascular networks.","volume":"32","author":"Secomb","year":"2004","journal-title":"Ann. Biomed. Eng."},{"key":"B262","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/s0014-4835(66)80011-8","article-title":"Studies on the permeability of the blood-retinal barrier. IV. Junctional complexes of the retinal vessels and their role in the permeability of the blood-retinal barrier.","volume":"5","author":"Shakib","year":"1966","journal-title":"Exp. Eye Res."},{"key":"B263","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1096\/fasebj.7.11.8370472","article-title":"Pericyte physiology.","volume":"7","author":"Shepro","year":"1993","journal-title":"FASEB J."},{"key":"B264","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1111\/ceo.12373","article-title":"Quantum biology of the retina.","volume":"42","author":"Sia","year":"2014","journal-title":"Clin. Exp. Ophthalmol."},{"key":"B265","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1002\/jemt.10086","article-title":"Transcytosis of plasma macromolecules in endothelial cells: a cell biological survey.","volume":"57","author":"Simionescu","year":"2002","journal-title":"Microsc. Res. Tech."},{"key":"B266","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1523\/JNEUROSCI.12-04-01169.1992","article-title":"Neural-vascular relationships in central retina of macaque monkeys (Macaca fascicularis).","volume":"12","author":"Snodderly","year":"1992","journal-title":"J. Neurosci."},{"key":"B267","doi-asserted-by":"publisher","first-page":"7376","DOI":"10.1167\/iovs.11-7199","article-title":"Variation of cone photoreceptor packing density with retinal eccentricity and age.","volume":"52","author":"Song","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B268","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.ajo.2016.07.023","article-title":"Choriocapillaris flow features follow a power law distribution: implications for characterization and mechanisms of disease progression.","volume":"170","author":"Spaide","year":"2016","journal-title":"Am. J. Ophthalmol."},{"key":"B269","first-page":"98","article-title":"Fracture faces of fenestrations and junctions of endothelial cells in human choroidal vessels.","volume":"14","author":"Spitznas","year":"1975","journal-title":"Int. Ophthalmol."},{"key":"B270","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/S0039-6257(99)00086-7","article-title":"Histologic and morphometric analysis of the choroid, Bruch\u2019s membrane, and retinal pigment epithelium in postmortem eyes with age-related macular degeneration and histologic examination of surgically excised choroidal neovascular membranes.","volume":"44","author":"Spraul","year":"1999","journal-title":"Surv. Ophthalmol."},{"key":"B271","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/s0042-6989(02)00022-6","article-title":"Morphometric changes of the choriocapillaris and the choroidal vasculature in eyes with advanced glaucomatous changes.","volume":"42","author":"Spraul","year":"2002","journal-title":"Vision Res."},{"key":"B272","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.bbamcr.2005.08.008","article-title":"Structure of caveolae.","volume":"1746","author":"Stan","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"B273","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1111\/j.1582-4934.2007.00075.x","article-title":"Endothelial stomatal and fenestral diaphragms in normal vessels and angiogenesis.","volume":"11","author":"Stan","year":"2007","journal-title":"J. Cell Mol. Med."},{"key":"B274","first-page":"762","article-title":"Localization of the site of major resistance to fluid transport in Bruch\u2019s membrane.","volume":"38","author":"Starita","year":"1997","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B275","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1136\/bjo.50.1.21","article-title":"Normal retinal vascular pattern. Arteriovenous ratio as a measure of arterial calibre.","volume":"50","author":"Stokoe","year":"1966","journal-title":"Br. J. Ophthalmol."},{"key":"B276","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1001\/archopht.118.2.211","article-title":"Choroidal laser Doppler flowmetry in healthy subjects.","volume":"118","author":"Straubhaar","year":"2000","journal-title":"Arch. Ophthalmol."},{"key":"B277","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1152\/physrev.00021.2004","article-title":"The retinal pigment epithelium in visual function.","volume":"85","author":"Strauss","year":"2005","journal-title":"Physiol. Rev."