{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T06:59:11Z","timestamp":1793170751491,"version":"4.5.0"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004772","name":"Natural Science Foundation of Ningxia Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004772","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>\n                    <jats:bold>Objectives<\/jats:bold>\n                    : This study was aimed to investigate the gender-related differences of regional cerebral glucose metabolism in healthy people along the age using 18F-FDG PET\/CT.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    : We recruited 344 healthy volunteers, including 217 males and 127 females (age range: 40\u201389 years old). All subjects underwent fluorine-18 fluorodeoxyglucose(18F-FDG) positron emission tomography (PET). All the data were divided into four groups for every 10 years old. Each participant was carefully screened from PET, MR, and other examinations in order to exclude the abnormalities, such as neurodegenerative or psychiatric disorders, alcohol\/abuse, cerebral vascular disorders, metabolic diseases like diabetes mellitus and hyperthyroidism, and other systemic malignancies. The 40\u201350 years old group was set as the baseline group. Statistical parametric mapping (SPM) analysis was employed to illustrate the differences among groups.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : Compared to the baseline group, whether in a cohort or different gender groups, the decrease of brain glucose metabolism was shown in the bilateral frontal lobe, anterior cingulate gyrus, and the bilateral temporal lobe. In males, the regions of decreased metabolism were bilateral frontal lobe, caudate nucleus, and cingulate gyrus, whereas that of females were left occipital lobe, cerebellum, and the thalamus. However, the overall decrease of brain metabolism in men and women began from the age of 60s, an aggravated decrease from 70s was only observed in males.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion<\/jats:bold>\n                    : (1) An obviously decreased brain metabolism was found from 60 years old, especially in the bilateral frontal lobe, bilateral temporal lobe, and inferior cingulate gyrus; (2) We found specific brain metabolic differences between genders, including the caudate nucleus region in males and the occipital lobe region in females; and (3) The aging trend is different between genders.\n                  <\/jats:p>","DOI":"10.3389\/fnagi.2022.809767","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T02:40:44Z","timestamp":1644460844000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Gender-Related Differences in Regional Cerebral Glucose Metabolism in Normal Aging Brain"],"prefix":"10.3389","volume":"14","author":[{"given":"Bei","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YaPing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HaiYan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YangHongYan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/0165-1781(94)90037-x","article-title":"Gender-related differences in regional cerebral glucose metabolism in normal volunteers","volume":"51","author":"Andreason","year":"1994","journal-title":"Psychiatry Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"73","DOI":"10.7334\/psicothema2016.11","article-title":"Should Broca\u2019s area include Brodmann area 47?","volume":"29","author":"Ardila","year":"2017","journal-title":"Psicothema"},{"key":"B3","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1159\/000381472","article-title":"Sex differences in longevity and in responses to anti-aging interventions: a mini-review","volume":"62","author":"Austad","year":"2015","journal-title":"Gerontology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0165-1781(87)90028-x","article-title":"Cerebral glucose metabolic rates in normal human females versus normal males","volume":"21","author":"Baxter","year":"1987","journal-title":"Psychiatry Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"xiii","DOI":"10.1016\/j.cpet.2014.02.001","article-title":"FDG PET\/CT: normal variations and benign findings - translation to PET\/MRI","volume":"9","author":"Beheshti","year":"2014","journal-title":"PET Clin."},{"key":"B6","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.neuroimage.2005.09.049","article-title":"Males and females differ in brain activation during cognitive tasks","volume":"30","author":"Bell","year":"2006","journal-title":"Neuroimage"},{"key":"B7","doi-asserted-by":"publisher","first-page":"4734","DOI":"10.1073\/pnas.0911855107","article-title":"Toward discovery science of human brain function","volume":"107","author":"Biswal","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B8","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1007\/s00259-016-3569-0","article-title":"Healthy brain ageing assessed with 18F-FDG PET and age-dependent recovery factors after partial volume effect correction","volume":"44","author":"Bonte","year":"2017","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"B9","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/s0926-6410(03)00085-5","article-title":"Striatal size, glucose metabolic rate and verbal learning in normal aging","volume":"17","author":"Brickman","year":"2003","journal-title":"Brain Res. Cogn. Brain Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/s0926-6410(03)00085-5","article-title":"Subtle changes in the ageing human brain","volume":"18","author":"Chance","year":"2006","journal-title":"Nutr. Health"},{"key":"B11","doi-asserted-by":"publisher","first-page":"4657","DOI":"10.1002\/hbm.24728","article-title":"Interregional causal influences of brain metabolic activity reveal the spread of aging effects during normal aging","volume":"40","author":"Di","year":"2019","journal-title":"Hum. Brain Mapp."},{"key":"B12","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.neubiorev.2015.03.008","article-title":"Thalamic structures and associated cognitive functions: relations with age and aging","volume":"54","author":"Fama","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B13","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.neuroimage.2013.04.122","article-title":"Transcranial cerebellar direct current stimulation (tcDCS): motor control, cognition, learning and emotions","volume":"85","author":"Ferrucci","year":"2014","journal-title":"Neuroimage"},{"key":"B14","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1056\/NEJMc1211767","article-title":"Clinical and biomarker changes in Alzheimer\u2019s disease","volume":"367","author":"Florez","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"B15","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.pscychresns.2006.12.014","article-title":"Changes in glucose metabolism due to aging and gender-related differences in the healthy human brain","volume":"164","author":"Fujimoto","year":"2008","journal-title":"Psychiatry Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.neubiorev.2013.01.002","article-title":"Localization