{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T20:05:22Z","timestamp":1760731522133,"version":"3.41.2"},"reference-count":179,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T00:00:00Z","timestamp":1652054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873361"],"award-info":[{"award-number":["81873361"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["18401970100"],"award-info":[{"award-number":["18401970100"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20200180","BK20211064"],"award-info":[{"award-number":["BK20200180","BK20211064"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007131","name":"Changzhou Science and Technology Bureau","doi-asserted-by":"publisher","award":["CJ20200089","CJ20200106"],"award-info":[{"award-number":["CJ20200089","CJ20200106"]}],"id":[{"id":"10.13039\/501100007131","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>Hypoxia and ischemia cause inflammatory injury and critically participate in the pathogenesis of various diseases in various organs. However, the protective strategies against hypoxic and ischemic insults are very limited in clinical settings up to date. It is of utmost importance to improve our understanding of hypoxic\/ischemic (H\/I) inflammation and find novel therapies for better prevention\/treatment of H\/I injury. Recent studies provide strong evidence that the expression of microRNAs (miRNAs), which regulate gene expression and affect H\/I inflammation through post-transcriptional mechanisms, are differentially altered in response to H\/I stress, while \u03b4-opioid receptors (DOR) play a protective role against H\/I insults in different organs, including both H\/I-sensitive organs (e.g., brain, kidney, and heart) and H\/I-insensitive organs (e.g., liver and muscle). Indeed, many studies have demonstrated the crucial role of the DOR-mediated cyto-protection against H\/I injury by several molecular pathways, including NLRP3 inflammasome modulated by miRNAs. In this review, we summarize our recent studies along with those of others worldwide, and compare the effects of DOR on H\/I expression of miRNAs in H\/I-sensitive and -insensitive organs. The alternation in miRNA expression profiles upon DOR activation and the potential impact on inflammatory injury in different organs under normoxic and hypoxic conditions are discussed at molecular and cellular levels. More in-depth investigations into this field may provide novel clues for new protective strategies against H\/I inflammation in different types of organs.<\/jats:p>","DOI":"10.3389\/fnagi.2022.847374","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T05:45:03Z","timestamp":1652075103000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Hypoxic\/Ischemic Inflammation, MicroRNAs and \u03b4-Opioid Receptors: Hypoxia\/Ischemia-Sensitive Versus-Insensitive Organs"],"prefix":"10.3389","volume":"14","author":[{"given":"Yimeng","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichen","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuchen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozhou","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"341","DOI":"10.14336\/AD.2019.0604","article-title":"Hypoxia-Induced Degenerative Protein Modifications Associated with Aging and Age-Associated Disorders.","volume":"11","author":"Adav","year":"2020","journal-title":"Aging Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"E118","DOI":"10.1208\/aapsj080114","article-title":"Opioid ligands with mixed mu\/delta opioid receptor interactions: an emerging approach to novel analgesics.","volume":"8","author":"Ananthan","year":"2006","journal-title":"AAPS J."},{"key":"B3","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.tem.2015.06.008","article-title":"HypoxamiRs: regulators of cardiac hypoxia and energy metabolism.","volume":"26","author":"Azzouzi","year":"2015","journal-title":"Trends Endocrinol. Metab."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1016\/j.kint.2018.12.028","article-title":"MicroRNA-214 promotes chronic kidney disease by disrupting mitochondrial oxidative phosphorylation.","volume":"95","author":"Bai","year":"2019","journal-title":"Kidney Int."},{"key":"B5","doi-asserted-by":"publisher","first-page":"5556","DOI":"10.1021\/jm020336e","article-title":"Potent delta-opioid receptor agonists containing the Dmt-Tic pharmacophore.","volume":"45","author":"Balboni","year":"2002","journal-title":"J. Med. Chem."},{"key":"B6","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions.","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093297","article-title":"Concordant changes of plasma and kidney microRNA in the early stages of acute kidney injury: time course in a mouse model of bilateral renal ischemia-reperfusion.","volume":"9","author":"Bellinger","year":"2014","journal-title":"PLoS One"},{"key":"B8","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/bs.ircmb.2017.03.006","article-title":"Impact of MicroRNAs in the Cellular Response to Hypoxia.","volume":"333","author":"Bertero","year":"2017","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"B9","first-page":"359","article-title":"SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist.","volume":"273","author":"Bilsky","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B10","doi-asserted-by":"publisher","first-page":"22575","DOI":"10.1074\/jbc.M600288200","article-title":"Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment.","volume":"281","author":"Bracken","year":"2006","journal-title":"J. Biol. Chem."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-02030-w","article-title":"Mesenchymal stem cell-derived exosome miR-542-3p suppresses inflammation and prevents cerebral infarction.","volume":"12","author":"Cai","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.763110","article-title":"The Potential Role of miRNAs in Cognitive Frailty.","volume":"13","author":"Carini","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1002\/jcb.22956","article-title":"Hypoxia-mediated biological control.","volume":"112","author":"Cassavaugh","year":"2011","journal-title":"J. Cell. Biochem."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-020-00280-9","article-title":"Inhibition of miR-19a-3p decreases cerebral ischemia\/reperfusion injury by targeting IGFBP3 in vivo and in vitro.","volume":"53","author":"Chai","year":"2020","journal-title":"Biol. Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1007\/s00018-009-8759-5","article-title":"Na+ mechanism of delta-opioid receptor induced protection from anoxic K+ leakage in the cortex.","volume":"66","author":"Chao","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1093\/cercor\/bhm247","article-title":"Activation of DOR attenuates anoxic K+ derangement via inhibition of Na+ entry in mouse cortex.","volume":"18","author":"Chao","year":"2008","journal-title":"Cereb. Cortex"},{"key":"B17","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/sj.jcbfm.9600352","article-title":"Cortical delta-opioid receptors potentiate K+ homeostasis during anoxia and oxygen-glucose deprivation.","volume":"27","author":"Chao","year":"2007","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B18","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.expneurol.2012.05.006","article-title":"DOR activation inhibits anoxic\/ischemic Na+ influx through Na+ channels via PKC mechanisms in the cortex.","volume":"236","author":"Chao","year":"2012","journal-title":"Exp. Neurol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.pneurobio.2009.12.007","article-title":"Ionic storm in hypoxic\/ischemic stress: can opioid receptors subside it?","volume":"90","author":"Chao","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1077-9","article-title":"IRE1alpha inhibition decreased TXNIP\/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic-ischemic brain injury in rats.","volume":"15","author":"Chen","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-020-01520-2","article-title":"Rno-microRNA-30c-5p promotes myocardial ischemia reperfusion injury in rats through activating NF-kappaB pathway and targeting SIRT1.","volume":"20","author":"Chen","year":"","journal-title":"BMC Cardiovasc. Disord."},{"key":"B22","doi-asserted-by":"crossref","first-page":"12154","DOI":"10.1111\/jcmm.15861","article-title":"A circulating exosomal microRNA panel as a novel biomarker for monitoring post-transplant renal graft function.","volume":"24","author":"Chen","year":"","journal-title":"J. Cell. Mol. Med."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00421","article-title":"delta-Opioid Receptors, microRNAs, and Neuroinflammation in Cerebral Ischemia\/Hypoxia.","volume":"11","author":"Chen","year":"","journal-title":"Front. Immunol."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00210","article-title":"Increased Salivary microRNAs That Regulate DJ-1 Gene Expression as Potential Markers for Parkinson\u2019s Disease.","volume":"12","author":"Chen","year":"","journal-title":"Front. Aging Neurosci."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117664","article-title":"MicroRNA-374a-5p inhibits neuroinflammation in neonatal hypoxic-ischemic encephalopathy via regulating NLRP3 inflammasome targeted Smad6.","volume":"252","author":"Chen","year":"","journal-title":"Life Sci."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00232","article-title":"MicroRNA-4639 is a regulator of DJ-1 expression and a potential early diagnostic marker for Parkinson\u2019s disease.","volume":"9","author":"Chen","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107339","article-title":"Up-regulating lncRNA OIP5-AS1 protects neuron injury against cerebral hypoxia-ischemia induced inflammation and oxidative stress in microglia\/macrophage through activating CTRP3 via sponging miR-186-5p.","volume":"92","author":"Chen","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1177\/0963689719872699","article-title":"Preservation Solutions for Kidney Transplantation: history, Advances and Mechanisms.","volume":"28","author":"Chen","year":"2019","journal-title":"Cell Transplant."},{"key":"B29","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s11010-020-03877-6","article-title":"LincRNA-Cox2 promotes pulmonary arterial hypertension by regulating the let-7a-mediated STAT3 signaling pathway.","volume":"475","author":"Cheng","year":"2020","journal-title":"Mol. Cell. Biochem."},{"key":"B30","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.molimm.2020.11.009","article-title":"microRNA-30e up-regulation alleviates myocardial ischemia-reperfusion injury and promotes ventricular remodeling via SOX9 repression.","volume":"130","author":"Cheng","year":"2021","journal-title":"Mol. Immunol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/j.transproceed.2020.01.046","article-title":"MicroRNA-146a Protects Against Ischemia\/Reperfusion Liver Injury Through Inhibition of Toll-like Receptor 4 Signaling Pathway in Rats.","volume":"52","author":"Chungen","year":"2020","journal-title":"Transplant. Proc."},{"key":"B32","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.atherosclerosis.2019.08.010","article-title":"Forced expression of microRNA-146b reduces TRAF6-dependent inflammation and improves ischemia-induced neovascularization in hypercholesterolemic conditions.","volume":"289","author":"Desjarlais","year":"2019","journal-title":"Atherosclerosis"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.587693","article-title":"Exosomal MicroRNA-374b-5p From Tubular Epithelial Cells Promoted M1 Macrophages Activation and Worsened Renal Ischemia\/Reperfusion Injury.","volume":"8","author":"Ding","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.cardiores.2007.01.014","article-title":"Reperfusion injury in humans: a review of clinical trials on reperfusion injury inhibitory strategies.","volume":"74","author":"Dirksen","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.freeradbiomed.2016.05.006","article-title":"Upregulation of microRNA-22 contributes to myocardial ischemia-reperfusion injury by interfering with the mitochondrial function.","volume":"96","author":"Du","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00054","article-title":"Hypoxia-Inducible Factor 1alpha and 2alpha Have Beneficial Effects in Remote Ischemic Preconditioning Against Stroke by Modulating Inflammatory Responses in Aged Rats.","volume":"12","author":"Du","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-015-0490-9","article-title":"MicroRNA-155 aggravates ischemia-reperfusion injury by modulation of inflammatory cell recruitment and the respiratory oxidative burst.","volume":"110","author":"Eisenhardt","year":"2015","journal-title":"Basic Res. Cardiol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.cmet.2013.08.009","article-title":"The hypoxia-inducible microRNA cluster miR-199a approximately 214 targets myocardial PPARdelta and impairs mitochondrial fatty acid oxidation.","volume":"18","author":"el Azzouzi","year":"2013","journal-title":"Cell Metab."