},{"key":"B278","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1001\/archopht.1969.00990010385017","article-title":"Development of the human retinal pigment epithelium and the posterior segment.","volume":"81","author":"Streeten","year":"1969","journal-title":"Arch. Ophthalmol."},{"key":"B279","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.preteyeres.2010.03.005","article-title":"Complexity of retinal cone bipolar cells.","volume":"29","author":"Strettoi","year":"2010","journal-title":"Prog. Retin. Eye Res."},{"key":"B280","doi-asserted-by":"publisher","first-page":"5728","DOI":"10.1167\/iovs.12-10017","article-title":"Quantitative confocal imaging of the retinal microvasculature in the human retina.","volume":"53","author":"Tan","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B281","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1038\/s41563-018-0241-z","article-title":"Avoiding common pitfalls in machine learning omic data science.","volume":"18","author":"Teschendorff","year":"2019","journal-title":"Nat. Mater."},{"key":"B282","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.5.27","article-title":"Differences in blood flow between superior and inferior retinal hemispheres.","volume":"61","author":"Tomita","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B283","article-title":"\u201cChoroid and Suprachoroid,\u201d in","author":"Torczynski","year":"1982","journal-title":"Ocular anatomy, embryology, and teratology"},{"key":"B284","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/0002-9394(76)90298-1","article-title":"The architecture of the choriocapillaris at the posterior pole.","volume":"81","author":"Torczynski","year":"1976","journal-title":"Am. J. Ophthalmol."},{"key":"B285","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1038\/eye.1990.41","article-title":"Permeability of ocular vessels and transport across the blood-retinal-barrier.","volume":"4","author":"T\u00f6rnquist","year":"1990","journal-title":"Eye"},{"key":"B286","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1001\/archopht.1961.01840020577022","article-title":"Retinal vascular patterns. II. Human retinal vessels studied in three dimensions.","volume":"65","author":"Toussaint","year":"1961","journal-title":"Arch. Ophthalmol."},{"key":"B287","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/0306-4522(93)90473-s","article-title":"The role of M\u00fcller cells in the formation of the blood-retinal barrier.","volume":"55","author":"Tout","year":"1993","journal-title":"Neuroscience"},{"key":"B288","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12006-1","article-title":"Formalin fixation and cryosectioning cause only minimal changes in shape or size of ocular tissues.","volume":"7","author":"Tran","year":"2017","journal-title":"Sci. Rep."},{"key":"B289","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-79424-6","article-title":"Modelling normal age-related changes in individual retinal layers using location-specific OCT analysis.","volume":"11","author":"Trinh","year":"2021","journal-title":"Sci. Rep."},{"key":"B290","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1001\/archopht.1968.00980050216012","article-title":"The retinal pigment epithelium. 3. Growth and development.","volume":"80","author":"Ts\u2019o","year":"1968","journal-title":"Arch. Ophthalmol."},{"key":"B291","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1016\/0042-6989(92)90042-h","article-title":"Gap junctions between the pedicles of macaque foveal cones.","volume":"32","author":"Tsukamoto","year":"1992","journal-title":"Vision Res."},{"key":"B292","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1152\/physiol.00027.2004","article-title":"The molecular physiology of tight junction pores.","volume":"19","author":"Van Itallie","year":"2004","journal-title":"Physiology"},{"key":"B293","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2015.06.003","article-title":"Glia-neuron interactions in the mammalian retina.","volume":"51","author":"Vecino","year":"2016","journal-title":"Prog. Retin. Eye Res."},{"key":"B294","doi-asserted-by":"publisher","DOI":"10.1016\/j.mbs.2021.108650","article-title":"Physics-based modeling of Age-related Macular Degeneration-A theoretical approach to quantify retinal and choroidal contributions to macular oxygenation.","volume":"339","author":"Verticchio Vercellin","year":"2021","journal-title":"Math. Biosci."