{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:55:06Z","timestamp":1792799706452,"version":"4.5.0"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study intended to investigate whether retinal nerve fiber layer (RNFL) thickness could become a potential marker in patients with Parkinson\u2019s disease with cognitive impairment (PD-CI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty-seven PD patients and 45 age-matched healthy controls (HCs) were recruited in our cross-sectional study and completed optical coherence tomography (OCT) evaluations. PD with normal cognition (PD-NC) and cognitive impairment (PD-CI) patients were divided following the 2015 Movement Disorder Society criteria. RNFL thickness was quantified in subfields of the 3.0-mm circle surrounding the optic disk; while a battery of neuropsychiatric assessments was conducted to estimate the Parkinsonism severity. General linear models and one-way ANOVA were adopted to assess RNFL thickness between subgroups with different cognitive statuses; logistic regression analyses were applied to determine the relation between RNFL and PD-CI cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with HCs, more thinning of the RNFL was observed in the inferior and temporal sectors in PD patients, especially in the PD-CI group. Inferior RNFL thickness was reduced in PD-CI compared with PD-NC patients. Logistic regression analysis found that inferior RNFL thickness was independently associated with PD-CI cases (odds ratio = 0.923,<jats:italic>p<\/jats:italic>= 0.014). Receiver operating characteristic analysis showed that the RNFL-involved combined model provided a high accuracy in screening cognitive deficiency in PD cases (area under the curve = 0.85,<jats:italic>p<\/jats:italic>&amp;lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reduced RNFL thickness especially in the inferior sector is independently associated with PD-CI patients. Our study present new perspectives into verifying possible indicators for neuropathological processes or disease severity in Parkinsonians with cognitive dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnagi.2022.832768","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T10:03:10Z","timestamp":1644487390000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Retinal Nerve Fiber Layer Thickness and Associations With Cognitive Impairment in Parkinson\u2019s Disease"],"prefix":"10.3389","volume":"14","author":[{"given":"Zihan","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feilan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzhen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohe","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/nrneurol.2017.27","article-title":"Cognitive decline in Parkinson disease.","volume":"13","author":"Aarsland","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1097\/WNO.0b013e31828c4e1a","article-title":"Correlation of inner retinal thickness evaluated by spectral-domain optical coherence tomography and contrast sensitivity in Parkinson disease.","volume":"33","author":"Adam","year":"2013","journal-title":"J. Neuroophthalmol."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000006157","article-title":"Retinal thinning associates with nigral dopaminergic loss in de novo Parkinson disease.","volume":"91","author":"Ahn","year":"2018","journal-title":"Neurology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"964","DOI":"10.14336\/ad.2021.0511","article-title":"NRF2 loss accentuates parkinsonian pathology and behavioral dysfunction in human \u03b1-synuclein overexpressing mice.","volume":"12","author":"Anandhan","year":"2021","journal-title":"Aging Dis."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1093\/brain\/awp068","article-title":"The retina in Parkinson\u2019s disease.","volume":"132","author":"Archibald","year":"2009","journal-title":"Brain"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00097","article-title":"Glucocerebrosidase defects as a major risk factor for Parkinson\u2019s disease.","volume":"12","author":"Avenali","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/mds.27902","article-title":"Prevalence and clinical aspects of mild cognitive impairment in Parkinson\u2019s disease: a meta-analysis.","volume":"35","author":"Baiano","year":"2020","journal-title":"Mov. Disord."},{"key":"B8","doi-asserted-by":"publisher","first-page":"618","DOI":"10.14336\/ad.2019.0617","article-title":"T1-weighted MRI-driven Brain age estimation in Alzheimer\u2019s disease and Parkinson\u2019s disease.","volume":"11","author":"Beheshti","year":"2020","journal-title":"Aging Dis."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-021-00176-9","article-title":"Improving estimation of Parkinson\u2019s disease risk-the enhanced PREDICT-PD algorithm.","volume":"7","author":"Bestwick","year":"2021","journal-title":"NPJ Parkinsons Dis."