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1038\/nm.2507","article-title":"Ischemia and reperfusion\u2013from mechanism to translation.","volume":"17","author":"Eltzschig","year":"2011","journal-title":"Nat. Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1111\/jcmm.16153","article-title":"Dexmedetomidine-up-regulated microRNA-381 exerts anti-inflammatory effects in rats with cerebral ischaemic injury via the transcriptional factor IRF4.","volume":"25","author":"Fang","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"B41","doi-asserted-by":"crossref","first-page":"230","DOI":"10.2174\/138945012799201612","article-title":"Current research on opioid receptor function.","volume":"13","author":"Feng","year":"2012","journal-title":"Curr. Drug Targets"},{"key":"B42","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4077\/CJP.2011.AMM047","article-title":"Effect of delta-opioid receptor over-expression on cortical expression of GABAA receptor alpha1-subunit in hypoxia.","volume":"54","author":"Feng","year":"2011","journal-title":"Chin. J. Physiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1093\/eurheartj\/eht090","article-title":"Myocardial reperfusion injury: looking beyond primary PCI.","volume":"34","author":"Frohlich","year":"2013","journal-title":"Eur. Heart J."},{"key":"B44","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1161\/CIRCULATIONAHA.116.025490","article-title":"A MicroRNA93-Interferon Regulatory Factor-9-Immunoresponsive Gene-1-Itaconic Acid Pathway Modulates M2-Like Macrophage Polarization to Revascularize Ischemic Muscle.","volume":"135","author":"Ganta","year":"2017","journal-title":"Circulation"},{"key":"B45","doi-asserted-by":"publisher","first-page":"116","DOI":"10.14336\/AD.2020.0320","article-title":"Ischemic Conditioning Ameliorated Hypertension and Vascular Remodeling of Spontaneously Hypertensive Rat via Inflammatory Regulation.","volume":"12","author":"Gao","year":"2021","journal-title":"Aging Dis."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.919601","article-title":"MicroRNA-668-3p Protects Against Oxygen-Glucose Deprivation in a Rat H9c2 Cardiomyocyte Model of Ischemia-Reperfusion Injury by Targeting the Stromal Cell-Derived Factor-1 (SDF-1)\/CXCR4 Signaling Pathway.","volume":"26","author":"Gao","year":"2020","journal-title":"Med. Sci. Monit."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.647015","article-title":"Circulating Inflamma-miRs as Potential Biomarkers of Cognitive Impairment in Patients Affected by Alzheimer\u2019s Disease.","volume":"13","author":"Giuliani","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"14339","DOI":"10.1073\/pnas.0912701107","article-title":"Identification of a microRNA signature of renal ischemia reperfusion injury.","volume":"107","author":"Godwin","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-81113-x","article-title":"Hsa-miR-494-3p attenuates gene HtrA3 transcription to increase inflammatory response in hypoxia\/reoxygenation HK2 Cells.","volume":"11","author":"Gong","year":"2021","journal-title":"Sci. Rep."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1089\/ars.2013.5403","article-title":"HypoxamiR regulation and function in ischemic cardiovascular diseases.","volume":"21","author":"Greco","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/907420","article-title":"Integrative analysis of miRNA-mRNA and miRNA-miRNA interactions.","volume":"2014","author":"Guo","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"B52","doi-asserted-by":"publisher","first-page":"261","DOI":"10.4161\/org.25970","article-title":"Hypoxia-based strategies for angiogenic induction: the dawn of a new era for ischemia therapy and tissue regeneration.","volume":"9","author":"Hadjipanayi","year":"2013","journal-title":"Organogenesis"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1161\/CIRCULATIONAHA.112.000860","article-title":"MicroRNA-93 controls perfusion recovery after hindlimb ischemia by modulating expression of multiple genes in the cell cycle pathway.","volume":"127","author":"Hazarika","year":"2013","journal-title":"Circulation"},{"key":"B54","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1007\/s00018-012-1167-2","article-title":"Neuroprotection against hypoxia\/ischemia: delta-opioid receptor-mediated cellular\/molecular events.","volume":"70","author":"He","year":"","journal-title":"Cell. Mol. Life Sci."},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061080","article-title":"delta-Opioid receptor activation modified microRNA expression in the rat kidney under prolonged hypoxia.","volume":"8","author":"He","year":"","journal-title":"PLoS One"},{"key":"B56","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1159\/000146075","article-title":"Renal parenchymal hypoxia, hypoxia response and the progression of chronic kidney disease.","volume":"28","author":"Heyman","year":"2008","journal-title":"Am. J. Nephrol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"325","DOI":"10.3349\/ymj.2021.62.4.325","article-title":"Inhibition of Long Noncoding RNA SNHG15 Ameliorates Hypoxia\/Ischemia-Induced Neuronal Damage by Regulating miR-302a-3p\/STAT1\/NF-kappaB Axis.","volume":"62","author":"Hu","year":"2021","journal-title":"Yonsei Med. J."},{"key":"B58","doi-asserted-by":"publisher","first-page":"3594","DOI":"10.1111\/bph.14428","article-title":"MicroRNA-351-5p aggravates intestinal ischaemia\/reperfusion injury through the targeting of MAPK13 and Sirtuin-6.","volume":"175","author":"Hu","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.expneurol.2017.10.024","article-title":"Inhibition of microRNA-210 suppresses pro-inflammatory response and reduces acute brain injury of ischemic stroke in mice.","volume":"300","author":"Huang","year":"2018","journal-title":"Exp. Neurol."},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2648-0","article-title":"Inhibition of miR-450b-5p ameliorates hepatic ischemia\/reperfusion injury via targeting CRYAB.","volume":"11","author":"Huang","year":"2020","journal-title":"Cell Death Dis."