},{"key":"B295","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2021.656000","article-title":"A metabolic landscape for maintaining retina integrity and function.","volume":"14","author":"Viegas","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"B296","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/S0161-6420(87)80009-X","article-title":"Anterior segment ischemia after recession of various recti. An experimental study.","volume":"94","author":"Virdi","year":"1987","journal-title":"Ophthalmology"},{"key":"B297","doi-asserted-by":"publisher","first-page":"24100","DOI":"10.1073\/pnas.1914143116","article-title":"Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration.","volume":"116","author":"Voigt","year":"","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B298","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddab140","article-title":"Human photoreceptor cells from different macular subregions have distinct transcriptional profiles.","volume":"2021","author":"Voigt","year":"2021","journal-title":"Hum. Mol. Genet."},{"key":"B299","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.exer.2019.05.001","article-title":"Molecular characterization of foveal versus peripheral human retina by single-cell RNA sequencing.","volume":"184","author":"Voigt","year":"","journal-title":"Exp. Eye Res."},{"key":"B300","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1111\/aos.13337","article-title":"Macular thickness in healthy eyes of adults (N = 4508) and relation to sex, age and refraction: the Troms\u00f8 Eye Study (2007-2008).","volume":"95","author":"von Hanno","year":"2017","journal-title":"Acta Ophthalmol."},{"key":"B301","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144156","article-title":"Correlation of Aging and Segmental Choroidal Thickness Measurement using Swept Source Optical Coherence Tomography in Healthy Eyes.","volume":"10","author":"Wakatsuki","year":"2015","journal-title":"PLoS One"},{"key":"B302","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1001\/archopht.1937.00850120046005","article-title":"Significance of the foveal depression.","volume":"18","author":"Walls","year":"1937","journal-title":"Arch. Ophthalmol."},{"key":"B303","author":"Walls","year":"1942","journal-title":"The vertebrate eye and its adaptive radiation."},{"key":"B304","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/s0025-5564(01)00074-8","article-title":"Capillary supply regions.","volume":"173","author":"Wang","year":"2001","journal-title":"Math. Biosci."},{"key":"B305","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-020-01591-x","article-title":"Visualization of deep choroidal vasculatures and measurement of choroidal vascular density: a swept-source optical coherence tomography angiography approach.","volume":"20","author":"Wang","year":"2020","journal-title":"BMC Ophthalmol."},{"key":"B306","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.7.6.25","article-title":"Visualization of Choriocapillaris and Choroidal Vasculature in Healthy Eyes With En Face Swept-Source Optical Coherence Tomography Versus Angiography.","volume":"7","author":"Wang","year":"2018","journal-title":"Transl. Vis. Sci. Technol."},{"key":"B307","first-page":"48","article-title":"Glucose metabolism in cat outer retina. Effects of light and hyperoxia.","volume":"38","author":"Wang","year":"1997","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B308","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1007\/s13238-020-00791-x","article-title":"Deciphering primate retinal aging at single-cell resolution.","volume":"12","author":"Wang","year":"2020","journal-title":"Protein Cell"},{"key":"B309","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.47148","article-title":"Human foveal cone photoreceptor topography and its dependence on eye length.","volume":"8","author":"Wang","year":"2019","journal-title":"Elife"},{"key":"B310","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1111\/j.1460-9568.1989.tb00350.x","article-title":"Horizontal Cells in the Monkey Retina: Cone connections and dendritic network.","volume":"1","author":"W\u00e4ssle","year":"1989","journal-title":"Eur. J. Neurosci."},{"key":"B311","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1002\/cne.903610315","article-title":"The rod pathway of the macaque monkey retina: identification of AII-amacrine cells with antibodies against calretinin.","volume":"361","author":"W\u00e4ssle","year":"1995","journal-title":"J. Comp. Neurol."