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.parkreldis.2012.07.012","article-title":"Foveal vision is impaired in Parkinson\u2019s disease.","volume":"19","author":"Bodis-Wollner","year":"2013","journal-title":"Parkinsonism Relat. Disord."},{"key":"B11","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1002\/ana.24182","article-title":"\u03b1-synuclein in the inner retina in parkinson disease.","volume":"75","author":"Bodis-Wollner","year":"2014","journal-title":"Ann. Neurol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.parkreldis.2019.04.023","article-title":"Retinal layers in Parkinson\u2019s disease: a meta-analysis of spectral-domain optical coherence tomography studies.","volume":"64","author":"Chrysou","year":"2019","journal-title":"Parkinsonism Relat. Disord."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1212\/WNL.0b013e3181fc29c9","article-title":"The MoCA: well-suited screen for cognitive impairment in Parkinson disease.","volume":"75","author":"Dalrymple-Alford","year":"2010","journal-title":"Neurology"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00701","article-title":"Optical coherence tomography in Alzheimer\u2019s disease and other neurodegenerative diseases.","volume":"8","author":"Doustar","year":"2017","journal-title":"Front. Neurol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1002\/mds.21507","article-title":"Clinical diagnostic criteria for dementia associated with Parkinson\u2019s disease.","volume":"22","author":"Emre","year":"2007","journal-title":"Mov. Disord."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.682633","article-title":"The unfolded protein response in immune cells as an emerging regulator of neuroinflammation.","volume":"13","author":"Fern\u00e1ndez","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.ajo.2013.09.028","article-title":"Distribution of retinal layer atrophy in patients with Parkinson disease and association with disease severity and duration.","volume":"157","author":"Garcia-Martin","year":"2014","journal-title":"Am. J. Ophthalmol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1007\/s12035-019-01714-6","article-title":"The interaction between neuroinflammation and \u03b2-amyloid in cognitive decline in Parkinson\u2019s disease.","volume":"57","author":"Ghadery","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1212\/wnl.0000000000003764","article-title":"Corpus callosal atrophy and associations with cognitive impairment in Parkinson disease.","volume":"88","author":"Goldman","year":"2017","journal-title":"Neurology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1002\/mds.27665","article-title":"Modifiable risk factors for cognitive impairment in Parkinson\u2019s disease: a systematic review and meta-analysis of prospective cohort studies.","volume":"34","author":"Guo","year":"2019","journal-title":"Mov. Disord."},{"key":"B21","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1111\/ene.14092","article-title":"Self-reported visual dysfunction in Parkinson disease: the survey of health, ageing and retirement in Europe.","volume":"27","author":"Hamedani","year":"2020","journal-title":"Eur. J. Neurol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1212\/wnl.17.5.427","article-title":"Parkinsonism: onset, progression and mortality.","volume":"17","author":"Hoehn","year":"1967","journal-title":"Neurology"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1212\/WNL.0b013e3181c34b47","article-title":"Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson disease.","volume":"73","author":"Hoops","year":"2009","journal-title":"Neurology"},{"key":"B24","doi-asserted-by":"publisher","first-page":"2793","DOI":"10.1016\/j.visres.2004.06.009","article-title":"Retinal nerve fiber layer thinning in Parkinson disease.","volume":"44","author":"Inzelberg","year":"2004","journal-title":"Vision Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/s0733-8619(02)00107-x","article-title":"Visual dysfunction, neurodegenerative diseases, and aging.","volume":"21","author":"Jackson","year":"2003","journal-title":"Neurol. Clin."},{"key":"B26","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1002\/mds.25747","article-title":"Development of a prediction formula of Parkinson disease severity by optical coherence tomography.","volume":"29","author":"Jimenez","year":"2014","journal-title":"Mov. Disord."