},{"key":"B61","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.pbb.2014.05.009","article-title":"Effects of the delta opioid agonist AZD2327 upon operant behaviors and assessment of its potential for abuse.","volume":"124","author":"Hudzik","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101530","article-title":"miR-146a ameliorates liver ischemia\/reperfusion injury by suppressing IRAK1 and TRAF6.","volume":"9","author":"Jiang","year":"2014","journal-title":"PLoS One"},{"key":"B63","doi-asserted-by":"publisher","first-page":"2198","DOI":"10.1212\/WNL.0000000000003354","article-title":"Leukocyte response is regulated by microRNA let7i in patients with acute ischemic stroke.","volume":"87","author":"Jickling","year":"2016","journal-title":"Neurology"},{"key":"B64","doi-asserted-by":"publisher","first-page":"3505","DOI":"10.1007\/s00018-009-0136-x","article-title":"delta-Opioid receptors protect from anoxic disruption of Na+ homeostasis via Na+ channel regulation.","volume":"66","author":"Kang","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aat4285","article-title":"The microRNA miR-7a-5p ameliorates ischemic brain damage by repressing alpha-synuclein.","volume":"11","author":"Kim","year":"2018","journal-title":"Sci. Signal."},{"key":"B66","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.suc.2010.04.003","article-title":"Molecular biology of liver ischemia\/reperfusion injury: established mechanisms and recent advancements.","volume":"90","author":"Klune","year":"2010","journal-title":"Surg. Clin. North Am."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1097\/01.TP.0000065282.46425.87","article-title":"Prognostic significance of free radicals: mediated injury occurring in the kidney donor.","volume":"75","author":"Kosieradzki","year":"2003","journal-title":"Transplantation"},{"key":"B68","doi-asserted-by":"publisher","first-page":"3279","DOI":"10.1016\/j.transproceed.2008.10.004","article-title":"Ischemia\/reperfusion injury in kidney transplantation: mechanisms and prevention.","volume":"40","author":"Kosieradzki","year":"2008","journal-title":"Transplant. Proc."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1177\/1947601911423654","article-title":"Hypoxia-induced angiogenesis: good and evil.","volume":"2","author":"Krock","year":"2011","journal-title":"Genes Cancer"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1128\/MCB.01395-06","article-title":"A microRNA signature of hypoxia.","volume":"27","author":"Kulshreshtha","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1681\/ASN.2012050438","article-title":"MicroRNA-494 reduces ATF3 expression and promotes AKI.","volume":"23","author":"Lan","year":"2012","journal-title":"J. Am. Soc. Nephrol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1101\/gr.089367.108","article-title":"New class of microRNA targets containing simultaneous 5\u2019-UTR and 3\u2019-UTR interaction sites.","volume":"19","author":"Lee","year":"2009","journal-title":"Genome Res."},{"key":"B73","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3325\/cmj.2019.60.439","article-title":"Adipose-derived mesenchymal stem cells attenuate ischemic brain injuries in rats by modulating miR-21-3p\/MAT2B signaling transduction.","volume":"60","author":"Li","year":"2019","journal-title":"Croat. Med. J."},{"key":"B74","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.kint.2018.09.013","article-title":"HIF-1alpha inducing exosomal microRNA-23a expression mediates the cross-talk between tubular epithelial cells and macrophages in tubulointerstitial inflammation.","volume":"95","author":"Li","year":"2019","journal-title":"Kidney Int."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1111\/liv.12441","article-title":"A role of microRNA-370 in hepatic ischaemia-reperfusion injury by targeting transforming growth factor-beta receptor II.","volume":"35","author":"Li","year":"2015","journal-title":"Liver Int."},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.700959","article-title":"Serum miR-214 Serves as a Biomarker for Prodromal Parkinson\u2019s Disease.","volume":"13","author":"Li","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-020-01742-4","article-title":"microRNA-130a-5p suppresses myocardial ischemia reperfusion injury by downregulating the HMGB2\/NF-kappaB axis.","volume":"21","author":"Li","year":"2021","journal-title":"BMC Cardiovasc. Disord."},{"key":"B78","doi-asserted-by":"publisher","first-page":"523","DOI":"10.14336\/AD.2019.0807","article-title":"Mib2 Deficiency Inhibits Microglial Activation and Alleviates Ischemia-Induced Brain Injury.","volume":"11","author":"Li","year":"2020","journal-title":"Aging Dis."},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104783","article-title":"MicroRNA-142-3p attenuates hepatic ischemia\/reperfusion injury via targeting of myristoylated alanine-rich C-kinase substrate.","volume":"156","author":"Li","year":"2020","journal-title":"Pharmacol. Res."},{"key":"B80","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.bbi.2018.09.002","article-title":"MicroRNA-125b mimic inhibits ischemia reperfusion-induced neuroinflammation and aberrant p53 apoptotic signalling activation through targeting TP53INP1.","volume":"74","author":"Li","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2019.113139","article-title":"Long non-coding RNA MEG3 promotes cerebral ischemia-reperfusion injury through increasing pyroptosis by targeting miR-485\/AIM2 axis.","volume":"325","author":"Liang","year":"2020","journal-title":"Exp. Neurol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"13169","DOI":"10.1002\/jcp.27987","article-title":"microRNA-665 silencing improves cardiac function in rats with heart failure through activation of the cAMP signaling pathway.","volume":"234","author":"Lin","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118817","article-title":"MicroRNA-1278 ameliorates the inflammation of cardiomyocytes during myocardial ischemia by targeting both IL-22 and CXCL14.","volume":"269","author":"Liu","year":"2021","journal-title":"Life Sci."},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-021-01040-3","article-title":"MircoRNA-29a in Astrocyte-derived Extracellular Vesicles Suppresses Brain Ischemia Reperfusion Injury via TP53INP1 and the NF-kappaB\/NLRP3 Axis.","author":"Liu","year":"2021","journal-title":"Cell. Mol. Neurobiol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"783","DOI":"10.3892\/ijmm.2015.2293","article-title":"Hypoxia promotes vasculogenic mimicry formation by the Twist1-Bmi1 connection in hepatocellular carcinoma.","volume":"36","author":"Liu","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"B86","doi-asserted-by":"publisher","first-page":"2717","DOI":"10.1681\/ASN.2013121329","article-title":"MicroRNA-24 antagonism prevents renal ischemia reperfusion injury.","volume":"25","author":"Lorenzen","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"2601","DOI":"10.1097\/TP.0000000000001411","article-title":"Innate Immune Regulations and Liver Ischemia-Reperfusion Injury.","volume":"100","author":"Lu","year":"2016","journal-title":"Transplantation"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01572","article-title":"The delta-Opioid Receptor Differentially Regulates MAPKs and Anti-inflammatory Cytokines in Rat Kidney Epithelial Cells Under Hypoxia.","volume":"10","author":"Luo","year":"2019","journal-title":"Front. Physiol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"16208","DOI":"10.1074\/jbc.M408055200","article-title":"Oxygen-sensitive {delta}-opioid receptor-regulated survival and death signals: novel insights into neuronal preconditioning and protection.","volume":"280","author":"Ma","year":"2005","journal-title":"J. Biol. Chem."