},{"key":"B312","doi-asserted-by":"publisher","first-page":"133","DOI":"10.3109\/02713689308999481","article-title":"Morphometric analysis of human retinal pigment epithelium: correlation with age and location.","volume":"12","author":"Watzke","year":"1993","journal-title":"Curr. Eye Res."},{"key":"B313","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/0278-4327(86)90005-2","article-title":"Chapter 2 Retinal senescence.","volume":"5","author":"Weale","year":"1986","journal-title":"Prog. Retin. Res."},{"key":"B314","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.survophthal.2018.03.003","article-title":"Assessment of flow dynamics in retinal and choroidal microcirculation.","volume":"63","author":"Wei","year":"2018","journal-title":"Surv. Ophthalmol."},{"key":"B315","doi-asserted-by":"publisher","first-page":"3804","DOI":"10.1167\/iovs.17-21460","article-title":"Age-Related Alterations in the Retinal Microvasculature, Microcirculation, and Microstructure.","volume":"58","author":"Wei","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B316","first-page":"327","article-title":"Control of intraocular blood flow. I. Intraocular pressure.","volume":"12","author":"Weiter","year":"1973","journal-title":"Invest. Ophthalmol."},{"key":"B317","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1117\/1.JBO.23.3.036003","article-title":"Volumetric imaging of rod and cone photoreceptor structure with a combined adaptive optics-optical coherence tomography-scanning laser ophthalmoscope.","volume":"23","author":"Wells-Gray","year":"2018","journal-title":"J. Biomed. Opt."},{"key":"B318","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1126\/science.276.5309.122","article-title":"A general model for the origin of allometric scaling laws in biology.","volume":"276","author":"West","year":"1997","journal-title":"Science"},{"key":"B319","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2103617118","article-title":"Chromosome 10q26-driven age-related macular degeneration is associated with reduced levels of HTRA1 in human retinal pigment epithelium.","volume":"118","author":"Williams","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B320","first-page":"3183","article-title":"Energy metabolism in human retinal M\u00fcller cells.","volume":"41","author":"Winkler","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B321","author":"Wise","year":"1975","journal-title":"The Retinal Circulation."},{"key":"B322","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1016\/j.ajpath.2015.11.019","article-title":"Plasmalemma Vesicle-Associated Protein Has a Key Role in Blood-Retinal Barrier Loss.","volume":"186","author":"Wisniewska-Kruk","year":"2016","journal-title":"Am. J. Pathol."},{"key":"B323","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1016\/0002-9394(56)91048-0","article-title":"The pericytes of the choroid of the human eye.","volume":"41","author":"Wolter","year":"1956","journal-title":"Am. J. Ophthalmol."},{"key":"B324","doi-asserted-by":"publisher","first-page":"99","DOI":"10.2147\/EB.S9078","article-title":"Energy metabolism of the visual system.","volume":"2","author":"Wong-Riley","year":"2010","journal-title":"Eye Brain"},{"key":"B325","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1136\/bjo.38.9.513","article-title":"Vascular anatomy of the choroid in relation to selective localization of ocular disease.","volume":"38","author":"Wybar","year":"1954","journal-title":"Br. J. Ophthalmol."},{"key":"B326","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-66092-9","article-title":"Cell atlas of the human fovea and peripheral retina.","volume":"10","author":"Yan","year":"2020","journal-title":"Sci. Rep."},{"key":"B327","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwaa179","article-title":"A single-cell transcriptome atlas of the aging human and macaque retina.","volume":"2020","author":"Yi","year":"2020","journal-title":"Natl. Sci. Rev"},{"key":"B328","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF00127637","article-title":"Patterns of the choriocapillaris. A method to study the choroidal vasculature of the enucleated human eye.","volume":"6","author":"Yoneya","year":"1983","journal-title":"Int. Ophthalmol."},{"key":"B329","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1083\/jcb.49.2.303","article-title":"The renewal of rod and cone outer segments in the rhesus monkey.","volume":"49","author":"Young","year":"1971","journal-title":"J. Cell Biol."},{"key":"B330","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S1350-9462(00)00027-6","article-title":"Oxygen distribution and consumption within the retina in vascularised and avascular retinas and in animal models of retinal disease.","volume":"20","author":"Yu","year":"2001","journal-title":"Prog. Retin. Eye Res."