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2020.100938","article-title":"Past, present and future role of retinal imaging in neurodegenerative disease.","volume":"83","author":"Kashani","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.93621","article-title":"Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer\u2019s disease.","volume":"2","author":"Koronyo","year":"2017","journal-title":"JCI Insight"},{"key":"B29","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1002\/ana.25236","article-title":"Serotonin, \u03b2-amyloid, and cognition in Parkinson disease.","volume":"83","author":"Kotagal","year":"2018","journal-title":"Ann. Neurol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.14336\/ad.2021.0418","article-title":"Intestinal Inflammation and Parkinson\u2019s Disease.","volume":"12","author":"Li","year":"2021","journal-title":"Aging Dis."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.574776","article-title":"Parkinson\u2019s disease with depression: the correlations between neuroinflammatory factors and neurotransmitters in cerebrospinal fluid.","volume":"12","author":"Lian","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1002\/mds.24893","article-title":"Diagnostic criteria for mild cognitive impairment in Parkinson\u2019s disease: movement disorder society task force guidelines.","volume":"27","author":"Litvan","year":"2012","journal-title":"Mov. Disord."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1002\/acn3.51429","article-title":"The influence of white matter hyperintensity on cognitive impairment in Parkinson\u2019s disease.","volume":"8","author":"Liu","year":"2021","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.682776","article-title":"Total cerebral small vessel score association with Hoehn and Yahr stage in Parkinson\u2019s Disease.","volume":"13","author":"Ma","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1007\/s13311-020-00894-7","article-title":"Therapy of Parkinson\u2019s disease subtypes.","volume":"17","author":"Marras","year":"2020","journal-title":"Neurotherapeutics"},{"key":"B36","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s13760-020-01274-w","article-title":"Does retina play a role in Parkinson\u2019s disease?","volume":"120","author":"Mohana Devi","year":"2020","journal-title":"Acta Neurol. Belg."},{"key":"B37","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1002\/mds.10473","article-title":"The Unified Parkinson\u2019s Disease Rating Scale (UPDRS): status and recommendations.","volume":"18","year":"2003","journal-title":"Mov. Disord."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011961.pub2","article-title":"Cognitive training interventions for dementia and mild cognitive impairment in Parkinson\u2019s disease.","volume":"2","author":"Orgeta","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1002\/mds.27392","article-title":"Phosphorylated alpha-synuclein in the retina is a biomarker of Parkinson\u2019s disease pathology severity.","volume":"33","author":"Ortuno-Lizaran","year":"2018","journal-title":"Mov. Disord."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00128","article-title":"Increased CSF NFL in non-demented Parkinson\u2019s disease subjects reflects early white matter damage.","volume":"12","author":"Papu\u0107","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/s41582-020-0333-7","article-title":"Protein transmission in neurodegenerative disease.","volume":"16","author":"Peng","year":"2020","journal-title":"Nat. Rev. Neurol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson\u2019s disease.","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov. Disord."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-021-00232-4","article-title":"Neurofilament light chain and \u03b1-synuclein RT-QuIC as differential diagnostic biomarkers in parkinsonisms and related syndromes.","volume":"7","author":"Quadalti","year":"2021","journal-title":"NPJ Parkinsons Dis."},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.794770","article-title":"Dl-3-n-butylphthalide rescues dopaminergic neurons in Parkinson\u2019s disease models by inhibiting the NLRP3 inflammasome and ameliorating mitochondrial impairment.","volume":"12","author":"Que","year":"2021","journal-title":"Front. Immunol."},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00214","article-title":"The role of microglia in retinal neurodegeneration: Alzheimer\u2019s disease, Parkinson, and glaucoma.","volume":"9","author":"Ramirez","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"2506","DOI":"10.1002\/mds.28798","article-title":"Identifying genetic markers associated with the progression of cognitive decline in Parkinson\u2019s disease: a call out for replication.","volume":"36","author":"Reyes-Perez","year":"2021","journal-title":"Mov. Disord."