},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-02068-w","article-title":"MicroRNA-210 downregulates TET2 and contributes to inflammatory response in neonatal hypoxic-ischemic brain injury.","volume":"18","author":"Ma","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"B91","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.hjc.2020.10.006","article-title":"MicroRNA-200a represses myocardial infarction-related cell death and inflammation by targeting the Keap1\/Nrf2 and beta-catenin pathways.","volume":"62","author":"Ma","year":"2021","journal-title":"Hellenic J. Cardiol."},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2293","article-title":"MicroRNA-410 serves as a candidate biomarker in hypoxic-ischemic encephalopathy newborns and provides neuroprotection in oxygen-glucose deprivation-injured PC12 and SH-SY5Y cells.","volume":"11","author":"Meng","year":"2021","journal-title":"Brain Behav."},{"key":"B93","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1177\/1753425920928449","article-title":"Inhibition of microRNA-128-3p alleviates liver ischaemia-reperfusion injury in mice through repressing the Rnd3\/NF-kappaB axis.","volume":"26","author":"Mou","year":"2020","journal-title":"Innate Immun."},{"key":"B94","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.freeradbiomed.2013.05.022","article-title":"Hypoxia: a master regulator of microRNA biogenesis and activity.","volume":"64","author":"Nallamshetty","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1007\/s00109-007-0278-y","article-title":"Hypoxia and the HIF system in kidney disease.","volume":"85","author":"Nangaku","year":"2007","journal-title":"J. Mol. Med."},{"key":"B96","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1242\/dmm.013490","article-title":"Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro.","volume":"7","author":"Ng","year":"2014","journal-title":"Dis. Model Mech."},{"key":"B97","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.bbi.2015.04.014","article-title":"MicroRNA let-7c-5p protects against cerebral ischemia injury via mechanisms involving the inhibition of microglia activation.","volume":"49","author":"Ni","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"B98","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1124\/jpet.111.188987","article-title":"delta-Opioid mechanisms for ADL5747 and ADL5859 effects in mice: analgesia, locomotion, and receptor internalization.","volume":"342","author":"Nozaki","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.586362","article-title":"Mir363-3p Treatment Attenuates Long-Term Cognitive Deficits Precipitated by an Ischemic Stroke in Middle-Aged Female Rats.","volume":"12","author":"Panta","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1161\/CIRCULATIONAHA.111.060269","article-title":"MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach.","volume":"125","author":"Parikh","year":"2012","journal-title":"Circulation"},{"key":"B101","doi-asserted-by":"publisher","first-page":"H344","DOI":"10.1152\/ajpheart.01100.2005","article-title":"Protection of adult rat cardiac myocytes from ischemic cell death: role of caveolar microdomains and delta-opioid receptors.","volume":"291","author":"Patel","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.vph.2005.02.003","article-title":"Opioid-induced preconditioning: recent advances and future perspectives.","volume":"42","author":"Peart","year":"2005","journal-title":"Vascul. Pharmacol."},{"key":"B103","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1038\/sj.bjp.0706686","article-title":"Delta opioid receptor ligands modulate anxiety-like behaviors in the rat.","volume":"147","author":"Perrine","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s00424-010-0910-5","article-title":"Invited review: decoding the microRNA response to hypoxia.","volume":"461","author":"Pocock","year":"2011","journal-title":"Pflugers Arch."},{"key":"B105","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1007\/s11357-020-00299-6","article-title":"Exogenous hydrogen sulfide and miR-21 antagonism attenuates macrophage-mediated inflammation in ischemia reperfusion injury of the aged kidney.","volume":"43","author":"Pushpakumar","year":"2021","journal-title":"Geroscience"},{"key":"B106","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1007\/s10753-020-01404-9","article-title":"MiR-708-3p Alleviates Inflammation and Myocardial Injury After Myocardial Infarction by Suppressing ADAM17 Expression.","volume":"44","author":"Qu","year":"2021","journal-title":"Inflammation"},{"key":"B107","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.3892\/mmr.2019.10317","article-title":"MicroRNA217 inhibition relieves cerebral ischemia\/reperfusion injury by targeting SIRT1.","volume":"20","author":"Rao","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.112370","article-title":"GAS5 knockdown ameliorates apoptosis and inflammatory response by modulating miR-26b-5p\/Smad1 axis in cerebral ischaemia\/reperfusion injury.","volume":"379","author":"Shangguan","year":"2020","journal-title":"Behav. Brain Res."},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023011","article-title":"MicroRNA expression data reveals a signature of kidney damage following ischemia reperfusion injury.","volume":"6","author":"Shapiro","year":"2011","journal-title":"PLoS One"},{"key":"B110","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.bbrc.2019.10.182","article-title":"MicroRNA-24-3p alleviates hepatic ischemia and reperfusion injury in mice through the repression of STING signaling.","volume":"522","author":"Shen","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28114","article-title":"MicroRNA-194 overexpression protects against hypoxia\/reperfusion-induced HK-2 cell injury through direct targeting Rheb.","author":"Shen","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2020.146835","article-title":"miR-217-regulated MEF2D-HDAC5\/ND6 signaling pathway participates in the oxidative stress and inflammatory response after cerebral ischemia.","volume":"1739","author":"Shi","year":"2020","journal-title":"Brain Res."