{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T00:26:46Z","timestamp":1793665606954,"version":"4.5.1"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T00:00:00Z","timestamp":1644796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate the diagnostic accuracy of cerebrospinal fluid (CSF) biomarkers in patients with probable cerebral amyloid angiopathy (CAA) according to the modified Boston criteria in a retrospective multicentric cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Beta-amyloid 1-40 (A\u03b240), beta-amyloid 1-42 (A\u03b242), total tau (t-tau), and phosphorylated tau 181 (p-tau\n                      <jats:sup>181<\/jats:sup>\n                      ) were measured in 31 patients with probable CAA, 28 patients with Alzheimer\u2019s disease (AD), and 30 controls. Receiver-operating characteristics (ROC) analyses were performed for the measured parameters as well as the A\u03b242\/40 ratio to estimate diagnostic parameters. A meta-analysis of all amenable published studies was conducted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In our data A\u03b242\/40 (AUC 0.88) discriminated best between CAA and controls while A\u03b240 did not perform well (AUC 0.63). Differentiating between CAA and AD, p-tau\n                      <jats:sup>181<\/jats:sup>\n                      (AUC 0.75) discriminated best in this study while A\u03b240 (AUC 0.58) and A\u03b242 (AUC 0.54) provided no discrimination. In the meta-analysis, A\u03b242\/40 (AUC 0.90) showed the best discrimination between CAA and controls followed by t-tau (AUC 0.79), A\u03b240 (AUC 0.76), and p-tau\n                      <jats:sup>181<\/jats:sup>\n                      (AUC 0.71). P-tau\n                      <jats:sup>181<\/jats:sup>\n                      (AUC 0.76), A\u03b240 (AUC 0.73), and t-tau (AUC 0.71) differentiated comparably between AD and CAA while A\u03b242 (AUC 0.54) did not. In agreement with studies examining AD biomarkers, A\u03b242\/40 discriminated excellently between AD and controls (AUC 0.92\u20130.96) in this study as well as the meta-analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The analyzed parameters differentiate between controls and CAA with clinically useful accuracy (AUC &amp;gt; \u223c0.85) but not between CAA and AD. Since there is a neuropathological, clinical and diagnostic continuum between CAA and AD, other diagnostic markers, e.g., novel CSF biomarkers or other parameters might be more successful.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnagi.2022.783996","type":"journal-article","created":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T11:05:17Z","timestamp":1644836717000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":40,"title":["Cerebrospinal Fluid Biomarkers in Cerebral Amyloid Angiopathy: New Data and Quantitative Meta-Analysis"],"prefix":"10.3389","volume":"14","author":[{"given":"Nils G.","family":"Margraf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Jensen-Kondering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Weiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Leypoldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Maetzler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Philippen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Bartsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Fl\u00fch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"R\u00f6cken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"M\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Royl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Br\u00fcggemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Roeben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Schulte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Bender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Kuhlenb\u00e4umer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.3233\/jad-191254","article-title":"Cerebrospinal fluid biomarkers in cerebral amyloid angiopathy.","volume":"74","author":"Banerjee","year":"2020","journal-title":"J. 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