},{"key":"B331","doi-asserted-by":"publisher","first-page":"4728","DOI":"10.1167\/iovs.05-0694","article-title":"Intraretinal oxygen distribution in the monkey retina and the response to systemic hyperoxia.","volume":"46","author":"Yu","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B332","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.preteyeres.2019.01.001","article-title":"Retinal capillary perfusion: Spatial and temporal heterogeneity.","volume":"70","author":"Yu","year":"2019","journal-title":"Prog. Retin. Eye Res."},{"key":"B333","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.10.1.29","article-title":"Use of the retinal vascular histology to validate an optical coherence tomography angiography technique.","volume":"10","author":"Yu","year":"2021","journal-title":"Transl. Vis. Sci. Technol."},{"key":"B334","author":"Zhang","year":"2008","journal-title":"Visual function declines during normal aging."},{"key":"B335","doi-asserted-by":"publisher","first-page":"290.e","DOI":"10.1016\/j.ajo.2015.04.034","article-title":"Variability in human cone topography assessed by adaptive optics scanning laser ophthalmoscopy.","volume":"160","author":"Zhang","year":"2015","journal-title":"Am. J. Ophthalmol."},{"key":"B336","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001504","article-title":"Dynamism of dot subretinal drusenoid deposits in age-related macular degeneration demonstrated with adaptive optics imaging.","volume":"2017","author":"Zhang","year":"2017","journal-title":"Retina"},{"key":"B337","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.ajo.2018.12.025","article-title":"Age-Dependent Changes in the Macular Choriocapillaris of Normal Eyes Imaged with Swept-Source OCT Angiography.","volume":"200","author":"Zheng","year":"2019","journal-title":"Am. J. Ophthalmol."},{"key":"B338","doi-asserted-by":"publisher","first-page":"4151","DOI":"10.1167\/iovs.10-6940","article-title":"Noninvasive measurements and analysis of blood velocity profiles in human retinal vessels.","volume":"52","author":"Zhong","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B339","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/nrm.2016.80","article-title":"Tight junctions: from simple barriers to multifunctional molecular gates.","volume":"17","author":"Zihni","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B340","first-page":"4628","article-title":"Computational analysis of the impact of a reduction of the blood flow in large choroidal arteries on the function of the choriocapillaris.","volume":"57","author":"Zouache","year":"","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B341","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-78059-x","article-title":"Macular retinal thickness differs markedly in age-related macular degeneration driven by risk polymorphisms on chromosomes 1 and 10.","volume":"10","author":"Zouache","year":"2020","journal-title":"Sci. Rep."},{"key":"B342","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1017\/jfm.2015.243","article-title":"Blood flow in the choriocapillaris.","volume":"774","author":"Zouache","year":"2015","journal-title":"J. Fluid Mech."},{"key":"B343","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151490","article-title":"Allometry and scaling of the intraocular pressure and aqueous humour flow rate in vertebrate eyes.","volume":"11","author":"Zouache","year":"","journal-title":"PLoS One"},{"key":"B344","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1017\/jfm.2018.771","article-title":"Flow and passive transport in planar multipolar flows.","volume":"858","author":"Zouache","year":"2019","journal-title":"J. Fluid Mech."},{"key":"B345","doi-asserted-by":"publisher","DOI":"10.1038\/srep35754","article-title":"Form, shape and function: segmented blood flow in the choriocapillaris.","volume":"6","author":"Zouache","year":"","journal-title":"Sci. Rep."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2022.778404\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T02:14:04Z","timestamp":1645755244000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2022.778404\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,25]]},"references-count":345,"alternative-id":["10.3389\/fnagi.2022.778404"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2022.778404","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,25]]},"article-number":"778404"}}