},{"key":"B113","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.26355\/eurrev_202002_20198","article-title":"MiR-155-5p accelerates cerebral ischemia-reperfusion injury via targeting DUSP14 by regulating NF-kappaB and MAPKs signaling pathways.","volume":"24","author":"Shi","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B114","doi-asserted-by":"publisher","first-page":"11528","DOI":"10.18632\/aging.202846","article-title":"MicroRNA-532-5p protects against cerebral ischemia-reperfusion injury by directly targeting CXCL1.","volume":"13","author":"Shi","year":"2021","journal-title":"Aging"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.646924","article-title":"Cellular Senescence in Brain Aging.","volume":"13","author":"Sikora","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"B116","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1111\/jvh.12138","article-title":"Studying the association of microRNA-210 level with chronic hepatitis B progression.","volume":"21","author":"Song","year":"2014","journal-title":"J. Viral Hepat."},{"key":"B117","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1159\/000502694","article-title":"Cortical Neuron-Derived Exosomal MicroRNA-181c-3p Inhibits Neuroinflammation by Downregulating CXCL1 in Astrocytes of a Rat Model with Ischemic Brain Injury.","volume":"26","author":"Song","year":"2019","journal-title":"Neuroimmunomodulation"},{"key":"B118","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1007\/s11064-020-02991-7","article-title":"MiR-1202 Exerts Neuroprotective Effects on OGD\/R Induced Inflammation in HM Cell by Negatively Regulating Rab1a Involved in TLR4\/NF-kappaB Signaling Pathway.","volume":"45","author":"Song","year":"2020","journal-title":"Neurochem. Res."},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1341-7","article-title":"The mechanism of miR-142-3p in coronary microembolization-induced myocardiac injury via regulating target gene IRAK-1.","volume":"10","author":"Su","year":"2019","journal-title":"Cell Death Dis."},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2021.115637","article-title":"MicroRNA-30c-5p protects against myocardial ischemia\/reperfusion injury via regulation of Bach1\/Nrf2.","volume":"426","author":"Sun","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.3892\/ijmm.2016.2719","article-title":"Overexpression of miR-200a protects cardiomyocytes against hypoxia-induced apoptosis by modulating the kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 signaling axis.","volume":"38","author":"Sun","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"B122","doi-asserted-by":"publisher","first-page":"15087","DOI":"10.3748\/wjg.v20.i41.15087","article-title":"Hypoxia and fatty liver.","volume":"20","author":"Suzuki","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1177\/0271678X19858637","article-title":"microRNA-367-3p regulation of GPRC5A is suppressed in ischemic stroke.","volume":"40","author":"Tabet","year":"2020","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118162","article-title":"Sevoflurane up-regulates microRNA-204 to ameliorate myocardial ischemia\/reperfusion injury in mice by suppressing Cotl1.","volume":"259","author":"Tan","year":"2020","journal-title":"Life Sci."},{"key":"B125","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1159\/000446336","article-title":"Signaling Crosstalk between Tubular Epithelial Cells and Interstitial Fibroblasts after Kidney Injury.","volume":"2","author":"Tan","year":"2016","journal-title":"Kidney Dis."},{"key":"B126","first-page":"817","article-title":"Structure-activity relationships of a series of [D-Ala2]deltorphin I and II analogues; in vitro blood-brain barrier permeability and stability.","volume":"281","author":"Thomas","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.781174","article-title":"Inflammation Mediated Epileptogenesis as Possible Mechanism Underlying Ischemic Post-stroke Epilepsy.","volume":"13","author":"Troscher","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"B128","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1007\/s11011-021-00724-5","article-title":"MiRNA-34c-5p protects against cerebral ischemia\/reperfusion injury: involvement of anti-apoptotic and anti-inflammatory activities.","volume":"36","author":"Tu","year":"2021","journal-title":"Metab. Brain Dis."},{"key":"B129","doi-asserted-by":"publisher","first-page":"344","DOI":"10.26355\/eurrev_202101_24401","article-title":"Upregulation of miR-335 reduces myocardial injury following myocardial infarction via targeting MAP3K2.","volume":"25","author":"Wang","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431X202010550","article-title":"MicroRNA-369 attenuates hypoxia-induced cardiomyocyte apoptosis and inflammation via targeting TRPV3.","volume":"54","author":"Wang","year":"2021","journal-title":"Braz. J. Med. Biol. Res."},{"key":"B131","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1007\/s10753-021-01443-w","article-title":"MiR-23a Is Involved in Myocardial Ischemia\/Reperfusion Injury by Directly Targeting CX43 and Regulating Mitophagy.","volume":"44","author":"Wang","year":"2021","journal-title":"Inflammation"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119725","article-title":"Anti-inflammatory role and mechanism of microRNA-92b-3p in the progression of hypoxic pulmonary hypertension.","author":"Wang","year":"2021","journal-title":"Life Sci."},{"key":"B133","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/nm.2282","article-title":"miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1.","volume":"17","author":"Wang","year":"2011","journal-title":"Nat. Med."},{"key":"B134","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.ejphar.2011.02.006","article-title":"Delta opioid peptide [D-Ala2, D-Leu5] enkephalin (DADLE) triggers postconditioning against transient forebrain ischemia.","volume":"658","author":"Wang","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.bbrc.2018.09.165","article-title":"MicroRNA-182-5p attenuates cerebral ischemia-reperfusion injury by targeting Toll-like receptor 4.","volume":"505","author":"Wang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-017-0014-7","article-title":"miRNA-3473b contributes to neuroinflammation following cerebral ischemia.","volume":"9","author":"Wang","year":"2018","journal-title":"Cell Death Dis."