},{"key":"B47","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/s1474-4422(16)30328-3","article-title":"Clinical variables and biomarkers in prediction of cognitive impairment in patients with newly diagnosed Parkinson\u2019s disease: a cohort study.","volume":"16","author":"Schrag","year":"2017","journal-title":"Lancet Neurol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"e02387","DOI":"10.1212\/wnl.0000000000011894","article-title":"Association of gyrification pattern, white matter changes, and phenotypic profile in patients with Parkinson disease.","volume":"96","author":"Tang","year":"2021","journal-title":"Neurology"},{"key":"B49","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/s1474-4422(21)00030-2","article-title":"Challenges in the diagnosis of Parkinson\u2019s disease.","volume":"20","author":"Tolosa","year":"2021","journal-title":"Lancet Neurol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"73","DOI":"10.2147\/EB.S193026","article-title":"Optical coherence tomography angiography in neurodegenerative diseases: a review.","volume":"12","author":"Tsokolas","year":"2020","journal-title":"Eye Brain"},{"key":"B51","doi-asserted-by":"publisher","first-page":"268","DOI":"10.7326\/M16-2607","article-title":"Sensitivity analysis in observational research: introducing the E-Value.","volume":"167","author":"VanderWeele","year":"2017","journal-title":"Ann. Intern. Med."},{"key":"B52","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1080\/13803395.2015.1073227","article-title":"Parkinson\u2019s disease dementia: diagnostic criteria and risk factor review.","volume":"37","author":"Vasconcellos","year":"2015","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.parkreldis.2021.05.016","article-title":"The inconsistency and instability of Parkinson\u2019s disease motor subtypes.","volume":"88","author":"von Coelln","year":"2021","journal-title":"Parkinsonism Relat. Disord."},{"key":"B54","doi-asserted-by":"publisher","first-page":"2571","DOI":"10.1093\/brain\/awab156","article-title":"The role of gut dysbiosis in Parkinson\u2019s disease: mechanistic insights and therapeutic options.","volume":"144","author":"Wang","year":"2021","journal-title":"Brain"},{"key":"B55","doi-asserted-by":"publisher","first-page":"15682","DOI":"10.18632\/aging.103776","article-title":"Vascular, inflammatory and metabolic risk factors in relation to dementia in Parkinson\u2019s disease patients with type 2 diabetes mellitus.","volume":"12","author":"Wang","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00053","article-title":"Contra-directional expression of plasma superoxide dismutase with lipoprotein cholesterol and high-sensitivity C-reactive protein as important markers of Parkinson\u2019s disease severity.","volume":"12","author":"Yang","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"B57","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4103\/aian.AIAN_424_17","article-title":"Assessment of neurodegeneration by optical coherence tomography and mini-mental test in Parkinson\u2019s disease.","volume":"22","author":"Y\u0131ld\u0131z","year":"2019","journal-title":"Ann. Indian Acad. Neurol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1111\/ene.14399","article-title":"Lee Silverman Voice Treatment for dysarthria in patients with Parkinson\u2019s disease: a systematic review and meta-analysis.","volume":"27","author":"Yuan","year":"2020","journal-title":"Eur. J. Neurol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1111\/ene.14613","article-title":"Optical coherence tomography measurements as potential imaging biomarkers for Parkinson\u2019s disease: a systematic review and meta-analysis.","volume":"28","author":"Zhou","year":"2021","journal-title":"Eur. J. Neurol."},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-021-00159-w","article-title":"\u201cHot cross bun\u201d is a potential imaging marker for the severity of cerebellar ataxia in MSA-C.","volume":"7","author":"Zhu","year":"","journal-title":"NPJ Parkinsons Dis."},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.592212","article-title":"Various diseases and clinical heterogeneity are associated with \u201cHot Cross Bun\u201d.","volume":"12","author":"Zhu","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.14336\/ad.2021.0214","article-title":"The pathogenesis and treatment of cardiovascular autonomic dysfunction in Parkinson\u2019s disease: what we know and where to go.","volume":"12","author":"Zhu","year":"","journal-title":"Aging Dis."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2022.832768\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T08:01:47Z","timestamp":1700208107000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2022.832768\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,10]]},"references-count":62,"alternative-id":["10.3389\/fnagi.2022.832768"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2022.832768","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,10]]},"article-number":"832768"}}