of function in anterior cingulate cortex: from psychosurgery to functional neuroimaging","volume":"37","author":"Gasquoine","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B17","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/j.1552-6569.2010.00543.x","article-title":"Sex- and age-related differences in brain FDG metabolism of healthy adults: an SPM analysis","volume":"22","author":"Hsieh","year":"2012","journal-title":"J. Neuroimaging"},{"key":"B18","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1007\/s12311-008-0034-z","article-title":"Mechanisms of ethanol-induced degeneration in the developing, mature and aging cerebellum","volume":"7","author":"Jaatinen","year":"2008","journal-title":"Cerebellum"},{"key":"B19","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/s0022-510x(02)00112-0","article-title":"Gender differences in cerebral glucose metabolism: a PET study","volume":"199","author":"Kawachi","year":"2002","journal-title":"J. Neurol. Sci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"176157","DOI":"10.1155\/2012\/176157","article-title":"Anatomy of the temporal lobe","volume":"2012","author":"Kiernan","year":"2012","journal-title":"Epilepsy Res. Treat."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.3109\/02841850903258058","article-title":"Age- and sex-associated changes in cerebral glucose metabolism in normal healthy subjects: statistical parametric mapping analysis of F-18 fluorodeoxyglucose brain positron emission tomography","volume":"50","author":"Kim","year":"2009","journal-title":"Acta Radiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1176\/appi.ajgp.12.4.395","article-title":"Cognitive rehabilitation of mildly impaired Alzheimer disease patients on cholinesterase inhibitors","volume":"12","author":"Loewenstein","year":"2004","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"B23","doi-asserted-by":"publisher","first-page":"373","DOI":"10.31887\/DCNS.2016.18.4\/jmarrocco","article-title":"Sex in the brain: hormones and sex differences","volume":"18","author":"Marrocco","year":"2016","journal-title":"Dialogues Clin. Neurosci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1097\/00004647-199605000-00005","article-title":"The metabolic topography of normal aging","volume":"16","author":"Moeller","year":"1996","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2550","DOI":"10.1523\/JNEUROSCI.18-07-02550.1998","article-title":"Estradiol increases dendritic spine density by reducing GABA neurotransmission in hippocampal neurons","volume":"18","author":"Murphy","year":"1998","journal-title":"J. Neurosci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1001\/archpsyc.1996.01830070031007","article-title":"Sex differences in human brain morphometry and metabolism: an in vivo quantitative magnetic resonance imaging and positron emission tomography study on the effect of aging","volume":"53","author":"Murphy","year":"1996","journal-title":"Arch. Gen. Psychiatry"},{"key":"B27","first-page":"357","article-title":"99mTc-HMPAO and 99mTc-ECD brain uptake correlates of verbal memory in Alzheimer\u2019s disease","volume":"51","author":"Nobili","year":"2007","journal-title":"Q. J. Nucl. Med. Mol. Imaging"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/j.neuroimage.2006.12.044","article-title":"Where the brain grows old: decline in anterior cingulate and medial prefrontal function with normal aging","volume":"35","author":"Pardo","year":"2007","journal-title":"Neuroimage"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pneurobio.2017.11.004","article-title":"Brodmann area 10: Collating, integrating and high level processing of nociception and pain","volume":"161","author":"Peng","year":"2018","journal-title":"Prog. Neurobiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1176\/appi.ajp.2010.10020233","article-title":"Association of frontal and posterior cortical gray matter volume with time to alcohol relapse: a prospective study","volume":"168","author":"Rando","year":"2011","journal-title":"Am. J. Psychiatry"},{"key":"B31","doi-asserted-by":"publisher","first-page":"e51517","DOI":"10.1371\/journal.pone.0051517","article-title":"The relationship between cerebral glucose metabolism and age: report of a large brain PET data set","volume":"7","author":"Shen","year":"2012","journal-title":"PLoS One"},{"key":"B32","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/s0165-6147(02)02093-x","article-title":"Estrogen and cognitive aging in women","volume":"23","author":"Sherwin","year":"2002","journal-title":"Trends Pharmacol. Sci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1016\/j.neuropsychologia.2008.10.017","article-title":"Improvement in speech-reading ability by auditory training: evidence from gender differences in normally hearing, deaf and cochlear implanted subjects","volume":"47","author":"Strelnikov","year":"2009","journal-title":"Neuropsychologia"},{"key":"B34","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41398-020-0705-1","article-title":"ENIGMA and global neuroscience: a decade of large-scale studies of the brain in health and disease across more than 40 countries","volume":"10","author":"Thompson","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1016\/s0010-9452(08)70880-3","article-title":"On the involvement of prefrontal networks in cognitive ageing","volume":"39","author":"Tisserand","year":"2003","journal-title":"Cortex"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.anl.2018.08.010","article-title":"Age-related hearing loss and cognitive decline - the potential mechanisms linking the two","volume":"46","author":"Uchida","year":"2019","journal-title":"Auris Nasus Larynx"},{"key":"B37","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.neuropsychologia.2015.06.033","article-title":"The anatomical and functional specialization of the fusiform gyrus","volume":"83","author":"Weiner","year":"2016","journal-title":"Neuropsychologia"},{"key":"B38","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.exger.2015.11.016","article-title":"Temporal lobe in human aging: a quantitative protein profiling study of samples from Chinese human brain bank","volume":"73","author":"Xu","year":"2016","journal-title":"Exp. Gerontol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1111\/j.1745-6924.2009.01127.x","article-title":"Big correlations in little studies: inflated fMRI correlations reflect low statistical power-commentary on Vul","volume":"4","author":"Yarkoni","year":"2009","journal-title":"Perspect. Psychol. Sci."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2022.809767\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T02:40:47Z","timestamp":1644460847000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2022.809767\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,10]]},"references-count":39,"alternative-id":["10.3389\/fnagi.2022.809767"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2022.809767","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,10]]},"article-number":"809767"}}