},{"key":"B137","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1038\/cdd.2014.200","article-title":"miR-361-regulated prohibitin inhibits mitochondrial fission and apoptosis and protects heart from ischemia injury.","volume":"22","author":"Wang","year":"2015","journal-title":"Cell Death Differ."},{"key":"B138","first-page":"2670","article-title":"A crosstalk triggered by hypoxia and maintained by MCP-1\/miR-98\/IL-6\/p38 regulatory loop between human aortic smooth muscle cells and macrophages leads to aortic smooth muscle cells apoptosis via Stat1 activation.","volume":"8","author":"Wang","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7913418","article-title":"MiR-181c-5p Promotes Inflammatory Response during Hypoxia\/Reoxygenation Injury by Downregulating Protein Tyrosine Phosphatase Nonreceptor Type 4 in H9C2 Cardiomyocytes.","volume":"2020","author":"Wang","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B140","doi-asserted-by":"publisher","first-page":"967","DOI":"10.3892\/mmr.2019.10333","article-title":"miR27a suppresses TLR4induced renal ischemiareperfusion injury.","volume":"20","author":"Wang","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6960941","article-title":"Let-7c-5p is involved in chronic kidney disease by targeting TGF-\u03b2 signaling","volume":"2020","author":"Wang","year":"2020","journal-title":"Biomed Res. Int."},{"key":"B142","doi-asserted-by":"publisher","first-page":"3895","DOI":"10.1021\/jm000229p","article-title":"N,N-Diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide: a novel, exceptionally selective, potent delta opioid receptor agonist with oral bioavailability and its analogues.","volume":"43","author":"Wei","year":"2000","journal-title":"J. Med. Chem."},{"key":"B143","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.bbrc.2018.03.161","article-title":"Hypertonic saline regulates microglial M2 polarization via miR-200b\/KLF4 in cerebral edema treatment.","volume":"499","author":"Wen","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B144","doi-asserted-by":"publisher","first-page":"6279","DOI":"10.26355\/eurrev_202006_21526","article-title":"MicroRNA-147 inhibits myocardial inflammation and apoptosis following myocardial infarction via targeting HIPK2.","volume":"24","author":"Wu","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B145","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1159\/000453218","article-title":"MiR-155 is Involved in Renal Ischemia-Reperfusion Injury via Direct Targeting of FoxO3a and Regulating Renal Tubular Cell Pyroptosis.","volume":"40","author":"Wu","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"B146","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1007\/s11064-019-02931-0","article-title":"miR-124-5p\/NOX2 Axis Modulates the ROS Production and the Inflammatory Microenvironment to Protect Against the Cerebral I\/R Injury.","volume":"45","author":"Wu","year":"2020","journal-title":"Neurochem. Res."},{"key":"B147","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-25495-1","author":"Xia","year":"2015","journal-title":"Neural Functions Of The Delta-Opioid Receptor."},{"key":"B148","doi-asserted-by":"publisher","first-page":"C579","DOI":"10.1152\/ajpcell.00001.2020","article-title":"Upregulating microRNA-874-3p inhibits CXCL12 expression to promote angiogenesis and suppress inflammatory response in ischemic stroke.","volume":"319","author":"Xie","year":"2020","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B149","doi-asserted-by":"publisher","first-page":"10235","DOI":"10.18632\/aging.103160","article-title":"miR-195-5p alleviates acute kidney injury through repression of inflammation and oxidative stress by targeting vascular endothelial growth factor A.","volume":"12","author":"Xu","year":"","journal-title":"Aging"},{"key":"B150","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1007\/s10753-020-01214-z","article-title":"Downregulation of lncRNA TUG1 attenuates inflammation and apoptosis of renal tubular epithelial cell induced by ischemia-reperfusion by sponging miR-449b-5p via targeting HMGB1 and MMP2.","volume":"43","author":"Xu","year":"","journal-title":"Inflammation"},{"key":"B151","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1111\/apm.13100","article-title":"USP7, negatively regulated by miR-409-5p, aggravates hypoxia-induced cardiomyocyte injury.","volume":"129","author":"Xue","year":"2021","journal-title":"APMIS"},{"key":"B152","doi-asserted-by":"publisher","first-page":"466","DOI":"10.14336\/AD.2020.0701","article-title":"Microglial Polarization: novel Therapeutic Strategy against Ischemic Stroke.","volume":"12","author":"Xue","year":"2021","journal-title":"Aging Dis."},{"key":"B153","doi-asserted-by":"publisher","first-page":"11752","DOI":"10.26355\/eurrev_202011_23827","article-title":"Inhibition of microRNA-346 inhibits myocardial inflammation and apoptosis after myocardial infarction via targeting NFIB.","volume":"24","author":"Yang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B154","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.2174\/0929867322666150209154755","article-title":"Effects of hypoxia and ischemia on microRNAs in the brain.","volume":"22","author":"Yang","year":"2015","journal-title":"Curr. Med. Chem."},{"key":"B155","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1159\/000493288","article-title":"Down-Regulation of miR-327 Alleviates Ischemia\/Reperfusion-Induced Myocardial Damage by Targeting RP105.","volume":"49","author":"Yang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051524","article-title":"delta-opioid receptor activation and microRNA expression of the rat cortex in hypoxia.","volume":"7","author":"Yang","year":"2012","journal-title":"PLoS One"},{"key":"B157","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1007\/s10753-020-01257-2","article-title":"KCNQ1OT1 Exacerbates Ischemia-Reperfusion Injury Through Targeted Inhibition of miR-140-3P.","volume":"43","author":"Yi","year":"2020","journal-title":"Inflammation"},{"key":"B158","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1002\/hep.24614","article-title":"Hypoxia-inducible microRNA-210 augments the metastatic potential of tumor cells by targeting vacuole membrane protein 1 in hepatocellular carcinoma.","volume":"54","author":"Ying","year":"2011","journal-title":"Hepatology"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.12314","article-title":"miR1405p alleviates mouse liver ischemia\/reperfusion injury by targeting CAPN1.","volume":"24","author":"Yu","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"B160","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1007\/s11064-021-03265-6","article-title":"Long Noncoding RNA SNHG14 Promotes Ischemic Brain Injury via Regulating miR-199b\/AQP4 Axis.","volume":"46","author":"Zhang","year":"2021","journal-title":"Neurochem. Res."},{"key":"B161","doi-asserted-by":"publisher","first-page":"C1225","DOI":"10.1152\/ajpcell.00226.2001","article-title":"Neuroprotective role of delta-opioid receptors in cortical neurons.","volume":"282","author":"Zhang","year":"2002","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B162","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0006-8993(00)02906-1","article-title":"delta-, but not mu- and kappa-, opioid receptor activation protects neocortical neurons from glutamate-induced excitotoxic injury.","volume":"885","author":"Zhang","year":"2000","journal-title":"Brain Res."},{"key":"B163","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1161\/01.STR.0000206444.29930.18","article-title":"Rapid hypoxia preconditioning protects cortical neurons from glutamate toxicity through delta-opioid receptor.","volume":"37","author":"Zhang","year":"2006","journal-title":"Stroke"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6458204","article-title":"miR-155 Knockdown Protects against Cerebral Ischemia and Reperfusion Injury by Targeting MafB.","volume":"2020","author":"Zhang","year":"","journal-title":"Biomed Res. Int."},{"key":"B165","doi-asserted-by":"publisher","first-page":"3683","DOI":"10.2147\/DDDT.S245445","article-title":"LncRNA SNHG4 Attenuates Inflammatory Responses by Sponging miR-449c-5p and Up-Regulating STAT6 in Microglial During Cerebral Ischemia-Reperfusion Injury.","volume":"14","author":"Zhang","year":"","journal-title":"Drug Des. Devel. Ther."},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcp.2020.101653","article-title":"miR-708 affords protective efficacy in anoxia\/reoxygenation-stimulated cardiomyocytes by blocking the TLR4 signaling via targeting HMGB1.","volume":"54","author":"Zhang","year":"","journal-title":"Mol. Cell. Probes"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106650","article-title":"MicroRNA-665-3p attenuates oxygen-glucose deprivation-evoked microglial cell apoptosis and inflammatory response by inhibiting NF-kappaB signaling via targeting TRIM8.","volume":"85","author":"Zhang","year":"","journal-title":"Int. Immunopharmacol."},{"key":"B168","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.ebiom.2018.01.025","article-title":"Ischemia-Reperfusion Injury Reduces Long Term Renal Graft Survival: mechanism and Beyond.","volume":"28","author":"Zhao","year":"2018","journal-title":"EBioMedicine"},{"key":"B169","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1161\/STROKEAHA.111.000504","article-title":"MiRNA-424 protects against permanent focal cerebral ischemia injury in mice involving suppressing microglia activation.","volume":"44","author":"Zhao","year":"2013","journal-title":"Stroke"},{"key":"B170","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1097\/FJC.0000000000000852","article-title":"MiR-7-5p Enhances Cerebral Ischemia-Reperfusion Injury by Degrading sirt1 mRNA.","volume":"76","author":"Zhao","year":"2020","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"B171","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.3892\/ijmm.2018.4043","article-title":"miRNA-20b inhibits cerebral ischemia-induced inflammation through targeting NLRP3.","volume":"43","author":"Zhao","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"B172","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1159\/000493716","article-title":"Role of miR-148a in Mitigating Hepatic Ischemia-Reperfusion Injury by Repressing the TLR4 Signaling Pathway via Targeting CaMKIIalpha in Vivo and in Vitro.","volume":"49","author":"Zheng","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106937","article-title":"microRNA-421-3p prevents inflammatory response in cerebral ischemia\/reperfusion injury through targeting m6A Reader YTHDF1 to inhibit p65 mRNA translation.","volume":"88","author":"Zheng","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"B174","doi-asserted-by":"publisher","first-page":"2296","DOI":"10.1159\/000486067","article-title":"Characteristic MicroRNA Expression Induced by delta-Opioid Receptor Activation in the Rat Liver Under Prolonged Hypoxia.","volume":"44","author":"Zhi","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"B175","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1159\/000447815","article-title":"delta-Opioid Receptor Activation and MicroRNA Expression in the Rat Heart Under Prolonged Hypoxia.","volume":"39","author":"Zhi","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"B176","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1159\/000493042","article-title":"MicroRNA-495 Ameliorates Cardiac Microvascular Endothelial Cell Injury and Inflammatory Reaction by Suppressing the NLRP3 Inflammasome Signaling Pathway.","volume":"49","author":"Zhou","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20170296","article-title":"MiR-138 protects cardiac cells against hypoxia through modulation of glucose metabolism by targetting pyruvate dehydrogenase kinase 1.","volume":"37","author":"Zhu","year":"2017","journal-title":"Biosci. Rep."},{"key":"B178","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1101\/gad.349066.121","article-title":"BMAL1 drives muscle repair through control of hypoxic NAD(+) regeneration in satellite cells.","volume":"36","author":"Zhu","year":"2022","journal-title":"Genes Dev"},{"key":"B179","doi-asserted-by":"publisher","first-page":"11251","DOI":"10.26355\/eurrev_202011_23614","article-title":"Inhibition of microRNA-184 reduces H2O2-mediated cardiomyocyte injury via targeting FBXO28.","volume":"24","author":"Zou","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2022.847374\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T05:45:16Z","timestamp":1652075116000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2022.847374\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,9]]},"references-count":179,"alternative-id":["10.3389\/fnagi.2022.847374"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2022.847374","relation":{},"ISSN":["1663-4365"],"issn-type":[{"type":"electronic","value":"1663-4365"}],"subject":[],"published":{"date-parts":[[2022,5,9]]},"article-number":"847374"}}